- 1. Department of Rehabilitation Medicine and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
- 2. Key Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan 610041, P. R. China;
HE Chengqi,
Email: hxkfhcq2015@126.com
Hypoxia and other factors are related to cognitive impairment. Hyperbaric oxygen therapy can improve tissue oxygen supply to improve brain hypoxia. Based on the basic principle of hyperbaric oxygen therapy, hyperbaric oxygen has been widely used in recent years for cognitive impairment caused by stroke, brain injury, neurodegenerative disease, neuroinflammatory disease and metabolic encephalopathy. This article will review the basic mechanism of hyperbaric oxygen, and summarize and discuss the improvement of hyperbaric oxygen therapy on cognitive and brain diseases, in order to provide relevant reference for clinical treatment.
Citation： REN Ling, HE Chengqi. Research progress of hyperbaric oxygen therapy in improving cognitive impairment. West China Medical Journal, 2023, 38(4): 597-602. doi: 10.7507/1002-0179.202203129 Copy
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- 1. Calvert JW, Cahill J, Zhang JH. Hyperbaric oxygen and cerebral physiology. Neurol Res, 2007, 29(2): 132-141.
- 2. Fu Q, Duan R, Sun Y, et al. Hyperbaric oxygen therapy for healthy aging: from mechanisms to therapeutics. Redox Biol, 2022, 53: 102352.
- 3. 中国医师协会神经内科医师分会脑与脊髓损害专业委员会. CO 中毒迟发性脑病诊断与治疗中国专家共识. 中国神经免疫学和神经病学杂志, 2021, 28(3): 173-179.
- 4. 花芸, 戎天艺, 陈贇, 等. 高压氧与神经变性疾病的相关性. 中国实用神经疾病杂志, 2017, 20(21): 111-113.
- 5. Hadanny A, Rittblat M, Bitterman M, et al. Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients - a retrospective analysis. Restor Neurol Neurosci, 2020, 38(1): 93-107.
- 6. 陈进, 彭智翔, 徐国平, 等. 高压氧治疗对颅脑损伤患者认知功能障碍的影响. 基层医学论坛, 2021, 25(25): 3598-3600.
- 7. 张丽, 卞立, 陈煜, 等. 脑卒中后认知功能障碍的康复评估与治疗进展. 中国康复, 2020, 35(12): 660-663.
- 8. Efrati S, Fishlev G, Bechor Y, et al. Hyperbaric oxygen induces late neuroplasticity in post stroke patients-randomized, prospective trial. PLoS One, 2013, 8(1): e53716.
- 9. Rosario ER, Kaplan SE, Khonsari S, et al. The effect of hyperbaric oxygen therapy on functional impairments caused by ischemic stroke. Neurol Res Int, 2018, 2018: 3172679.
- 10. Marcinkowska AB, Mankowska ND, Kot J, et al. Impact of hyperbaric oxygen therapy on cognitive functions: a systematic review. Neuropsychol Rev, 2022, 32(1): 99-126.
- 11. 史智超, 邱立军, 陈强, 等. 高压氧治疗对急性缺血性脑卒中保护作用机制研究进展. 中国医学物理学杂志, 2018, 35(4): 466-469.
- 12. 于秋红, 郁军超, 吉康祥, 等. 大剂量高压氧对脑梗死大鼠细胞色素 C 及 caspase-3 的影响. 中国康复理论与实践, 2016, 22(5): 540-543.
- 13. Mu J, Ostrowski RP, Soejima Y, et al. Delayed hyperbaric oxygen therapy induces cell proliferation through stabilization of cAMP responsive element binding protein in the rat model of MCAO-induced ischemic brain injury. Neurobiol Dis, 2013, 51: 133-143.
- 14. Zhong X, Shan A, Xu J, et al. Hyperbaric oxygen for severe traumatic brain injury: a randomized trial. J Int Med Res, 2020, 48(10): 300060520939824.
- 15. Chen L, Li F, Gu D. Hyperbaric oxygen therapy for cerebral blood flow and electroencephalogram in patients with acute cerebral infarction: choice for therapeutic occasion. Neural Regen Res, 2007, 2(3): 171-174.
- 16. Yan Y, Zhang X, An X, et al. The application and perspective of hyperbaric oxygen therapy in acute ischemic stroke: from the bench to a starter?. Front Neurol, 2022, 13: 928802.
- 17. 阮俊勇. 急性低压低氧环境下膜法氧气机富氧干预对大鼠认知功能及海马结构的影响. 西安: 空军军医大学, 2019.
- 18. 周惠琴, 陈培峰, 周慧霞, 等. 银杏达莫注射液联合高压氧治疗血管性痴呆的效果及对氧化应激和脑血流动力学的影响. 解放军医药杂志, 2021, 33(3): 108-111.
- 19. 郭大志, 齐亚南, 潘树义. 高压氧对轻度认知障碍的脑白质疏松症患者的疗效和安全性研究. 重庆医学, 2020, 49(16): 2637-2641.
- 20. Helms A, Evans AW, Chu J, et al. Hyperbaric oxygen for neurologic indications-action plan for multicenter trials in: stroke, traumatic brain injury, radiation encephalopathy & status migrainosus. Undersea Hyperb Med, 2011, 38(5): 309-319.
- 21. 徐玉振, 王茜, 单敏, 等. 高压氧治疗对阿尔茨海默病患者认知功能及血清 Humanin 水平的影响. 中华诊断学电子杂志, 2019, 7(2): 83-86.
- 22. 冯宝静, 宋国亮, 张天麟, 等. 头针联合高压氧治疗高血压脑出血临床疗效及对患者脑水肿、认知功能的影响. 河北中医, 2020, 42(2): 264-269.
- 23. 张明明, 籍文强, 张瑛琪, 等. 高压氧联合早期运动治疗一氧化碳中毒迟发性脑病的临床研究. 现代中西医结合杂志, 2021, 30(9): 996-998.
- 24. 秦抗洪. 高压氧联合重复经颅磁刺激对脑小血管病认知损害和抑郁症状的影响. 合肥: 安徽医科大学, 2019.
- 25. Vila JF, Balcarce PE, Abiusi GR, et al. Improvement in motor and cognitive impairment after hyperbaric oxygen therapy in a selected group of patients with cerebrovascular disease: a prospective single-blind controlled trial. Undersea Hyperb Med, 2005, 32(5): 341-349.
- 26. Chen J, Zhang F, Zhao L, et al. Hyperbaric oxygen ameliorates cognitive impairment in patients with Alzheimer’s disease and amnestic mild cognitive impairment. Alzheimers Dement (N Y), 2020, 6(1): e12030.
- 27. Harch PG, Fogarty EF. Hyperbaric oxygen therapy for Alzheimer’s dementia with positron emission tomography imaging: a case report. Med Gas Res, 2019, 8(4): 181-184.
- 28. Xu Y, Wang Q, Qu Z, et al. Protective effect of hyperbaric oxygen therapy on cognitive function in patients with vascular dementia. Cell Transplant, 2019, 28(8): 1071-1075.
- 29. 茹凝玉, 李金声, 王文岚, 等. 高压氧联合凋亡信号调节激酶抑制剂 NQDI-1 对大鼠脑缺血半暗带区神经细胞及血脑屏障通透性的保护作用. 中国急救医学, 2021, 41(4): 347-352.
- 30. 周磊, 应英, 范茂丹, 等. 高压氧治疗对慢性脑缺血大鼠认知功能的影响及其作用机制. 中国卒中杂志, 2020, 15(8): 836-841.
- 31. Shapira R, Gdalyahu A, Gottfried I, et al. Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer’s disease mouse model and in elderly patients. Aging (Albany NY), 2021, 13(17): 20935-20961.
- 32. 刘霄霄, 刘涛, 李隽, 等. 近 3 年有关认知障碍的非药物治疗研究进展. 针灸临床杂志, 2015(6): 94-96.
- 33. 曾金明, 孙利波, 王苗苗, 等. 高压氧治疗对老年认知功能及生活能力的影响. 中国医药指南, 2019, 17(18): 1, 3.
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