• College of Life Sciences, Fujian Normal University, Fuzhou Fujian, 350108, P.R.China. Corresponding author: LI Min, E-mail: mli@fjnu.edu.cn;
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Objective To review the research progress of cell-scaffold complex in the tendon tissue engineering. Methods Recent literature concerning cell-scaffold complex in the tendon tissue engineering was reviewed, the research situation of the cell-scaffold complex was elaborated in the aspects of seed cells, scaffolds, cell culture, and application. Results In tendon tissue engineering, a cell-scaffold complex is built by appropriate seed cells and engineered scaffolds. Experiments showed that modified seed cells had better therapeutic effects. Further, scaffold functionality could be improved through surface modification, growth factor cure, mechanical stimulation, and contact guidance. Among these methods, mechanical stimulation revealed the most significant results in promoting cell proliferation and function. Through a variety of defect models, it is demonstrated that the use of cell-scaffold complex could achieve satisfactory results for tendon regeneration. Conclusion The cell-scaffold complex for tendon tissue engineering is a popular research topic. Although it has not yet met the requirement of clinical use, it has broad application prospects.

Citation: ZHU Ying,LI Min.. RESEARCH PROGRESS OF CELL-SCAFFOLD COMPLEX IN TENDON TISSUE ENGINEERING. Chinese Journal of Reparative and Reconstructive Surgery, 2013, 27(4): 481-485. doi: 10.7507/1002-1892.20130109 Copy

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