Application of hydrogel materials in renal tissue engineering_West China Medical Journal

Authors：

WANG Haiyang ¹ , LU Zijie ² , FANG Chao ³ ,  LI Xiang ^1,2,3,4

1. ZJU-Xinchang Joint Innovation Center (TianMu Laboratory), Shaoxing, Zhejiang 312532, P. R. China;
2. Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, Zhejiang 310018, P. R. China;
3. iBioMat PharmTek Co. Ltd, Hangzhou, Zhejiang 311100, P. R. China;
4. School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China;

Corresponding author：

LI Xiang, Email: xiang.li@zju.edu.cn

Keywords：

Acute kidney injury; kidney tissue engineering; hydrogels; renal replacement therapy

DOI：

10.7507/1002-0179.202406086

Video：

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Abstract Full text Figures/Tables Video References Cited by

Acute kidney injury is a worldwide public health issue, and its treatment and management strategies continue to advance. In addition to traditional kidney replacement therapy, research in recent years has been focused on whole organ engineering and biofabrication of kidney assistive devices and bioinjections for in-body regeneration. Hydrogel materials show great potential in renal tissue engineering because of their good biocompatibility, thermal stability and controllable biochemical and mechanical properties. This article reviews the application of various hydrogel materials in renal tissue engineering to promote kidney regeneration and discusses the characteristics and applications of natural hydrogels and synthetic hydrogels, which is expected to further promote their clinical applications.

Citation： WANG Haiyang, LU Zijie, FANG Chao, LI Xiang. Application of hydrogel materials in renal tissue engineering. West China Medical Journal, 2024, 39(7): 1010-1014. doi: 10.7507/1002-0179.202406086 Copy

1.	Lewington AJ, Cerdá J, Mehta RL. Raising awareness of acute kidney injury: a global perspective of a silent killer. Kidney Int, 2013, 84(3): 457-467.
2.	Kellum JA, Romagnani P, Ashuntantang G, et al. Acute kidney injury. Nat Rev Dis Primers, 2021, 7(1): 52.
3.	Peerapornratana S, Manrique-Caballero CL, Gómez H, et al. Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int, 2019, 96(5): 1083-1099.
4.	James MT, Bhatt M, Pannu N, et al. Long-term outcomes of acute kidney injury and strategies for improved care. Nat Rev Nephrol, 2020, 16(4): 193-205.
5.	Syed Mohamed SMD, Welsh GI, Roy I. Renal tissue engineering for regenerative medicine using polymers and hydrogels. Biomater Sci, 2023, 11(17): 5706-5726.
6.	Kharkar PM, Kiick KL, Kloxin AM. Designing degradable hydrogels for orthogonal control of cell microenvironments. Chem Soc Rev, 2013, 42(17): 7335-7372.
7.	Magno V, Friedrichs J, Weber HM, et al. Macromolecular crowding for tailoring tissue-derived fibrillated matrices. Acta Biomater, 2017, 55: 109-119.
8.	Lih E, Park W, Park KW, et al. A bioinspired scaffold with anti-inflammatory magnesium hydroxide and decellularized extracellular matrix for renal tissue regeneration. ACS Cent Sci, 2019, 5(3): 458-467.
9.	Ali M, Pr AK, Yoo JJ, et al. A photo-crosslinkable kidney ECM-derived bioink accelerates renal tissue formation. Adv Healthc Mater, 2019, 8(7): e1800992.
10.	Wu H, Zhang R, Hu B, et al. A porous hydrogel scaffold mimicking the extracellular matrix with swim bladder derived collagen for renal tissue regeneration. Chinese Chem Lett, 2021, 32(12): 3940-3947.
11.	Chu TL, Tripathi G, Park M, et al. In-vitro and in-vivo biocompatibility of dECM-alginate as a promising candidate in cell delivery for kidney regeneration. Int J Biol Macromol, 2022, 211: 616-625.
12.	Trouche E, Girod Fullana S, Mias C, et al. Evaluation of alginate microspheres for mesenchymal stem cell engraftment on solid organ. Cell Transplant, 2010, 19(12): 1623-1633.
13.	Fu Z, Chu Y, Geng X, et al. Artificial kidney capsule packed with mesenchymal stem cell-laden hydrogel for the treatment of rhabdomyolysis-induced acute kidney injury. ACS Biomater Sci Eng, 2022, 8(4): 1726-1734.
14.	Liu S, Zhao M, Zhou Y, et al. A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury. Acta Biomater, 2019, 103: 102-114.
15.	Wang H, Shang Y, Chen X, et al. Delivery of MSCs with a hybrid β-sheet peptide hydrogel consisting IGF-1C domain and D-form peptide for acute kidney injury therapy. Int J Nanomedicine, 2020, 15: 4311-4324.
16.	Gao J, Liu R, Wu J, et al. The use of chitosan based hydrogel for enhancing the therapeutic benefits of adipose-derived MSCs for acute kidney injury. Biomaterials, 2012, 33(14): 3673-3681.
17.	Han DS, Erickson C, Hansen KC, et al. Mesenchymal stem cells delivered locally to ischemia-reperfused kidneys via injectable hyaluronic acid hydrogels decrease extracellular matrix remodeling 1 month after injury in male mice. Cells, 2023, 12(13): 1771.
18.	Tsurkan MV, Hauser PV, Zieris A, et al. Growth factor delivery from hydrogel particle aggregates to promote tubular regeneration after acute kidney injury. J Control Release, 2013, 167(3): 248-255.
19.	Deng L, Liu Y, Yang L, et al. Injectable and bioactive methylcellulose hydrogel carrying bone mesenchymal stem cells as a filler for critical-size defects with enhanced bone regeneration. Colloids Surf B Biointerfaces, 2020, 194: 111159.

1. Lewington AJ, Cerdá J, Mehta RL. Raising awareness of acute kidney injury: a global perspective of a silent killer. Kidney Int, 2013, 84(3): 457-467.
2. Kellum JA, Romagnani P, Ashuntantang G, et al. Acute kidney injury. Nat Rev Dis Primers, 2021, 7(1): 52.
3. Peerapornratana S, Manrique-Caballero CL, Gómez H, et al. Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int, 2019, 96(5): 1083-1099.
4. James MT, Bhatt M, Pannu N, et al. Long-term outcomes of acute kidney injury and strategies for improved care. Nat Rev Nephrol, 2020, 16(4): 193-205.
5. Syed Mohamed SMD, Welsh GI, Roy I. Renal tissue engineering for regenerative medicine using polymers and hydrogels. Biomater Sci, 2023, 11(17): 5706-5726.
6. Kharkar PM, Kiick KL, Kloxin AM. Designing degradable hydrogels for orthogonal control of cell microenvironments. Chem Soc Rev, 2013, 42(17): 7335-7372.
7. Magno V, Friedrichs J, Weber HM, et al. Macromolecular crowding for tailoring tissue-derived fibrillated matrices. Acta Biomater, 2017, 55: 109-119.
8. Lih E, Park W, Park KW, et al. A bioinspired scaffold with anti-inflammatory magnesium hydroxide and decellularized extracellular matrix for renal tissue regeneration. ACS Cent Sci, 2019, 5(3): 458-467.
9. Ali M, Pr AK, Yoo JJ, et al. A photo-crosslinkable kidney ECM-derived bioink accelerates renal tissue formation. Adv Healthc Mater, 2019, 8(7): e1800992.
10. Wu H, Zhang R, Hu B, et al. A porous hydrogel scaffold mimicking the extracellular matrix with swim bladder derived collagen for renal tissue regeneration. Chinese Chem Lett, 2021, 32(12): 3940-3947.
11. Chu TL, Tripathi G, Park M, et al. In-vitro and in-vivo biocompatibility of dECM-alginate as a promising candidate in cell delivery for kidney regeneration. Int J Biol Macromol, 2022, 211: 616-625.
12. Trouche E, Girod Fullana S, Mias C, et al. Evaluation of alginate microspheres for mesenchymal stem cell engraftment on solid organ. Cell Transplant, 2010, 19(12): 1623-1633.
13. Fu Z, Chu Y, Geng X, et al. Artificial kidney capsule packed with mesenchymal stem cell-laden hydrogel for the treatment of rhabdomyolysis-induced acute kidney injury. ACS Biomater Sci Eng, 2022, 8(4): 1726-1734.
14. Liu S, Zhao M, Zhou Y, et al. A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury. Acta Biomater, 2019, 103: 102-114.
15. Wang H, Shang Y, Chen X, et al. Delivery of MSCs with a hybrid β-sheet peptide hydrogel consisting IGF-1C domain and D-form peptide for acute kidney injury therapy. Int J Nanomedicine, 2020, 15: 4311-4324.
16. Gao J, Liu R, Wu J, et al. The use of chitosan based hydrogel for enhancing the therapeutic benefits of adipose-derived MSCs for acute kidney injury. Biomaterials, 2012, 33(14): 3673-3681.
17. Han DS, Erickson C, Hansen KC, et al. Mesenchymal stem cells delivered locally to ischemia-reperfused kidneys via injectable hyaluronic acid hydrogels decrease extracellular matrix remodeling 1 month after injury in male mice. Cells, 2023, 12(13): 1771.
18. Tsurkan MV, Hauser PV, Zieris A, et al. Growth factor delivery from hydrogel particle aggregates to promote tubular regeneration after acute kidney injury. J Control Release, 2013, 167(3): 248-255.
19. Deng L, Liu Y, Yang L, et al. Injectable and bioactive methylcellulose hydrogel carrying bone mesenchymal stem cells as a filler for critical-size defects with enhanced bone regeneration. Colloids Surf B Biointerfaces, 2020, 194: 111159.

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