ADVANCEMENT OF ADIPOSE-DERIVED STEM CELLS ASSISTED AUTOLOGOUS LIPOTRANSFER IN BREAST REPAIR AND RECONSTRUCTION_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

TIAN Chunxiang , LUuml

Department of Thyroid &;
Breast Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China. Corresponding author: LÜ;
Qing, E-mail: lqlq1963@163.com;

Corresponding author：

Keywords：

Adipose-derived stem cells; Autologous lipotransfer; Breast repair and reconstruction

DOI：

10.7507/1002-1892.20130273

Video：

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Objective To review the latest progress in the major biological properties of adipose-derived stem cells (ADSCs) and ADSCs assisted autologous lipotransfer in breast repair and reconstruction. Methods Recent literature about ADSCs assisted autologous lipotransfer in breast repair and reconstruction was reviewed. Results ADSCs have multipotential differentiation capacity, and they could promote angiogenesis and regulate immune reactions. ADSCs assisted autologous lipotransfer can obtain satisfactory effectiveness in breast repair and reconstruction with few complications, but more studies are needed to confirm the long-term safety. Conclusion ADSCs assisted autologous lipotransfer has good effectiveness in breast repaired and reconstruction. But further clinical trials are needed to confirm the long-term safety.

Citation： TIAN Chunxiang,LUuml,Qing.. ADVANCEMENT OF ADIPOSE-DERIVED STEM CELLS ASSISTED AUTOLOGOUS LIPOTRANSFER IN BREAST REPAIR AND RECONSTRUCTION. Chinese Journal of Reparative and Reconstructive Surgery, 2013, 27(10): 1252-1255. doi: 10.7507/1002-1892.20130273 Copy

1.	Yoshimura K, Sato K, Aoi N, et al. Cell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells. Dermatol Surg, 2008, 34(9): 1178-1185.
2.	Yoshimura K, Sato K, Aoi N, et al. Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells. Aesthetic Plast Surg, 2008, 32(1): 48-55.
3.	Coleman SR, Saboeiro AP. Fat grafting to the breast revisited: safety and efficacy. Plast Reconstr Surg, 2007, 119(3): 775-785.
4.	Gutowski KA, ASPS Fat Graft Force. Current applications and safety of autologous fat grafts: a report of the ASPS fat graft task force. Plast Reconstr Surg, 2009, 124(1): 272-280.
5.	王琳, 陆毅, 罗旋, 等. 细胞辅助的脂肪移植法隆乳术: 18 例报告. 中华整形外科杂志, 2012, 28(1): 1-6.
6.	Castro-Govea Y, La Garza-Pineda D, Lara-Arias J, et al. Cell-assisted lipotransfer for the treatment of parry-romberg syndrome. Arch Plast Surg, 2012, 39(6): 659-662.
7.	Wu AY, Morrow DM. Autologous fat transfer with in-situ mediation (AIM): a novel and compliant method of adult mesenchymal stem cell therapy. J Transl Med, 2013, 11(1): 136.
8.	Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng, 2001, 7(2): 211-228.
9.	Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell, 2002, 13(12): 4279-4295.
10.	Patrick CW. Tissue engineering strategies for adipose tissue repair. Anat Rec, 2001, 263(4): 361-366.
11.	Gimble JM, Katz AJ, Bunnell BA. Adipose-derived stem cells for regenerative medicine. Circ Res, 2007, 100(9): 1249-1260.
12.	Dobson DE, Kambe A, Block E, et al. 1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes. Cell, 1990, 61(2): 223-230.
13.	袁艺, 鲁峰, 高建华. 血管基质片段辅助游离脂肪移植早期移植物组织学变化及相关实验研究. 中国修复重建外科杂志, 2013, 27(4): 449-453.
14.	McIntosh K, Zvonic S, Garrett S, et al. The immunogenicity of human adipose-derived cells: temporal changes in vitro. Stem Cells, 2006, 24(5): 1246-1253.
15.	Illouz YG. Study of subcutaneous fat. Aesthetic Plast Surg, 1990, 14(3): 165-177.
16.	Gonzalez AM, Lobocki C, Kelly CP, et al. An alternative method for harvest and processing fat grafts: An in vitro study of cell viability and survival. Plast Reconstr Surg, 2007, 120(1): 285-294.
17.	Sterodimas A, de Faria J, Nicaretta B, et al. Cell-assisted lipotransfer. Aesthetic Surg J, 2010, 30(1): 78-81.
18.	李劫, 高建华, 鲁峰, 等. 脂肪组织来源干细胞提高游离脂肪组织存活率的研究. 中华整形外科杂志, 2009, 25(2): 129-133.
19.	付冰川, 高建华, 鲁峰, 等. 新鲜分离的脂肪 SVF 细胞促进脂肪移植存活的实验研究. 中华整形外科杂志, 2010, 26(4): 289-294.
20.	谭新颖, 张海霞, 刘斌, 等. 自体基质血管成分改善脂肪组织移植效果的实验研究. 中国美容医学, 2011, 20(3): 425-427.
21.	Matsumoto D, Sato K, Gonda K, et al. Cell-assisted lipotransfer: supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection. Tissue Eng, 2006, 12(12): 3375-3382.
22.	Yoshimura K, Suga H, Eto H. Adipose-derived stem/progenitor cells: roles in adipose tissue remodeling and potential use for soft tissue augmentation. Regen Med, 2009, 4(2): 265-273.
23.	Mizuno H, Hyakusoku H. Fat grafting to the breast and adipose-derived stem cells: Recent scientific consensus and controversy. Aesthetic Surg J, 2010, 30(3): 381-387.
24.	Rehman J, Traktuev D, Li J, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation, 2004, 109(10): 1292-1298.
25.	Rigotti G, Marchi A, Galiè M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg, 2007, 119(5): 1409-1424.
26.	Kamakura T, Ito K. Autologous cell-enriched fat grafting for breast augmentation. Aesthet Plast Surg, 2011, 35(6): 1022-1030.
27.	Weiler-Mithoff E, Cano PR, Calabrese C, et al. Cell-enhanced reconstruction after breast conservation therapy: a proven technique. Cancer Res, 2009, 69(24): 748-748.
28.	Pérez-Cano R, Vranckx JJ, Lasso JM, et al. Prospective trial of adipose-derived regenerative cell (ADRC)-enriched fat grafting for partial mastectomy defects: the RESTORE-2 trial. Eur J Surg Oncol, 2012, 38(5): 382-389.
29.	Asano Y, Yoshimura K. Cell-assisted lipotransfer for breast reconstruction after breast conserving therapy. Eur J Caner (Suppl), 2010, 8(6): 3.
30.	Chajchir A. Fat injection: Long-term follow-up. Aesthetic Plast Surg, 1996, 20(4): 291-296.
31.	Niechajev I, Sevćuk O. Long-term results of fat transplantation: clinical and histologic studies. Plast Reconstr Surg, 1994, 94(3): 496-506.
32.	Valdatta L, Thione A, Buoro M, et al. A case of life-threatening sepsis after breast augmentation by fat injection. Aesthetic Plast Surg, 2001, 25(5): 347-349.
33.	Pulagam SR, Poulton T, Mamounas EP. Long-term clinical and radiologic results with autologous fat transplantation for breast augmentation: case reports and review of the literature. Breast J, 2006, 12(1): 63-65.
34.	Cheung M, Houssami N, Lim E. The unusual mammographic appearance of breasts augmented by autologous fat injection. Breast, 2000, 9(4): 220-222.
35.	Gimble JM, Floyd ZE. Fat circadian biology. J Appl Physiol, 2009, 107(5): 1629-1637.
36.	Vona-Davis L, Rose DP. Angiogenesis, adipokines and breast cancer. Cytokine Growth Factor Rev, 2009, 20(3): 193-201.
37.	Yu JM, Jun ES, Bae YC, et al. Mesenchymal stem cells derived from human adipose tissues favor tumor cell growth in vivo. Stem Cells Dev, 2008, 17(3): 463-473.
38.	Manabe Y, Toda S, Miyazaki K, et al. Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions. J Pathol, 2003, 201(2): 221-228.

1. Yoshimura K, Sato K, Aoi N, et al. Cell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells. Dermatol Surg, 2008, 34(9): 1178-1185.
2. Yoshimura K, Sato K, Aoi N, et al. Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells. Aesthetic Plast Surg, 2008, 32(1): 48-55.
3. Coleman SR, Saboeiro AP. Fat grafting to the breast revisited: safety and efficacy. Plast Reconstr Surg, 2007, 119(3): 775-785.
4. Gutowski KA, ASPS Fat Graft Force. Current applications and safety of autologous fat grafts: a report of the ASPS fat graft task force. Plast Reconstr Surg, 2009, 124(1): 272-280.
5. 王琳, 陆毅, 罗旋, 等. 细胞辅助的脂肪移植法隆乳术: 18 例报告. 中华整形外科杂志, 2012, 28(1): 1-6.
6. Castro-Govea Y, La Garza-Pineda D, Lara-Arias J, et al. Cell-assisted lipotransfer for the treatment of parry-romberg syndrome. Arch Plast Surg, 2012, 39(6): 659-662.
7. Wu AY, Morrow DM. Autologous fat transfer with in-situ mediation (AIM): a novel and compliant method of adult mesenchymal stem cell therapy. J Transl Med, 2013, 11(1): 136.
8. Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng, 2001, 7(2): 211-228.
9. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell, 2002, 13(12): 4279-4295.
10. Patrick CW. Tissue engineering strategies for adipose tissue repair. Anat Rec, 2001, 263(4): 361-366.
11. Gimble JM, Katz AJ, Bunnell BA. Adipose-derived stem cells for regenerative medicine. Circ Res, 2007, 100(9): 1249-1260.
12. Dobson DE, Kambe A, Block E, et al. 1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes. Cell, 1990, 61(2): 223-230.
13. 袁艺, 鲁峰, 高建华. 血管基质片段辅助游离脂肪移植早期移植物组织学变化及相关实验研究. 中国修复重建外科杂志, 2013, 27(4): 449-453.
14. McIntosh K, Zvonic S, Garrett S, et al. The immunogenicity of human adipose-derived cells: temporal changes in vitro. Stem Cells, 2006, 24(5): 1246-1253.
15. Illouz YG. Study of subcutaneous fat. Aesthetic Plast Surg, 1990, 14(3): 165-177.
16. Gonzalez AM, Lobocki C, Kelly CP, et al. An alternative method for harvest and processing fat grafts: An in vitro study of cell viability and survival. Plast Reconstr Surg, 2007, 120(1): 285-294.
17. Sterodimas A, de Faria J, Nicaretta B, et al. Cell-assisted lipotransfer. Aesthetic Surg J, 2010, 30(1): 78-81.
18. 李劫, 高建华, 鲁峰, 等. 脂肪组织来源干细胞提高游离脂肪组织存活率的研究. 中华整形外科杂志, 2009, 25(2): 129-133.
19. 付冰川, 高建华, 鲁峰, 等. 新鲜分离的脂肪 SVF 细胞促进脂肪移植存活的实验研究. 中华整形外科杂志, 2010, 26(4): 289-294.
20. 谭新颖, 张海霞, 刘斌, 等. 自体基质血管成分改善脂肪组织移植效果的实验研究. 中国美容医学, 2011, 20(3): 425-427.
21. Matsumoto D, Sato K, Gonda K, et al. Cell-assisted lipotransfer: supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection. Tissue Eng, 2006, 12(12): 3375-3382.
22. Yoshimura K, Suga H, Eto H. Adipose-derived stem/progenitor cells: roles in adipose tissue remodeling and potential use for soft tissue augmentation. Regen Med, 2009, 4(2): 265-273.
23. Mizuno H, Hyakusoku H. Fat grafting to the breast and adipose-derived stem cells: Recent scientific consensus and controversy. Aesthetic Surg J, 2010, 30(3): 381-387.
24. Rehman J, Traktuev D, Li J, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation, 2004, 109(10): 1292-1298.
25. Rigotti G, Marchi A, Galiè M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg, 2007, 119(5): 1409-1424.
26. Kamakura T, Ito K. Autologous cell-enriched fat grafting for breast augmentation. Aesthet Plast Surg, 2011, 35(6): 1022-1030.
27. Weiler-Mithoff E, Cano PR, Calabrese C, et al. Cell-enhanced reconstruction after breast conservation therapy: a proven technique. Cancer Res, 2009, 69(24): 748-748.
28. Pérez-Cano R, Vranckx JJ, Lasso JM, et al. Prospective trial of adipose-derived regenerative cell (ADRC)-enriched fat grafting for partial mastectomy defects: the RESTORE-2 trial. Eur J Surg Oncol, 2012, 38(5): 382-389.
29. Asano Y, Yoshimura K. Cell-assisted lipotransfer for breast reconstruction after breast conserving therapy. Eur J Caner (Suppl), 2010, 8(6): 3.
30. Chajchir A. Fat injection: Long-term follow-up. Aesthetic Plast Surg, 1996, 20(4): 291-296.
31. Niechajev I, Sevćuk O. Long-term results of fat transplantation: clinical and histologic studies. Plast Reconstr Surg, 1994, 94(3): 496-506.
32. Valdatta L, Thione A, Buoro M, et al. A case of life-threatening sepsis after breast augmentation by fat injection. Aesthetic Plast Surg, 2001, 25(5): 347-349.
33. Pulagam SR, Poulton T, Mamounas EP. Long-term clinical and radiologic results with autologous fat transplantation for breast augmentation: case reports and review of the literature. Breast J, 2006, 12(1): 63-65.
34. Cheung M, Houssami N, Lim E. The unusual mammographic appearance of breasts augmented by autologous fat injection. Breast, 2000, 9(4): 220-222.
35. Gimble JM, Floyd ZE. Fat circadian biology. J Appl Physiol, 2009, 107(5): 1629-1637.
36. Vona-Davis L, Rose DP. Angiogenesis, adipokines and breast cancer. Cytokine Growth Factor Rev, 2009, 20(3): 193-201.
37. Yu JM, Jun ES, Bae YC, et al. Mesenchymal stem cells derived from human adipose tissues favor tumor cell growth in vivo. Stem Cells Dev, 2008, 17(3): 463-473.
38. Manabe Y, Toda S, Miyazaki K, et al. Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions. J Pathol, 2003, 201(2): 221-228.

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ADVANCEMENT OF ADIPOSE-DERIVED STEM CELLS ASSISTED AUTOLOGOUS LIPOTRANSFER IN BREAST REPAIR AND RECONSTRUCTION

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