Research progress of miR-92a and target genes_West China Medical Journal

Authors：

GAO Ziping ¹ ,  LIANG Weidong ² , CHEN Hu ¹ , SI Yingli ³ , YANG Bo ¹

1. Department of Cardiothoracic Surgery, the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P. R. China;
2. General Surgery Department, the second People’s Hospital of Pengzhou, Pengzhou, Sichuan 611934, P. R. China;
3. School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan 610500, P. R. China;

Corresponding author：

LIANG Weidong, Email: 53701944@qq.com

Keywords：

Target gene; microRNA-92a; clinical diagnosis and treatment; target

DOI：

10.7507/1002-0179.202208158

Video：

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MicroRNA-92a (miR-92a) is an evolutionarily highly conserved pathogenic microRNA that is a member of the microRNA-17-92 gene cluster and is involved in the regulation of biological activities such as cell proliferation, apoptosis and differentiation. Recent studies have revealed that disorders of miR-92a expression are associated with disease development and exert pathogenic effects mainly through the regulation of target genes or target proteins. The current research related to miR-92a is mainly focused on malignant tumors, and its high expression has been found to be associated with cancer cell malignancy and reduced sensitivity of tumors to radiotherapy. miR-92a targeting target genes or target proteins to cause disease and its relationship with radiotherapy has been a hot research topic in recent years. Based on this, This article reviews the latest research on miR-92a target gene or target protein pathogenesis and its impact on chemotherapy in order to provide targets for clinical disease treatment.

Citation： GAO Ziping, LIANG Weidong, CHEN Hu, SI Yingli, YANG Bo. Research progress of miR-92a and target genes. West China Medical Journal, 2023, 38(6): 930-937. doi: 10.7507/1002-0179.202208158 Copy

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2. Alcantara KMM, Garcia RL. MicroRNA-92a promotes cell proliferation, migration and survival by directly targeting the tumor suppressor gene NF2 in colorectal and lung cancer cells. Oncol Rep, 2019, 41(4): 2103-2116.
3. Lu F, Ye Y, Zhang H, et al. miR-497/Wnt3a/c-jun feedback loop regulates growth and epithelial-to-mesenchymal transition phenotype in glioma cells. Int J Biol Macromol, 2018, 120 (Pt A): 985-991.
4. Sun D, Mu Y, Piao H. MicroRNA-153-3p enhances cell radiosensitivity by targeting BCL2 in human glioma. Biol Res, 2018, 51(1): 56.
5. Xu Y, Liu R, Liao C, et al. High expression of immunity-related GTPase family M protein in glioma promotes cell proliferation and autophagy protein expression. Pathol Res Pract, 2019, 215(1): 90-96.
6. Zhang H, Cao H, Xu D, et al. MicroRNA-92a promotes metastasis of nasopharyngeal carcinoma by targeting the PTEN/AKT pathway. Onco Targets Ther, 2016, 9: 3579-3588.
7. 龙彩云. miR-92a-2-5p/PRKCA/β-catenin 在 ETU 诱导的肛门直肠畸形胎鼠中作用的研究. 辽宁: 中国医科大学, 2019.
8. 胡爱妮, 王豫萍, 路毅斌, 等. miR-92a 靶向 PTEN/PI3K/Akt 通路抑制非小细胞肺癌细胞的自噬. 第三军医大学学报, 2020, 42(13): 1301-1307.
9. 李利发. MiR-92a 通过激活 Wnt/β-catenin 信号通路促进结直肠癌干细胞样特性. 南充: 川北医学院, 2017.
10. Yang C, Pan Y. Fluoroururacil induces autophagy-related gastric carcinoma cell death through Beclin-1 upregulation by miR-30 suppression. Tumour Biol, 2016, 37: 15489-15494.
11. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell, 2009, 136(2): 215-233.
12. Ren P, Gong F, Zhang Y, et al. MicroRNA-92a promotes growth, metastasis, and chemoresistance in non-small cell lung cancer cells by targeting PTEN. Tumour Biol, 2016, 37(3): 3215-3225.
13. 王生. miR-21、miR-31、miR-92a 及 Let-7 对非小细胞肺癌的诊断价值及机制研究. 郑州: 郑州大学, 2018.
14. Li X, Guo S, Min L, et al. miR-92a-3p promotes the proliferation, migration and invasion of esophageal squamous cell cancer by regulating PTEN. Int J Mol Med, 2019, 44(3): 973-981.
15. 刘宇, 胡庆, 敖晶晶, 等. 微小 RNA-92a-3p 靶向 PTEN 调控胰腺癌细胞增殖和转移. 中南大学学报(医学版), 2020, 45(3): 280-289.
16. Bai Y, Wang YL, Yao WJ, et al. Expression of miR-32 in human non-small cell lung cancer and its correlation with tumor progression and patient survival. Int J Clin Exp Pathol, 2015, 8(1): 824-829.
17. He Z, Liao Z, Chen S, et al. Downregulated miR-17, miR-29c, miR-92a and miR-214 may be related to BCL11B overexpression in T cell acute lymphoblastic leukemia. Asia Pac J Clin Oncol, 2018, 14(5): e259-e265.
18. Wang Y, Tian Y, Li Z, et al. miR-92 regulates the proliferation, migration, invasion and apoptosis of glioma cells by targeting neogenin. Open Med (Wars), 2020, 15: 283-291.
19. Liao C, Chen W, Wang J. MicroRNA-20a regulates glioma cell proliferation, invasion, and apoptosis by targeting CUGBP elav-like family member 2. World Neurosurg, 2019, 121: e519-e527.
20. Li J, Li Q, Lin L, et al. Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT). BMC Neurol, 2018, 18(1): 133.
21. Li P, Xue WJ, Feng Y, et al. MicroRNA-205 functions as a tumor suppressor in colorectal cancer by targeting cAMP responsive element binding protein 1 (CREB1). Am J Transl Res, 2015, 7(10): 2053-2059.
22. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 1993, 75(5): 843-854.
23. Li M, Guan X, Sun Y, et al. miR-92a family and their target genes in tumorigenesis and metastasis. Exp Cell Res, 2014, 323(1): 1-6.
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