- 1. Department of Nephrology, the People’s Hospital of Renshou County, Meishan, Sichuan 620500, P. R. China;
- 2. Department of Nephrology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan 621000, P. R. China;
- 3. Jiange People’s Hospital, Guangyuan, Sichuan 628399, P. R. China;
DAI Xiaoyu,
Email: daixy001@163.com
The incidence of chronic kidney disease is on the rise and has become an important factor affecting global public health issues. The intake of sweet beverage remains high worldwide, which has been proved to be related to chronic health problems such as obesity, type 2 diabetes, some cancers and cardiovascular diseases. In recent years, some studies have found that a higher intake of sweet beverage is associated with chronic kidney disease and its risk factors. This article mainly reviews the current research status and potential mechanisms of the correlation between different types of sweet beverages and risk of chronic kidney disease.
Citation： CHEN Xiangyu, DAI Xiaoyu. Research progress on the correlation between sweet beverage and risk of chronic kidney disease. West China Medical Journal, 2025, 40(2): 318-323. doi: 10.7507/1002-0179.202408116 Copy
Copyright © the editorial department of West China Medical Journal of West China Medical Publisher. All rights reserved
| 1. | GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2020, 395(10225): 709-733. |
| 2. | Wang L, Xu X, Zhang M, et al. Prevalence of chronic kidney disease in China: results from the sixth China chronic disease and risk factor surveillance. JAMA Intern Med, 2023, 183(4): 298-310. |
| 3. | Tuttle KR, Alicic RZ, Duru OK, et al. Clinical characteristics of and risk factors for chronic kidney disease among adults and children: an analysis of the CURE-CKD registry. JAMA Netw Open, 2019, 2(12): e1918169. |
| 4. | GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2017, 390(10100): 1345-1422. |
| 5. | Qin P, Li Q, Zhao Y, et al. Sugar and artificially sweetened beverages and risk of obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol, 2020, 35(7): 655-671. |
| 6. | Ebrahimpour-Koujan S, Saneei P, Larijani B, et al. Consumption of sugar sweetened beverages and dietary fructose in relation to risk of gout and hyperuricemia: a systematic review and meta-analysis. Crit Rev Food Sci Nutr, 2020, 60(1): 1-10. |
| 7. | Llaha F, Gil-Lespinard M, Unal P, et al. Consumption of sweet beverages and cancer risk. a systematic review and meta-analysis of observational studies. Nutrients, 2021, 13(2): 516. |
| 8. | Toews I, Lohner S, Küllenberg de Gaudry D, et al. Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies. BMJ, 2019, 364: k4718. |
| 9. | Lo WC, Ou SH, Chou CL, et al. Sugar- and artificially-sweetened beverages and the risks of chronic kidney disease: a systematic review and dose-response meta-analysis. J Nephrol, 2021, 34(6): 1791-1804. |
| 10. | Cheungpasitporn W, Thongprayoon C, O’Corragain OA, et al. Associations of sugar-sweetened and artificially sweetened soda with chronic kidney disease: a systematic review and meta-analysis. Nephrology (Carlton), 2014, 19(12): 791-797. |
| 11. | Malik VS, Hu FB. The role of sugar-sweetened beverages in the global epidemics of obesity and chronic diseases. Nat Rev Endocrinol, 2022, 18(4): 205-218. |
| 12. | DiNicolantonio JJ, O’Keefe JH, Wilson WL. Sugar addiction: is it real? A narrative review. Br J Sports Med, 2018, 52(14): 910-913. |
| 13. | Singh GM, Micha R, Khatibzadeh S, et al. Global, regional, and national consumption of sugar-sweetened beverages, fruit juices, and milk: a systematic assessment of beverage intake in 187 countries. PLoS One, 2015, 10(8): e0124845. |
| 14. | Sun H, Liu Y, Xu Y, et al. Global disease burden attributed to high sugar-sweetened beverages in 204 countries and territories from 1990 to 2019. Prev Med, 2023, 175: 107690. |
| 15. | Xi B, Huang Y, Reilly KH, et al. Sugar-sweetened beverages and risk of hypertension and CVD: a dose-response meta-analysis. Br J Nutr, 2015, 113(5): 709-717. |
| 16. | Chen H, Wang J, Li Z, et al. Consumption of sugar-sweetened beverages has a dose-dependent effect on the risk of non-alcoholic fatty liver disease: an updated systematic review and dose-response meta-analysis. Int J Environ Res Public Health, 2019, 16(12): 2192. |
| 17. | Singh N, Baby D, Rajguru JP, et al. Inflammation and cancer. Ann Afr Med, 2019, 18(3): 121-126. |
| 18. | WHO Guidelines Review Committee. Use of non-sugar sweeteners: WHO guideline. Geneva: World Health Organization, 2023. |
| 19. | Zhang YB, Jiang YW, Chen JX, et al. Association of consumption of sugar-sweetened beverages or artificially sweetened beverages with mortality: a systematic review and dose-response meta-analysis of prospective cohort studies. Adv Nutr, 2021, 12(2): 374-383. |
| 20. | Li Y, Guo L, He K, et al. Consumption of sugar-sweetened beverages and fruit juice and human cancer: a systematic review and dose-response meta-analysis of observational studies. J Cancer, 2021, 12(10): 3077-3088. |
| 21. | Suez J, Korem T, Zeevi D, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, 514(7521): 181-186. |
| 22. | Suez J, Cohen Y, Valdés-Mas R, et al. Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. Cell, 2022, 185(18): 3307-3328. e19. |
| 23. | Ahmad SY, Friel J, Mackay D. The effects of non-nutritive artificial sweeteners, aspartame and sucralose, on the gut microbiome in healthy adults: secondary outcomes of a randomized double-blinded crossover clinical trial. Nutrients, 2020, 12(11): 3408. |
| 24. | Del Río-Celestino M, Font R. The health benefits of fruits and vegetables. Foods, 2020, 9(3): 369. |
| 25. | Ruxton CH, Gardner EJ, Walker D. Can pure fruit and vegetable juices protect against cancer and cardiovascular disease too? A review of the evidence. Int J Food Sci Nutr, 2006, 57(3/4): 249-272. |
| 26. | Gugliucci A. Sugar and dyslipidemia: a double-hit, perfect storm. J Clin Med, 2023, 12(17): 5660. |
| 27. | Muraki I, Imamura F, Manson JE, et al. Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies. BMJ, 2013, 347: f5001. |
| 28. | Ravn-Haren G, Dragsted LO, Buch-Andersen T, et al. Intake of whole apples or clear apple juice has contrasting effects on plasma lipids in healthy volunteers. Eur J Nutr, 2013, 52(8): 1875-1889. |
| 29. | Pepin A, Stanhope KL, Imbeault P. Are fruit juices healthier than sugar-sweetened beverages? A review. Nutrients, 2019, 11(5): 1006. |
| 30. | Mortera RR, Bains Y, Gugliucci A. Fructose at the crossroads of the metabolic syndrome and obesity epidemics. Front Biosci (Landmark Ed), 2019, 24(2): 186-211. |
| 31. | Imamura F, O’Connor L, Ye Z, et al. Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction. BMJ, 2015, 351: h3576. |
| 32. | Diaz C, Rezende LFM, Sabag A, et al. Artificially sweetened beverages and health outcomes: an umbrella review. Adv Nutr, 2023, 14(4): 710-717. |
| 33. | Rebholz CM, Young BA, Katz R, et al. Patterns of beverages consumed and risk of incident kidney disease. Clin J Am Soc Nephrol, 2019, 14(1): 49-56. |
| 34. | Yuzbashian E, Asghari G, Mirmiran P, et al. Sugar-sweetened beverage consumption and risk of incident chronic kidney disease: Tehran lipid and glucose study. Nephrology (Carlton), 2016, 21(7): 608-616. |
| 35. | Bomback AS, Derebail VK, Shoham DA, et al. Sugar-sweetened soda consumption, hyperuricemia, and kidney disease. Kidney Int, 2010, 77(7): 609-616. |
| 36. | Lin J, Curhan GC. Associations of sugar and artificially sweetened soda with albuminuria and kidney function decline in women. Clin J Am Soc Nephrol, 2011, 6(1): 160-166. |
| 37. | Heo GY, Koh HB, Park JT, et al. Sweetened beverage intake and incident chronic kidney disease in the UK biobank study. JAMA Netw Open, 2024, 7(2): e2356885. |
| 38. | Dai XY, Chen XY, Jia LN, et al. Sugary beverages intake and risk of chronic kidney disease: the mediating role of metabolic syndrome. Front Nutr, 2024, 11: 1401081. |
| 39. | Collin LJ, Judd S, Safford M, et al. Association of sugary beverage consumption with mortality risk in US adults: a secondary analysis of data from the REGARDS study. JAMA Netw Open, 2019, 2(5): e193121. |
| 40. | Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr, 2011, 93(1): 73-80. |
| 41. | Tonin FS, Steimbach LM, Wiens A, et al. Impact of natural juice consumption on plasma antioxidant status: a systematic review and meta-analysis. Molecules, 2015, 20(12): 22146-22156. |
| 42. | Lubawy M, Formanowicz D. High-fructose diet-induced hyperuricemia accompanying metabolic syndrome-mechanisms and dietary therapy proposals. Int J Environ Res Public Health, 2023, 20(4): 3596. |
| 43. | Siqueira JH, Pereira TSS, Velasquez-Melendez G, et al. Sugar-sweetened soft drinks consumption and risk of hyperuricemia: results of the ELSA-Brasil study. Nutr Metab Cardiovasc Dis, 2021, 31(7): 2004-2013. |
| 44. | Ebrahimpour-Koujan S, Saneei P, Larijani B, et al. Consumption of sugar-sweetened beverages and serum uric acid concentrations: a systematic review and meta-analysis. J Hum Nutr Diet, 2021, 34(2): 305-313. |
| 45. | Li QH, Zou YW, Lian SY, et al. Sugar-sweeten beverage consumption is associated with more obesity and higher serum uric acid in Chinese male gout patients with early onset. Front Nutr, 2022, 9: 916811. |
| 46. | Barberi S, Menè P. Role of uric acid in hypertension and in the progression of chronic renal disease. G Ital Nefrol, 2006, 23(1): 4-11. |
| 47. | Johnson RJ, Perez-Pozo SE, Lillo JL, et al. Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress. BMC Nephrol, 2018, 9(1): 315. |
| 48. | Ng HY, Lee YT, Kuo WH, et al. Alterations of renal epithelial glucose and uric acid transporters in fructose induced metabolic syndrome. Kidney Blood Press Res, 2018, 43(6): 1822-1831. |
| 49. | Mancia G, Grassi G, Borghi C. Hyperuricemia, urate deposition and the association with hypertension. Curr Med Res Opin, 2015, 31(Suppl 2): 15-19. |
| 50. | Berger L, Yü TF. Renal function in gout. IV. An analysis of 524 gouty subjects including long-term follow-up studies. Am J Med, 1975, 59(5): 605-613. |
| 51. | Uedono H, Tsuda A, Ishimura E, et al. Relationship between serum uric acid levels and intrarenal hemodynamic parameters. Kidney Blood Press Res, 2015, 40(3): 315-322. |
| 52. | Mallat SG, Al Kattar S, Tanios BY, et al. Hyperuricemia, hypertension, and chronic kidney disease: an emerging association. Curr Hypertens Rep, 2016, 18(10): 74. |
| 53. | Lanaspa MA, Kuwabara M, Andres-Hernando A, et al. High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism. Proc Natl Acad Sci U S A, 2018, 115(12): 3138-3143. |
| 54. | Johnson RJ, Stenvinkel P, Andrews P, et al. Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts. J Intern Med, 2020, 287(3): 252-262. |
| 55. | Bankir L, Bichet DG, Morgenthaler NG. Vasopressin: physiology, assessment and osmosensation. J Intern Med, 2017, 282(4): 284-297. |
| 56. | Fay MJ, Du J, Yu X, et al. Evidence for expression of vasopressin V2 receptor mRNA in human lung. Peptides, 1996, 17(3): 477-481. |
| 57. | Watts JA, Arroyo JP. Rethinking vasopressin: new insights into vasopressin signaling and its implications. Kidney360, 2023, 4(8): 1174-1180. |
| 58. | Roncal-Jimenez CA, Milagres T, Andres-Hernando A, et al. Effects of exogenous desmopressin on a model of heat stress nephropathy in mice. Am J Physiol Renal Physiol, 2017, 312(3): F418-F426. |
| 59. | Andres-Hernando A, Johnson RJ, Lanaspa MA. Endogenous fructose production: what do we know and how relevant is it?. Curr Opin Clin Nutr Metab Care, 2019, 22(4): 289-294. |
| 60. | Cirillo P, Gersch MS, Mu W, et al. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol, 2009, 20(3): 545-553. |
| 61. | Roncal Jimenez CA, Ishimoto T, Lanaspa MA, et al. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int, 2014, 86(2): 294-302. |
| 62. | Song Z, Roncal-Jimenez CA, Lanaspa-Garcia MA, et al. Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice. J Neurophysiol, 2017, 117(2): 646-654. |
| 63. | Chapman CL, Johnson BD, Sackett JR, et al. Soft drink consumption during and following exercise in the heat elevates biomarkers of acute kidney injury. Am J Physiol Regul Integr Comp Physiol, 2019, 316(3): R189-R198. |
| 64. | Solomi L, Rees GA, Redfern KM. The acute effects of the non-nutritive sweeteners aspartame and acesulfame-K in UK diet cola on glycaemic response. Int J Food Sci Nutr, 2019, 70(7): 894-900. |
| 65. | Brand-Miller J, Dickinson S, Barclay A, et al. Glycemic index, glycemic load, and thrombogenesis. Semin Thromb Hemost, 2009, 35(1): 111-118. |
| 66. | Forouhi NG. Beverages and health outcomes in adults with type 2 diabetes. BMJ, 2023, 381: 841. |
| 67. | Haslam DE, Peloso GM, Guirette M, et al. Sugar-sweetened beverage consumption may modify associations between genetic variants in the CHREBP (carbohydrate responsive element binding protein) locus and HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. Circ Genom Precis Med, 2021, 14(4): e003288. |
| 68. | Spoto B, Pisano A, Zoccali C. Insulin resistance in chronic kidney disease: a systematic review. Am J Physiol Renal Physiol, 2016, 311(6): F1087-F1108. |
| 69. | Zhang R, Noronha JC, Khan TA, et al. The effect of non-nutritive sweetened beverages on postprandial glycemic and endocrine responses: a systematic review and network meta-analysis. Nutrients, 2023, 15(4): 1050. |
| 70. | Swithers SE. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Trends Endocrinol Metab, 2013, 24(9): 431-441. |
| 71. | Sigala DM, Hieronimus B, Medici V, et al. Consuming sucrose- or HFCS-sweetened beverages increases hepatic lipid and decreases insulin sensitivity in adults. J Clin Endocrinol Metab, 2021, 106(11): 3248-3264. |
| 72. | Fulgoni K, Fulgoni VL 3rd. Trends in total, added, and natural phosphorus intake in adult Americans, NHANES 1988-1994 to NHANES 2015-2016. Nutrients, 2021, 13(7): 2249. |
| 73. | Cozzolino M, Ciceri P, Galassi A, et al. The key role of phosphate on vascular calcification. Toxins (Basel), 2019, 11(4): 213. |
| 74. | Mackay EM, Oliver J. Renal damage following the ingestion of a diet containing an excess of inorganic phosphate. J Exp Med, 1935, 61(3): 319-334. |
| 75. | Sim JJ, Bhandari SK, Smith N, et al. Phosphorus and risk of renal failure in subjects with normal renal function. Am J Med, 2013, 126(4): 311-318. |
| 76. | Shoag J, Halpern J, Goldfarb DS, et al. Risk of chronic and end stage kidney disease in patients with nephrolithiasis. J Urol, 2014, 192(5): 1440-1445. |
| 77. | Ferraro PM, Taylor EN, Gambaro G, et al. Soda and other beverages and the risk of kidney stones. Clin J Am Soc Nephrol, 2013, 8(8): 1389-1395. |
| 78. | Shuster J, Jenkins A, Logan C, et al. Soft drink consumption and urinary stone recurrence: a randomized prevention trial. J Clin Epidemiol, 1992, 45(8): 911-916. |
| 79. | Siener R. Nutrition and kidney stone disease. Nutrients, 2021, 13(6): 1917. |
- 1. GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2020, 395(10225): 709-733.
- 2. Wang L, Xu X, Zhang M, et al. Prevalence of chronic kidney disease in China: results from the sixth China chronic disease and risk factor surveillance. JAMA Intern Med, 2023, 183(4): 298-310.
- 3. Tuttle KR, Alicic RZ, Duru OK, et al. Clinical characteristics of and risk factors for chronic kidney disease among adults and children: an analysis of the CURE-CKD registry. JAMA Netw Open, 2019, 2(12): e1918169.
- 4. GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2017, 390(10100): 1345-1422.
- 5. Qin P, Li Q, Zhao Y, et al. Sugar and artificially sweetened beverages and risk of obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol, 2020, 35(7): 655-671.
- 6. Ebrahimpour-Koujan S, Saneei P, Larijani B, et al. Consumption of sugar sweetened beverages and dietary fructose in relation to risk of gout and hyperuricemia: a systematic review and meta-analysis. Crit Rev Food Sci Nutr, 2020, 60(1): 1-10.
- 7. Llaha F, Gil-Lespinard M, Unal P, et al. Consumption of sweet beverages and cancer risk. a systematic review and meta-analysis of observational studies. Nutrients, 2021, 13(2): 516.
- 8. Toews I, Lohner S, Küllenberg de Gaudry D, et al. Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies. BMJ, 2019, 364: k4718.
- 9. Lo WC, Ou SH, Chou CL, et al. Sugar- and artificially-sweetened beverages and the risks of chronic kidney disease: a systematic review and dose-response meta-analysis. J Nephrol, 2021, 34(6): 1791-1804.
- 10. Cheungpasitporn W, Thongprayoon C, O’Corragain OA, et al. Associations of sugar-sweetened and artificially sweetened soda with chronic kidney disease: a systematic review and meta-analysis. Nephrology (Carlton), 2014, 19(12): 791-797.
- 11. Malik VS, Hu FB. The role of sugar-sweetened beverages in the global epidemics of obesity and chronic diseases. Nat Rev Endocrinol, 2022, 18(4): 205-218.
- 12. DiNicolantonio JJ, O’Keefe JH, Wilson WL. Sugar addiction: is it real? A narrative review. Br J Sports Med, 2018, 52(14): 910-913.
- 13. Singh GM, Micha R, Khatibzadeh S, et al. Global, regional, and national consumption of sugar-sweetened beverages, fruit juices, and milk: a systematic assessment of beverage intake in 187 countries. PLoS One, 2015, 10(8): e0124845.
- 14. Sun H, Liu Y, Xu Y, et al. Global disease burden attributed to high sugar-sweetened beverages in 204 countries and territories from 1990 to 2019. Prev Med, 2023, 175: 107690.
- 15. Xi B, Huang Y, Reilly KH, et al. Sugar-sweetened beverages and risk of hypertension and CVD: a dose-response meta-analysis. Br J Nutr, 2015, 113(5): 709-717.
- 16. Chen H, Wang J, Li Z, et al. Consumption of sugar-sweetened beverages has a dose-dependent effect on the risk of non-alcoholic fatty liver disease: an updated systematic review and dose-response meta-analysis. Int J Environ Res Public Health, 2019, 16(12): 2192.
- 17. Singh N, Baby D, Rajguru JP, et al. Inflammation and cancer. Ann Afr Med, 2019, 18(3): 121-126.
- 18. WHO Guidelines Review Committee. Use of non-sugar sweeteners: WHO guideline. Geneva: World Health Organization, 2023.
- 19. Zhang YB, Jiang YW, Chen JX, et al. Association of consumption of sugar-sweetened beverages or artificially sweetened beverages with mortality: a systematic review and dose-response meta-analysis of prospective cohort studies. Adv Nutr, 2021, 12(2): 374-383.
- 20. Li Y, Guo L, He K, et al. Consumption of sugar-sweetened beverages and fruit juice and human cancer: a systematic review and dose-response meta-analysis of observational studies. J Cancer, 2021, 12(10): 3077-3088.
- 21. Suez J, Korem T, Zeevi D, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, 514(7521): 181-186.
- 22. Suez J, Cohen Y, Valdés-Mas R, et al. Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. Cell, 2022, 185(18): 3307-3328. e19.
- 23. Ahmad SY, Friel J, Mackay D. The effects of non-nutritive artificial sweeteners, aspartame and sucralose, on the gut microbiome in healthy adults: secondary outcomes of a randomized double-blinded crossover clinical trial. Nutrients, 2020, 12(11): 3408.
- 24. Del Río-Celestino M, Font R. The health benefits of fruits and vegetables. Foods, 2020, 9(3): 369.
- 25. Ruxton CH, Gardner EJ, Walker D. Can pure fruit and vegetable juices protect against cancer and cardiovascular disease too? A review of the evidence. Int J Food Sci Nutr, 2006, 57(3/4): 249-272.
- 26. Gugliucci A. Sugar and dyslipidemia: a double-hit, perfect storm. J Clin Med, 2023, 12(17): 5660.
- 27. Muraki I, Imamura F, Manson JE, et al. Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies. BMJ, 2013, 347: f5001.
- 28. Ravn-Haren G, Dragsted LO, Buch-Andersen T, et al. Intake of whole apples or clear apple juice has contrasting effects on plasma lipids in healthy volunteers. Eur J Nutr, 2013, 52(8): 1875-1889.
- 29. Pepin A, Stanhope KL, Imbeault P. Are fruit juices healthier than sugar-sweetened beverages? A review. Nutrients, 2019, 11(5): 1006.
- 30. Mortera RR, Bains Y, Gugliucci A. Fructose at the crossroads of the metabolic syndrome and obesity epidemics. Front Biosci (Landmark Ed), 2019, 24(2): 186-211.
- 31. Imamura F, O’Connor L, Ye Z, et al. Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction. BMJ, 2015, 351: h3576.
- 32. Diaz C, Rezende LFM, Sabag A, et al. Artificially sweetened beverages and health outcomes: an umbrella review. Adv Nutr, 2023, 14(4): 710-717.
- 33. Rebholz CM, Young BA, Katz R, et al. Patterns of beverages consumed and risk of incident kidney disease. Clin J Am Soc Nephrol, 2019, 14(1): 49-56.
- 34. Yuzbashian E, Asghari G, Mirmiran P, et al. Sugar-sweetened beverage consumption and risk of incident chronic kidney disease: Tehran lipid and glucose study. Nephrology (Carlton), 2016, 21(7): 608-616.
- 35. Bomback AS, Derebail VK, Shoham DA, et al. Sugar-sweetened soda consumption, hyperuricemia, and kidney disease. Kidney Int, 2010, 77(7): 609-616.
- 36. Lin J, Curhan GC. Associations of sugar and artificially sweetened soda with albuminuria and kidney function decline in women. Clin J Am Soc Nephrol, 2011, 6(1): 160-166.
- 37. Heo GY, Koh HB, Park JT, et al. Sweetened beverage intake and incident chronic kidney disease in the UK biobank study. JAMA Netw Open, 2024, 7(2): e2356885.
- 38. Dai XY, Chen XY, Jia LN, et al. Sugary beverages intake and risk of chronic kidney disease: the mediating role of metabolic syndrome. Front Nutr, 2024, 11: 1401081.
- 39. Collin LJ, Judd S, Safford M, et al. Association of sugary beverage consumption with mortality risk in US adults: a secondary analysis of data from the REGARDS study. JAMA Netw Open, 2019, 2(5): e193121.
- 40. Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr, 2011, 93(1): 73-80.
- 41. Tonin FS, Steimbach LM, Wiens A, et al. Impact of natural juice consumption on plasma antioxidant status: a systematic review and meta-analysis. Molecules, 2015, 20(12): 22146-22156.
- 42. Lubawy M, Formanowicz D. High-fructose diet-induced hyperuricemia accompanying metabolic syndrome-mechanisms and dietary therapy proposals. Int J Environ Res Public Health, 2023, 20(4): 3596.
- 43. Siqueira JH, Pereira TSS, Velasquez-Melendez G, et al. Sugar-sweetened soft drinks consumption and risk of hyperuricemia: results of the ELSA-Brasil study. Nutr Metab Cardiovasc Dis, 2021, 31(7): 2004-2013.
- 44. Ebrahimpour-Koujan S, Saneei P, Larijani B, et al. Consumption of sugar-sweetened beverages and serum uric acid concentrations: a systematic review and meta-analysis. J Hum Nutr Diet, 2021, 34(2): 305-313.
- 45. Li QH, Zou YW, Lian SY, et al. Sugar-sweeten beverage consumption is associated with more obesity and higher serum uric acid in Chinese male gout patients with early onset. Front Nutr, 2022, 9: 916811.
- 46. Barberi S, Menè P. Role of uric acid in hypertension and in the progression of chronic renal disease. G Ital Nefrol, 2006, 23(1): 4-11.
- 47. Johnson RJ, Perez-Pozo SE, Lillo JL, et al. Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress. BMC Nephrol, 2018, 9(1): 315.
- 48. Ng HY, Lee YT, Kuo WH, et al. Alterations of renal epithelial glucose and uric acid transporters in fructose induced metabolic syndrome. Kidney Blood Press Res, 2018, 43(6): 1822-1831.
- 49. Mancia G, Grassi G, Borghi C. Hyperuricemia, urate deposition and the association with hypertension. Curr Med Res Opin, 2015, 31(Suppl 2): 15-19.
- 50. Berger L, Yü TF. Renal function in gout. IV. An analysis of 524 gouty subjects including long-term follow-up studies. Am J Med, 1975, 59(5): 605-613.
- 51. Uedono H, Tsuda A, Ishimura E, et al. Relationship between serum uric acid levels and intrarenal hemodynamic parameters. Kidney Blood Press Res, 2015, 40(3): 315-322.
- 52. Mallat SG, Al Kattar S, Tanios BY, et al. Hyperuricemia, hypertension, and chronic kidney disease: an emerging association. Curr Hypertens Rep, 2016, 18(10): 74.
- 53. Lanaspa MA, Kuwabara M, Andres-Hernando A, et al. High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism. Proc Natl Acad Sci U S A, 2018, 115(12): 3138-3143.
- 54. Johnson RJ, Stenvinkel P, Andrews P, et al. Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts. J Intern Med, 2020, 287(3): 252-262.
- 55. Bankir L, Bichet DG, Morgenthaler NG. Vasopressin: physiology, assessment and osmosensation. J Intern Med, 2017, 282(4): 284-297.
- 56. Fay MJ, Du J, Yu X, et al. Evidence for expression of vasopressin V2 receptor mRNA in human lung. Peptides, 1996, 17(3): 477-481.
- 57. Watts JA, Arroyo JP. Rethinking vasopressin: new insights into vasopressin signaling and its implications. Kidney360, 2023, 4(8): 1174-1180.
- 58. Roncal-Jimenez CA, Milagres T, Andres-Hernando A, et al. Effects of exogenous desmopressin on a model of heat stress nephropathy in mice. Am J Physiol Renal Physiol, 2017, 312(3): F418-F426.
- 59. Andres-Hernando A, Johnson RJ, Lanaspa MA. Endogenous fructose production: what do we know and how relevant is it?. Curr Opin Clin Nutr Metab Care, 2019, 22(4): 289-294.
- 60. Cirillo P, Gersch MS, Mu W, et al. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol, 2009, 20(3): 545-553.
- 61. Roncal Jimenez CA, Ishimoto T, Lanaspa MA, et al. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int, 2014, 86(2): 294-302.
- 62. Song Z, Roncal-Jimenez CA, Lanaspa-Garcia MA, et al. Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice. J Neurophysiol, 2017, 117(2): 646-654.
- 63. Chapman CL, Johnson BD, Sackett JR, et al. Soft drink consumption during and following exercise in the heat elevates biomarkers of acute kidney injury. Am J Physiol Regul Integr Comp Physiol, 2019, 316(3): R189-R198.
- 64. Solomi L, Rees GA, Redfern KM. The acute effects of the non-nutritive sweeteners aspartame and acesulfame-K in UK diet cola on glycaemic response. Int J Food Sci Nutr, 2019, 70(7): 894-900.
- 65. Brand-Miller J, Dickinson S, Barclay A, et al. Glycemic index, glycemic load, and thrombogenesis. Semin Thromb Hemost, 2009, 35(1): 111-118.
- 66. Forouhi NG. Beverages and health outcomes in adults with type 2 diabetes. BMJ, 2023, 381: 841.
- 67. Haslam DE, Peloso GM, Guirette M, et al. Sugar-sweetened beverage consumption may modify associations between genetic variants in the CHREBP (carbohydrate responsive element binding protein) locus and HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. Circ Genom Precis Med, 2021, 14(4): e003288.
- 68. Spoto B, Pisano A, Zoccali C. Insulin resistance in chronic kidney disease: a systematic review. Am J Physiol Renal Physiol, 2016, 311(6): F1087-F1108.
- 69. Zhang R, Noronha JC, Khan TA, et al. The effect of non-nutritive sweetened beverages on postprandial glycemic and endocrine responses: a systematic review and network meta-analysis. Nutrients, 2023, 15(4): 1050.
- 70. Swithers SE. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Trends Endocrinol Metab, 2013, 24(9): 431-441.
- 71. Sigala DM, Hieronimus B, Medici V, et al. Consuming sucrose- or HFCS-sweetened beverages increases hepatic lipid and decreases insulin sensitivity in adults. J Clin Endocrinol Metab, 2021, 106(11): 3248-3264.
- 72. Fulgoni K, Fulgoni VL 3rd. Trends in total, added, and natural phosphorus intake in adult Americans, NHANES 1988-1994 to NHANES 2015-2016. Nutrients, 2021, 13(7): 2249.
- 73. Cozzolino M, Ciceri P, Galassi A, et al. The key role of phosphate on vascular calcification. Toxins (Basel), 2019, 11(4): 213.
- 74. Mackay EM, Oliver J. Renal damage following the ingestion of a diet containing an excess of inorganic phosphate. J Exp Med, 1935, 61(3): 319-334.
- 75. Sim JJ, Bhandari SK, Smith N, et al. Phosphorus and risk of renal failure in subjects with normal renal function. Am J Med, 2013, 126(4): 311-318.
- 76. Shoag J, Halpern J, Goldfarb DS, et al. Risk of chronic and end stage kidney disease in patients with nephrolithiasis. J Urol, 2014, 192(5): 1440-1445.
- 77. Ferraro PM, Taylor EN, Gambaro G, et al. Soda and other beverages and the risk of kidney stones. Clin J Am Soc Nephrol, 2013, 8(8): 1389-1395.
- 78. Shuster J, Jenkins A, Logan C, et al. Soft drink consumption and urinary stone recurrence: a randomized prevention trial. J Clin Epidemiol, 1992, 45(8): 911-916.
- 79. Siener R. Nutrition and kidney stone disease. Nutrients, 2021, 13(6): 1917.