Re-recognition of defibrinogen therapy in prevention and management of artery-venous ischemic stroke_West China Medical Journal

Authors：

GU Yaqin ^1,2 ,  DUAN Jiangang ^1,2 , HU Shuyuan ² , JI Xunming ²

1. Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing 100053, P. R. China;
2. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, P. R. China;

Corresponding author：

DUAN Jiangang, Email: duanjiangang@xwhosp.org

Keywords：

Fibrinogen; acute ischemic stroke; transient ischemic attack; venous sinus thrombosis; defibrinogen therapy

DOI：

10.7507/1002-0179.202205045

Video：

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Abstract Full text Figures/Tables Video References Cited by

As a risk factor for vascular diseases and inflammatory diseases, fibrinogen has received more and more attention. Hyperfibrinogenemia is associated with the occurrence, development, and poor outcome of artery-venous ischemic stroke (acute ischemic stroke, transient ischemic attack and cerebral venous thrombosis). Therefore, fibrinogen may be a potential therapeutic target for the prevention and management of artery-venous ischemic stroke. However, there has been controversy regarding the defibrinogen therapy in artery-venous ischemic stroke. Therefore, this paper introduces the efficacy and safety of defibrinogen therapy alone, combined with antiplatelet or combined with anticoagulant in prevention and management of artery-venous ischemic stroke in detail, in order to re-understand the role of defibrinogen therapy in the prevention and management of artery-venous ischemic stroke.

Citation： GU Yaqin, DUAN Jiangang, HU Shuyuan, JI Xunming. Re-recognition of defibrinogen therapy in prevention and management of artery-venous ischemic stroke. West China Medical Journal, 2022, 37(6): 806-812. doi: 10.7507/1002-0179.202205045 Copy

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1. Zhou M, Wang H, Zeng X, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2019, 394(10204): 1145-1158.
2. Wu S, Wu B, Liu M, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol, 2019, 18(4): 394-405.
3. Degan D, Ornello R, Tiseo C, et al. Epidemiology of transient ischemic attacks using time- or tissue-based definitions: a population-based study. Stroke, 2017, 48(3): 530-536.
4. Wang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med, 2013, 369(1): 11-19.
5. Powers WJ, Rabinstein AA, Ackerson T, et al. 2018 guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 2018, 49(3): e46-e110.
6. Long B, Gottlieb M. Antiplatelet agents for preventing early recurrence of ischemic stroke or TIA. Am Fam Physician, 2021, 103(5): online.
7. Wang Y, Meng X, Wang A, et al. Ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA. N Engl J Med, 2021, 385(27): 2520-2530.
8. Devasagayam S, Wyatt B, Leyden J, et al. Cerebral venous sinus thrombosis incidence is higher than previously thought: a retrospective population-based study. Stroke, 2016, 47(9): 2180-2182.
9. Silvis SM, de Sousa DA, Ferro JM, et al. Cerebral venous thrombosis. Nat Rev Neurol, 2017, 13(9): 555-565.
10. Ferro JM, Aguiar de Sousa D. Cerebral venous thrombosis: an update. Curr Neurol Neurosci Rep, 2019, 19(10): 74.
11. Ferro JM, Canhão P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke, 2004, 35(3): 664-670.
12. Qizilbash N. Fibrinogen and cerebrovascular disease. Eur Heart J, 1995, 16(Suppl A): 42-45.
13. Tsuda Y, Satoh K, Kitadai M, et al. Hemorheologic profiles of plasma fibrinogen and blood viscosity from silent to acute and chronic cerebral infarctions. J Neurol Sci, 1997, 147(1): 49-54.
14. Meng R, Wang X, Hussain M, et al. Evaluation of plasma D-dimer plus fibrinogen in predicting acute CVST. Int J Stroke, 2014, 9(2): 166-173.
15. 中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南 2018. 中华神经科杂志, 2018, 51(9): 666-682.
16. Saposnik G, Barinagarrementeria F, Brown RD Jr, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 2011, 42(4): 1158-1192.
17. Fan Y, Yu J, Chen H, et al. Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of cerebral venous sinus thrombosis. Stroke Vasc Neurol, 2020, 5(2): 152-158.
18. Pieters M, Wolberg AS. Fibrinogen and fibrin: an illustrated review. Res Pract Thromb Haemost, 2019, 3(2): 161-172.
19. Di Napoli M, Singh P. Is plasma fibrinogen useful in evaluating ischemic stroke patients? Why, how, and when. Stroke, 2009, 40(5): 1549-1552.
20. Surma S, Banach M. Fibrinogen and atherosclerotic cardiovascular diseases-review of the literature and clinical studies. Int J Mol Sci, 2021, 23(1): 193.
21. Mirshahi F, Vasse M, Vincent L, et al. Fibrinogen: a vascular risk factor, why? Contributing effect of oncostatin M on both fibrinogen biosynthesis by hepatocytes and participation in atherothrombotic risk related to modifications of endothelial cells. Ann N Y Acad Sci, 2001, 936: 621-624.
22. Davalos D, Akassoglou K. Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol, 2012, 34(1): 43-62.
23. Spencer JI, Crane M, Pisa M, et al. Out with the old, in with the new: could plasma exchange be used to fill a therapeutic gap in neurology?. J Neurol Sci, 2022, 432: 120056.
24. Gaule TG, Ajjan RA. Fibrin(ogen) as a therapeutic target: opportunities and challenges. Int J Mol Sci, 2021, 22(13): 6916.
25. Handtke S, Thiele T. Large and small platelets-(when) do they differ?. J Thromb Haemost, 2020, 18(6): 1256-1267.
26. Feng D, Lindpaintner K, Larson MG, et al. Platelet glycoprotein Ⅲa Pl(a) polymorphism, fibrinogen, and platelet aggregability: the Framingham Heart Study. Circulation, 2001, 104(2): 140-144.
27. Gillespie AH, Doctor A. Red blood cell contribution to hemostasis. Front Pediatr, 2021, 9: 629824.
28. Sen U, Tyagi N, Patibandla PK, et al. Fibrinogen-induced endothelin-1 production from endothelial cells. Am J Physiol Cell Physiol, 2009, 296(4): C840-C847.
29. Welin L, Svärdsudd K, Wilhelmsen L, et al. Analysis of risk factors for stroke in a cohort of men born in 1913. N Engl J Med, 1987, 317(9): 521-526.
30. Fibrinogen Studies Collaboration, Danesh J, Lewington S, et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA, 2005, 294(14): 1799-1809.
31. Aono Y, Ohkubo T, Kikuya M, et al. Plasma fibrinogen, ambulatory blood pressure, and silent cerebrovascular lesions: the Ohasama study. Arterioscler Thromb Vasc Biol, 2007, 27(4): 963-968.
32. Green D, Foiles N, Chan C, et al. Elevated fibrinogen levels and subsequent subclinical atherosclerosis: the CARDIA study. Atherosclerosis, 2009, 202(2): 623-631.
33. Rothwell PM, Howard SC, Power DA, et al. Fibrinogen concentration and risk of ischemic stroke and acute coronary events in 5113 patients with transient ischemic attack and minor ischemic stroke. Stroke, 2004, 35(10): 2300-2305.
34. Woodward M, Lowe GD, Campbell DJ, et al. Associations of inflammatory and hemostatic variables with the risk of recurrent stroke. Stroke, 2005, 36(10): 2143-2147.
35. 吴跃华, 林黎明, 刘燕平, 等. 纤维蛋白原、颈动脉粥样硬化斑块与短暂性脑缺血发作后脑梗死相关性. 齐齐哈尔医学院学报, 2018, 39(13): 1527-1529.
36. 高素颖, 冀瑞俊, 颜应琳, 等. 血清同型半胱氨酸、纤维蛋白原、胱抑素 C 水平与急性脑梗死患者 NIHSS 评分的相关性分析. 中国卒中杂志, 2020, 15(4): 389-393.
37. Lee SJ, Hong JM, Lee SE, et al. Association of fibrinogen level with early neurological deterioration among acute ischemic stroke patients with diabetes. BMC Neurol, 2017, 17(1): 101.
38. 朴玉顺, 刘照寒, 靳春风, 等. D-二聚体及纤维蛋白原与进展性缺血性脑卒中的相关性. 中风与神经疾病杂志, 2015, 32(6): 538-540.
39. Swarowska M, Janowska A, Polczak A, et al. The sustained increase of plasma fibrinogen during ischemic stroke predicts worse outcome independently of baseline fibrinogen level. Inflammation, 2014, 37(4): 1142-1147.
40. Rallidis LS, Vikelis M, Panagiotakos DB, et al. Usefulness of inflammatory and haemostatic markers to predict short-term risk for death in middle-aged ischaemic stroke patients. Acta Neurol Scand, 2008, 117(6): 415-420.
41. Turaj W, Słowik A, Dziedzic T, et al. Increased plasma fibrinogen predicts one-year mortality in patients with acute ischemic stroke. J Neurol Sci, 2006, 246(1/2): 13-19.
42. Hou HQ, Xiang XL, Pan YS, et al. Baseline or 90-day fibrinogen levels and long-term outcomes after ischemic stroke or TIA: results from the China national stroke registry Ⅲ. Atherosclerosis, 2021, 337: 35-41.
43. Swarowska M, Polczak A, Pera J, et al. Hyperfibrinogenemia predicts long-term risk of death after ischemic stroke. J Thromb Thrombolysis, 2014, 38(4): 517-521.
44. Shi J, Shi R, Qin W, et al. Dynamic changes in fibrinogen and prognosis of acute ischemic stroke patients treated with intravenous thrombolysis. Neurotox Res, 2020, 38(3): 775-784.
45. Liu Y, Chen H, Zhao K, et al. High levels of plasma fibrinogen are related to post-stroke cognitive impairment. Brain Behav, 2019, 9(10): e01391.
46. 陈清棠. 东菱精纯克栓酶(DF-521)治疗急性脑梗塞的临床研究. 中风与神经疾病杂志, 1996(4): 213-215.
47. 陈清棠, 赵玉宾, 郑亚文, 等. 巴曲酶注射液(东菱迪芙, 即东菱精纯克栓酶)治疗急性脑梗死的临床试验. 中风与神经疾病杂志, 2000, 17(1): 27-30.
48. 庞英, 孙玉衡, 韩仰同, 等. 巴曲酶注射液治疗发病 72h 后急性脑梗死的研究. 中风与神经疾病杂志, 2008, 25(1): 73-75.
49. 黄一宁. 尿激酶和巴曲酶治疗早期急性脑梗死的疗效和安全性研究. 中华老年心脑血管病杂志, 2006, 8(2): 104-107.
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