Correlation analysis of frailty syndrome and lower limb motor function in hospitalized elderly patients_West China Medical Journal

Authors：

CHUN Xueli ¹ , PENG Chunlan ² , LI Qian ² , HU Cuilin ² , ZHOU Qianyun ² , XU Qinyue ² , LIANG Yuxiang ³ ,  HUANG Wenxia ⁴

1. West China School of Nursing, Sichuan University / Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
3. Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
4. Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University / West China School of Nursing, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

HUANG Wenxia, Email: 1437454655@qq.com

Keywords：

Elderly impatient; frailty; lower limb motor function

DOI：

10.7507/1002-0179.202306060

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the correlation between frailty syndrome and lower limb motor function in hospitalized elderly patients. Methods Convenience sampling method was used to select inpatients aged 65 and above from the Center of Gerontology and Geriatrics of West China Hospital, Sichuan University between December 2022 and May 2023. The FRAIL Scale, Short Physical Performance Battery (SPPB), and Timed Up and Go Test (TUGT) were used to evaluate the degree of frailty and lower limb motor function, and to explore the correlation between frailty and lower limb motor function. Results A total of 501 elderly patients were included, including 325 males (64.9%) and 176 females (35.1%); 256 cases of frailty (51.1%), 161 cases of pre-frailty (32.1%), and 84 cases of non-frailty (16.8%). The incidence of frailty in hospitalized elderly male patients was higher than that in female patients (P<0.05); The incidence of frailty in patients aged 80-99 was higher than that in patients aged 65-79 (P<0.05). The Spearman correlation analysis results showed that all dimensions of SPPB were negatively correlated with frailty (P<0.001), while TUGT was positively correlated with frailty (r=0.776, P<0.001). The results of multiple linear regression analysis showed that the worse the motor function of the lower limbs, the higher the debilitation score. Conclusions Frailty syndrome in hospitalized elderly patients is closely related to lower limb motor function. Lower limb motor function assessment can be used to predict the onset of frailty in clinical practice, and interventions to improve lower limb motor function can be used to improve the frailty of elderly patients.

Citation： CHUN Xueli, PENG Chunlan, LI Qian, HU Cuilin, ZHOU Qianyun, XU Qinyue, LIANG Yuxiang, HUANG Wenxia. Correlation analysis of frailty syndrome and lower limb motor function in hospitalized elderly patients. West China Medical Journal, 2024, 39(1): 42-47. doi: 10.7507/1002-0179.202306060 Copy

1.	Walston J, Bandeen-Roche K, Buta B, et al. Moving frailty toward clinical practice: NIA intramural frailty science symposium summary. J Am Geriatr Soc, 2019, 67(8): 1559-1564.
2.	黄小媛, 钟美容. 衰弱老年人生活质量的研究进展. 护士进修杂志, 2022, 37(11): 983-987.
3.	Dent E, Morley JE, Cruz-Jentoft AJ, et al. Physical frailty: ICFSR international clinical practice guidelines for identification and management. J Nutr Health Aging, 2019, 23(9): 771-787.
4.	中华医学会老年医学分会, 《中华老年医学杂志》编辑委员会. 老年人衰弱预防中国专家共识(2022). 中华老年医学杂志, 2022, 41(5): 503-511.
5.	蒲虹杉, 董碧蓉. 老年肌少症与衰弱和营养. 中国临床保健杂志, 2021, 24(5): 577-581.
6.	侯志涛. 老年人抗阻训练健身方案制定和效果研究. 北京: 北京体育大学, 2015.
7.	Morley JE, Malmstrom TK, Miller DK. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging, 2012, 16(7): 601-608.
8.	中华医学会老年医学分会. 老年患者衰弱评估与干预中国专家共识. 中华老年医学杂志, 2017, 36(3): 251-256.
9.	景冬梅, 沈冲, 莫永珍, 等. 中文版衰弱量表在老年衰弱评价中的信效度研究. 护士进修杂志, 2021, 36(9): 784-788.
10.	Guralnik JM, Winograd CH. Physical performance measures in the assessment of older persons. Aging (Milano), 1994, 6(5): 303-305.
11.	刘娟, 丁清清, 周白瑜, 等. 中国老年人肌少症诊疗专家共识(2021). 中华老年医学杂志, 2021, 40(8): 943-952.
12.	杨黎, 邝小迪, 苏爱华. 老年人失能及其测评工具的研究进展. 护理研究, 2019, 33(10): 1722-1726.
13.	Mathias S, Nayak US, Isaacs B. Balance in elderly patients: the “get-up and go” test. Arch Phys Med Rehabil, 1986, 67(6): 387-389.
14.	Iwase H, Murata S, Nakano H, et al. Relationship between age-related changes in skeletal muscle mass and physical function: a cross-sectional study of an elderly Japanese population. Cureus, 2022, 14(4): e24260.
15.	中国老年保健医学研究会老龄健康服务与标准化分会, 《中国老年保健医学》杂志编辑委员会. 中国老年人跌倒风险评估专家共识(草案). 中国老年保健医学, 2019, 17(4): 47-48, 50.
16.	李燕, 黄丽华. 老年人平衡能力评估及干预的研究进展. 中华护理杂志, 2019, 54(4): 603-608.
17.	卫尹, 曹艳佩, 杨晓莉, 等. 老年住院患者衰弱综合征现状及影响因素. 复旦学报 (医学版), 2018, 45(4): 496-502.
18.	赖小星, 霍晓鹏, 薄琳, 等. 高龄老年住院患者衰弱现状及影响因素的研究. 北京医学, 2021, 43(3): 198-202.
19.	田鹏, 杨宁, 郝秋奎, 等. 中国老年衰弱患病率的系统评价. 中国循证医学杂志, 2019, 19(6): 657-664.
20.	Veronese N, Custodero C, Cella A, et al. Prevalence of multidimensional frailty and pre-frailty in older people in different settings: a systematic review and meta-analysis. Ageing Res Rev, 2021, 72: 101498.
21.	李晓凯, 陈长香, 张敏, 等. 唐山市中高龄老年人健康促进生活方式与衰弱的相关性. 中国老年学杂志, 2019, 39(15): 3783-3786.
22.	吴剑卿, 陈波, 毛拥军, 等. 老年人躯体功能受损防控干预中国专家共识(2022). 中华老年医学杂志, 2022, 41(10): 1137-1145.
23.	Cesari M, Landi F, Vellas B, et al. Sarcopenia and physical frailty: two sides of the same coin. Front Aging Neurosci, 2014, 6: 192.
24.	宁晓暄, 欧阳敏, Leng Sean X. 老年人衰弱综合征的发病机制和评估及管理. 中华老年医学杂志, 2015, 34(12): 1282-1285.
25.	Yao SS, Meng X, Cao GY, et al. Associations between multimorbidity and physical performance in older chinese adults. Int J Environ Res Public Health, 2020, 17(12): 4546.
26.	Wang DXM, Yao J, Zirek Y, et al. Muscle mass, strength, and physical performance predicting activities of daily living: a meta-analysis. J Cachexia Sarcopenia Muscle, 2020, 11(1): 3-25.
27.	Volpi E, Nazemi R, Fujita S. Muscle tissue changes with aging. Curr Opin Clin Nutr Metab Care, 2004, 7(4): 405-410.
28.	Corsonello A, Lattanzio F, Pedone C, et al. Prognostic significance of the short physical performance battery in older patients discharged from acute care hospitals. Rejuvenation Res, 2012, 15(1): 41-48.
29.	Fortes-Filho SQ, Aliberti MJR, Apolinario D, et al. Role of gait speed, strength, and balance in predicting adverse outcomes of acutely ill older outpatients. J Nutr Health Aging, 2020, 24(1): 113-118.
30.	高志鹏. 八段锦对衰弱前期老年人衰弱状态及下肢运动功能的康复效果. 河北唐山: 华北理工大学, 2020.
31.	Jung HW, Baek JY, Jang IY, et al. Short physical performance battery as a crosswalk between frailty phenotype and deficit-accumulation frailty index. J Gerontol A Biol Sci Med Sci, 2021, 76(12): 2249-2255.
32.	李凌, 王玉梅, 张艳玲, 等. 老年病人衰弱综合征与肌肉功能的相关性研究. 护理研究, 2019, 33(6): 917-920.
33.	马昊哲, 赵良渊, 张晓红. 中国老年人简易机体功能评估结果及其影响因素分析. 护理研究, 2022, 36(14): 2491-2496.
34.	Bergland A, Strand BH. Norwegian reference values for the short physical performance battery (sppb): the tromsø study. BMC Geriatr, 2019, 19(1): 216.
35.	Fyfe JJ, Hamilton DL, Daly RM. Minimal-dose resistance training for improving muscle mass, strength, and function: a narrative review of current evidence and practical considerations. Sports Med, 2022, 52(3): 463-479.
36.	Nayasista AH, Tinduh D, Alit Pawana IP, et al. Effect of combined locomotor training and aerobic exercise on increasing handgrip strength in elderly with locomotive syndrome: a randomised controlled trial. Ann Med Surg (Lond), 2022, 78: 103800.
37.	Sung JH, Son SR, Baek SH, et al. The association of aerobic, resistance, and combined exercises with the handgrip strength of middle-aged and elderly Korean adults: a nationwide cross-sectional study. BMC Geriatr, 2022, 22(1): 676.
38.	Puthucheary ZA, Rawal J, McPhail M, et al, et al. Acute skeletal muscle wasting in critical illness. JAMA, 2013, 310(15): 1591-1600.

1. Walston J, Bandeen-Roche K, Buta B, et al. Moving frailty toward clinical practice: NIA intramural frailty science symposium summary. J Am Geriatr Soc, 2019, 67(8): 1559-1564.
2. 黄小媛, 钟美容. 衰弱老年人生活质量的研究进展. 护士进修杂志, 2022, 37(11): 983-987.
3. Dent E, Morley JE, Cruz-Jentoft AJ, et al. Physical frailty: ICFSR international clinical practice guidelines for identification and management. J Nutr Health Aging, 2019, 23(9): 771-787.
4. 中华医学会老年医学分会, 《中华老年医学杂志》编辑委员会. 老年人衰弱预防中国专家共识(2022). 中华老年医学杂志, 2022, 41(5): 503-511.
5. 蒲虹杉, 董碧蓉. 老年肌少症与衰弱和营养. 中国临床保健杂志, 2021, 24(5): 577-581.
6. 侯志涛. 老年人抗阻训练健身方案制定和效果研究. 北京: 北京体育大学, 2015.
7. Morley JE, Malmstrom TK, Miller DK. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging, 2012, 16(7): 601-608.
8. 中华医学会老年医学分会. 老年患者衰弱评估与干预中国专家共识. 中华老年医学杂志, 2017, 36(3): 251-256.
9. 景冬梅, 沈冲, 莫永珍, 等. 中文版衰弱量表在老年衰弱评价中的信效度研究. 护士进修杂志, 2021, 36(9): 784-788.
10. Guralnik JM, Winograd CH. Physical performance measures in the assessment of older persons. Aging (Milano), 1994, 6(5): 303-305.
11. 刘娟, 丁清清, 周白瑜, 等. 中国老年人肌少症诊疗专家共识(2021). 中华老年医学杂志, 2021, 40(8): 943-952.
12. 杨黎, 邝小迪, 苏爱华. 老年人失能及其测评工具的研究进展. 护理研究, 2019, 33(10): 1722-1726.
13. Mathias S, Nayak US, Isaacs B. Balance in elderly patients: the “get-up and go” test. Arch Phys Med Rehabil, 1986, 67(6): 387-389.
14. Iwase H, Murata S, Nakano H, et al. Relationship between age-related changes in skeletal muscle mass and physical function: a cross-sectional study of an elderly Japanese population. Cureus, 2022, 14(4): e24260.
15. 中国老年保健医学研究会老龄健康服务与标准化分会, 《中国老年保健医学》杂志编辑委员会. 中国老年人跌倒风险评估专家共识(草案). 中国老年保健医学, 2019, 17(4): 47-48, 50.
16. 李燕, 黄丽华. 老年人平衡能力评估及干预的研究进展. 中华护理杂志, 2019, 54(4): 603-608.
17. 卫尹, 曹艳佩, 杨晓莉, 等. 老年住院患者衰弱综合征现状及影响因素. 复旦学报 (医学版), 2018, 45(4): 496-502.
18. 赖小星, 霍晓鹏, 薄琳, 等. 高龄老年住院患者衰弱现状及影响因素的研究. 北京医学, 2021, 43(3): 198-202.
19. 田鹏, 杨宁, 郝秋奎, 等. 中国老年衰弱患病率的系统评价. 中国循证医学杂志, 2019, 19(6): 657-664.
20. Veronese N, Custodero C, Cella A, et al. Prevalence of multidimensional frailty and pre-frailty in older people in different settings: a systematic review and meta-analysis. Ageing Res Rev, 2021, 72: 101498.
21. 李晓凯, 陈长香, 张敏, 等. 唐山市中高龄老年人健康促进生活方式与衰弱的相关性. 中国老年学杂志, 2019, 39(15): 3783-3786.
22. 吴剑卿, 陈波, 毛拥军, 等. 老年人躯体功能受损防控干预中国专家共识(2022). 中华老年医学杂志, 2022, 41(10): 1137-1145.
23. Cesari M, Landi F, Vellas B, et al. Sarcopenia and physical frailty: two sides of the same coin. Front Aging Neurosci, 2014, 6: 192.
24. 宁晓暄, 欧阳敏, Leng Sean X. 老年人衰弱综合征的发病机制和评估及管理. 中华老年医学杂志, 2015, 34(12): 1282-1285.
25. Yao SS, Meng X, Cao GY, et al. Associations between multimorbidity and physical performance in older chinese adults. Int J Environ Res Public Health, 2020, 17(12): 4546.
26. Wang DXM, Yao J, Zirek Y, et al. Muscle mass, strength, and physical performance predicting activities of daily living: a meta-analysis. J Cachexia Sarcopenia Muscle, 2020, 11(1): 3-25.
27. Volpi E, Nazemi R, Fujita S. Muscle tissue changes with aging. Curr Opin Clin Nutr Metab Care, 2004, 7(4): 405-410.
28. Corsonello A, Lattanzio F, Pedone C, et al. Prognostic significance of the short physical performance battery in older patients discharged from acute care hospitals. Rejuvenation Res, 2012, 15(1): 41-48.
29. Fortes-Filho SQ, Aliberti MJR, Apolinario D, et al. Role of gait speed, strength, and balance in predicting adverse outcomes of acutely ill older outpatients. J Nutr Health Aging, 2020, 24(1): 113-118.
30. 高志鹏. 八段锦对衰弱前期老年人衰弱状态及下肢运动功能的康复效果. 河北唐山: 华北理工大学, 2020.
31. Jung HW, Baek JY, Jang IY, et al. Short physical performance battery as a crosswalk between frailty phenotype and deficit-accumulation frailty index. J Gerontol A Biol Sci Med Sci, 2021, 76(12): 2249-2255.
32. 李凌, 王玉梅, 张艳玲, 等. 老年病人衰弱综合征与肌肉功能的相关性研究. 护理研究, 2019, 33(6): 917-920.
33. 马昊哲, 赵良渊, 张晓红. 中国老年人简易机体功能评估结果及其影响因素分析. 护理研究, 2022, 36(14): 2491-2496.
34. Bergland A, Strand BH. Norwegian reference values for the short physical performance battery (sppb): the tromsø study. BMC Geriatr, 2019, 19(1): 216.
35. Fyfe JJ, Hamilton DL, Daly RM. Minimal-dose resistance training for improving muscle mass, strength, and function: a narrative review of current evidence and practical considerations. Sports Med, 2022, 52(3): 463-479.
36. Nayasista AH, Tinduh D, Alit Pawana IP, et al. Effect of combined locomotor training and aerobic exercise on increasing handgrip strength in elderly with locomotive syndrome: a randomised controlled trial. Ann Med Surg (Lond), 2022, 78: 103800.
37. Sung JH, Son SR, Baek SH, et al. The association of aerobic, resistance, and combined exercises with the handgrip strength of middle-aged and elderly Korean adults: a nationwide cross-sectional study. BMC Geriatr, 2022, 22(1): 676.
38. Puthucheary ZA, Rawal J, McPhail M, et al, et al. Acute skeletal muscle wasting in critical illness. JAMA, 2013, 310(15): 1591-1600.

West China Medical Journal

Correlation analysis of frailty syndrome and lower limb motor function in hospitalized elderly patients

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