Research progress on the relationship between benign paroxysmal positional vertigo and osteoporosis_West China Medical Journal

Authors：

YU Libo , REN Jianjun , PANG Wendu ,  ZHAO Yu

Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

ZHAO Yu, Email: yutzhao@vip.163.com

Keywords：

Benign paroxysmal positional vertigo; osteoporosis; relationship

DOI：

10.7507/1002-0179.202206063

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

With the aging of the population, the incidence of benign paroxysmal positional vertigo (BPPV) and osteoporosis have been increasing year by year, and the incidence of BPPV in vertigo related diseases has also been ranked first. There are similarities in structure, formation and metabolic mechanism between bone and otolith, but there is no consistent conclusion on the relationship between BPPV and osteoporosis. This article summarizes the current situation of the research on the correlation between BPPV and osteoporosis, the common risk factors and the related co-occurring mechanisms, aiming to provide more ideas for the prevention and treatment of BPPV patients, and improve the prevention and treatment ability of the co-diseases in the elderly.

Citation： YU Libo, REN Jianjun, PANG Wendu, ZHAO Yu. Research progress on the relationship between benign paroxysmal positional vertigo and osteoporosis. West China Medical Journal, 2023, 38(4): 616-620. doi: 10.7507/1002-0179.202206063 Copy

1.	Kim JS, Zee DS. Clinical practice. Benign paroxysmal positional vertigo. N Engl J Med, 2014, 370(12): 1138-1147.
2.	Hülse R, Biesdorf A, Hörmann K, et al. Peripheral vestibular disorders: an epidemiologic survey in 70 million individuals. Otol Neurotol, 2019, 40(1): 88-95.
3.	Hughes I, Thalmann I, Thalmann R, et al. Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development. Brain Res, 2006, 1091(1): 58-74.
4.	Harada Y, Takumida M. Functional aspects of the vestibular dark cells in the guinea pig: morphological investigation using ruthenium red staining technique. Auris Nasus Larynx, 1990, 17(2): 77-85.
5.	Campos A, Crespo PV, García JM, et al. The crystalline pattern of calcium in different topographical regions of the otoconial membrane. An electron probe and spectroscopic diffraction study. Acta Otolaryngol, 1999, 119(2): 203-206.
6.	Cohen HS, Jerabek J. Efficacy of treatments for posterior canal benign paroxysmal positional vertigo. Laryngoscope, 1999, 109(4): 584-590.
7.	Vibert D, Kompis M, Häusler R. Benign paroxysmal positional vertigo in older women may be related to osteoporosis and osteopenia. Ann Otol Rhinol Laryngol, 2003, 112(10): 885-889.
8.	Yu S, Liu F, Cheng Z, et al. Association between osteoporosis and benign paroxysmal positional vertigo: a systematic review. BMC Neurol, 2014, 14: 110.
9.	He LL, Li XY, Hou MM, et al. Association between bone mineral density and benign paroxysmal positional vertigo: a meta-analysis. Eur Arch Otorhinolaryngol, 2019, 276(6): 1561-1571.
10.	Wang Z, Yao G, Tao X, et al. Evaluation of bone mineral density and 25-(OH) vitamin D levels in middle-aged and elderly women with recurrent benign paroxysmal positional vertigo. Acta Otolaryngol, 2020, 140(2): 89-93.
11.	Kim SY, Kim HJ, Min C, et al. Association between benign paroxysmal positional vertigo and osteoporosis: two nested case-control studies. Osteoporos Int, 2020, 31(10): 2017-2024.
12.	Choi HG, Lee JK, Kong IG, et al. Osteoporosis increases the risk of benign paroxysmal positional vertigo: a nested case-control study using a national sample cohort. Eur Arch Otorhinolaryngol, 2019, 276(2): 335-342.
13.	Byun H, Chung JH, Lee SH, et al. Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study. Sci Rep, 2019, 9(1): 3469.
14.	Wu Y, Gu C, Han W, et al. Reduction of bone mineral density in native Chinese female idiopathic benign paroxysmal positional vertigo patients. Am J Otolaryngol, 2018, 39(1): 31-33.
15.	Lee SB, Lee CH, Kim YJ, et al. Biochemical markers of bone turnover in benign paroxysmal positional vertigo. PLoS One, 2017, 12(5): e0176011.
16.	Kim SY, Han SH, Kim YH, et al. Clinical features of recurrence and osteoporotic changes in benign paroxysmal positional vertigo. Auris Nasus Larynx, 2017, 44(2): 156-161.
17.	Chan KC, Tsai YT, Yang YH, et al. Osteoporosis is associated with increased risk for benign paroxysmal positional vertigo: a nationwide population-based study. Arch Osteoporos, 2017, 12(1): 106.
18.	Yamanaka T, Shirota S, Sawai Y, et al. Osteoporosis as a risk factor for the recurrence of benign paroxysmal positional vertigo. Laryngoscope, 2013, 123(11): 2813-2816.
19.	Karataş A, Acar Yüceant G, Yüce T, et al. Association of benign paroxysmal positional vertigo with osteoporosis and vitamin D deficiency: a case controlled study. J Int Adv Otol, 2017, 13(2): 259-265.
20.	Bruintjes TD, van der Zaag-Loonen HJ, Eggelmeijer F, et al. The prevalence of benign paroxysmal positional vertigo in patients with osteoporosis. Eur Arch Otorhinolaryngol, 2018, 275(12): 3083-3086.
21.	Kwack DW, Lee H, Kim D. Intravenous zoledronic acid in elderly patients with benign paroxysmal positional vertigo and osteoporosis. Res Vet Sci, 2020, 19(3): 95-98.
22.	Talaat HS, Abuhadied G, Talaat AS, et al. Low bone mineral density and vitamin D deficiency in patients with benign positional paroxysmal vertigo. Eur Arch Otorhinolaryngol, 2015, 272(9): 2249-2253.
23.	Melis A, Rizzo D, Gallus R, et al. Relationship between calcium metabolism and benign paroxysmal positional vertigo in north Sardinia population. J Vestib Res, 2020, 30(6): 375-382.
24.	Han SJ, Kim CY, Shim DB, et al. Analysis of risk factors for recurrence of benign paroxysmal positional vertigo: an 11-year nationwide population-based study. Korean J Otorhinolaryngol Head Neck Surg, 2018, 62(1): 15-22.
25.	Kim JM, Cho BH, Lee JK, et al. Clinical characteristics of recurrent benign paroxysmal positional vertigo: a retrospective cohort study. Res Vet Sci, 2021, 20(2): 45-50.
26.	De Stefano A, Dispenza F, Suarez H, et al. A multicenter observational study on the role of comorbidities in the recurrent episodes of benign paroxysmal positional vertigo. Auris Nasus Larynx, 2014, 41(1): 31-36.
27.	González-Aguado R, Domènech-Vadillo E, Álvarez-Morujo de Sande MG, et al. Subjective benign paroxysmal positional vertigo in patients with osteoporosis or migraine. Braz J Otorhinolaryngol, 2020, 86(1): 83-90.
28.	Jiang X, He L, Gai Y, et al. Risk factors for residual dizziness in patients successfully treated for unilateral benign posterior semicircular canal paroxysmal positional vertigo. J Int Med Res, 2020, 48(12): 300060520973093.
29.	Kitahara T, Ota I, Horinaka A, et al. Idiopathic benign paroxysmal positional vertigo with persistent vertigo/dizziness sensation is associated with latent canal paresis, endolymphatic hydrops, and osteoporosis. Auris Nasus Larynx, 2019, 46(1): 27-33.
30.	Mikulec AA, Kowalczyk KA, Pfitzinger ME, et al. Negative association between treated osteoporosis and benign paroxysmal positional vertigo in women. J Laryngol Otol, 2010, 124(4): 374-376.
31.	中华医学会骨质疏松和骨矿盐疾病分会. 原发性骨质疏松症诊疗指南(2017). 中国骨质疏松杂志, 2019, 25(3): 281-309.
32.	Compston J, Cooper A, Cooper C, et al. UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos, 2017, 12(1): 43.
33.	Muelleman T, Shew M, Subbarayan R, et al. Epidemiology of dizzy patient population in a neurotology clinic and predictors of peripheral etiology. Otol Neurotol, 2017, 38(6): 870-875.
34.	Penger M, Strobl R, Grill E. Country-specific and individual determinants of dizziness in Europe: results from the Survey of Health Ageing and Retirement in Europe (SHARE). Public Health, 2017, 149: 1-10.
35.	Neuhauser HK. Epidemiology of vertigo. Curr Opin Neurol, 2007, 20(1): 40-46.
36.	Yang L, Xu Y, Zhang Y, et al. Mechanism underlying the effects of estrogen deficiency on otoconia. J Assoc Res Otolaryngol, 2018, 19(4): 353-362.
37.	von Brevern M, Radtke A, Lezius F, et al. Epidemiology of benign paroxysmal positional vertigo: a population based study. J Neurol Neurosurg Psychiatry, 2007, 78(7): 710-715.
38.	Baloh RW, Honrubia V, Jacobson K. Benign positional vertigo: clinical and oculographic features in 240 cases. Neurology, 1987, 37(3): 371-378.
39.	Marciano E, Marcelli V. Postural restrictions in labyrintholithiasis. Eur Arch Otorhinolaryngol, 2002, 259(5): 262-265.
40.	Andrade LR, Lins U, Farina M, et al. Immunogold TEM of otoconin 90 and otolin - relevance to mineralization of otoconia, and pathogenesis of benign positional vertigo. Hear Res, 2012, 292(1/2): 14-25.
41.	Jang YS, Hwang CH, Shin JY, et al. Age-related changes on the morphology of the otoconia. Laryngoscope, 2006, 116(6): 996-1001.
42.	Grimby A, Rosenhall U. Health-related quality of life and dizziness in old age. Gerontology, 1995, 41(5): 286-298.
43.	Oghalai JS, Manolidis S, Barth JL, et al. Unrecognized benign paroxysmal positional vertigo in elderly patients. Otolaryngol Head Neck Surg, 2000, 122(5): 630-634.
44.	Curtis EM, Moon RJ, Dennison EM, et al. Recent advances in the pathogenesis and treatment of osteoporosis. Clin Med (Lond), 2015, 15(Suppl 6): s92-s96.
45.	Howe TE, Shea B, Dawson LJ, et al. Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev, 2011(7): CD000333.
46.	Shim DB, Kim JH, Park KC, et al. Correlation between the head-lying side during sleep and the affected side by benign paroxysmal positional vertigo involving the posterior or horizontal semicircular canal. Laryngoscope, 2012, 122(4): 873-876.
47.	Lopez-Escámez JA, Gámiz MJ, Fiñana MG, et al. Position in bed is associated with left or right location in benign paroxysmal positional vertigo of the posterior semicircular canal. Am J Otolaryngol, 2002, 23(5): 263-266.
48.	Pollak L, Kushnir M, Goldberg HS. Physical inactivity as a contributing factor for onset of idiopathic benign paroxysmal positional vertigo. Acta Otolaryngol, 2011, 131(6): 624-627.
49.	Weaver CM, Alexander DD, Boushey CJ, et al. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int, 2016, 27(1): 367-376.
50.	Abdelmaksoud AA, Fahim DFM, Bazeed SES, et al. Relation between vitamin D deficiency and benign paroxysmal positional vertigo. Sci Rep, 2021, 11(1): 16855.
51.	Gu X, Dong F, Gu J. Analysis of effect of 1α-hydroxyvitamin D3 on benign paroxysmal positional vertigo and risk factors. Exp Ther Med, 2018, 15(3): 2321-2326.
52.	Büki B, Ecker M, Jünger H, et al. Vitamin D deficiency and benign paroxysmal positioning vertigo. Med Hypotheses, 2013, 80(2): 201-204.
53.	Yamauchi D, Raveendran NN, Pondugula SR, et al. Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal. Biochem Biophys Res Commun, 2005, 331(4): 1353-1357.
54.	Kwon HJ. Vitamin D receptor deficiency impairs inner ear development in zebrafish. Biochem Biophys Res Commun, 2016, 478(2): 994-998.
55.	Paschou SA, Dede AD, Anagnostis PG, et al. Type 2 diabetes and osteoporosis: a guide to optimal management. J Clin Endocrinol Metab, 2017, 102(10): 3621-3634.
56.	Yoda S, Cureoglu S, Yildirim-Baylan M, et al. Association between type 1 diabetes mellitus and deposits in the semicircular canals. Otolaryngol Head Neck Surg, 2011, 145(3): 458-462.
57.	Chen J, Zhang S, Cui K, et al. Risk factors for benign paroxysmal positional vertigo recurrence: a systematic review and meta-analysis. J Neurol, 2021, 268(11): 4117-4127.
58.	Maia CA, Campos CA. Diabetes mellitus as etiological factor of hearing loss. Braz J Otorhinolaryngol, 2005, 71(2): 208-214.
59.	张祎, 刘博, 田晓波, 等. 特发性良性阵发性位置性眩晕患者的骨代谢研究. 临床耳鼻咽喉头颈外科杂志, 2019, 33(3): 237-241.
60.	Wu Y, Fan Z, Jin H, et al. Assessment of bone metabolism in male patients with benign paroxysmal positional vertigo. Front Neurol, 2018, 9: 742.
61.	Vibert D, Sans A, Kompis M, et al. Ultrastructural changes in otoconia of osteoporotic rats. Audiol Neurootol, 2008, 13(5): 293-301.
62.	Lundberg YW, Zhao X, Yamoah EN. Assembly of the otoconia complex to the macular sensory epithelium of the vestibule. Brain Res, 2006, 1091(1): 47-57.
63.	Lins U, Farina M, Kurc M, et al. The otoconia of the guinea pig utricle: internal structure, surface exposure, and interactions with the filament matrix. J Struct Biol, 2000, 131(1): 67-78.
64.	Yang H, Zhao X, Xu Y, et al. Matrix recruitment and calcium sequestration for spatial specific otoconia development. PLoS One, 2011, 6(5): e20498.
65.	Uno Y, Horii A, Umemoto M, et al. Effects of hypergravity on morphology and osteopontin expression in the rat otolith organs. J Vestib Res, 2000, 10(6): 283-289.
66.	Takemura T, Sakagami M, Nakase T, et al. Localization of osteopontin in the otoconial organs of adult rats. Hear Res, 1994, 79(1/2): 99-104.
67.	Xu Y, Zhang H, Yang H, et al. Expression, functional, and structural analysis of proteins critical for otoconia development. Dev Dyn, 2010, 239(10): 2659-2673.
68.	Zhao X, Jones SM, Thoreson WB, et al. Osteopontin is not critical for otoconia formation or balance function. J Assoc Res Otolaryngol, 2008, 9(2): 191-201.
69.	Okamura H, Yoshida K, Yang D, et al. Protein phosphatase 2A Cα regulates osteoblast differentiation and the expressions of bone sialoprotein and osteocalcin via osterix transcription factor. J Cell Physiol, 2013, 228(5): 1031-1037.
70.	Guo T, Xing Y, Zhu H, et al. Relationship between osteoporosis and benign paroxysmal positional vertigo based on evidence-based medicine and bioinformatics. Arch Osteoporos, 2021, 16(1): 173.

1. Kim JS, Zee DS. Clinical practice. Benign paroxysmal positional vertigo. N Engl J Med, 2014, 370(12): 1138-1147.
2. Hülse R, Biesdorf A, Hörmann K, et al. Peripheral vestibular disorders: an epidemiologic survey in 70 million individuals. Otol Neurotol, 2019, 40(1): 88-95.
3. Hughes I, Thalmann I, Thalmann R, et al. Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development. Brain Res, 2006, 1091(1): 58-74.
4. Harada Y, Takumida M. Functional aspects of the vestibular dark cells in the guinea pig: morphological investigation using ruthenium red staining technique. Auris Nasus Larynx, 1990, 17(2): 77-85.
5. Campos A, Crespo PV, García JM, et al. The crystalline pattern of calcium in different topographical regions of the otoconial membrane. An electron probe and spectroscopic diffraction study. Acta Otolaryngol, 1999, 119(2): 203-206.
6. Cohen HS, Jerabek J. Efficacy of treatments for posterior canal benign paroxysmal positional vertigo. Laryngoscope, 1999, 109(4): 584-590.
7. Vibert D, Kompis M, Häusler R. Benign paroxysmal positional vertigo in older women may be related to osteoporosis and osteopenia. Ann Otol Rhinol Laryngol, 2003, 112(10): 885-889.
8. Yu S, Liu F, Cheng Z, et al. Association between osteoporosis and benign paroxysmal positional vertigo: a systematic review. BMC Neurol, 2014, 14: 110.
9. He LL, Li XY, Hou MM, et al. Association between bone mineral density and benign paroxysmal positional vertigo: a meta-analysis. Eur Arch Otorhinolaryngol, 2019, 276(6): 1561-1571.
10. Wang Z, Yao G, Tao X, et al. Evaluation of bone mineral density and 25-(OH) vitamin D levels in middle-aged and elderly women with recurrent benign paroxysmal positional vertigo. Acta Otolaryngol, 2020, 140(2): 89-93.
11. Kim SY, Kim HJ, Min C, et al. Association between benign paroxysmal positional vertigo and osteoporosis: two nested case-control studies. Osteoporos Int, 2020, 31(10): 2017-2024.
12. Choi HG, Lee JK, Kong IG, et al. Osteoporosis increases the risk of benign paroxysmal positional vertigo: a nested case-control study using a national sample cohort. Eur Arch Otorhinolaryngol, 2019, 276(2): 335-342.
13. Byun H, Chung JH, Lee SH, et al. Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study. Sci Rep, 2019, 9(1): 3469.
14. Wu Y, Gu C, Han W, et al. Reduction of bone mineral density in native Chinese female idiopathic benign paroxysmal positional vertigo patients. Am J Otolaryngol, 2018, 39(1): 31-33.
15. Lee SB, Lee CH, Kim YJ, et al. Biochemical markers of bone turnover in benign paroxysmal positional vertigo. PLoS One, 2017, 12(5): e0176011.
16. Kim SY, Han SH, Kim YH, et al. Clinical features of recurrence and osteoporotic changes in benign paroxysmal positional vertigo. Auris Nasus Larynx, 2017, 44(2): 156-161.
17. Chan KC, Tsai YT, Yang YH, et al. Osteoporosis is associated with increased risk for benign paroxysmal positional vertigo: a nationwide population-based study. Arch Osteoporos, 2017, 12(1): 106.
18. Yamanaka T, Shirota S, Sawai Y, et al. Osteoporosis as a risk factor for the recurrence of benign paroxysmal positional vertigo. Laryngoscope, 2013, 123(11): 2813-2816.
19. Karataş A, Acar Yüceant G, Yüce T, et al. Association of benign paroxysmal positional vertigo with osteoporosis and vitamin D deficiency: a case controlled study. J Int Adv Otol, 2017, 13(2): 259-265.
20. Bruintjes TD, van der Zaag-Loonen HJ, Eggelmeijer F, et al. The prevalence of benign paroxysmal positional vertigo in patients with osteoporosis. Eur Arch Otorhinolaryngol, 2018, 275(12): 3083-3086.
21. Kwack DW, Lee H, Kim D. Intravenous zoledronic acid in elderly patients with benign paroxysmal positional vertigo and osteoporosis. Res Vet Sci, 2020, 19(3): 95-98.
22. Talaat HS, Abuhadied G, Talaat AS, et al. Low bone mineral density and vitamin D deficiency in patients with benign positional paroxysmal vertigo. Eur Arch Otorhinolaryngol, 2015, 272(9): 2249-2253.
23. Melis A, Rizzo D, Gallus R, et al. Relationship between calcium metabolism and benign paroxysmal positional vertigo in north Sardinia population. J Vestib Res, 2020, 30(6): 375-382.
24. Han SJ, Kim CY, Shim DB, et al. Analysis of risk factors for recurrence of benign paroxysmal positional vertigo: an 11-year nationwide population-based study. Korean J Otorhinolaryngol Head Neck Surg, 2018, 62(1): 15-22.
25. Kim JM, Cho BH, Lee JK, et al. Clinical characteristics of recurrent benign paroxysmal positional vertigo: a retrospective cohort study. Res Vet Sci, 2021, 20(2): 45-50.
26. De Stefano A, Dispenza F, Suarez H, et al. A multicenter observational study on the role of comorbidities in the recurrent episodes of benign paroxysmal positional vertigo. Auris Nasus Larynx, 2014, 41(1): 31-36.
27. González-Aguado R, Domènech-Vadillo E, Álvarez-Morujo de Sande MG, et al. Subjective benign paroxysmal positional vertigo in patients with osteoporosis or migraine. Braz J Otorhinolaryngol, 2020, 86(1): 83-90.
28. Jiang X, He L, Gai Y, et al. Risk factors for residual dizziness in patients successfully treated for unilateral benign posterior semicircular canal paroxysmal positional vertigo. J Int Med Res, 2020, 48(12): 300060520973093.
29. Kitahara T, Ota I, Horinaka A, et al. Idiopathic benign paroxysmal positional vertigo with persistent vertigo/dizziness sensation is associated with latent canal paresis, endolymphatic hydrops, and osteoporosis. Auris Nasus Larynx, 2019, 46(1): 27-33.
30. Mikulec AA, Kowalczyk KA, Pfitzinger ME, et al. Negative association between treated osteoporosis and benign paroxysmal positional vertigo in women. J Laryngol Otol, 2010, 124(4): 374-376.
31. 中华医学会骨质疏松和骨矿盐疾病分会. 原发性骨质疏松症诊疗指南(2017). 中国骨质疏松杂志, 2019, 25(3): 281-309.
32. Compston J, Cooper A, Cooper C, et al. UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos, 2017, 12(1): 43.
33. Muelleman T, Shew M, Subbarayan R, et al. Epidemiology of dizzy patient population in a neurotology clinic and predictors of peripheral etiology. Otol Neurotol, 2017, 38(6): 870-875.
34. Penger M, Strobl R, Grill E. Country-specific and individual determinants of dizziness in Europe: results from the Survey of Health Ageing and Retirement in Europe (SHARE). Public Health, 2017, 149: 1-10.
35. Neuhauser HK. Epidemiology of vertigo. Curr Opin Neurol, 2007, 20(1): 40-46.
36. Yang L, Xu Y, Zhang Y, et al. Mechanism underlying the effects of estrogen deficiency on otoconia. J Assoc Res Otolaryngol, 2018, 19(4): 353-362.
37. von Brevern M, Radtke A, Lezius F, et al. Epidemiology of benign paroxysmal positional vertigo: a population based study. J Neurol Neurosurg Psychiatry, 2007, 78(7): 710-715.
38. Baloh RW, Honrubia V, Jacobson K. Benign positional vertigo: clinical and oculographic features in 240 cases. Neurology, 1987, 37(3): 371-378.
39. Marciano E, Marcelli V. Postural restrictions in labyrintholithiasis. Eur Arch Otorhinolaryngol, 2002, 259(5): 262-265.
40. Andrade LR, Lins U, Farina M, et al. Immunogold TEM of otoconin 90 and otolin - relevance to mineralization of otoconia, and pathogenesis of benign positional vertigo. Hear Res, 2012, 292(1/2): 14-25.
41. Jang YS, Hwang CH, Shin JY, et al. Age-related changes on the morphology of the otoconia. Laryngoscope, 2006, 116(6): 996-1001.
42. Grimby A, Rosenhall U. Health-related quality of life and dizziness in old age. Gerontology, 1995, 41(5): 286-298.
43. Oghalai JS, Manolidis S, Barth JL, et al. Unrecognized benign paroxysmal positional vertigo in elderly patients. Otolaryngol Head Neck Surg, 2000, 122(5): 630-634.
44. Curtis EM, Moon RJ, Dennison EM, et al. Recent advances in the pathogenesis and treatment of osteoporosis. Clin Med (Lond), 2015, 15(Suppl 6): s92-s96.
45. Howe TE, Shea B, Dawson LJ, et al. Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev, 2011(7): CD000333.
46. Shim DB, Kim JH, Park KC, et al. Correlation between the head-lying side during sleep and the affected side by benign paroxysmal positional vertigo involving the posterior or horizontal semicircular canal. Laryngoscope, 2012, 122(4): 873-876.
47. Lopez-Escámez JA, Gámiz MJ, Fiñana MG, et al. Position in bed is associated with left or right location in benign paroxysmal positional vertigo of the posterior semicircular canal. Am J Otolaryngol, 2002, 23(5): 263-266.
48. Pollak L, Kushnir M, Goldberg HS. Physical inactivity as a contributing factor for onset of idiopathic benign paroxysmal positional vertigo. Acta Otolaryngol, 2011, 131(6): 624-627.
49. Weaver CM, Alexander DD, Boushey CJ, et al. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int, 2016, 27(1): 367-376.
50. Abdelmaksoud AA, Fahim DFM, Bazeed SES, et al. Relation between vitamin D deficiency and benign paroxysmal positional vertigo. Sci Rep, 2021, 11(1): 16855.
51. Gu X, Dong F, Gu J. Analysis of effect of 1α-hydroxyvitamin D3 on benign paroxysmal positional vertigo and risk factors. Exp Ther Med, 2018, 15(3): 2321-2326.
52. Büki B, Ecker M, Jünger H, et al. Vitamin D deficiency and benign paroxysmal positioning vertigo. Med Hypotheses, 2013, 80(2): 201-204.
53. Yamauchi D, Raveendran NN, Pondugula SR, et al. Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal. Biochem Biophys Res Commun, 2005, 331(4): 1353-1357.
54. Kwon HJ. Vitamin D receptor deficiency impairs inner ear development in zebrafish. Biochem Biophys Res Commun, 2016, 478(2): 994-998.
55. Paschou SA, Dede AD, Anagnostis PG, et al. Type 2 diabetes and osteoporosis: a guide to optimal management. J Clin Endocrinol Metab, 2017, 102(10): 3621-3634.
56. Yoda S, Cureoglu S, Yildirim-Baylan M, et al. Association between type 1 diabetes mellitus and deposits in the semicircular canals. Otolaryngol Head Neck Surg, 2011, 145(3): 458-462.
57. Chen J, Zhang S, Cui K, et al. Risk factors for benign paroxysmal positional vertigo recurrence: a systematic review and meta-analysis. J Neurol, 2021, 268(11): 4117-4127.
58. Maia CA, Campos CA. Diabetes mellitus as etiological factor of hearing loss. Braz J Otorhinolaryngol, 2005, 71(2): 208-214.
59. 张祎, 刘博, 田晓波, 等. 特发性良性阵发性位置性眩晕患者的骨代谢研究. 临床耳鼻咽喉头颈外科杂志, 2019, 33(3): 237-241.
60. Wu Y, Fan Z, Jin H, et al. Assessment of bone metabolism in male patients with benign paroxysmal positional vertigo. Front Neurol, 2018, 9: 742.
61. Vibert D, Sans A, Kompis M, et al. Ultrastructural changes in otoconia of osteoporotic rats. Audiol Neurootol, 2008, 13(5): 293-301.
62. Lundberg YW, Zhao X, Yamoah EN. Assembly of the otoconia complex to the macular sensory epithelium of the vestibule. Brain Res, 2006, 1091(1): 47-57.
63. Lins U, Farina M, Kurc M, et al. The otoconia of the guinea pig utricle: internal structure, surface exposure, and interactions with the filament matrix. J Struct Biol, 2000, 131(1): 67-78.
64. Yang H, Zhao X, Xu Y, et al. Matrix recruitment and calcium sequestration for spatial specific otoconia development. PLoS One, 2011, 6(5): e20498.
65. Uno Y, Horii A, Umemoto M, et al. Effects of hypergravity on morphology and osteopontin expression in the rat otolith organs. J Vestib Res, 2000, 10(6): 283-289.
66. Takemura T, Sakagami M, Nakase T, et al. Localization of osteopontin in the otoconial organs of adult rats. Hear Res, 1994, 79(1/2): 99-104.
67. Xu Y, Zhang H, Yang H, et al. Expression, functional, and structural analysis of proteins critical for otoconia development. Dev Dyn, 2010, 239(10): 2659-2673.
68. Zhao X, Jones SM, Thoreson WB, et al. Osteopontin is not critical for otoconia formation or balance function. J Assoc Res Otolaryngol, 2008, 9(2): 191-201.
69. Okamura H, Yoshida K, Yang D, et al. Protein phosphatase 2A Cα regulates osteoblast differentiation and the expressions of bone sialoprotein and osteocalcin via osterix transcription factor. J Cell Physiol, 2013, 228(5): 1031-1037.
70. Guo T, Xing Y, Zhu H, et al. Relationship between osteoporosis and benign paroxysmal positional vertigo based on evidence-based medicine and bioinformatics. Arch Osteoporos, 2021, 16(1): 173.

West China Medical Journal

Research progress on the relationship between benign paroxysmal positional vertigo and osteoporosis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content