Research progress of regenerative rehabilitation_West China Medical Journal

Authors：

QI Tong ^1,2 ,  HE Chengqi ^1,2

1. Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

HE Chengqi, Email: hxkfhcq2015@126.com

Keywords：

Regenerative medicine; rehabilitation medicine; regenerative rehabilitation; stem cells; platelet-rich plasma

DOI：

10.7507/1002-0179.202404123

Video：

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Abstract Full text Figures/Tables Video References Cited by

In recent years, regenerative medical technology and modern rehabilitation technology complement each other and develop rapidly. Regenerative rehabilitation with tissue regeneration and functional recovery as the core concept arises at the historic moment. Regenerative rehabilitation can quickly repair damaged or diseased tissues and organs, and restore or improve the function of patients to the greatest extent. This paper introduces the origin and development of regenerative rehabilitation, discusses the research progress and significance of related strategies from three aspects of neurological, motor and circulatory diseases, and stress the importance of regenerative rehabilitation in helping patients to obtain the best curative effect.

Citation： QI Tong, HE Chengqi. Research progress of regenerative rehabilitation. West China Medical Journal, 2024, 39(6): 845-850. doi: 10.7507/1002-0179.202404123 Copy

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1. Greising SM, Call JA. Regenerative rehabilitation: from basic science to the clinic. Cham: Springer Nature, 2022.
2. Rose LF, Wolf EJ, Brindle T, et al. The convergence of regenerative medicine and rehabilitation: federal perspectives. NPJ Regen Med, 2018, 3(1): 19.
3. Head PL. Rehabilitation considerations in regenerative medicine. Phys Med Rehabil Clin N Am, 2016, 27(4): 1043-1054.
4. 付小兵, 程飚. 再生康复医学:新需求新融合新方向. 中华烧伤与创面修复杂志, 2018, 34(2): 65-68.
5. Daar AS, Greenwood HL. A proposed definition of regenerative medicine. J Tissue Eng Regen Med, 2007, 1(3): 179-184.
6. Atanelov L, Stiens SA, Young MA. History of physical medicine and rehabilitation and its ethical dimensions. AMA J Ethics, 2015, 17(6): 568-574.
7. Rodriguez AM, Elabd C, Amri EZ, et al. The human adipose tissue is a source of multipotent stem cells. Biochimie, 2005, 87(1): 125-128.
8. Perez-Terzic C, Childers MK. Regenerative rehabilitation: a new future?. Am J Phys Med Rehabil, 2014, 93(11 Suppl 3): S73-S78.
9. Willett NJ, Boninger ML, Miller LJ, et al. Taking the next steps in regenerative rehabilitation: establishment of a new interdisciplinary field. Arch Phys Med Rehabil, 2020, 101(5): 917-923.
10. 付小兵. 组织再生:梦想、希望和挑战. 中国工程科学, 2009, 11(10): 122-128.
11. 付小兵. 对组织再生和再生医学发展的再思考. 中华烧伤杂志, 2011, 27(1): 1-2.
12. Budde H, Wegner M, Soya H, et al. Neuroscience of exercise: neuroplasticity and its behavioral consequences. Neural Plast, 2016, 2016: 3643879.
13. Grumbles RM, Liu Y, Thomas CM, et al. Acute stimulation of transplanted neurons improves motoneuron survival, axon growth, and muscle reinnervation. J Neurotrauma, 2013, 30(12): 1062-1069.
14. Kurimoto S, Kato S, Nakano T, et al. Transplantation of embryonic motor neurons into peripheral nerve combined with functional electrical stimulation restores functional muscle activity in the rat sciatic nerve transection model. J Tissue Eng Regen Med, 2016, 10(10): E477-E484.
15. Zipser CM, Cragg JJ, Guest JD, et al. Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials. Lancet Neurol, 2022, 21(7): 659-670.
16. Canning CG, Allen NE, Nackaerts E, et al. Virtual reality in research and rehabilitation of gait and balance in Parkinson disease. Nat Rev Neurol, 2020, 16(8): 409-425.
17. Wang YY, Cheng J, Liu YD, et al. Exosome-based regenerative rehabilitation: a novel ice breaker for neurological disorders. Biomed Pharmacother, 2023, 169: 115920.
18. Červenka J, Tylečková J, Kupcová Skalníková H, et al. Proteomic characterization of human neural stem cells and their secretome during in vitro differentiation. Front Cell Neurosci, 2021, 14: 612560.
19. Centeno CJ, Pastoriza SM. Past, current and future interventional orthobiologics techniques and how they relate to regenerative rehabilitation: a clinical commentary. Int J Sports Phys Ther, 2020, 15(2): 301.
20. Xing Y, Bai Y. A review of exercise-induced neuroplasticity in ischemic stroke: pathology and mechanisms. Mol Neurobiol, 2020, 57(10): 4218-4231.
21. Szelenberger R, Kostka J, Saluk-Bijak J, et al. Pharmacological interventions and rehabilitation approach for enhancing brain self-repair and stroke recovery. Curr Neuropharmacol, 2020, 18(1): 51-64.
22. Zhang YX, Yuan MZ, Cheng L, et al. Treadmill exercise enhances therapeutic potency of transplanted bone mesenchymal stem cells in cerebral ischemic rats via anti-apoptotic effects. BMC Neurosci, 2015, 16: 1-8.
23. Ito A, Kubo N, Liang N, et al. Regenerative rehabilitation for stroke recovery by inducing synergistic effects of cell therapy and neurorehabilitation on motor function: a narrative review of pre-clinical studies. Int J Mol Sci, 2020, 21(9): 3135.
24. Lin L, Skakavac N, Lin X, et al. Acupuncture-induced analgesia: the role of microglial inhibition. Cell Transplant, 2016, 25(4): 621-628.
25. Iwasa SN, Babona-Pilipos R, Morshead CM. Environmental factors that influence stem cell migration: an “electric field”. Stem Cells Int, 2017, 2017: 4276927.
26. Emmons R, Niemiro GM, De Lisio M. Exercise as an adjuvant therapy for hematopoietic stem cell mobilization. Stem Cells Int, 2016, 2016: 7131359.
27. Wang Y, Gao Z, Zhang Y, et al. Attenuated reactive gliosis and enhanced functional recovery following spinal cord injury in null mutant mice of platelet-activating factor receptor. Mol Neurobiol, 2016, 53(5): 3448-3461.
28. Wang HF, Liu XK, Li R, et al. Effect of glial cells on remyelination after spinal cord injury. Neural Regen Res, 2017, 12(10): 1724-1732.
29. Moritz CT, Ambrosio F. Regenerative rehabilitation: combining stem cell therapies and activity-dependent stimulation. Pediatr Phys Ther, 2017, 29(Suppl 3): S10-S15.
30. Balbinot G. Neuromodulation to guide circuit reorganization with regenerative therapies in upper extremity rehabilitation following cervical spinal cord injury. Front Rehabil Sci, 2024, 4: 1320211.
31. Balbinot G, Li G, Gauthier C, et al. Functional electrical stimulation therapy for upper extremity rehabilitation following spinal cord injury: a pilot study. Spinal Cord Ser Cases, 2023, 9(1): 11.
32. Cataln LE, Villegas AM, Liber LT, et al. Synthesis of nine safrole derivatives and their antiproliferative activity towards human cancer cells. J Chil Chem Soc, 2010, 55(2): 219-222.
33. Tashiro S, Shinozaki M, Mukaino M, et al. BDNF induced by treadmill training contributes to the suppression of spasticity and allodynia after spinal cord injury via upregulation of KCC2. Neurorehabil Neural Repair, 2015, 29(7): 677-689.
34. Saunders D, Rose L. Regenerative rehabilitation of catastrophic extremity injury in military conflicts and a review of recent developmental efforts. Connect Tissue Res, 2021, 62(1): 83-98.
35. Ross HH, Ambrosio F, Trumbower RD, et al. Neural stem cell therapy and rehabilitation in the central nervous system: emerging partnerships. Phys Ther, 2016, 96(5): 734-742.
36. Gurjar AA, Manto KM, Estrada JA, et al. 4-aminopyridine: a single-dose diagnostic agent to differentiate axonal continuity in nerve injuries. Mil Med, 2021, 186(Suppl 1): 479-485.
37. Qi T, Zhang X, Gu X, et al. Experimental study on repairing peripheral nerve defects with novel bionic tissue engineering. Adv Healthc Mater, 2023, 12(17): e2203199.
38. Song J, Sun B, Liu S, et al. Polymerizing pyrrole coated poly (l-lactic acid-co-ε-caprolactone)(PLCL) conductive nanofibrous conduit combined with electric stimulation for long-range peripheral nerve regeneration. Front Mol Neurosci, 2016, 9: 117.
39. Glatt V, Evans CH, Stoddart MJ. Regenerative rehabilitation: the role of mechanotransduction in orthopaedic regenerative medicine. J Orthop Res, 2019, 37(6): 1263-1269.
40. Thompson WR, Scott A, Loghmani MT, et al. Understanding mechanobiology: physical therapists as a force in mechanotherapy and musculoskeletal regenerative rehabilitation. Phys Ther, 2016, 96(4): 560-569.
41. Cheuy V, Picciolini S, Bedoni M. Progressing the field of regenerative rehabilitation through novel interdisciplinary interaction. NPJ Regen Med, 2020, 5: 16.
42. Emery AE. The muscular dystrophies. Lancet, 2002, 359(9307): 687-695.
43. Bouchentouf M, Benabdallah BF, Mills P, et al. Exercise improves the success of myoblast transplantation in mdx mice. Neuromuscul Disord, 2006, 16(8): 518-529.
44. Call JA, McKeehen JN, Novotny SA, et al. Progressive resistance voluntary wheel running in the mdx mouse. Muscle Nerve, 2010, 42(6): 871-880.
45. Lindsay A, Larson AA, Verma M, et al. Isometric resistance training increases strength and alters histopathology of dystrophin-deficient mouse skeletal muscle. J Appl Physiol (1985), 2019, 126(2): 363-375.
46. Teixeira E, Duarte JA. Skeletal muscle loading changes its regenerative capacity. Sports Med, 2016, 46(6): 783-792.
47. Partridge TA, Morgan JE, Coulton GR, et al. Conversion of mdx myofibres from dystrophin-negative to -positive by injection of normal myoblasts. Nature, 1989, 337(6203): 176-179.
48. Gentile NE, Stearns KM, Brown EH, et al. Targeted rehabilitation after extracellular matrix scaffold transplantation for the treatment of volumetric muscle loss. Am J Phys Med Rehabil, 2014, 93(11 Suppl 3): S79-S87.
49. Garg K, Ward CL, Hurtgen BJ, et al. Volumetric muscle loss: persistent functional deficits beyond frank loss of tissue. J Orthop Res, 2015, 33(1): 40-46.
50. Dziki J, Badylak S, Yabroudi M, et al. An acellular biologic scaffold treatment for volumetric muscle loss: results of a 13-patient cohort study. NPJ Regen Med, 2016, 1: 16008.
51. Greising SM, Corona BT, McGann C, et al. Therapeutic approaches for volumetric muscle loss injury: a systematic review and meta-analysis. Tissue Eng Part B Rev, 2019, 25(6): 510-525.
52. Frost HM. Bone’s mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol, 2003, 275(2): 1081-1101.
53. Heckman JD, Ryaby JP, McCabe J, et al. Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. J Bone Joint Surg Am, 1994, 76(1): 26-34.
54. Kristiansen TK, Ryaby JP, Mccabe J, et al. Accelerated healing of distal radial fractures with the use of specific, low-intensity ultrasound. A multicenter, prospective, randomized, double-blind, placebo-controlled study. JBJS, 1997, 79(7): 961-973.
55. Kubiak EN, Beebe MJ, North K, et al. Early weight bearing after lower extremity fractures in adults. J Am Acad Orthop Surg, 2013, 21(12): 727-738.
56. Leppik L, Zhihua H, Mobini S, et al. Combining electrical stimulation and tissue engineering to treat large bone defects in a rat model. Sci Rep, 2018, 8(1): 6307.
57. Hardy JG, Villancio-Wolter MK, Sukhavasi RC, et al. Electrical stimulation of human mesenchymal stem cells on conductive nanofibers enhances their differentiation toward osteogenic outcomes. Macromol Rapid Commun, 2015, 36(21): 1884-1890.
58. Cheung WH, Chin WC, Wei FY, et al. Applications of exogenous mesenchymal stem cells and low intensity pulsed ultrasound enhance fracture healing in rat model. Ultrasound Med Biol, 2013, 39(1): 117-125.
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