Research progress of microRNA in intervertebral disc degeneration_West China Medical Journal

Authors：

WANG Juehan , ZHU Ce , HUANG Yong , DING Hong , WU Ruibang , HUANG Leizhen , CHEN Qian , FENG Ganjun ,  LIU Limin , SONG Yueming

Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

LIU Limin, Email: liulimin_spine@163.com

Keywords：

Intervertebral disc degeneration; microRNA; molecular mechanism

DOI：

10.7507/1002-0179.202207140

Video：

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Abstract Full text Figures/Tables Video References Cited by

Intervertebral disc degeneration is a multifactorial pathological process which is one of the leading causes of disability worldwide. The main pathological changes of intervertebral disc degeneration are the degradation of extracellular matrix, apoptosis, autophagy, senescence and inflammation. Dysregulation of microRNAs has been implicated in various pathologies, including various degenerative diseases such as disc degeneration. This article reviews the research status of microRNA in degenerative disc pathology, with emphasis on the biological mechanisms and potential therapeutic prospects of microRNA in extracellular matrix degradation, apoptosis, inflammation, and cartilage endplate degeneration.

Citation： WANG Juehan, ZHU Ce, HUANG Yong, DING Hong, WU Ruibang, HUANG Leizhen, CHEN Qian, FENG Ganjun, LIU Limin, SONG Yueming. Research progress of microRNA in intervertebral disc degeneration. West China Medical Journal, 2022, 37(10): 1554-1564. doi: 10.7507/1002-0179.202207140 Copy

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2. Pinho AR, Pereira PA, Leite MJ, et al. The surgical vascular anatomy of the lower lumbar arteries and its implications in minimally invasive spine surgery: a cadaveric study. Int J Spine Surg, 2022, 16(4): 631-637.
3. Boubriak OA, Watson N, Sivan SS, et al. Factors regulating viable cell density in the intervertebral disc: blood supply in relation to disc height. J Anat, 2013, 222(3): 341-348.
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6. David G, Ciurea AV, Iencean SM, et al. Angiogenesis in the degeneration of the lumbar intervertebral disc. J Med Life, 2010, 3(2): 154-161.
7. Vergroesen PP, Kingma I, Emanuel KS, et al. Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthritis Cartilage, 2015, 23(7): 1057-1070.
8. McCann MR, Patel P, Pest MA, et al. Repeated exposure to high-frequency low-amplitude vibration induces degeneration of murine intervertebral discs and knee joints. Arthritis Rheumatol, 2015, 67(8): 2164-2175.
9. Hangai M, Kaneoka K, Hinotsu S, et al. Lumbar intervertebral disk degeneration in athletes. Am J Sports Med, 2009, 37(1): 149-155.
10. Battié MC, Videman T, Parent E. Lumbar disc degeneration: epidemiology and genetic influences. Spine (Phila Pa 1976), 2004, 29(23): 2679-2690.
11. Yang L, Gao Q, Lv F, et al. miR-519d-3p promotes TGFβ/Smad mediated postoperative epidural scar formation via suppression of Bambi. Mol Med Rep, 2019, 20(4): 3901-3909.
12. Chen H, Wang J, Hu B, et al. MiR-34a promotes Fas-mediated cartilage endplate chondrocyte apoptosis by targeting Bcl-2. Mol Cell Biochem, 2015, 406(1/2): 21-30.
13. Wang X, Lv G, Li J, et al. LncRNA-RP11-296A18.3/miR-138/HIF1A pathway regulates the proliferation ECM synthesis of human nucleus pulposus cells (HNPCs). J Cell Biochem, 2017, 118(12): 4862-4871.
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17. Su Q, Kumar V, Sud N, et al. MicroRNAs in the pathogenesis and treatment of progressive liver injury in NAFLD and liver fibrosis. Adv Drug Deliv Rev, 2018, 129: 54-63.
18. Afify AY. A miRNA’s insight into the regenerating heart: a concise descriptive analysis. Heart Fail Rev, 2020, 25(6): 1047-1061.
19. Saliminejad K, Khorshid HR, Fard SS, et al. An overview of microRNAs: biology, functions, therapeutics, and analysis methods. J Cell Physiol, 2019, 234(5): 5451-5465.
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