- 1. Department of Emergency Medicine and Laboratory of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
- 2. Disaster Medical Center, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
Poisoning is a frequent reason for patients to seek emergency medical attention, and in severe cases, it can result in severe cardiac disease or cardiac arrest. American Heart Association published the guideline for the management of patients with cardiac arrest or life-threatening toxicity due to poisoning in Circulation on September 18, 2023. Based on the literature, this article interprets the suggestions related to neurotoxic substances in this guideline, mainly involving the clinical management of benzodiazepines, opioids, cocaine, local anesthetics, and sympathomimetic substances poisoning. By interpreting the recommended points of the guide in detail, it is hoped that it will be helpful for the diagnosis and treatment of readers.
Citation: XIANG Xinjie, CHU Lili, YAO Peng, XIE Xuxin, LI Yingyi, PENG Aihua, CAO Yu. Interpretation of 2023 American Heart Association guideline for the management of patients with cardiac arrest or life-threatening toxicity due to poisoning (Ⅰ): management of neurotoxic substances poisoning. West China Medical Journal, 2023, 38(11): 1616-1624. doi: 10.7507/1002-0179.202310267 Copy
1. | 中华人民共和国国家卫生健康委员会. 2022 中国卫生健康统计年鉴. 北京: 中国协和医科大学出版社, 2022: 148-151. |
2. | Lavonas EJ, Akpunonu PD, Arens AM, et al. 2023 American Heart Association focused update on the management of patients with cardiac arrest or life-threatening toxicity due to poisoning: an update to the American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation, 2023, 148(16): e149-e184. |
3. | Höjer J, Baehrendtz S, Gustafsson L. Benzodiazepine poisoning: experience of 702 admissions to an intensive care unit during a 14-year period. J Intern Med, 1989, 226(2): 117-122. |
4. | Gummin DD, Mowry JB, Beuhler MC, et al. 2020 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 38th annual report. Clin Toxicol (Phila), 2021, 59(12): 1282-1501. |
5. | Liu S, O’Donnell J, Gladden RM, et al. Trends in nonfatal and fatal overdoses involving benzodiazepines - 38 states and the district of Columbia, 2019-2020. MMWR Morb Mortal Wkly Rep, 2021, 70(34): 1136-1141. |
6. | Greene SL, Dargan PI, Jones AL. Acute poisoning: understanding 90% of cases in a nutshell. Postgrad Med J, 2005, 81(954): 204-216. |
7. | An H, Godwin J. Flumazenil in benzodiazepine overdose. CMAJ, 2016, 188(17/18): E537. |
8. | Penninga EI, Graudal N, Ladekarl MB, et al. Adverse events associated with flumazenil treatment for the management of suspected benzodiazepine intoxication--a systematic review with meta-analyses of randomised trials. Basic Clin Pharmacol Toxicol, 2016, 118(1): 37-44. |
9. | Dart RC, Borron SW, Caravati EM, et al. Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care. Ann Emerg Med, 2009, 54(3): 386-394. e1. |
10. | Sivilotti ML. Flumazenil, naloxone and the ‘coma cocktail’. Br J Clin Pharmacol, 2016, 81(3): 428-436. |
11. | Gomes T, Ledlie S, Tadrous M, et al. Trends in opioid toxicity-related deaths in the US before and after the start of the COVID-19 pandemic, 2011-2021. JAMA Netw Open, 2023, 6(7): e2322303. |
12. | Clarke SF, Dargan PI, Jones AL. Naloxone in opioid poisoning: walking the tightrope. Emerg Med J, 2005, 22(9): 612-616. |
13. | Etherington J, Christenson J, Innes G, et al. Is early discharge safe after naloxone reversal of presumed opioid overdose?. CJEM, 2000, 2(3): 156-162. |
14. | Whittall JP, Orkin AM, Handford C, et al. Resuscitation simulation among people who are likely to witness opioid overdose: experiences from the SOONER trial. PLoS One, 2022, 17(7): e0270829. |
15. | Katzman JG, Greenberg NH, Takeda MY, et al. Characteristics of patients with opioid use disorder associated with performing overdose reversals in the community: an opioid treatment program analysis. J Addict Med, 2019, 13(2): 131-138. |
16. | Pietrusza LM, Puskar KR, Ren D, et al. Evaluation of an opiate overdose educational intervention and naloxone prescribing program in homeless adults who use opiates. J Addict Nurs, 2018, 29(3): 188-195. |
17. | Walley AY, Doe-Simkins M, Quinn E, et al. Opioid overdose prevention with intranasal naloxone among people who take methadone. J Subst Abuse Treat, 2013, 44(2): 241-247. |
18. | Tobin KE, Sherman SG, Beilenson P, et al. Evaluation of the staying alive programme: training injection drug users to properly administer naloxone and save lives. Int J Drug Policy, 2009, 20(2): 131-136. |
19. | Piper TM, Stancliff S, Rudenstine S, et al. Evaluation of a naloxone distribution and administration program in New York city. Subst Use Misuse, 2008, 43(7): 858-870. |
20. | Pergolizzi JV Jr, Magnusson P, LeQuang JAK, et al. Cocaine and cardiotoxicity: a literature review. Cureus, 2021, 13(4): e14594. |
21. | Callaway CW, Clark RF. Hyperthermia in psychostimulant overdose. Ann Emerg Med, 1994, 24(1): 68-76. |
22. | Roberts JR, Quattrocchi E, Howland MA. Severe hyperthermia secondary to intravenous drug abuse. Am J Emerg Med, 1984, 2(4): 373. |
23. | Catravas JD, Waters IW. Acute cocaine intoxication in the conscious dog: studies on the mechanism of lethality. J Pharmacol Exp Ther, 1981, 217(2): 350-356. |
24. | Liao X, Zhou Z, Zhou M, et al. Effects of endovascular and surface cooling on resuscitation in patients with cardiac arrest and a comparison of effectiveness, stability, and safety: a systematic review and meta-analysis. Crit Care, 2020, 24(1): 27. |
25. | Douma MJ, Aves T, Allan KS, et al. First aid cooling techniques for heat stroke and exertional hyperthermia: a systematic review and meta-analysis. Resuscitation, 2020, 148: 173-190. |
26. | Sonder P, Janssens GN, Beishuizen A, et al. Efficacy of different cooling technologies for therapeutic temperature management: a prospective intervention study. Resuscitation, 2018, 124: 14-20. |
27. | Rosman J, Hentzien M, Dramé M, et al. A comparison between intravascular and traditional cooling for inducing and maintaining temperature control in patients following cardiac arrest. Anaesth Crit Care Pain Med, 2018, 37(2): 129-134. |
28. | Zhang Y, Davis JK, Casa DJ, et al. Optimizing cold water immersion for exercise-induced hyperthermia: a meta-analysis. Med Sci Sports Exerc, 2015, 47(11): 2464-2472. |
29. | McDermott BP, Casa DJ, Ganio MS, et al. Acute whole-body cooling for exercise-induced hyperthermia: a systematic review. J Athl Train, 2009, 44(1): 84-93. |
30. | Casa DJ, McDermott BP, Lee EC, et al. Cold water immersion: the gold standard for exertional heatstroke treatment. Exerc Sport Sci Rev, 2007, 35(3): 141-149. |
31. | Proulx CI, Ducharme MB, Kenny GP. Effect of water temperature on cooling efficiency during hyperthermia in humans. J Appl Physiol (1985), 2003, 94(4): 1317-1323. |
32. | Okada T, Shioda K, Makiguchi A, et al. Risperidone and 5-HT2A receptor antagonists attenuate and reverse cocaine-induced hyperthermia in rats. Int J Neuropsychopharmacol, 2020, 23(12): 811-820. |
33. | 付灵华, 洪葵, 苏海. 可卡因与急性心肌梗死. 中国老年学杂志, 2016, 36(9): 2267-2270. |
34. | 王海燕. 可卡因滥用的心血管毒性. 新医学, 2010, 41(10): 691-694. |
35. | 姜醒华, 程晓曙, 吴延庆, 等. 吸食可卡因致急性心肌梗死一例. 中国介入心脏病学杂志, 2008, 16(4): 233-235. |
36. | 姜醒华, 程晓曙, 吴延庆, 等. 吸食可卡因引致急性心肌梗死. 江西医药, 2008, 43(12): 1343-1345. |
37. | Arenas DJ, Beltran S, Zhou S, et al. Cocaine, cardiomyopathy, and heart failure: a systematic review and meta-analysis. Sci Rep, 2020, 10(1): 19795. |
38. | Przywara DA, Dambach GE. Direct actions of cocaine on cardiac cellular electrical activity. Circ Res, 1989, 65(1): 185-192. |
39. | Vaughan Williams EM. A classification of antiarrhythmic actions reassessed after a decade of new drugs. J Clin Pharmacol, 1984, 24(4): 129-147. |
40. | Heit J, Hoffman RS, Goldfrank LR. The effects of lidocaine pretreatment on cocaine neurotoxicity and lethality in mice. Acad Emerg Med, 1994, 1(5): 438-442. |
41. | Shih RD, Hollander JE, Burstein JL, et al. Clinical safety of lidocaine in patients with cocaine-associated myocardial infarction. Ann Emerg Med, 1995, 26(6): 702-706. |
42. | Lormans P, Gaumann D, Schwieger I, et al. Ventricular fibrillation following local application of cocaine and epinephrine for nasal surgery. ORL J Otorhinolaryngol Relat Spec, 1992, 54(3): 160-162. |
43. | Kerns W 2nd, Garvey L, Owens J. Cocaine-induced wide complex dysrhythmia. J Emerg Med, 1997, 15(3): 321-329. |
44. | Baumann BM, Perrone J, Hornig SE, et al. Randomized, double-blind, placebo-controlled trial of diazepam, nitroglycerin, or both for treatment of patients with potential cocaine-associated acute coronary syndromes. Acad Emerg Med, 2000, 7(8): 878-885. |
45. | Wang RY. pH-dependent cocaine-induced cardiotoxicity. Am J Emerg Med, 1999, 17(4): 364-369. |
46. | Ortega-Carnicer J, Bertos-Polo J, Gutiérrez-Tirado C. Aborted sudden death, transient Brugada pattern, and wide QRS dysrrhythmias after massive cocaine ingestion. J Electrocardiol, 2001, 34(4): 345-349. |
47. | Irani F, Kasmani R, Kanjwal Y. Hyperkalemia and cocaine induced dynamic Brugada-type electrocardiogram. Eur J Emerg Med, 2010, 17(2): 113-115. |
48. | Tanen DA, Graeme KA, Curry SC. Crack cocaine ingestion with prolonged toxicity requiring electrical pacing. J Toxicol Clin Toxicol, 2000, 38(6): 653-657. |
49. | Hollander JE, Hoffman RS, Gennis P, et al. Nitroglycerin in the treatment of cocaine associated chest pain--clinical safety and efficacy. J Toxicol Clin Toxicol, 1994, 32(3): 243-256. |
50. | Lange RA, Hillis LD. Cardiovascular complications of cocaine use. N Engl J Med, 2001, 345(5): 351-358. |
51. | Richards JR, Garber D, Laurin EG, et al. Treatment of cocaine cardiovascular toxicity: a systematic review. Clin Toxicol (Phila), 2016, 54(5): 345-364. |
52. | Brogan WC 3rd, Lange RA, Kim AS, et al. Alleviation of cocaine-induced coronary vasoconstriction by nitroglycerin. J Am Coll Cardiol, 1991, 18(2): 581-586. |
53. | Pitts WR, Lange RA, Cigarroa JE, et al. Cocaine-induced myocardial ischemia and infarction: pathophysiology, recognition, and management. Prog Cardiovasc Dis, 1997, 40(1): 65-76. |
54. | Lucyk SN. Acute cardiovascular toxicity of cocaine. Can J Cardiol, 2022, 38(9): 1384-1394. |
55. | Muntaner C, Kumor KM, Nagoshi C, et al. Effects of nifedipine pretreatment on subjective and cardiovascular responses to intravenous cocaine in humans. Psychopharmacology (Berl), 1991, 105(1): 37-41. |
56. | Stenberg RG, Winniford MD, Hillis LD, et al. Simultaneous acute thrombosis of two major coronary arteries following intravenous cocaine use. Arch Pathol Lab Med, 1989, 113(5): 521-524. |
57. | Schindler CW, Tella SR, Prada J, et al. Calcium channel blockers antagonize some of cocaine’s cardiovascular effects, but fail to alter cocaine’s behavioral effects. J Pharmacol Exp Ther, 1995, 272(2): 791-798. |
58. | Potocka-Banaś B, Janus T, Majdanik S, et al. Fatal Intoxication with α-PVP, a synthetic cathinone derivative. J Forensic Sci, 2017, 62(2): 553-556. |
59. | Bosak A, LoVecchio F, Levine M. Recurrent seizures and serotonin syndrome following “2C-I” ingestion. J Med Toxicol, 2013, 9(2): 196-198. |
60. | Refstad S. Paramethoxyamphetamine (PMA) poisoning; a ‘party drug’ with lethal effects. Acta Anaesthesiol Scand, 2003, 47(10): 1298-1299. |
61. | Mueller PD, Korey WS. Death by “ecstasy”: the serotonin syndrome?. Ann Emerg Med, 1998, 32(3): 377-380. |
62. | Tsai C, Quidgley-Martin M, Laub N, et al. Methamphetamine-associated pulseless electrical activity in a young child. Am J Emerg Med, 2021, 39: 257.e1-257.e2. |
63. | Dagli C, Duman I. Successful use of early therapeutic hypothermia in an MDMA and amphetamine intoxication-induced out-of-hospital cardiac arrest: a case report. J Emerg Med, 2020, 59(3): e89-e92. |
64. | Mende L, Böhm R, Regenthal R, et al. Cardiac arrest caused by an ecstasy intoxication. Anasthesiol Intensivmed Notfallmed Schmerzther, 2005, 40(12): 762-765. |
65. | Packe GE, Garton MJ, Jennings K. Acute myocardial infarction caused by intravenous amphetamine abuse. Br Heart J, 1990, 64(1): 23-24. |
66. | Yap CYL, Taylor DM, Knott JC, et al. Intravenous midazolam-droperidol combination, droperidol or olanzapine monotherapy for methamphetamine-related acute agitation: subgroup analysis of a randomized controlled trial. Addiction, 2017, 112(7): 1262-1269. |
67. | Hofer KE, Faber K, Müller DM, et al. Acute toxicity associated with the recreational use of the novel psychoactive benzofuran N-methyl-5-(2 aminopropyl)benzofuran. Ann Emerg Med, 2017, 69(1): 79-82. |
68. | Richards JR, Albertson TE, Derlet RW, et al. Treatment of toxicity from amphetamines, related derivatives, and analogues: a systematic clinical review. Drug Alcohol Depend, 2015, 150: 1-13. |
69. | Martel M, Sterzinger A, Miner J, et al. Management of acute undifferentiated agitation in the emergency department: a randomized double-blind trial of droperidol, ziprasidone, and midazolam. Acad Emerg Med, 2005, 12(12): 1167-1172. |
70. | Knott JC, Taylor DM, Castle DJ. Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department. Ann Emerg Med, 2006, 47(1): 61-67. |
71. | Nobay F, Simon BC, Levitt MA, et al. A prospective, double-blind, randomized trial of midazolam versus haloperidol versus lorazepam in the chemical restraint of violent and severely agitated patients. Acad Emerg Med, 2004, 11(7): 744-749. |
72. | Derlet RW, Albertson TE, Rice P. Protection against d-amphetamine toxicity. Am J Emerg Med, 1990, 8(2): 105-108. |
73. | Derlet RW, Albertson TE, Rice P. Antagonism of cocaine, amphetamine, and methamphetamine toxicity. Pharmacol Biochem Behav, 1990, 36(4): 745-749. |
74. | Strömmer EMF, Leith W, Zeegers MP, et al. The role of restraint in fatal excited delirium: a research synthesis and pooled analysis. Forensic Sci Med Pathol, 2020, 16(4): 680-692. |
75. | Otahbachi M, Cevik C, Bagdure S, et al. Excited delirium, restraints, and unexpected death: a review of pathogenesis. Am J Forensic Med Pathol, 2010, 31(2): 107-112. |
76. | Qasim A, Townend J, Davies MK. Ecstasy induced acute myocardial infarction. Heart, 2001, 85(6): E10. |
77. | Pollanen MS, Chiasson DA, Cairns JT, et al. Unexpected death related to restraint for excited delirium: a retrospective study of deaths in police custody and in the community. CMAJ, 1998, 158(12): 1603-1607. |
78. | Douglas N, Carew J, Johnson D, et al. Safety and efficacy of an on-site intensive treatment protocol for mild and moderate sympathomimetic toxicity at Australian music festivals. Prehosp Disaster Med, 2020, 35(1): 41-45. |
79. | Laskowski LK, Landry A, Vassallo SU, et al. Ice water submersion for rapid cooling in severe drug-induced hyperthermia. Clin Toxicol (Phila), 2015, 53(3): 181-184. |
80. | Armenian P, Mamantov TM, Tsutaoka BT, et al. Multiple MDMA (Ecstasy) overdoses at a rave event: a case series. J Intensive Care Med, 2013, 28(4): 252-258. |
81. | Chen JP. Methamphetamine-associated acute myocardial infarction and cardiogenic shock with normal coronary arteries: refractory global coronary microvascular spasm. J Invasive Cardiol, 2007, 19(4): E89-E92. |
82. | Wijetunga M, Bhan R, Lindsay J, et al. Acute coronary syndrome and crystal methamphetamine use: a case series. Hawaii Med J, 2004, 63(1): 8-13, 25. |
83. | Hong R, Matsuyama E, Nur K. Cardiomyopathy associated with the smoking of crystal methamphetamine. JAMA, 1991, 265(9): 1152-1154. |
84. | Minhaj FS, Schult RF, Dvorak P, et al. Amphetamine and clonidine toxicity resulting in posterior reversible encephalopathy syndrome. Pediatr Emerg Care, 2021, 37(12): e1721-e1723. |
85. | White C, Jeanmonod R. Reverse takotsubo cardiomyopathy after accidental exposure to an illicit substance: a case report. Cureus, 2022, 14(4): e24282. |
86. | Cotinet PA, Bizouarn P, Roux F, et al. Management of cardiogenic shock by circulatory support during reverse Tako-Tsubo following amphetamine exposure: a report of two cases. Heart Lung, 2021, 50(3): 465-469. |
87. | Aly SM, Deheul S, Puymirat E, et al. Takotsubo cardiomyopathy as a consequence of 4-fluoroamphetamine mono-intoxication documented by toxicological analyses. Clin Toxicol (Phila), 2021, 59(1): 73-74. |
88. | Simões MV, Maciel BC, Marin-Neto JA. Reversible segmental left-ventricular dysfunction caused by accidental administration of sympathomimetic drug in human. Int J Cardiol, 1997, 61(1): 93-96. |
89. | Al-Abri S, Meier KH, Colby JM, et al. Cardiogenic shock after use of fluoroamphetamine confirmed with serum and urine levels. Clin Toxicol (Phila), 2014, 52(10): 1292-1295. |
90. | 谢伟, 徐前程, 王涛, 等. 静脉-动脉体外膜氧合联合主动脉球囊反搏治疗对重症心源性休克患者预后的临床分析. 齐齐哈尔医学院学报, 2023, 44(2): 122-126. |
91. | 潘晨亮, 赵晶, 胡思雄, 等. 急性心肌梗死合并心原性休克患者应用 VA-ECMO 联合 IABP 的时机探索. 中华心血管病杂志, 2023, 51(8): 851-858. |
92. | 崔晓娜, 冯瑞霞, 韩雨澎, 等. 静脉-动脉体外膜肺氧合和主动脉内球囊反搏联合辅助顺序对急性心肌梗死合并心源性休克患者的临床效果比较研究. 中国全科医学, 2023, 26(35): 4439-4445. |
93. | Wang D, Chao V, Yap KH, et al. Does concurrent use of intra-aortic balloon pumps improve survival in patients with cardiogenic shock requiring venoarterial extracorporeal membrane oxygenation?. Interact Cardiovasc Thorac Surg, 2020, 30(2): 312-315. |
94. | Di Gregorio G, Neal JM, Rosenquist RW, et al. Clinical presentation of local anesthetic systemic toxicity: a review of published cases, 1979 to 2009. Reg Anesth Pain Med, 2010, 35(2): 181-187. |
95. | Neal JM, Barrington MJ, Fettiplace MR, et al. The third American Society of Regional Anesthesia and Pain Medicine Practice Advisory on local anesthetic systemic toxicity: executive summary 2017. Reg Anesth Pain Med, 2018, 43(2): 113-123. |
96. | Dickerson DM, Apfelbaum JL. Local anesthetic systemic toxicity. Aesthet Surg J, 2014, 34(7): 1111-1119. |
97. | Weinberg GL. Treatment of local anesthetic systemic toxicity (LAST). Reg Anesth Pain Med, 2010, 35(2): 188-193. |
98. | Gitman M, Barrington MJ. Local anesthetic systemic toxicity: a review of recent case reports and registries. Reg Anesth Pain Med, 2018, 43(2): 124-130. |
99. | Hoegberg LC, Bania TC, Lavergne V, et al. Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity. Clin Toxicol (Phila), 2016, 54(3): 167-193. |
100. | Mallampati SR, Liu PL, Knapp RM. Convulsions and ventricular tachycardia from bupivacaine with epinephrine: successful resuscitation. Anesth Analg, 1984, 63(9): 856-859. |
101. | Zaballos M, Callejo D, Sevilla R, et al. Comparative effects of sodium bicarbonate and intravenous lipid emulsions on reversing bupivacaine-induced electrophysiological toxicity in a porcine experimental model. Anesth Analg, 2019, 129(1): 63-72. |
102. | Fettiplace MR, Weinberg G. The mechanisms underlying lipid resuscitation therapy. Reg Anesth Pain Med, 2018, 43(2): 138-149. |
103. | Gosselin S, Hoegberg LC, Hoffman RS, et al. Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clin Toxicol (Phila), 2016, 54(10): 899-923. |
104. | Neal JM, Neal EJ, Weinberg GL. American Society of Regional Anesthesia and Pain Medicine Local Anesthetic Systemic Toxicity checklist: 2020 version. Reg Anesth Pain Med, 2021, 46(1): 81-82. |
105. | Dureau P, Charbit B, Nicolas N, et al. Effect of intralipid® on the dose of ropivacaine or levobupivacaine tolerated by volunteers: a clinical and pharmacokinetic study. Anesthesiology, 2016, 125(3): 474-483. |
106. | Groban L. Central nervous system and cardiac effects from long-acting amide local anesthetic toxicity in the intact animal model. Reg Anesth Pain Med, 2003, 28(1): 3-11. |
107. | Wolfe JW, Butterworth JF. Local anesthetic systemic toxicity: update on mechanisms and treatment. Curr Opin Anaesthesiol, 2011, 24(5): 561-566. |
- 1. 中华人民共和国国家卫生健康委员会. 2022 中国卫生健康统计年鉴. 北京: 中国协和医科大学出版社, 2022: 148-151.
- 2. Lavonas EJ, Akpunonu PD, Arens AM, et al. 2023 American Heart Association focused update on the management of patients with cardiac arrest or life-threatening toxicity due to poisoning: an update to the American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation, 2023, 148(16): e149-e184.
- 3. Höjer J, Baehrendtz S, Gustafsson L. Benzodiazepine poisoning: experience of 702 admissions to an intensive care unit during a 14-year period. J Intern Med, 1989, 226(2): 117-122.
- 4. Gummin DD, Mowry JB, Beuhler MC, et al. 2020 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 38th annual report. Clin Toxicol (Phila), 2021, 59(12): 1282-1501.
- 5. Liu S, O’Donnell J, Gladden RM, et al. Trends in nonfatal and fatal overdoses involving benzodiazepines - 38 states and the district of Columbia, 2019-2020. MMWR Morb Mortal Wkly Rep, 2021, 70(34): 1136-1141.
- 6. Greene SL, Dargan PI, Jones AL. Acute poisoning: understanding 90% of cases in a nutshell. Postgrad Med J, 2005, 81(954): 204-216.
- 7. An H, Godwin J. Flumazenil in benzodiazepine overdose. CMAJ, 2016, 188(17/18): E537.
- 8. Penninga EI, Graudal N, Ladekarl MB, et al. Adverse events associated with flumazenil treatment for the management of suspected benzodiazepine intoxication--a systematic review with meta-analyses of randomised trials. Basic Clin Pharmacol Toxicol, 2016, 118(1): 37-44.
- 9. Dart RC, Borron SW, Caravati EM, et al. Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care. Ann Emerg Med, 2009, 54(3): 386-394. e1.
- 10. Sivilotti ML. Flumazenil, naloxone and the ‘coma cocktail’. Br J Clin Pharmacol, 2016, 81(3): 428-436.
- 11. Gomes T, Ledlie S, Tadrous M, et al. Trends in opioid toxicity-related deaths in the US before and after the start of the COVID-19 pandemic, 2011-2021. JAMA Netw Open, 2023, 6(7): e2322303.
- 12. Clarke SF, Dargan PI, Jones AL. Naloxone in opioid poisoning: walking the tightrope. Emerg Med J, 2005, 22(9): 612-616.
- 13. Etherington J, Christenson J, Innes G, et al. Is early discharge safe after naloxone reversal of presumed opioid overdose?. CJEM, 2000, 2(3): 156-162.
- 14. Whittall JP, Orkin AM, Handford C, et al. Resuscitation simulation among people who are likely to witness opioid overdose: experiences from the SOONER trial. PLoS One, 2022, 17(7): e0270829.
- 15. Katzman JG, Greenberg NH, Takeda MY, et al. Characteristics of patients with opioid use disorder associated with performing overdose reversals in the community: an opioid treatment program analysis. J Addict Med, 2019, 13(2): 131-138.
- 16. Pietrusza LM, Puskar KR, Ren D, et al. Evaluation of an opiate overdose educational intervention and naloxone prescribing program in homeless adults who use opiates. J Addict Nurs, 2018, 29(3): 188-195.
- 17. Walley AY, Doe-Simkins M, Quinn E, et al. Opioid overdose prevention with intranasal naloxone among people who take methadone. J Subst Abuse Treat, 2013, 44(2): 241-247.
- 18. Tobin KE, Sherman SG, Beilenson P, et al. Evaluation of the staying alive programme: training injection drug users to properly administer naloxone and save lives. Int J Drug Policy, 2009, 20(2): 131-136.
- 19. Piper TM, Stancliff S, Rudenstine S, et al. Evaluation of a naloxone distribution and administration program in New York city. Subst Use Misuse, 2008, 43(7): 858-870.
- 20. Pergolizzi JV Jr, Magnusson P, LeQuang JAK, et al. Cocaine and cardiotoxicity: a literature review. Cureus, 2021, 13(4): e14594.
- 21. Callaway CW, Clark RF. Hyperthermia in psychostimulant overdose. Ann Emerg Med, 1994, 24(1): 68-76.
- 22. Roberts JR, Quattrocchi E, Howland MA. Severe hyperthermia secondary to intravenous drug abuse. Am J Emerg Med, 1984, 2(4): 373.
- 23. Catravas JD, Waters IW. Acute cocaine intoxication in the conscious dog: studies on the mechanism of lethality. J Pharmacol Exp Ther, 1981, 217(2): 350-356.
- 24. Liao X, Zhou Z, Zhou M, et al. Effects of endovascular and surface cooling on resuscitation in patients with cardiac arrest and a comparison of effectiveness, stability, and safety: a systematic review and meta-analysis. Crit Care, 2020, 24(1): 27.
- 25. Douma MJ, Aves T, Allan KS, et al. First aid cooling techniques for heat stroke and exertional hyperthermia: a systematic review and meta-analysis. Resuscitation, 2020, 148: 173-190.
- 26. Sonder P, Janssens GN, Beishuizen A, et al. Efficacy of different cooling technologies for therapeutic temperature management: a prospective intervention study. Resuscitation, 2018, 124: 14-20.
- 27. Rosman J, Hentzien M, Dramé M, et al. A comparison between intravascular and traditional cooling for inducing and maintaining temperature control in patients following cardiac arrest. Anaesth Crit Care Pain Med, 2018, 37(2): 129-134.
- 28. Zhang Y, Davis JK, Casa DJ, et al. Optimizing cold water immersion for exercise-induced hyperthermia: a meta-analysis. Med Sci Sports Exerc, 2015, 47(11): 2464-2472.
- 29. McDermott BP, Casa DJ, Ganio MS, et al. Acute whole-body cooling for exercise-induced hyperthermia: a systematic review. J Athl Train, 2009, 44(1): 84-93.
- 30. Casa DJ, McDermott BP, Lee EC, et al. Cold water immersion: the gold standard for exertional heatstroke treatment. Exerc Sport Sci Rev, 2007, 35(3): 141-149.
- 31. Proulx CI, Ducharme MB, Kenny GP. Effect of water temperature on cooling efficiency during hyperthermia in humans. J Appl Physiol (1985), 2003, 94(4): 1317-1323.
- 32. Okada T, Shioda K, Makiguchi A, et al. Risperidone and 5-HT2A receptor antagonists attenuate and reverse cocaine-induced hyperthermia in rats. Int J Neuropsychopharmacol, 2020, 23(12): 811-820.
- 33. 付灵华, 洪葵, 苏海. 可卡因与急性心肌梗死. 中国老年学杂志, 2016, 36(9): 2267-2270.
- 34. 王海燕. 可卡因滥用的心血管毒性. 新医学, 2010, 41(10): 691-694.
- 35. 姜醒华, 程晓曙, 吴延庆, 等. 吸食可卡因致急性心肌梗死一例. 中国介入心脏病学杂志, 2008, 16(4): 233-235.
- 36. 姜醒华, 程晓曙, 吴延庆, 等. 吸食可卡因引致急性心肌梗死. 江西医药, 2008, 43(12): 1343-1345.
- 37. Arenas DJ, Beltran S, Zhou S, et al. Cocaine, cardiomyopathy, and heart failure: a systematic review and meta-analysis. Sci Rep, 2020, 10(1): 19795.
- 38. Przywara DA, Dambach GE. Direct actions of cocaine on cardiac cellular electrical activity. Circ Res, 1989, 65(1): 185-192.
- 39. Vaughan Williams EM. A classification of antiarrhythmic actions reassessed after a decade of new drugs. J Clin Pharmacol, 1984, 24(4): 129-147.
- 40. Heit J, Hoffman RS, Goldfrank LR. The effects of lidocaine pretreatment on cocaine neurotoxicity and lethality in mice. Acad Emerg Med, 1994, 1(5): 438-442.
- 41. Shih RD, Hollander JE, Burstein JL, et al. Clinical safety of lidocaine in patients with cocaine-associated myocardial infarction. Ann Emerg Med, 1995, 26(6): 702-706.
- 42. Lormans P, Gaumann D, Schwieger I, et al. Ventricular fibrillation following local application of cocaine and epinephrine for nasal surgery. ORL J Otorhinolaryngol Relat Spec, 1992, 54(3): 160-162.
- 43. Kerns W 2nd, Garvey L, Owens J. Cocaine-induced wide complex dysrhythmia. J Emerg Med, 1997, 15(3): 321-329.
- 44. Baumann BM, Perrone J, Hornig SE, et al. Randomized, double-blind, placebo-controlled trial of diazepam, nitroglycerin, or both for treatment of patients with potential cocaine-associated acute coronary syndromes. Acad Emerg Med, 2000, 7(8): 878-885.
- 45. Wang RY. pH-dependent cocaine-induced cardiotoxicity. Am J Emerg Med, 1999, 17(4): 364-369.
- 46. Ortega-Carnicer J, Bertos-Polo J, Gutiérrez-Tirado C. Aborted sudden death, transient Brugada pattern, and wide QRS dysrrhythmias after massive cocaine ingestion. J Electrocardiol, 2001, 34(4): 345-349.
- 47. Irani F, Kasmani R, Kanjwal Y. Hyperkalemia and cocaine induced dynamic Brugada-type electrocardiogram. Eur J Emerg Med, 2010, 17(2): 113-115.
- 48. Tanen DA, Graeme KA, Curry SC. Crack cocaine ingestion with prolonged toxicity requiring electrical pacing. J Toxicol Clin Toxicol, 2000, 38(6): 653-657.
- 49. Hollander JE, Hoffman RS, Gennis P, et al. Nitroglycerin in the treatment of cocaine associated chest pain--clinical safety and efficacy. J Toxicol Clin Toxicol, 1994, 32(3): 243-256.
- 50. Lange RA, Hillis LD. Cardiovascular complications of cocaine use. N Engl J Med, 2001, 345(5): 351-358.
- 51. Richards JR, Garber D, Laurin EG, et al. Treatment of cocaine cardiovascular toxicity: a systematic review. Clin Toxicol (Phila), 2016, 54(5): 345-364.
- 52. Brogan WC 3rd, Lange RA, Kim AS, et al. Alleviation of cocaine-induced coronary vasoconstriction by nitroglycerin. J Am Coll Cardiol, 1991, 18(2): 581-586.
- 53. Pitts WR, Lange RA, Cigarroa JE, et al. Cocaine-induced myocardial ischemia and infarction: pathophysiology, recognition, and management. Prog Cardiovasc Dis, 1997, 40(1): 65-76.
- 54. Lucyk SN. Acute cardiovascular toxicity of cocaine. Can J Cardiol, 2022, 38(9): 1384-1394.
- 55. Muntaner C, Kumor KM, Nagoshi C, et al. Effects of nifedipine pretreatment on subjective and cardiovascular responses to intravenous cocaine in humans. Psychopharmacology (Berl), 1991, 105(1): 37-41.
- 56. Stenberg RG, Winniford MD, Hillis LD, et al. Simultaneous acute thrombosis of two major coronary arteries following intravenous cocaine use. Arch Pathol Lab Med, 1989, 113(5): 521-524.
- 57. Schindler CW, Tella SR, Prada J, et al. Calcium channel blockers antagonize some of cocaine’s cardiovascular effects, but fail to alter cocaine’s behavioral effects. J Pharmacol Exp Ther, 1995, 272(2): 791-798.
- 58. Potocka-Banaś B, Janus T, Majdanik S, et al. Fatal Intoxication with α-PVP, a synthetic cathinone derivative. J Forensic Sci, 2017, 62(2): 553-556.
- 59. Bosak A, LoVecchio F, Levine M. Recurrent seizures and serotonin syndrome following “2C-I” ingestion. J Med Toxicol, 2013, 9(2): 196-198.
- 60. Refstad S. Paramethoxyamphetamine (PMA) poisoning; a ‘party drug’ with lethal effects. Acta Anaesthesiol Scand, 2003, 47(10): 1298-1299.
- 61. Mueller PD, Korey WS. Death by “ecstasy”: the serotonin syndrome?. Ann Emerg Med, 1998, 32(3): 377-380.
- 62. Tsai C, Quidgley-Martin M, Laub N, et al. Methamphetamine-associated pulseless electrical activity in a young child. Am J Emerg Med, 2021, 39: 257.e1-257.e2.
- 63. Dagli C, Duman I. Successful use of early therapeutic hypothermia in an MDMA and amphetamine intoxication-induced out-of-hospital cardiac arrest: a case report. J Emerg Med, 2020, 59(3): e89-e92.
- 64. Mende L, Böhm R, Regenthal R, et al. Cardiac arrest caused by an ecstasy intoxication. Anasthesiol Intensivmed Notfallmed Schmerzther, 2005, 40(12): 762-765.
- 65. Packe GE, Garton MJ, Jennings K. Acute myocardial infarction caused by intravenous amphetamine abuse. Br Heart J, 1990, 64(1): 23-24.
- 66. Yap CYL, Taylor DM, Knott JC, et al. Intravenous midazolam-droperidol combination, droperidol or olanzapine monotherapy for methamphetamine-related acute agitation: subgroup analysis of a randomized controlled trial. Addiction, 2017, 112(7): 1262-1269.
- 67. Hofer KE, Faber K, Müller DM, et al. Acute toxicity associated with the recreational use of the novel psychoactive benzofuran N-methyl-5-(2 aminopropyl)benzofuran. Ann Emerg Med, 2017, 69(1): 79-82.
- 68. Richards JR, Albertson TE, Derlet RW, et al. Treatment of toxicity from amphetamines, related derivatives, and analogues: a systematic clinical review. Drug Alcohol Depend, 2015, 150: 1-13.
- 69. Martel M, Sterzinger A, Miner J, et al. Management of acute undifferentiated agitation in the emergency department: a randomized double-blind trial of droperidol, ziprasidone, and midazolam. Acad Emerg Med, 2005, 12(12): 1167-1172.
- 70. Knott JC, Taylor DM, Castle DJ. Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department. Ann Emerg Med, 2006, 47(1): 61-67.
- 71. Nobay F, Simon BC, Levitt MA, et al. A prospective, double-blind, randomized trial of midazolam versus haloperidol versus lorazepam in the chemical restraint of violent and severely agitated patients. Acad Emerg Med, 2004, 11(7): 744-749.
- 72. Derlet RW, Albertson TE, Rice P. Protection against d-amphetamine toxicity. Am J Emerg Med, 1990, 8(2): 105-108.
- 73. Derlet RW, Albertson TE, Rice P. Antagonism of cocaine, amphetamine, and methamphetamine toxicity. Pharmacol Biochem Behav, 1990, 36(4): 745-749.
- 74. Strömmer EMF, Leith W, Zeegers MP, et al. The role of restraint in fatal excited delirium: a research synthesis and pooled analysis. Forensic Sci Med Pathol, 2020, 16(4): 680-692.
- 75. Otahbachi M, Cevik C, Bagdure S, et al. Excited delirium, restraints, and unexpected death: a review of pathogenesis. Am J Forensic Med Pathol, 2010, 31(2): 107-112.
- 76. Qasim A, Townend J, Davies MK. Ecstasy induced acute myocardial infarction. Heart, 2001, 85(6): E10.
- 77. Pollanen MS, Chiasson DA, Cairns JT, et al. Unexpected death related to restraint for excited delirium: a retrospective study of deaths in police custody and in the community. CMAJ, 1998, 158(12): 1603-1607.
- 78. Douglas N, Carew J, Johnson D, et al. Safety and efficacy of an on-site intensive treatment protocol for mild and moderate sympathomimetic toxicity at Australian music festivals. Prehosp Disaster Med, 2020, 35(1): 41-45.
- 79. Laskowski LK, Landry A, Vassallo SU, et al. Ice water submersion for rapid cooling in severe drug-induced hyperthermia. Clin Toxicol (Phila), 2015, 53(3): 181-184.
- 80. Armenian P, Mamantov TM, Tsutaoka BT, et al. Multiple MDMA (Ecstasy) overdoses at a rave event: a case series. J Intensive Care Med, 2013, 28(4): 252-258.
- 81. Chen JP. Methamphetamine-associated acute myocardial infarction and cardiogenic shock with normal coronary arteries: refractory global coronary microvascular spasm. J Invasive Cardiol, 2007, 19(4): E89-E92.
- 82. Wijetunga M, Bhan R, Lindsay J, et al. Acute coronary syndrome and crystal methamphetamine use: a case series. Hawaii Med J, 2004, 63(1): 8-13, 25.
- 83. Hong R, Matsuyama E, Nur K. Cardiomyopathy associated with the smoking of crystal methamphetamine. JAMA, 1991, 265(9): 1152-1154.
- 84. Minhaj FS, Schult RF, Dvorak P, et al. Amphetamine and clonidine toxicity resulting in posterior reversible encephalopathy syndrome. Pediatr Emerg Care, 2021, 37(12): e1721-e1723.
- 85. White C, Jeanmonod R. Reverse takotsubo cardiomyopathy after accidental exposure to an illicit substance: a case report. Cureus, 2022, 14(4): e24282.
- 86. Cotinet PA, Bizouarn P, Roux F, et al. Management of cardiogenic shock by circulatory support during reverse Tako-Tsubo following amphetamine exposure: a report of two cases. Heart Lung, 2021, 50(3): 465-469.
- 87. Aly SM, Deheul S, Puymirat E, et al. Takotsubo cardiomyopathy as a consequence of 4-fluoroamphetamine mono-intoxication documented by toxicological analyses. Clin Toxicol (Phila), 2021, 59(1): 73-74.
- 88. Simões MV, Maciel BC, Marin-Neto JA. Reversible segmental left-ventricular dysfunction caused by accidental administration of sympathomimetic drug in human. Int J Cardiol, 1997, 61(1): 93-96.
- 89. Al-Abri S, Meier KH, Colby JM, et al. Cardiogenic shock after use of fluoroamphetamine confirmed with serum and urine levels. Clin Toxicol (Phila), 2014, 52(10): 1292-1295.
- 90. 谢伟, 徐前程, 王涛, 等. 静脉-动脉体外膜氧合联合主动脉球囊反搏治疗对重症心源性休克患者预后的临床分析. 齐齐哈尔医学院学报, 2023, 44(2): 122-126.
- 91. 潘晨亮, 赵晶, 胡思雄, 等. 急性心肌梗死合并心原性休克患者应用 VA-ECMO 联合 IABP 的时机探索. 中华心血管病杂志, 2023, 51(8): 851-858.
- 92. 崔晓娜, 冯瑞霞, 韩雨澎, 等. 静脉-动脉体外膜肺氧合和主动脉内球囊反搏联合辅助顺序对急性心肌梗死合并心源性休克患者的临床效果比较研究. 中国全科医学, 2023, 26(35): 4439-4445.
- 93. Wang D, Chao V, Yap KH, et al. Does concurrent use of intra-aortic balloon pumps improve survival in patients with cardiogenic shock requiring venoarterial extracorporeal membrane oxygenation?. Interact Cardiovasc Thorac Surg, 2020, 30(2): 312-315.
- 94. Di Gregorio G, Neal JM, Rosenquist RW, et al. Clinical presentation of local anesthetic systemic toxicity: a review of published cases, 1979 to 2009. Reg Anesth Pain Med, 2010, 35(2): 181-187.
- 95. Neal JM, Barrington MJ, Fettiplace MR, et al. The third American Society of Regional Anesthesia and Pain Medicine Practice Advisory on local anesthetic systemic toxicity: executive summary 2017. Reg Anesth Pain Med, 2018, 43(2): 113-123.
- 96. Dickerson DM, Apfelbaum JL. Local anesthetic systemic toxicity. Aesthet Surg J, 2014, 34(7): 1111-1119.
- 97. Weinberg GL. Treatment of local anesthetic systemic toxicity (LAST). Reg Anesth Pain Med, 2010, 35(2): 188-193.
- 98. Gitman M, Barrington MJ. Local anesthetic systemic toxicity: a review of recent case reports and registries. Reg Anesth Pain Med, 2018, 43(2): 124-130.
- 99. Hoegberg LC, Bania TC, Lavergne V, et al. Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity. Clin Toxicol (Phila), 2016, 54(3): 167-193.
- 100. Mallampati SR, Liu PL, Knapp RM. Convulsions and ventricular tachycardia from bupivacaine with epinephrine: successful resuscitation. Anesth Analg, 1984, 63(9): 856-859.
- 101. Zaballos M, Callejo D, Sevilla R, et al. Comparative effects of sodium bicarbonate and intravenous lipid emulsions on reversing bupivacaine-induced electrophysiological toxicity in a porcine experimental model. Anesth Analg, 2019, 129(1): 63-72.
- 102. Fettiplace MR, Weinberg G. The mechanisms underlying lipid resuscitation therapy. Reg Anesth Pain Med, 2018, 43(2): 138-149.
- 103. Gosselin S, Hoegberg LC, Hoffman RS, et al. Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clin Toxicol (Phila), 2016, 54(10): 899-923.
- 104. Neal JM, Neal EJ, Weinberg GL. American Society of Regional Anesthesia and Pain Medicine Local Anesthetic Systemic Toxicity checklist: 2020 version. Reg Anesth Pain Med, 2021, 46(1): 81-82.
- 105. Dureau P, Charbit B, Nicolas N, et al. Effect of intralipid® on the dose of ropivacaine or levobupivacaine tolerated by volunteers: a clinical and pharmacokinetic study. Anesthesiology, 2016, 125(3): 474-483.
- 106. Groban L. Central nervous system and cardiac effects from long-acting amide local anesthetic toxicity in the intact animal model. Reg Anesth Pain Med, 2003, 28(1): 3-11.
- 107. Wolfe JW, Butterworth JF. Local anesthetic systemic toxicity: update on mechanisms and treatment. Curr Opin Anaesthesiol, 2011, 24(5): 561-566.