Value of serum microRNAs in predicting early neurological deterioration of non-traumatic cerebral hemorrhage_West China Medical Journal

Authors：

WANG Jiuji ¹ ,  GUO Hongmin ¹ , ZHAO Haiyang ² , YANG Jinfei ³ , ZHANG Jiangtao ³

1. Emergency Department, Chengde Central Hospital, Chengde, Hebei 067000, P. R. China;
2. Department of Orthopedics for Severe Trauma, Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, P. R. China;
3. Department of Neurology, Chengde Central Hospital, Chengde, Hebei 067000, P. R. China;

Corresponding author：

GUO Hongmin, Email: wpnla8@163.com

Keywords：

miR-141-3p; miR-130a; miR-29a-3p; miR-210; non-traumatic cerebral hemorrhage; early neurological deterioration; value of prediction

DOI：

10.7507/1002-0179.202301007

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Objective To analyze the value of serum levels of miR-141-3p, miR-130a, miR-29a-3p, and miR-210 in predicting early neurological deterioration (END) in non-traumatic intracerebral hemorrhage. Methods The patients with non-traumatic cerebral hemorrhage who met the selection criteria and were admitted to Chengde Central Hospital between February 2021 and October 2022 were prospectively selected by convenience sampling method. The serum miR-141-3p, miR-130a, miR-29a-3p, and miR-210 levels upon admission and the occurrence of neurological deterioration within 24 h were collected, and the patients were divided into a deterioration group and a non-deterioration group according to whether neurological deterioration occurred. The correlation of serum miR-141-3p, miR-130a, miR-29a-3p, and miR-210 levels with the END of non-traumatic intracerebral hemorrhage and their predictive value to the END of non-traumatic intracerebral hemorrhage were analyzed. Results A total of 235 patient were enrolled. Of the 235 patients, 45 (19.1%) showed neurological deterioration and 190 (80.9%) showed no neurological deterioration. The levels of miR-141-3p and miR-29a-3p in the deteriorating group were significantly lower than those in the non-deteriorating group [(1.11±0.32) vs. (1.76±0.51) ng/mL, P<0.001; (1.19±0.31) vs. (1.71±0.51) ng/mL, P<0.001], and the levels of miR-130a and miR-210 were significantly higher than those in the non-deteriorating group [(5.13±1.11) vs. (3.82±1.03) ng/mL, P<0.001; (3.96±0.76) vs. (2.78±0.50) ng/mL, P<0.001]. Multivariate logistic regression analysis showed that serum miR-141-3p and miR-29a-3p levels were protective factors for the occurrence of END in non-traumatic intracerebral hemorrhage patients [odds ratio (OR)=0.513, 95% confidence interval (CI) (0.330, 0.798), P=0.003; OR=0.582, 95%CI (0.380, 0.893), P=0.013], and serum miR-130a and miR-210 levels were independent risk factors for that [OR=2.046, 95%CI (1.222, 3.426), P=0.007; OR=2.377, 95%CI (1.219, 4.638), P=0.011]. The area under the receiver operating characteristic curve was 0.857 [95%CI (0.760, 0.954)] in predicting the END of non-traumatic intracerebral hemorrhage by the combined probability of the serum miR-141-3p, miR-130a, miR-29a-3p, and miR-210 levels obtained by logistic regression, and the sensitivity was 86.7%, the specificity was 94.7%, the positive predictive value was 79.6%, and the negative predictive value was 96.8% according to the cut-off value of the prediction probability of the combined test. Conclusion The combined detection of serum miR-141-3p, miR-130a, miR-29a-3p, and miR-210 has a high predictive value in the occurrence of END in non-traumatic intracerebral hemorrhage patients.

Citation： WANG Jiuji, GUO Hongmin, ZHAO Haiyang, YANG Jinfei, ZHANG Jiangtao. Value of serum microRNAs in predicting early neurological deterioration of non-traumatic cerebral hemorrhage. West China Medical Journal, 2023, 38(5): 704-709. doi: 10.7507/1002-0179.202301007 Copy

1.	Ponamgi SP, Ward R, DeSimone CV, et al. High mortality rates among patients with non-traumatic intracerebral hemorrhage and atrial fibrillation on antithrombotic therapy are independent of the presence of cerebral amyloid angiopathy: insights from a population-based study. J Am Heart Assoc, 2020, 9(15): e016893.
2.	Sallinen H, Putaala J, Strbian D. Triggering factors in non-traumatic intracerebral hemorrhage. J Stroke Cerebrovasc Dis, 2020, 29(8): 104921.
3.	Jiang Q, Wang Y, Shi X. Propofol inhibits neurogenesis of rat neural stem cells by upregulating microRNA-141-3p. Stem Cells Dev, 2017, 26(3): 189-196.
4.	Zhang CY, Ren XM, Li HB, et al. Effect of miR-130a on neuronal injury in rats with intracranial hemorrhage through PTEN/PI3K/AKT signaling pathway. Eur Rev Med Pharmacol Sci, 2019, 23(11): 4890-4897.
5.	Gao XZ, Zhang ZX, Han GL. miR-29a-3p enhances the viability of rat neuronal cells that injured by oxygen-glucose deprivation/reoxygenation treatment through targeting TNFRSF1A and regulating NF-κB signaling pathway. J Stroke Cerebrovasc Dis, 2020, 29(11): 105210.
6.	李光波, 王新港, 张旭伟. 自发性脑出血患者血清 microRNA-130a、microRNA-210 表达水平及与早期神经功能恶化的关系. 中国现代医学杂志, 2022, 32(8): 79-84.
7.	婉玲, 于瀛, 黄清海. 自发性脑出血诊疗指南-美国心脏协会/美国卒中协会的健康职业者指南. 中国脑血管病杂志, 2015(9): 490-504.
8.	中华医学会神经外科学分会, 中国医师协会急诊医师分会, 国家卫生和计划生育委员会脑卒中筛查与防治工程委员会. 自发性脑出血诊断治疗中国多学科专家共识. 中华急诊医学杂志, 2015, 24(12): 1319-1323.
9.	Elmegiri M, Koivunen RJ, Tatlisumak T, et al. MRI characterization of non-traumatic intracerebral hemorrhage in young adults. Front Neurol, 2020, 11: 558680.
10.	孙婷婷, 张强. 自发性脑出血早期神经功能恶化的预后因素分析. 卒中与神经疾病, 2020, 27(3): 355-358.
11.	Loggini A, Ammar FE, Awad IA, et al. Temporal evolution and outcomes of non-traumatic intracerebral hemorrhage in hospitalized patients. J Stroke Cerebrovasc Dis, 2021, 30(3): 105584.
12.	Khatri GD, Sarikaya B, Cross NM, et al. The role of imaging in the management of non-traumatic subarachnoid hemorrhage: a practical review. Emerg Radiol, 2021, 28(4): 797-808.
13.	黄四妹, 储照虎, 胡文杰, 等. 外泌体 microRNA 在脑出血中的研究进展. 卒中与神经疾病, 2020, 27(6): 844-846.
14.	Kim CK, Pak TR. miRNA degradation in the mammalian brain. Am J Physiol Cell Physiol, 2020, 319(4): C624-C629.
15.	王瑞丽, 李晔. 《颅脑损伤康复》出版: 血清 miRNA 标志物检测对颅脑损伤修复情况预测研究. 介入放射学杂志, 2022, 31(4): 后插 6.
16.	Lim Y, Beane-Ebel JE, Tanaka Y, et al. Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks. Transl Psychiatry, 2021, 11(1): 504.
17.	张亮, 张凤岐, 郑贵超, 等. 血清 miRNA 的表达对急性脑出血患者神经功能重建的指导价值. 临床血液学杂志, 2020, 33(12): 835-839.
18.	Yu M, Tian T, Zhang J, et al. miR-141-3p protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by targeting ZEB2. J Clin Neurosci, 2022, 99: 253-260.
19.	臧雪风, 史明语, 王礼玲. 高血压性脑出血患者血清 miR-141-3p、miR-29a-3p 水平变化及临床意义. 山东医药, 2022, 62(4): 16-21.

1. Ponamgi SP, Ward R, DeSimone CV, et al. High mortality rates among patients with non-traumatic intracerebral hemorrhage and atrial fibrillation on antithrombotic therapy are independent of the presence of cerebral amyloid angiopathy: insights from a population-based study. J Am Heart Assoc, 2020, 9(15): e016893.
2. Sallinen H, Putaala J, Strbian D. Triggering factors in non-traumatic intracerebral hemorrhage. J Stroke Cerebrovasc Dis, 2020, 29(8): 104921.
3. Jiang Q, Wang Y, Shi X. Propofol inhibits neurogenesis of rat neural stem cells by upregulating microRNA-141-3p. Stem Cells Dev, 2017, 26(3): 189-196.
4. Zhang CY, Ren XM, Li HB, et al. Effect of miR-130a on neuronal injury in rats with intracranial hemorrhage through PTEN/PI3K/AKT signaling pathway. Eur Rev Med Pharmacol Sci, 2019, 23(11): 4890-4897.
5. Gao XZ, Zhang ZX, Han GL. miR-29a-3p enhances the viability of rat neuronal cells that injured by oxygen-glucose deprivation/reoxygenation treatment through targeting TNFRSF1A and regulating NF-κB signaling pathway. J Stroke Cerebrovasc Dis, 2020, 29(11): 105210.
6. 李光波, 王新港, 张旭伟. 自发性脑出血患者血清 microRNA-130a、microRNA-210 表达水平及与早期神经功能恶化的关系. 中国现代医学杂志, 2022, 32(8): 79-84.
7. 婉玲, 于瀛, 黄清海. 自发性脑出血诊疗指南-美国心脏协会/美国卒中协会的健康职业者指南. 中国脑血管病杂志, 2015(9): 490-504.
8. 中华医学会神经外科学分会, 中国医师协会急诊医师分会, 国家卫生和计划生育委员会脑卒中筛查与防治工程委员会. 自发性脑出血诊断治疗中国多学科专家共识. 中华急诊医学杂志, 2015, 24(12): 1319-1323.
9. Elmegiri M, Koivunen RJ, Tatlisumak T, et al. MRI characterization of non-traumatic intracerebral hemorrhage in young adults. Front Neurol, 2020, 11: 558680.
10. 孙婷婷, 张强. 自发性脑出血早期神经功能恶化的预后因素分析. 卒中与神经疾病, 2020, 27(3): 355-358.
11. Loggini A, Ammar FE, Awad IA, et al. Temporal evolution and outcomes of non-traumatic intracerebral hemorrhage in hospitalized patients. J Stroke Cerebrovasc Dis, 2021, 30(3): 105584.
12. Khatri GD, Sarikaya B, Cross NM, et al. The role of imaging in the management of non-traumatic subarachnoid hemorrhage: a practical review. Emerg Radiol, 2021, 28(4): 797-808.
13. 黄四妹, 储照虎, 胡文杰, 等. 外泌体 microRNA 在脑出血中的研究进展. 卒中与神经疾病, 2020, 27(6): 844-846.
14. Kim CK, Pak TR. miRNA degradation in the mammalian brain. Am J Physiol Cell Physiol, 2020, 319(4): C624-C629.
15. 王瑞丽, 李晔. 《颅脑损伤康复》出版: 血清 miRNA 标志物检测对颅脑损伤修复情况预测研究. 介入放射学杂志, 2022, 31(4): 后插 6.
16. Lim Y, Beane-Ebel JE, Tanaka Y, et al. Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks. Transl Psychiatry, 2021, 11(1): 504.
17. 张亮, 张凤岐, 郑贵超, 等. 血清 miRNA 的表达对急性脑出血患者神经功能重建的指导价值. 临床血液学杂志, 2020, 33(12): 835-839.
18. Yu M, Tian T, Zhang J, et al. miR-141-3p protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by targeting ZEB2. J Clin Neurosci, 2022, 99: 253-260.
19. 臧雪风, 史明语, 王礼玲. 高血压性脑出血患者血清 miR-141-3p、miR-29a-3p 水平变化及临床意义. 山东医药, 2022, 62(4): 16-21.

West China Medical Journal

Value of serum microRNAs in predicting early neurological deterioration of non-traumatic cerebral hemorrhage

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