Intervention effect of music therapy on children with autism spectrum disorder: a meta-analysis_West China Medical Journal

Authors：

WANG Wei , WANG Qi ,  YU Qinming

School of Humanities and Management, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P. R. China;

Corresponding author：

YU Qinming, Email: 4773615@qq.com

Keywords：

Music therapy; autism spectrum disorder; children; meta-analysis

DOI：

10.7507/1002-0179.202210209

Video：

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Objective To explore the intervention effect of music therapy on children with autism spectrum disorder. Methods The China National Knowledge Infrastructure, Wanfang, Chongqing VIP, PubMed, Embase, Cochrane Library were searched by computer to comprehensively collect randomized controlled trials on the intervention effect of music therapy on children with autism spectrum disorder. The search period was from the establishment of the database to December 31, 2022. RevMan 5.4 software was used for meta-analysis. Results Finally, 20 articles were included, including 913 cases in the music therapy group and 811 cases in the control group, with a total sample size of 1724 cases. The meta-analysis results showed that the overall treatment effect [standardized mean difference (SMD)=−0.95, 95% confidence interval (CI) (−1.12, −0.78)], the treatment effect of language [SMD=−0.71, 95%CI (−0.84, −0.57)], behavior [SMD=−0.65, 95%CI (−0.78, −0.52)], social interaction [SMD=−0.52, 95%CI (−0.63, −0.40)], cognition [SMD=1.37, 95%CI (1.00, 1.74)] and sensory perception [SMD=−0.89, 95%CI (−1.03, −0.74)] of the music therapy group were better than those of the control group (P<0.05). Conclusion The existing data show that music therapy applied to children with autism spectrum disorder can effectively improve their language, behavior, social interaction, cognition, and sensory perception, thereby having a positive impact on the overall treatment effect of children. However, due to the limitations of the number and quality of included studies, more high-quality studies are needed to verify.

Citation： WANG Wei, WANG Qi, YU Qinming. Intervention effect of music therapy on children with autism spectrum disorder: a meta-analysis. West China Medical Journal, 2023, 38(7): 1065-1072. doi: 10.7507/1002-0179.202210209 Copy

1.	Amonkar N, Su WC, Bhat AN, et al. Effects of creative movement therapies on social communication, behavioral-affective, sensorimotor, cognitive, and functional participation skills of individuals with autism spectrum disorder: a systematic review. Front Psychiatry, 2021, 12: 722874.
2.	Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators, Centers for Disease Control and Prevention (CDC). Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveill Summ, 2014, 63(2): 1-21.
3.	Roman-Urrestarazu A, van Kessel R, Allison C, et al. Association of race/ethnicity and social disadvantage with autism prevalence in 7 million school children in England. JAMA Pediatr, 2021, 175(6): e210054.
4.	许洁霜, 梁霁, 诸臻颖. 上海市儿童孤独症康复机构现状研究. 中国妇幼健康研究, 2016, 27(10): 1221-1224.
5.	寇聪, 柯晓殷, 张英, 等. 孤独症流行病学和病因学探讨. 国际精神病学杂志, 2015, 42(2): 132-135.
6.	丁一芸, 卫利, 王素梅. 自闭症中西医研究进展及中医研究思路浅析. 世界中医药, 2014(6): 820-823.
7.	陈蕾, 陶洪梅, 李红, 等. 音乐治疗干预自闭症儿童临床效果的实证研究. 重庆医学, 2010, 39(18): 2481-2482, 2485.
8.	宋黎喆雄, 李晓宇, 仇雅岚, 等. 音乐疗法在身心疾病中的应用. 中华中医药杂志, 2019, 34(9): 4186-4189.
9.	Kim J, Wigram T, Gold C. Emotional, motivational and interpersonal responsiveness of children with autism in improvisational music therapy. Autism, 2009, 13(4): 389-409.
10.	Finnigan E, Starr E. Increasing social responsiveness in a child with autism. A comparison of music and non-music interventions. Autism, 2010, 14(4): 321-348.
11.	Katagiri J. The effect of background music and song texts on the emotional understanding of children with autism. J Music Ther, 2009, 46(1): 15-31.
12.	陈毅克, 王月, 陈翠蓉, 等. 音乐疗法及构音训练对自闭症儿童言语功能及自闭症评定量表评分的影响. 安徽医药, 2022, 26(1): 61-65.
13.	Hampton LH, Stern Y, Roberts M. Meta-analysis suggests early intervention for infants and toddlers at risk for autism may be effective for improving developmental outcomes. Evid Based Commun Assess Interv, 2018, 12(4): 1-3.
14.	Sharma SR, Gonda X, Tarazi FI. Autism spectrum disorder: classification, diagnosis and therapy. Pharmacol Ther, 2018, 190: 91-104.
15.	廖娟, 叶晓婉, 曹栋, 等. 中国传统音乐疗法对肿瘤相关抑郁状态的影响—系统评价和荟萃分析. 世界科学技术-中医药现代化, 2023, 25(1): 331-340.
16.	Bieleninik L, Geretsegger M, Mössler K, et al. Effects of improvisational music therapy vs enhanced standard care on symptom severity among children with autism spectrum disorder: the TIME-A randomized clinical trial. JAMA, 2017, 318(6): 525-535.
17.	何迎霜, 刘桂华, 张钰红, 等. 亲子合作式音乐疗法对孤独症谱系障碍儿童及其母亲影响的前瞻性随机对照研究. 中国当代儿科杂志, 2022, 24(5): 472-481.
18.	周凡. 自闭症儿童康复中音乐治疗的临床应用分析. 名医, 2019(11): 71.
19.	周宇航. 音乐疗法联合语言训练对孤独症患儿语言功能康复的影响. 中国疗养医学, 2018, 27(11): 1157-1159.
20.	张海燕, 史雅宁, 李凯. 音乐疗法联合系统康复训练对自闭症患儿病情控制及社交沟通能力的影响. 中国实用医刊, 2022, 49(22): 66-69.
21.	曹彩红. 音乐疗法结合语言训练对孤独症儿童语言康复的效果. 中国保健营养, 2019, 29(10): 335.
22.	李倩, 高超. 音乐疗法在儿童孤独症康复治疗中的应用效果观察. 中国民康医学, 2018, 30(14): 69-70.
23.	李潘红. 音乐护理在自闭症儿童护理中的应用. 河南医学研究, 2020, 29(3): 549-551.
24.	段奕. 音乐疗法与语言训练联合应用于孤独症的效果研究. 实用中西医结合临床, 2019, 19(11): 45-46.
25.	牛源. 音乐治疗在自闭症儿童康复中的应用价值体会. 北方音乐, 2019(16): 248-249.
26.	王献娜, 李华钰, 骆维维. 音乐治疗在孤独症谱系障碍儿童康复训练中的应用研究. 中国妇幼健康研究, 2017(增刊 2): 2.
27.	田利媛. 音乐干预疗法对自闭症患儿语言障碍的康复效果分析. 临床研究, 2018, 26(9): 108-109.
28.	聂曼蒂, 李霞. 音乐疗法对儿童孤独症康复训练的影响. 中国继续医学教育, 2017, 9(19): 192-193.
29.	胡世园, 吴佳妮, 张尹佳. 语言认知训练联合音乐疗法对儿童孤独症患者语言表达、理解能力的改善效果. 现代实用医学, 2021, 33(6): 802-804.
30.	赵永红, 闻春波, 戚亚敏, 等. 组内音乐疗法治疗自闭症患儿临床观察. 实用中医内科杂志, 2020, 34(8): 23-26.
31.	陈云静, 牛帅杨, 宋燕燕, 等. 音乐疗法联合语言认知训练治疗儿童孤独症的疗效观察. 中外女性健康研究, 2019(23): 86, 97.
32.	陈雅燕, 曾丽玉, 张义王. 可视音乐训练孤独症谱系障碍患儿的效果. 中国民康医学, 2022, 34(1): 58-60.
33.	随广红. 音乐治疗对儿童孤独症的疗效研究. 天津: 天津医科大学, 2017.
34.	饶艳君. 音乐疗法在自闭症儿童护理干预中的应用. 妇幼护理, 2022, 2(2): 397-399, 403.
35.	黄零一. 音乐治疗在自闭症儿童康复中的应用. 中国继续医学教育, 2015(18): 153-154.
36.	王悦, 雷晓梅, 杨媛媛, 等. 音乐疗法对孤独症谱系障碍患儿干预效果的 Meta 分析. 中国儿童保健杂志, 2019, 27(1): 66-72.
37.	刘加柱, 王诗雨, 余光武. 语言与音乐关系认知神经研究述评. 解放军外国语学院学报, 2022, 45(6): 58-65.
38.	Patel AD. Language, music, syntax and the brain. Nat Neurosci, 2003, 6(7): 674-681.
39.	Sandiford GA, Mainess KJ, Daher NS. A pilot study on the efficacy of melodic based communication therapy for eliciting speech in nonverbal children with autism. J Autism Dev Disord, 2013, 43(6): 1298-1307.
40.	Choi YK. The effect of music and progressive muscle relaxation on anxiety, fatigue, and quality of life in family caregivers of hospice patients. J Music Ther, 2010, 47(1): 53-69.
41.	American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-IV-TR). United States: American Psychiatric Association, 2000.
42.	LaGasse AB. Social outcomes in children with autism spectrum disorder: a review of music therapy outcomes. Patient Relat Outcome Meas, 2017, 8: 23-32.
43.	郝小路, 周娜, 刘安国, 等. 音乐疗法干预轻度认知障碍机制的研究进展. 中外医学研究, 2023, 21(13): 171-175.
44.	Maseda A, Cibeira N, Lorenzo-López L, et al. Multisensory stimulation and individualized music sessions on older adults with severe dementia: effects on mood, behavior, and biomedical parameters. J Alzheimers Dis, 2018, 63(4): 1415-1425.
45.	章艳, 黄雪花. 第三版 PEP-3 孤独症评估量表在 ASD 患儿早期筛查及疗效评价价值. 四川医学, 2021, 42(2): 149-152.
46.	Standley JM. A meta-analysis on the effects of music as reinforcement for education/therapy objectives. J Res Music Educ. 1996, 44(2): 28.
47.	齐巍. 国内外音乐疗法对自闭症患者干预效果的元分析研究. 长春: 吉林大学, 2011.
48.	Geretsegger M, Elefant C, Mössler KA, et al. Music therapy for people with autism spectrum disorder. Cochrane Database Syst Rev, 2014, 2014(6): CD004381.
49.	石志敏, 林桂红, 谢清. 音乐疗法对自闭症患儿情绪、语言、行为、社交能力影响的 Meta 分析. 护理研究, 2016(8): 922-926.
50.	Mayer-Benarous H, Benarous X, Vonthron F, et al. Music therapy for children with autistic spectrum disorder and/or other neurodevelopmental disorders: a systematic review. Front Psychiatry, 2021, 12: 643234.
51.	Gassner L, Geretsegger M, Mayer-Ferbas J. Effectiveness of music therapy for autism spectrum disorder, dementia, depression, insomnia and schizophrenia: update of systematic reviews. Eur J Public Health, 2022, 32(1): 27-34.
52.	Ke X, Song W, Yang M, et al. Effectiveness of music therapy in children with autism spectrum disorder: a systematic review and meta-analysis. Front Psychiatry, 2022, 13: 905113.

1. Amonkar N, Su WC, Bhat AN, et al. Effects of creative movement therapies on social communication, behavioral-affective, sensorimotor, cognitive, and functional participation skills of individuals with autism spectrum disorder: a systematic review. Front Psychiatry, 2021, 12: 722874.
2. Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators, Centers for Disease Control and Prevention (CDC). Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveill Summ, 2014, 63(2): 1-21.
3. Roman-Urrestarazu A, van Kessel R, Allison C, et al. Association of race/ethnicity and social disadvantage with autism prevalence in 7 million school children in England. JAMA Pediatr, 2021, 175(6): e210054.
4. 许洁霜, 梁霁, 诸臻颖. 上海市儿童孤独症康复机构现状研究. 中国妇幼健康研究, 2016, 27(10): 1221-1224.
5. 寇聪, 柯晓殷, 张英, 等. 孤独症流行病学和病因学探讨. 国际精神病学杂志, 2015, 42(2): 132-135.
6. 丁一芸, 卫利, 王素梅. 自闭症中西医研究进展及中医研究思路浅析. 世界中医药, 2014(6): 820-823.
7. 陈蕾, 陶洪梅, 李红, 等. 音乐治疗干预自闭症儿童临床效果的实证研究. 重庆医学, 2010, 39(18): 2481-2482, 2485.
8. 宋黎喆雄, 李晓宇, 仇雅岚, 等. 音乐疗法在身心疾病中的应用. 中华中医药杂志, 2019, 34(9): 4186-4189.
9. Kim J, Wigram T, Gold C. Emotional, motivational and interpersonal responsiveness of children with autism in improvisational music therapy. Autism, 2009, 13(4): 389-409.
10. Finnigan E, Starr E. Increasing social responsiveness in a child with autism. A comparison of music and non-music interventions. Autism, 2010, 14(4): 321-348.
11. Katagiri J. The effect of background music and song texts on the emotional understanding of children with autism. J Music Ther, 2009, 46(1): 15-31.
12. 陈毅克, 王月, 陈翠蓉, 等. 音乐疗法及构音训练对自闭症儿童言语功能及自闭症评定量表评分的影响. 安徽医药, 2022, 26(1): 61-65.
13. Hampton LH, Stern Y, Roberts M. Meta-analysis suggests early intervention for infants and toddlers at risk for autism may be effective for improving developmental outcomes. Evid Based Commun Assess Interv, 2018, 12(4): 1-3.
14. Sharma SR, Gonda X, Tarazi FI. Autism spectrum disorder: classification, diagnosis and therapy. Pharmacol Ther, 2018, 190: 91-104.
15. 廖娟, 叶晓婉, 曹栋, 等. 中国传统音乐疗法对肿瘤相关抑郁状态的影响—系统评价和荟萃分析. 世界科学技术-中医药现代化, 2023, 25(1): 331-340.
16. Bieleninik L, Geretsegger M, Mössler K, et al. Effects of improvisational music therapy vs enhanced standard care on symptom severity among children with autism spectrum disorder: the TIME-A randomized clinical trial. JAMA, 2017, 318(6): 525-535.
17. 何迎霜, 刘桂华, 张钰红, 等. 亲子合作式音乐疗法对孤独症谱系障碍儿童及其母亲影响的前瞻性随机对照研究. 中国当代儿科杂志, 2022, 24(5): 472-481.
18. 周凡. 自闭症儿童康复中音乐治疗的临床应用分析. 名医, 2019(11): 71.
19. 周宇航. 音乐疗法联合语言训练对孤独症患儿语言功能康复的影响. 中国疗养医学, 2018, 27(11): 1157-1159.
20. 张海燕, 史雅宁, 李凯. 音乐疗法联合系统康复训练对自闭症患儿病情控制及社交沟通能力的影响. 中国实用医刊, 2022, 49(22): 66-69.
21. 曹彩红. 音乐疗法结合语言训练对孤独症儿童语言康复的效果. 中国保健营养, 2019, 29(10): 335.
22. 李倩, 高超. 音乐疗法在儿童孤独症康复治疗中的应用效果观察. 中国民康医学, 2018, 30(14): 69-70.
23. 李潘红. 音乐护理在自闭症儿童护理中的应用. 河南医学研究, 2020, 29(3): 549-551.
24. 段奕. 音乐疗法与语言训练联合应用于孤独症的效果研究. 实用中西医结合临床, 2019, 19(11): 45-46.
25. 牛源. 音乐治疗在自闭症儿童康复中的应用价值体会. 北方音乐, 2019(16): 248-249.
26. 王献娜, 李华钰, 骆维维. 音乐治疗在孤独症谱系障碍儿童康复训练中的应用研究. 中国妇幼健康研究, 2017(增刊 2): 2.
27. 田利媛. 音乐干预疗法对自闭症患儿语言障碍的康复效果分析. 临床研究, 2018, 26(9): 108-109.
28. 聂曼蒂, 李霞. 音乐疗法对儿童孤独症康复训练的影响. 中国继续医学教育, 2017, 9(19): 192-193.
29. 胡世园, 吴佳妮, 张尹佳. 语言认知训练联合音乐疗法对儿童孤独症患者语言表达、理解能力的改善效果. 现代实用医学, 2021, 33(6): 802-804.
30. 赵永红, 闻春波, 戚亚敏, 等. 组内音乐疗法治疗自闭症患儿临床观察. 实用中医内科杂志, 2020, 34(8): 23-26.
31. 陈云静, 牛帅杨, 宋燕燕, 等. 音乐疗法联合语言认知训练治疗儿童孤独症的疗效观察. 中外女性健康研究, 2019(23): 86, 97.
32. 陈雅燕, 曾丽玉, 张义王. 可视音乐训练孤独症谱系障碍患儿的效果. 中国民康医学, 2022, 34(1): 58-60.
33. 随广红. 音乐治疗对儿童孤独症的疗效研究. 天津: 天津医科大学, 2017.
34. 饶艳君. 音乐疗法在自闭症儿童护理干预中的应用. 妇幼护理, 2022, 2(2): 397-399, 403.
35. 黄零一. 音乐治疗在自闭症儿童康复中的应用. 中国继续医学教育, 2015(18): 153-154.
36. 王悦, 雷晓梅, 杨媛媛, 等. 音乐疗法对孤独症谱系障碍患儿干预效果的 Meta 分析. 中国儿童保健杂志, 2019, 27(1): 66-72.
37. 刘加柱, 王诗雨, 余光武. 语言与音乐关系认知神经研究述评. 解放军外国语学院学报, 2022, 45(6): 58-65.
38. Patel AD. Language, music, syntax and the brain. Nat Neurosci, 2003, 6(7): 674-681.
39. Sandiford GA, Mainess KJ, Daher NS. A pilot study on the efficacy of melodic based communication therapy for eliciting speech in nonverbal children with autism. J Autism Dev Disord, 2013, 43(6): 1298-1307.
40. Choi YK. The effect of music and progressive muscle relaxation on anxiety, fatigue, and quality of life in family caregivers of hospice patients. J Music Ther, 2010, 47(1): 53-69.
41. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-IV-TR). United States: American Psychiatric Association, 2000.
42. LaGasse AB. Social outcomes in children with autism spectrum disorder: a review of music therapy outcomes. Patient Relat Outcome Meas, 2017, 8: 23-32.
43. 郝小路, 周娜, 刘安国, 等. 音乐疗法干预轻度认知障碍机制的研究进展. 中外医学研究, 2023, 21(13): 171-175.
44. Maseda A, Cibeira N, Lorenzo-López L, et al. Multisensory stimulation and individualized music sessions on older adults with severe dementia: effects on mood, behavior, and biomedical parameters. J Alzheimers Dis, 2018, 63(4): 1415-1425.
45. 章艳, 黄雪花. 第三版 PEP-3 孤独症评估量表在 ASD 患儿早期筛查及疗效评价价值. 四川医学, 2021, 42(2): 149-152.
46. Standley JM. A meta-analysis on the effects of music as reinforcement for education/therapy objectives. J Res Music Educ. 1996, 44(2): 28.
47. 齐巍. 国内外音乐疗法对自闭症患者干预效果的元分析研究. 长春: 吉林大学, 2011.
48. Geretsegger M, Elefant C, Mössler KA, et al. Music therapy for people with autism spectrum disorder. Cochrane Database Syst Rev, 2014, 2014(6): CD004381.
49. 石志敏, 林桂红, 谢清. 音乐疗法对自闭症患儿情绪、语言、行为、社交能力影响的 Meta 分析. 护理研究, 2016(8): 922-926.
50. Mayer-Benarous H, Benarous X, Vonthron F, et al. Music therapy for children with autistic spectrum disorder and/or other neurodevelopmental disorders: a systematic review. Front Psychiatry, 2021, 12: 643234.
51. Gassner L, Geretsegger M, Mayer-Ferbas J. Effectiveness of music therapy for autism spectrum disorder, dementia, depression, insomnia and schizophrenia: update of systematic reviews. Eur J Public Health, 2022, 32(1): 27-34.
52. Ke X, Song W, Yang M, et al. Effectiveness of music therapy in children with autism spectrum disorder: a systematic review and meta-analysis. Front Psychiatry, 2022, 13: 905113.

West China Medical Journal

Intervention effect of music therapy on children with autism spectrum disorder: a meta-analysis

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