Current status and influencing factors of salivation in patients with orotracheal cannula_West China Medical Journal

Authors：

DU Jinlei ¹ , NIE Chencong ¹ ,  LEI Ling ¹ , ZHAO Hongxiang ¹ , ZHANG Qiyu ² , YE Qun ³ , PENG Gutao ⁴ , CHEN Zhimei ⁵ , ZHANG Shangshu ⁶

1. Department of Intensive Care Medicine, Zigong Fourth People’s Hospital, Zigong, Sichuan 643000, P. R. China;
2. School of Nursing, North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;
3. Department of Critical Care Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, P. R. China;
4. Department of Neurosurgery, the Affiliated Fuling Hospital of Chongqing University, Chongqing 408000, P. R. China;
5. Department of Critical Care Medicine, the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550000, P. R. China;
6. Department of Critical Care Medicine, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, P. R. China;

Corresponding author：

LEI Ling, Email: 837024980@qq.com

Keywords：

Tracheal intubation; salivation; occurrence status; influencing factor

DOI：

10.7507/1002-0179.202312058

Video：

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Objective To investigate the current situation of salivation in patients with orotracheal cannula, and to systematically analyze its influencing factors. Methods Patients who underwent tracheal intubation treatment in 47 tertiary comprehensive medical institutions were selected between October 10th and 20th, 2023. A cross-sectional survey method was used to conduct an online survey of the patient’s salivation status. The patients were divided into the salivation group and no-salivation group. Results A total of 565 questionnaires were collected and 561 were valid, with an effective recovery rate of 99%. Among 561 patients, 284 were males (50.62%) and 277 were females (49.38%), with an age of (59.80±10.96) years; 159 cases of salivation occurred, with a total static saliva flow rate of (7.21±3.15) mL and the incidence of salivation was 28.34% (159/561). There were statistically significant differences in age, education level, body mass index, primary disease, number of concurrent functional impairments, concurrent oral diseases, smoking, intubation days, intubation depth, intubation process, sedation and/or analgesia days, and enteral nutrition treatment between the two groups (P<0.05). There was no statistically significant difference in other indicators between the two groups (P>0.05). The results of multivariate logistic regression analysis showed that body mass index, neurological diseases, number of concurrent functional impairments, concurrent oral diseases, smoking, intubation days and intubation process were independent risk factors for salivation in patients with oral catheterization. Conclusion The incidence of salivation in patients with orotracheal cannula is 28.34%, which is directly related to body mass index, neurological diseases, number of concurrent functional impairments, concurrent oral diseases, smoking, intubation days and intubation process.

Citation： DU Jinlei, NIE Chencong, LEI Ling, ZHAO Hongxiang, ZHANG Qiyu, YE Qun, PENG Gutao, CHEN Zhimei, ZHANG Shangshu. Current status and influencing factors of salivation in patients with orotracheal cannula. West China Medical Journal, 2024, 39(6): 913-919. doi: 10.7507/1002-0179.202312058 Copy

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13.	Ladwig KH, Schriever SC, Atasoy S, et al. Association of generalized and central obesity with serum and salivary cortisol secretion patterns in the elderly: findings from the cross sectional KORA-age study. Sci Rep, 2020, 10(1): 14321.
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21.	唐莉, 李敏, 姚倩. 经口气管插管病人口腔黏膜压力性损伤护理的研究进展. 护理研究, 2023, 37(20): 3682-3686.

1. Yoshimura J, Yamakawa K, Ohta Y, et al. Effect of Gram stain-guided initial antibiotic therapy on clinical response in patients with ventilator-associated pneumonia: the GRACE-vap randomized clinical trial. JAMA Netw Open, 2022, 5(4): e226136.
2. 赵顺杰, 白莎, 王恬, 等. 肌萎缩侧索硬化患者流涎症评估方法的研究进展. 护理学报, 2022, 29(19): 25-29.
3. Verhoeff MC, Koutris M, Vries R, et al. Salivation in Parkinson’s disease: a scoping review. Gerodontology, 2023, 40(1): 26-38.
4. Subra M, Dezi M, Bigay J, et al. VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites. Dev Cell, 2023, 58(2): 121-138.
5. Shrimpton AJ, O’Farrell G, Howes HM, et al. A quantitative evaluation of aerosol generation during awake tracheal intubation. Anaesthesia, 2023, 78(5): 587-597.
6. 杜金磊, 聂臣聪, 雷玲, 等. 基于信息化平台对机械通气患者声门下分泌物精准化管理方案的探索研究. 山西医药杂志, 2022, 51(1): 92-97.
7. 杨和金. 观察针刺联合口腔感觉运动疗法治疗小儿脑性瘫痪流涎症疗效. 保健医学研究与实践, 2021, 18(S1): 4-6.
8. 肖王静, 王万胜, 彭玲, 等. 超声引导下注射 A 型肉毒毒素治疗脑卒中后流涎症 1 例报道及文献复习. 实用老年医学, 2023, 37(1): 104-106.
9. 王红梅, BOSOMTWE Samuel, 杜金磊, 等. 经口气管插管患者流涎症影响因素和干预措施的研究进展. 中华全科医学, 2021, 19(12): 2102-2105.
10. 王松灵, 窦慧昕, 秦力铮, 等. 流唾症的病因、诊断与治疗. 口腔疾病防治, 2019, 27(8): 477-484.
11. 欧平花, 李翠, 苏华, 等. 口腔疾病规范化诊治方案. 长沙: 中南大学出版社, 2022.
12. Du J, Chengcong N, Wu X. Volume-based subglottic secretion drainage: a randomized controlled trial. Ann Med Surg (Lond), 2024, 86(3): 1426-1432.
13. Ladwig KH, Schriever SC, Atasoy S, et al. Association of generalized and central obesity with serum and salivary cortisol secretion patterns in the elderly: findings from the cross sectional KORA-age study. Sci Rep, 2020, 10(1): 14321.
14. Naeem F, Reid J, Bailey M, et al. Pharmacological interventions for sialorrhoea in people with Parkinson’s disease: a systematic review and meta-analysis. Mov Disord Clin Pract, 2023, 10(4): 558-568.
15. 苗久旺, 苗久旺. 药理学. 北京: 中国医药科技出版社, 2022.
16. 吴振波, 陈虹宇, 彭潇, 等. 氯氮平治疗精神分裂症期间流涎的影响因素. 中国药物与临床, 2022, 22(7): 618-621.
17. 孔艳玲, 张少波. 胞磷胆碱钠注射液致流涎 1 例. 中国药物警戒, 2017, 14(9): 569, 571.
18. Proctor GB, Shaalan AM. Disease-induced changes in salivary gland function and the composition of saliva. J Dent Res, 2021, 100(11): 1201-1209.
19. Yoon NY, Yun I, Park YS, et al. Associations between environmental tobacco smoke exposure and oral health symptoms in adolescents. BMC Oral Health, 2022, 22(1): 397.
20. Ahonen H, Neher M, Fransson EI, et al. Views on oral health determinants as described by persons with continuous positive airway pressure-treated obstructive sleep apnoea: a qualitative study. BMC Oral Health, 2023, 23(1): 407.
21. 唐莉, 李敏, 姚倩. 经口气管插管病人口腔黏膜压力性损伤护理的研究进展. 护理研究, 2023, 37(20): 3682-3686.

West China Medical Journal

Current status and influencing factors of salivation in patients with orotracheal cannula

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