Correlation analysis of cervical Modic changes with blood lipid and glucose levels_West China Medical Journal

Authors：

ZHOU Qingsong ^1,2 , WANG Shengtao ¹ , CAI Jieyong ¹ ,  DENG Wei ¹ ,  YIN Yong ¹

1. Department of Orthopedics, Pidu District People’s Hospital, the Third Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 611730, P. R. China;
2. Department of Orthopedics, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;

Corresponding author：

DENG Wei, Email: 9388532@qq.com; YIN Yong, Email: piduyinyong@163.com

Keywords：

Cervical Modic changes; blood lipid; blood sugar

DOI：

10.7507/1002-0179.202207160

Video：

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Objective To investigate the correlation between cervical Modic change (MC) and blood lipid and glucose levels. Methods Patients hospitalized with neck and shoulder pain in the Affiliated Hospital of North Sichuan Medical College between January 2015 and January 2021 were selected and divided into MC group and non-MC group according to whether the signal changes of cervical vertebral endplate occurred on MRI. The general data (age, gender, smoking history, drinking history), blood lipid indicators (high-density lipoprotein, low-density lipoprotein, lipoprotein a, total cholesterol, triglyceride) and blood glucose indicators (glycosylated hemoglobin, fasting blood glucose) were compared between the two groups. Multivariate logistic regression analysis was used to explore the correlation between MC and various indicators. Results A total of 160 patients were included, including 48 patients in MC group and 112 patients in non-MC group. The age [(61.46±12.10) vs. (56.22±10.65) years], total cholesterol [(5.06±1.17) vs. (4.44±1.31) mmol/L], triglyceride [(1.61±0.64) vs. (1.38±0.58) mmol/L], glycosylated hemoglobin (6.78%±1.27% vs. 5.79%±0.85%), and fasting blood glucose [(7.84±1.51) vs. (6.93±1.47) mmol/L] of the patients in MC group were significantly higher than those in non-MC group (P<0.05). There was no significant difference in gender, smoking ratio, drinking ratio, high-density lipoprotein, low-density lipoprotein or lipoprotein a between the two groups (P>0.05). Logistic regression analysisshowed that age [odds ratio (OR)=1.064, 95% confidence interval (CI) (1.022, 1.109), P=0.003], total cholesterol [OR=1.788, 95%CI (1.187, 2.694), P=0.005], triglyceride [OR=2.624, 95%CI (1.257, 5.479), P=0.010] and glycosylated hemoglobin [OR=4.942, 95%CI (2.446, 9.987), P<0.001] were risk factors of cervical MC. Conclusions Age, total cholesterol, triglyceride and glycosylated hemoglobin are risk factors of cervical MC. Elderly patients with hyperlipidemia and hyperglycemia should be alert to the occurrence of cervical MC. Controlling the levels of blood lipid and glucose may reduce the risk of cervical MC.

Citation： ZHOU Qingsong, WANG Shengtao, CAI Jieyong, DENG Wei, YIN Yong. Correlation analysis of cervical Modic changes with blood lipid and glucose levels. West China Medical Journal, 2022, 37(10): 1503-1506. doi: 10.7507/1002-0179.202207160 Copy

1.	Yang X, Karis DSA, Vleggeert-Lankamp CLA. Association between Modic changes, disc degeneration, and neck pain in the cervical spine: a systematic review of literature. Spine J, 2020, 20(5): 754-764.
2.	Song J, Wang HL, Ma XS, et al. The value of radiographic indexes in the diagnosis of discogenic low back pain: a retrospective analysis of imaging results. Oncotarget, 2017, 8(36): 60558-60567.
3.	Din RU, Cheng X, Yang H. Diagnostic role of magnetic resonance imaging in low back pain caused by vertebral endplate degeneration. J Magn Reson Imaging, 2022, 55(3): 755-771.
4.	Modic MT, Steinberg PM, Ross JS, et al. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology, 1988, 166(1): 193-199.
5.	Mostofi K, Moghaddam BG, Peyravi M. Late appearance of low back pain relating to Modic change after lumbar discectomy. J Craniovertebr Junction Spine, 2018, 9(2): 93-95.
6.	Guo R, Yang X, Zhong Y, et al. Correlations between Modic change and degeneration in 3-joint complex of the lower lumbar spine: a retrospective study. Medicine (Baltimore), 2018, 97(38): e12496.
7.	Leung A, Amaram V, Natarajan R. Linking diabetic vascular complications with LncRNAs. Vascul Pharmacol, 2019, 114: 139-144.
8.	杨海源, 张帆, 许灏铖, 等. 颈椎 Modic 改变研究进展. 中国脊柱脊髓杂志, 2021, 31(9): 856-859.
9.	An Y, Li J, Li Y, et al. Characteristics of Modic changes in cervical kyphosis and their association with axial neck pain. J Pain Res, 2017, 10: 1657-1661.
10.	Kressig M, Peterson CK, McChurch K, et al. Relationship of Modic changes, disk herniation morphology, and axial location to outcomes in symptomatic cervical disk herniation patients treated with high-velocity, low-amplitude spinal manipulation: a prospective study. J Manipulative Physiol Ther, 2016, 39(8): 565-575.
11.	Zhou J, Li L, Li T, et al. Preoperative Modic changes are related to axial symptoms after anterior cervical discectomy and fusion. J Pain Res, 2018, 11: 2617-2623.
12.	Tsuji T, Fujiwara H, Nishiwaki Y, et al. Modic changes in the cervical spine: prospective 20-year follow-up study in asymptomatic subjects. J Orthop Sci, 2019, 24(4): 612-617.
13.	Peters SAE, MacMahon S, Woodward M. Obesity as a risk factor for COVID-19 mortality in women and men in the UK biobank: comparisons with influenza/pneumonia and coronary heart disease. Diabetes Obes Metab, 2021, 23(1): 258-262.
14.	赵水平. 严格管理好血脂, 从源头防治动脉粥样硬化性心血管疾病. 中华心血管病杂志, 2021, 49(6): 545-547.
15.	Hotamisligil GS. Inflammation, metaflammation and immunometabolic disorders. Nature, 2017, 542(7640): 177-185.
16.	Blaser H, Dostert C, Mak TW, et al. TNF and ROS crosstalk in inflammation. Trends Cell Biol, 2016, 26(4): 249-261.
17.	Wu Y, Li X, Tan F, et al. Lactobacillus fermentum CQPC07 attenuates obesity, inflammation and dyslipidemia by modulating the antioxidant capacity and lipid metabolism in high-fat diet induced obese mice. J Inflamm (Lond), 2021, 18(1): 5.
18.	Corral-Fernández NE, Salgado-Bustamante M, Martínez-Leija ME, et al. Dysregulated miR-155 expression in peripheral blood mononuclear cells from patients with type 2 diabetes. Exp Clin Endocrinol Diabetes, 2013, 121(6): 347-353.
19.	Zhang L, He S, Guo S, et al. Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1. J Diabetes Complications, 2014, 28(3): 259-264.
20.	Assar ME, Angulo J, Rodríguez-Mañas L. Diabetes and ageing-induced vascular inflammation. J Physiol, 2016, 594(8): 2125-2146.
21.	Wang C, Ye D, Xie Z, et al. Assessment of cardiovascular risk factors and their interactions in the risk of coronary heart disease in patients with type 2 diabetes with different weight levels, 2013-2018. Diabetes Metab Syndr Obes, 2021, 14: 4253-4262.
22.	LeRoith D, Biessels GJ, Braithwaite SS, et al. Treatment of diabetes in older adults: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 2019, 104(5): 1520-1574.
23.	Rysz J, Franczyk B, Rysz-Górzyńska M, et al. Ageing, age-related cardiovascular risk and the beneficial role of natural components intake. Int J Mol Sci, 2021, 23(1): 183.
24.	Sinclair A, Dunning T, Rodriguez-Mañas L. Diabetes in older people: new insights and remaining challenges. Lancet Diabetes Endocrinol, 2015, 3(4): 275-285.

1. Yang X, Karis DSA, Vleggeert-Lankamp CLA. Association between Modic changes, disc degeneration, and neck pain in the cervical spine: a systematic review of literature. Spine J, 2020, 20(5): 754-764.
2. Song J, Wang HL, Ma XS, et al. The value of radiographic indexes in the diagnosis of discogenic low back pain: a retrospective analysis of imaging results. Oncotarget, 2017, 8(36): 60558-60567.
3. Din RU, Cheng X, Yang H. Diagnostic role of magnetic resonance imaging in low back pain caused by vertebral endplate degeneration. J Magn Reson Imaging, 2022, 55(3): 755-771.
4. Modic MT, Steinberg PM, Ross JS, et al. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology, 1988, 166(1): 193-199.
5. Mostofi K, Moghaddam BG, Peyravi M. Late appearance of low back pain relating to Modic change after lumbar discectomy. J Craniovertebr Junction Spine, 2018, 9(2): 93-95.
6. Guo R, Yang X, Zhong Y, et al. Correlations between Modic change and degeneration in 3-joint complex of the lower lumbar spine: a retrospective study. Medicine (Baltimore), 2018, 97(38): e12496.
7. Leung A, Amaram V, Natarajan R. Linking diabetic vascular complications with LncRNAs. Vascul Pharmacol, 2019, 114: 139-144.
8. 杨海源, 张帆, 许灏铖, 等. 颈椎 Modic 改变研究进展. 中国脊柱脊髓杂志, 2021, 31(9): 856-859.
9. An Y, Li J, Li Y, et al. Characteristics of Modic changes in cervical kyphosis and their association with axial neck pain. J Pain Res, 2017, 10: 1657-1661.
10. Kressig M, Peterson CK, McChurch K, et al. Relationship of Modic changes, disk herniation morphology, and axial location to outcomes in symptomatic cervical disk herniation patients treated with high-velocity, low-amplitude spinal manipulation: a prospective study. J Manipulative Physiol Ther, 2016, 39(8): 565-575.
11. Zhou J, Li L, Li T, et al. Preoperative Modic changes are related to axial symptoms after anterior cervical discectomy and fusion. J Pain Res, 2018, 11: 2617-2623.
12. Tsuji T, Fujiwara H, Nishiwaki Y, et al. Modic changes in the cervical spine: prospective 20-year follow-up study in asymptomatic subjects. J Orthop Sci, 2019, 24(4): 612-617.
13. Peters SAE, MacMahon S, Woodward M. Obesity as a risk factor for COVID-19 mortality in women and men in the UK biobank: comparisons with influenza/pneumonia and coronary heart disease. Diabetes Obes Metab, 2021, 23(1): 258-262.
14. 赵水平. 严格管理好血脂, 从源头防治动脉粥样硬化性心血管疾病. 中华心血管病杂志, 2021, 49(6): 545-547.
15. Hotamisligil GS. Inflammation, metaflammation and immunometabolic disorders. Nature, 2017, 542(7640): 177-185.
16. Blaser H, Dostert C, Mak TW, et al. TNF and ROS crosstalk in inflammation. Trends Cell Biol, 2016, 26(4): 249-261.
17. Wu Y, Li X, Tan F, et al. Lactobacillus fermentum CQPC07 attenuates obesity, inflammation and dyslipidemia by modulating the antioxidant capacity and lipid metabolism in high-fat diet induced obese mice. J Inflamm (Lond), 2021, 18(1): 5.
18. Corral-Fernández NE, Salgado-Bustamante M, Martínez-Leija ME, et al. Dysregulated miR-155 expression in peripheral blood mononuclear cells from patients with type 2 diabetes. Exp Clin Endocrinol Diabetes, 2013, 121(6): 347-353.
19. Zhang L, He S, Guo S, et al. Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1. J Diabetes Complications, 2014, 28(3): 259-264.
20. Assar ME, Angulo J, Rodríguez-Mañas L. Diabetes and ageing-induced vascular inflammation. J Physiol, 2016, 594(8): 2125-2146.
21. Wang C, Ye D, Xie Z, et al. Assessment of cardiovascular risk factors and their interactions in the risk of coronary heart disease in patients with type 2 diabetes with different weight levels, 2013-2018. Diabetes Metab Syndr Obes, 2021, 14: 4253-4262.
22. LeRoith D, Biessels GJ, Braithwaite SS, et al. Treatment of diabetes in older adults: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 2019, 104(5): 1520-1574.
23. Rysz J, Franczyk B, Rysz-Górzyńska M, et al. Ageing, age-related cardiovascular risk and the beneficial role of natural components intake. Int J Mol Sci, 2021, 23(1): 183.
24. Sinclair A, Dunning T, Rodriguez-Mañas L. Diabetes in older people: new insights and remaining challenges. Lancet Diabetes Endocrinol, 2015, 3(4): 275-285.

West China Medical Journal

Correlation analysis of cervical Modic changes with blood lipid and glucose levels

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