Research on the awareness and clinical needs of wearable artificial kidney among maintenance hemodialysis patients_West China Medical Journal

Authors：

CHEN Shanshan ¹ , LI Yupei ¹ , YANG Mei ² ,  SU Baihai ^1,3 , ZHAO Changsheng ^3,4,5

1. Department of Nephrology and Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Nephrology, the First People’s Hospital of Shuangliu District, Chengdu, Sichuan 610200, P. R. China;
3. Med-X Center for Materials, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
4. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials and Engineering, Sichuan University, Chengdu, Sichuan 610065, P. R. China;
5. College of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, P. R. China;

Corresponding author：

SU Baihai, Email: subaihai@scu.edu.cn

Keywords：

Maintenance hemodialysis; wearable artificial kidney; investigation

DOI：

10.7507/1002-0179.202205139

Video：

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Objective To investigate the awareness and clinical needs of wearable artificial kidney among maintenance hemodialysis (MHD) patients, and to analyze the related influencing factors. Methods MHD patients were recruited from 2 tertiary hospitals in Sichuan province between April and June 2021. The convenient sampling method was used to select patients. The factors influencing the awareness and demand of MHD patients for wearable artificial kidney were analyzed. Results A total of 119 MHD patients were included. The awareness of wearable artificial kidney among the patients was mainly “never heard” (61 cases) and “heard” (58 cases). Most MHD patients (60 cases) were willing to use and participate in clinical trials in the future. The results of logistic regression indicated that the cost on household economy and treatment effect on life quality were the influencing factors for MHD patients’ awareness of wearable artificial kidney (P＜0.05). The average duration of single dialysis and the impact of treatment on working or studying were the influencing factors for MHD patients’ needs of wearable artificial kidney (P＜0.05). Conclusions The awareness of wearable artificial kidney is low among MHD patients. However, most MHD patients showed great interest in the wearable artificial kidney after preliminary understanding, suggesting that the future clinical application of wearable artificial kidney has great demand.

Citation： CHEN Shanshan, LI Yupei, YANG Mei, SU Baihai, ZHAO Changsheng. Research on the awareness and clinical needs of wearable artificial kidney among maintenance hemodialysis patients. West China Medical Journal, 2023, 38(7): 1034-1041. doi: 10.7507/1002-0179.202205139 Copy

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21.	周煜, 王文秀, 曹晓翼, 等. 维持性血液透析患者自我管理行为及影响因素研究. 华西医学, 2021, 36(8): 1077-1082.
22.	郎晓慧, 白玉贤, 李惠艳, 等. 肿瘤患者对新药临床试验参与意愿影响因素的调查. 哈尔滨医科大学学报, 2019, 53(5): 544-548.
23.	Chu SH, Kim EJ, Jeong SH, et al. Factors associated with willingness to participate in clinical trials: a nationwide survey study. BMC Public Health, 2015, 15: 10.
24.	Comis RL, Miller JD, Aldigé CR, et al. Public attitudes toward participation in cancer clinical trials. J Clin Oncol, 2003, 21(5): 830-835.
25.	徐宜咏, 曹羽明, 李斐, 等. 武汉某医院门诊患者对药物临床试验知晓度分析. 武汉大学学报(医学版), 2016, 37(6): 1023-1026, 1034.

1. Zhang L, Zhao MH, Zuo L, et al. China Kidney Disease Network (CK-NET) 2015 Annual Data Report. Kidney Int Suppl (2011), 2019, 9(1): e1-e81.
2. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis, 2002, 39 (2 Suppl 1): S1-S266.
3. 李菊, 李建兰, 高爱民. 中国终末期肾病患者行维持性血液透析的流行病学现况. 实用临床医药杂志, 2018, 22(21): 160-162.
4. 中国医师协会肾脏病医师分会血液透析充分性协作组. 中国血液透析充分性临床实践指南. 中华医学杂志, 2015, 95(34): 2748-2753.
5. 张晓庆, 张红梅, 常立阳. 维持性血液透析患者症状负担的调查与分析. 中国中西医结合肾病杂志, 2016, 17(9): 818-820.
6. 肖小玉. 血液透析患者日常生活能力现状的调查分析. 临床医学工程, 2013, 20(11): 1451-1452.
7. 翁晓羽, 徐淑娟, 陶明芬, 等. 维持性血液透析患者家庭日常活动状况相关因素分析. 长江大学学报(自然科学版), 2019, 16(6): 98-102.
8. 农生斌, 杨发奋. 维持性血液透析患者生存质量及影响因素的研究进展. 右江医学, 2020, 48(1): 70-75.
9. 陈虹宇. 终末期肾病患者疾病直接经济负担调查研究. 广州: 广州中医药大学, 2010.
10. 田诗音. 我国慢性肾脏病疾病负担与患者生命质量研究. 上海: 中国人民解放军海军军医大学, 2022.
11. 赵伟锋, 孙树东, 赵长生. 聚醚砜血液净化膜的研究进展. 高分子通报, 2017(10): 80-88.
12. 赵长生, 赵伟锋, 张翔, 等. 新型血液净化材料及佩戴式人工肾的研究构想和预期成果展望. 工程科学与技术, 2018, 50(1): 1-8.
13. 刘秀娟, 涂晓文, 黄国明. 可佩戴型人工肾的研究进展. 中国临床医学, 2012, 19(1): 89-90.
14. Gura V, Rivara MB, Bieber S, et al. A wearable artificial kidney for patients with end-stage renal disease. JCI Insight, 2016, 1(8): e86397.
15. Salani M, Roy S, Fissell WH 4th. Innovations in wearable and implantable artificial kidneys. Am J Kidney Dis, 2018, 72(5): 745-751.
16. Castro AC, Neri M, Nayak Karopadi A, et al. Wearable artificial kidney and wearable ultrafiltration device vascular access-future directions. Clin Kidney J, 2018, 12(2): 300-307.
17. Ramada DL, de Vries J, Vollenbroek J, et al. Portable, wearable and implantable artificial kidney systems: needs, opportunities and challenges. Nat Rev Nephrol, 2023: 1-10.
18. 孙振球. 医学统计学. 3 版. 北京: 人民卫生出版社, 2007: 293.
19. 张晓华, 李静, 王利华. 近 5 年维持性血液透析患者的流行病学调查分析. 中国血液净化, 2015, 14(11): 698-702.
20. 吴佳. 维持性血液透析患者家庭动力学改变相关研究. 成都: 成都医学院, 2022.
21. 周煜, 王文秀, 曹晓翼, 等. 维持性血液透析患者自我管理行为及影响因素研究. 华西医学, 2021, 36(8): 1077-1082.
22. 郎晓慧, 白玉贤, 李惠艳, 等. 肿瘤患者对新药临床试验参与意愿影响因素的调查. 哈尔滨医科大学学报, 2019, 53(5): 544-548.
23. Chu SH, Kim EJ, Jeong SH, et al. Factors associated with willingness to participate in clinical trials: a nationwide survey study. BMC Public Health, 2015, 15: 10.
24. Comis RL, Miller JD, Aldigé CR, et al. Public attitudes toward participation in cancer clinical trials. J Clin Oncol, 2003, 21(5): 830-835.
25. 徐宜咏, 曹羽明, 李斐, 等. 武汉某医院门诊患者对药物临床试验知晓度分析. 武汉大学学报(医学版), 2016, 37(6): 1023-1026, 1034.

West China Medical Journal

Research on the awareness and clinical needs of wearable artificial kidney among maintenance hemodialysis patients

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