Research progress of amanitin-containing mushroom poisoning_West China Medical Journal

Authors：

MA Chunmao ^1,2 , PENG Aihua ^1,3 ,  CAO Yu ^1,3

1. Department of Emergency Medicine and Laboratory of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Emergency Department of Pengzhou People’s Hospital, Pengzhou, Sichuan 611930, P. R. China;
3. Disaster Medical Center, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

CAO Yu, Email: yuyuer@126.com

Keywords：

Mushroom poisoning; amanitin; poisoning mechanism; toxic detection; clinical diagnosis and treatment

DOI：

10.7507/1002-0179.202309217

Video：

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Abstract Full text Figures/Tables Video References Cited by

Amanitin-containing mushroom poisoning is one of the most harmful and lethal types of mushroom poisoning events. Its basic medical and clinical medical knowledge has not been fully understood and mastered, so the basic and clinical diagnosis and treatment of amanitin-containing mushroom poisoning has always been a hot research field of acute mushroom poisoning. This article focuses on the new progress in the epidemiology, toxicological properties, poisoning mechanism, clinical diagnosis and treatment of amanitin-containing mushroom poisoning, in order to provide the basis for further study, diagnosis and treatment of amanitin-containing mushroom poisoning for basic researchers and clinical medical staff.

Citation： MA Chunmao, PENG Aihua, CAO Yu. Research progress of amanitin-containing mushroom poisoning. West China Medical Journal, 2023, 38(11): 1748-1754. doi: 10.7507/1002-0179.202309217 Copy

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1. Govorushko S, Rezaee R, Dumanov J, et al. Poisoning associated with the use of mushrooms: a review of the global pattern and main characteristics. Food Chem Toxicol, 2019, 128: 267-279.
2. 钟加菊, 姚群梅, 唐燕, 等. 活性炭对鹅膏毒肽及鬼笔毒肽的体外吸附研究. 中国急救医学, 2021, 41(8): 709-713.
3. Lecot J, Cellier M, Courtois A, et al. Cyclopeptide mushroom poisoning: a retrospective series of 204 patients. Basic Clin Pharmacol Toxicol, 2023, 132(6): 533-542.
4. 余成敏, 李海蛟. 中国含鹅膏毒肽蘑菇中毒临床诊断治疗专家共识. 中华危重症医学杂志(电子版), 2020, 13(1): 20-28.
5. Cervellin G, Comelli I, Rastelli G, et al. Epidemiology and clinics of mushroom poisoning in Northern Italy: a 21-year retrospective analysis. Hum Exp Toxicol, 2018, 37(7): 697-703.
6. Li W, Pires SM, Liu Z, et al. Mushroom poisoning outbreaks - China, 2010-2020. China CDC Wkly, 2021, 3(24): 518-522.
7. Chen L, Sun L, Zhang R, et al. Epidemiological analysis of wild mushroom poisoning in Zhejiang province, China, 2016-2018. Food Sci Nutr, 2021, 10(1): 60-66.
8. 图力古尔, 包海鹰, 李玉. 中国毒蘑菇名录. 菌物学报, 2014, 33(3): 517-548.
9. Lewinsohn D, Lurie Y, Gaon A, et al. The epidemiology of wild mushroom poisoning in Israel. Mycologia, 2023, 115(3): 317-325.
10. Cai Q, Cui YY, Yang ZL. Lethal Amanita species in China. Mycologia, 2016, 108(5): 993-1009.
11. Vo KT, Montgomery ME, Mitchell ST, et al. Amanita phalloides mushroom poisonings - Northern California, December 2016. MMWR Morb Mortal Wkly Rep, 2017, 66(21): 549-553.
12. Cassidy N, Duggan E, Tracey JA. Mushroom poisoning in Ireland: the collaboration between the National Poisons Information Centre and expert mycologists. Clin Toxicol (Phila), 2011, 49(3): 171-176.
13. Somrithipol S, Pinruan U, Sommai S, et al. Mushroom poisoning in Thailand between 2003 and 2017. Mycoscience, 2022, 63(6): 267-273.
14. Meng H, Chen Z, Chen L, et al. An outbreak of Amanita exitialis poisoning. Clin Toxicol (Phila), 2023, 61(4): 270-275.
15. Li H, Zhang H, Zhang Y, et al. Mushroom poisoning outbreaks - China, 2021. China CDC Wkly, 2022, 4(3): 35-40.
16. Li H, Zhang Y, Zhang H, et al. Mushroom poisoning outbreaks - China, 2022. China CDC Wkly, 2023, 5(3): 45-50.
17. Li H, Zhang H, Zhang Y, et al. Mushroom poisoning outbreaks - China, 2020. China CDC Wkly, 2021, 3(3): 41-45.
18. 邓旺秋, 李泰辉, 张明, 等. 华南常见毒鹅膏菌及其中毒事件分析. 菌物学报, 2020, 39(9): 1750-1758.
19. Brandenburg WE, Ward KJ. Mushroom poisoning epidemiology in the United States. Mycologia, 2018, 110(4): 637-641.
20. Sun J, Li HJ, Zhang HS, et al. Investigating and analyzing three cohorts of mushroom poisoning caused by Amanita exitialis in Yunnan, China. Hum Exp Toxicol, 2018, 37(7): 665-678.
21. Liu J, Bai L, Li W, et al. Trends of foodborne diseases in China: lessons from laboratory-based surveillance since 2011. Front Med, 2018, 12(1): 48-57.
22. Karami Matin B, Amrollahi-Sharifabadi M, Rezaei S, et al. Epidemiology and economic burden of an outbreak of cyclopeptide-containing mushroom poisoning in the west of Iran. Front Public Health, 2022, 10: 910024.
23. White J, Weinstein SA, De Haro L, et al. Mushroom poisoning: a proposed new clinical classification. Toxicon, 2019(157): 53-65.
24. Diaz JH. Nephrotoxic mushroom poisoning: global epidemiology, clinical manifestations, and management. Wilderness Environ Med, 2021, 32(4): 537-544.
25. Diaz JH. Evolving global epidemiology, syndromic classification, general management, and prevention of unknown mushroom poisonings. Crit Care Med, 2005, 33(2): 419-426.
26. Gold J, Kiernan E, Yeh M, et al. Health care utilization and outcomes associated with accidental poisonous mushroom ingestions - United States, 2016-2018. MMWR Morb Mortal Wkly Rep, 2021, 70(10): 337-341.
27. Garcia J, Costa VM, Carvalho A, et al. Amanita phalloides poisoning: mechanisms of toxicity and treatment. Food Chem Toxicol, 2015, 86: 41-55.
28. 王晶, 史振霞, 乔洁, 等. 毒鹅膏菌和鹅膏肽类毒素研究进展. 廊坊师范学院学报(自然科学版), 2018, 18(1): 46-53, 57.
29. 秦琪, 田恩静, 包海鹰. 蘑菇毒素分类及其结构式. 菌物研究, 2022, 20(2): 128-140.
30. Faulstich H, Buku A, Bodenmueller H, et al. Virotoxins: actin-binding cyclic peptides of Amanita virosa mushrooms. Biochemistry (Easton), 1980, 19(14): 3334-3343.
31. Lim CH, Song I, Lee J, et al. Toxicokinetics and tissue distribution of phalloidin in mice. Food Chem Toxicol, 2023, 179: 113994.
32. Wieland T, Faulstich H. Amatoxins, phallotoxins, phallolysin, and antamanide: the biologically active components of poisonous Amanita mushrooms. CRC Crit Rev Biochem, 1978, 5(3): 185-260.
33. Xue J, Lou X, Ning D, et al. Mechanism and treatment of α-amanitin poisoning. Arch Toxicol, 2023, 97(1): 121-131.
34. 许悦, 王婵, 林纾丞, 等. α-鹅膏毒肽诱导肝细胞毒性作用机制的研究进展. 昆明医科大学学报, 2022, 43(12): 153-158.
35. Barbosa I, Domingues C, Ramos F, et al. Analytical methods for amatoxins: a comprehensive review. J Pharm Biomed Anal, 2023, 232: 115421.
36. Yilmaz I, Ermis F, Akata I, et al. A case study: what doses of Amanita phalloides and amatoxins are lethal to humans?. Wilderness Environ Med, 2015, 26(4): 491-496.
37. 孙健. 致命鹅膏肝毒性及鹅膏肽类毒素在比格犬体内毒代动力学初步研究. 北京: 中国疾病预防控制中心, 2018.
38. Park R, Choi WG, Lee MS, et al. Pharmacokinetics of α-amanitin in mice using liquid chromatography-high resolution mass spectrometry and in vitro drug-drug interaction potentials. J Toxicol Environ Health A, 2021, 84(20): 821-835.
39. Tiewsoh I, Bhattacharya PK, Barman B, et al. Delayed liver toxicity and delayed gastroenteritis: a 5 year retrospective analysis of the cause of death in mushroom poisoning. J Family Med Prim Care, 2022, 11(5): 1963-1969.
40. Letschert K, Faulstich H, Keller D, et al. Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Toxicol Sci, 2006, 91(1): 140-149.
41. Escoda O, Reverter E, To-Figueras J, et al. Potential value of urinary amatoxin quantification in patients with hepatotoxic mushroom poisoning. Liver Int, 2019, 39(6): 1128-1135.
42. 卢中秋, 洪广亮, 孙承业, 等. 中国蘑菇中毒诊治临床专家共识. 临床急诊杂志, 2019, 20(8): 583-598.
43. Wieland T. The toxic peptides from Amanita mushrooms. Int J Pept Protein Res, 1983, 22(3): 257-276.
44. Bushnell DA, Cramer P, Kornberg RD. Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution. Proc Natl Acad Sci U S A, 2002, 99(3): 1218-1222.
45. Kaplan CD, Larsson KM, Kornberg RD. The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. Mol Cell, 2008, 30(5): 547-556.
46. Wang D, Bushnell DA, Westover KD, et al. Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis. Cell, 2006, 127(5): 941-954.
47. Nguyen VT, Giannoni F, Dubois MF, et al. In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin. Nucleic Acids Res, 1996, 24(15): 2924-2929.
48. Andera L, Wasylyk B. Transcription abnormalities potentiate apoptosis of normal human fibroblasts. Molecular medicine (Cambridge, Mass. ), 1997, 3(12): 852-863.
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Research progress of amanitin-containing mushroom poisoning

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