RESEARCH DEVELOPMENT OF AMNIOTIC FLUID-DERIVED STEM CELLS IN REGENERATIVE MEDICINE_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

LI Chun ¹ , LI Weisong ¹ , LIU Hu ¹ , WANG Jie ²

1Department of Pediatric Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei Anhui, 230022, P.R.China;;
2Department of Dermatology, the Fourth Affiliated Hospital of Anhui Medical University. Corresponding author: LI Weisong, E-mail: dr_liweisong@126.com;

Corresponding author：

Keywords：

Amniotic; fluid-derived stem cells; Multipotent differentiation; Regenerative medicine; Tissue engineering

DOI：

10.7507/1002-1892.20130275

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To review the latest development of amniotic fluid-derived stem cells (AFSCs) in regenerative medicine, and to discuss issues related to the studies in the field of AFSCs. Methods The recent articles about AFSCs were extensively reviewed. The important knowledge of AFSCs was introduced in the field of regenerative medicine, and the basic and clinical researches of AFSCs were summarized and discussed. Results Currently, it is confirmed that AFSCs have a multi-directional differentiation capacity, therefore, they have a wide application prospect in regenerative medicine, anti-tumor, and other fields. Conclusion AFSCs will become one of the ideal seed cells in the field of regenerative medicine with extensive research value because of the advantages of easy amniotic fluid sampling, little maternal and child trauma, no tumorigenesis, and no ethical restrictions.

Citation： LI Chun,LI Weisong,LIU Hu,WANG Jie. RESEARCH DEVELOPMENT OF AMNIOTIC FLUID-DERIVED STEM CELLS IN REGENERATIVE MEDICINE. Chinese Journal of Reparative and Reconstructive Surgery, 2013, 27(10): 1262-1266. doi: 10.7507/1002-1892.20130275 Copy

1.	Torricelli F, Brizzi L, Bernabei PA, et al. Identification of hematopoietic progenitor cells in human amniotic fluid before the 12th week of gestation. Ital J Anat Embryol, 1993, 98(2): 119-126.
2.	Rosner M, Schipany K, Shanmugasundaram B, et al. Amniotic fluid stem cells: future perspectives. Stem Cells, 2012, 2012: 741810.
3.	Gundacker C, Dolznig H, Mikula M, et al. Amniotic fluid stem cell-based models to study the effects of genemutations and toxicants onmale germ cell formation. Asian J Androl, 2012, 14(2): 247-250.
4.	Rosner M, Dolznig H, Schipany K, et al. Human amniotic fluid stem cells as a model for functional studies of genes involved in human genetic diseases or oncogenesis. Oncotarget, 2011, 2(9): 705-712.
5.	Rosner M, Schipany K, Gundacker C, et al. Renal differentiation of amniotic fluid stem cells: perspectives for clinical application and for studies on specific human genetic diseases. Euro J Clin Invest, 2012, 42(6): 677-684.
6.	Da Sacco S, Sedrakyan S, Boldrin F, et al. Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. J Urol, 2010, 183(3): 1193-1200.
7.	Kang NH, Hwang KA, Kim YB, et al. Potential antitumor therapeutic strategies of human amniotic membrane and amniotic fluid-derived stem cells. Cancer Gene Ther, 2012, 19(8): 517-522.
8.	Cabral AC, Angelo PC, Leite HV, et al. Isolation differentiation and biochemical aspects of amniotic fluid stem cell. Rev Assoc Med Bras, 2008, 54(6): 489-493.
9.	Soncini M, Vertua E, Gibelli L, et al. Isolation and characterization of mesenchymal cells from human fetal membranes. J Tissue Eng Regen Med, 2007, 1(4) : 296-305.
10.	Atala A, Bauer SB, Soker S, et al. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet, 2006, 367(9518): 1241-1246 .
11.	Raya-Rivera A, Esquiliano DR, Yoo JJ, et al. Tissue-engineered autologous urethras for patients who need reconstruction: an observational study. Lancet, 2011, 377(9772): 1175-1182.
12.	Yang DY, Sheu ML, Su HL, et al. Dual regeneration of muscle and nerve by intravenous administration of human amniotic fluid-derived mesenchymal stem cells regulated by stromal cell-derived factor-1α in a sciatic nerve injury model. J Neurosurg, 2012, 116(6): 1357-1367.
13.	Joo S, Kol K, Atala A, et al. Amniotic fluid-derived stem cells in regenerative medicine research. Arch Pharm Res, 2012, 35(2): 271-280.
14.	Prasongchean W, Bagni M, Calzarossa C, et al. Amniotic fluid stem cells increase embryo survival following injury. Stem Cells, 2012, 21(5): 675-688.
15.	De Coppi P, Callegari A, Chiavegato A, et al. Amniotic fluid and bone marrow derived mesenchymal stem cells can be converted to smooth muscle cells in the cryo-injured rat bladder and prevent compensatory hypertrophy of surviving smooth muscle cells. J Urol, 2007, 177(1): 369-376.
16.	Lee WY, Wei HJ, Lin WW, et al. Enhancement of cell retention and functional benefits in myocardial infarction using human amniotic-fluid stemcell bodies enriched with endogenous ECM. Biomaterials, 2011, 32(24): 5558-5567.
17.	Mirabella T, Cilli M, Carlone S, et al. Amniotic liquid derived stem cells as reservoir of secreted angiogenic factors capable of stimulating neo-arteriogenesis in an ischemic model. Biomaterials, 2011, 32(15): 3689-3699.
18.	Carraro G, Perin L, Sedrakyan S, et al. Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells, 2008, 26(11): 2902-2911.
19.	Menasche P. Cell-based therapy for heart disease: a clinically oriented perspective. Mol Ther, 2009, 17(5): 758-766.
20.	Bollini S, Pozzobon M, Nobles M, et al. In vitro and in vivo cardiomyogenic differentiation of amniotic fluid stem cells. Stem Cell Rev, 2011, 7(2): 364-380.
21.	Yeh YC, Wei HJ, Lee WY, et al. Cellular cardiomyoplasty with human amniotic fluid stem cells: in vitro and in vivo studies. Tissue Eng Part A, 2010, 16(6): 1925-1936.
22.	Weber B, Zeisberger SM, Hoerstrup SP. Prenatally harvested cells for cardiovascular tissue engineering: fabrication of autologous implants prior to birth. Placenta, 2011, 32 Suppl 4: S316-S319.
23.	Schmidt D, Achermann J, Odermatt B, et al. Cryopreserved amniotic fluid-derived cells: a lifelong autologous fetal stem cell source for heart valve tissue engineering. J Heart Valve Dis, 2008, 17(4): 446-455.
24.	Parolini O, Soncini M, Evangelista M, et al. Amniotic membrane and amniotic fluid-derived cells: potential tools for regenerative medicine? Regen Med, 2009, 4(2): 275-291.
25.	Fauza DO, Marler JJ, Koka R, et al. Fetal tissue engineering: diaphragmatic replacement. J Pediatr Surg , 2001, 36(1): 146-151.
26.	Zheng YB, Zhang XH, Huang ZL, et al. Amniotic-fluid-derived mesenchymal stem cells overexpressing interleukin-1 receptor antagonist improve fulminant hepatic failure. PLoS One, 2012, 7(7): e41392.
27.	Perin L, Giuliani S, Jin D, et al. Renal differentiation of amniotic fluid stem cells. Cell Prolif, 2007, 40(6): 936-948.
28.	Sedrakyan S, Da Sacco S, Milanesi A, et al. Injection of amniotic fluid stem cells delays progression of renal fibrosis. J Am Soc Nephrol, 2012, 23(4): 661-673.
29.	Perin L, Sedrakyan S, Giuliani S, et al. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS One, 2010, 5(2): e9357.
30.	Sun H, Feng K, Hu J, et al. Osteogenic differentiation of human amniotic fluid-derived stem cells induced by bone morphogenetic protein-7 and enhanced by nanofibrous scaffolds. Biomaterials, 2010, 31(6): 1133-1139.
31.	De Coppi P, Bartsch G Jr, Siddiqui MM, et al. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol, 2007, 25(1): 100-106.
32.	Peister A, Deutsch ER, Kolambkar Y, et al. Amniotic fluid stem cells produce robust mineral deposits on biodegradable scaffolds. Tissue Eng Part A, 2009, 15(10): 3129-3138.
33.	Dupont KM, Boerckel JD, Stevens HY, et al. Synthetic scaffold coating with adeno-associated virus encoding BMP2 to promote endogenous bone repair. Cell Tissue Res, 2012, 347(3): 575-588.
34.	Turner CG, Klein JD, Gray FL, et al. Craniofacial repair with fetal bone grafts engineered from amniotic mesenchymal stem cells. J Surg Res, 2012, 178(2): 785-790.
35.	Kolambkar YM, Peister A, Soker S, et al. Chondrogenic differentiation of amniotic fluid-derived stem cells. J Mol Histol, 2007, 38(5): 405-413.
36.	Iacono E, Merlo B, Pirrone A, et al. Effects of mesenchymal stem cells isolated from amniotic fluid and platelet-rich plasma gel on severe decubitus ulcers in a septic neonatal foal. Res Vet Sci, 2012, 93(3): 1439-1440.
37.	Kim K, Doi A, Wen B, et al. Epigenetic memory in induced pluripotent stem cells. Nature, 2010, 467(7313): 285-290.
38.	Fuchs C, Rosner M, Dolznig H, et al. Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem cell differentiation. Hum Mol Genet, 2012, 21(5): 1049-1061.
39.	Phermthai T, Odglun Y, Julavijitphong S, et al. A novel method to derive amniotic fluid stem cells for therapeutic purposes. BMC Cell Biol, 2010, 11: 79.
40.	Bitsika V, Roubelakis MG, Zagoura D, et al. Human amniotic fluid-derived mesenchymal stem cells as therapeutic vehicles: a novel approach for the treatment of bladder cancer. Stem Cells Dev, 2012, 21(7): 1097-1111.
41.	Kang NH, Hwang KA, Yi BR, et al. Human amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse models. Cancer Gene Ther, 2012, 19(6): 412-419.
42.	Rosner M, Siegel N, Fuchs C, et al. Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem cells. Nature Protocols, 2010, 5(6): 1081-1095.
43.	Manuelpillai U, Moodley Y, Borlongan CV, et al. Amniotic membrane and amniotic cells: Potential therapeutic tools to combat tissue inflammation and fibrosis? Placenta, 2011, 32 Suppl 4: S320-S325.
44.	罗宏武, 黄湘俊, 黄飞舟, 等. 人羊膜上皮细胞横向分化及脾内移植的初步研究. 中国修复重建外科杂志, 2011, 25(2): 144-148.
45.	涂长玉, 程敏, 李华锋, 等. 羊水穿刺超声定位的有关问题探讨. 中国优生优育, 2009, 15(1): 25-26.

1. Torricelli F, Brizzi L, Bernabei PA, et al. Identification of hematopoietic progenitor cells in human amniotic fluid before the 12th week of gestation. Ital J Anat Embryol, 1993, 98(2): 119-126.
2. Rosner M, Schipany K, Shanmugasundaram B, et al. Amniotic fluid stem cells: future perspectives. Stem Cells, 2012, 2012: 741810.
3. Gundacker C, Dolznig H, Mikula M, et al. Amniotic fluid stem cell-based models to study the effects of genemutations and toxicants onmale germ cell formation. Asian J Androl, 2012, 14(2): 247-250.
4. Rosner M, Dolznig H, Schipany K, et al. Human amniotic fluid stem cells as a model for functional studies of genes involved in human genetic diseases or oncogenesis. Oncotarget, 2011, 2(9): 705-712.
5. Rosner M, Schipany K, Gundacker C, et al. Renal differentiation of amniotic fluid stem cells: perspectives for clinical application and for studies on specific human genetic diseases. Euro J Clin Invest, 2012, 42(6): 677-684.
6. Da Sacco S, Sedrakyan S, Boldrin F, et al. Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. J Urol, 2010, 183(3): 1193-1200.
7. Kang NH, Hwang KA, Kim YB, et al. Potential antitumor therapeutic strategies of human amniotic membrane and amniotic fluid-derived stem cells. Cancer Gene Ther, 2012, 19(8): 517-522.
8. Cabral AC, Angelo PC, Leite HV, et al. Isolation differentiation and biochemical aspects of amniotic fluid stem cell. Rev Assoc Med Bras, 2008, 54(6): 489-493.
9. Soncini M, Vertua E, Gibelli L, et al. Isolation and characterization of mesenchymal cells from human fetal membranes. J Tissue Eng Regen Med, 2007, 1(4) : 296-305.
10. Atala A, Bauer SB, Soker S, et al. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet, 2006, 367(9518): 1241-1246 .
11. Raya-Rivera A, Esquiliano DR, Yoo JJ, et al. Tissue-engineered autologous urethras for patients who need reconstruction: an observational study. Lancet, 2011, 377(9772): 1175-1182.
12. Yang DY, Sheu ML, Su HL, et al. Dual regeneration of muscle and nerve by intravenous administration of human amniotic fluid-derived mesenchymal stem cells regulated by stromal cell-derived factor-1α in a sciatic nerve injury model. J Neurosurg, 2012, 116(6): 1357-1367.
13. Joo S, Kol K, Atala A, et al. Amniotic fluid-derived stem cells in regenerative medicine research. Arch Pharm Res, 2012, 35(2): 271-280.
14. Prasongchean W, Bagni M, Calzarossa C, et al. Amniotic fluid stem cells increase embryo survival following injury. Stem Cells, 2012, 21(5): 675-688.
15. De Coppi P, Callegari A, Chiavegato A, et al. Amniotic fluid and bone marrow derived mesenchymal stem cells can be converted to smooth muscle cells in the cryo-injured rat bladder and prevent compensatory hypertrophy of surviving smooth muscle cells. J Urol, 2007, 177(1): 369-376.
16. Lee WY, Wei HJ, Lin WW, et al. Enhancement of cell retention and functional benefits in myocardial infarction using human amniotic-fluid stemcell bodies enriched with endogenous ECM. Biomaterials, 2011, 32(24): 5558-5567.
17. Mirabella T, Cilli M, Carlone S, et al. Amniotic liquid derived stem cells as reservoir of secreted angiogenic factors capable of stimulating neo-arteriogenesis in an ischemic model. Biomaterials, 2011, 32(15): 3689-3699.
18. Carraro G, Perin L, Sedrakyan S, et al. Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells, 2008, 26(11): 2902-2911.
19. Menasche P. Cell-based therapy for heart disease: a clinically oriented perspective. Mol Ther, 2009, 17(5): 758-766.
20. Bollini S, Pozzobon M, Nobles M, et al. In vitro and in vivo cardiomyogenic differentiation of amniotic fluid stem cells. Stem Cell Rev, 2011, 7(2): 364-380.
21. Yeh YC, Wei HJ, Lee WY, et al. Cellular cardiomyoplasty with human amniotic fluid stem cells: in vitro and in vivo studies. Tissue Eng Part A, 2010, 16(6): 1925-1936.
22. Weber B, Zeisberger SM, Hoerstrup SP. Prenatally harvested cells for cardiovascular tissue engineering: fabrication of autologous implants prior to birth. Placenta, 2011, 32 Suppl 4: S316-S319.
23. Schmidt D, Achermann J, Odermatt B, et al. Cryopreserved amniotic fluid-derived cells: a lifelong autologous fetal stem cell source for heart valve tissue engineering. J Heart Valve Dis, 2008, 17(4): 446-455.
24. Parolini O, Soncini M, Evangelista M, et al. Amniotic membrane and amniotic fluid-derived cells: potential tools for regenerative medicine? Regen Med, 2009, 4(2): 275-291.
25. Fauza DO, Marler JJ, Koka R, et al. Fetal tissue engineering: diaphragmatic replacement. J Pediatr Surg , 2001, 36(1): 146-151.
26. Zheng YB, Zhang XH, Huang ZL, et al. Amniotic-fluid-derived mesenchymal stem cells overexpressing interleukin-1 receptor antagonist improve fulminant hepatic failure. PLoS One, 2012, 7(7): e41392.
27. Perin L, Giuliani S, Jin D, et al. Renal differentiation of amniotic fluid stem cells. Cell Prolif, 2007, 40(6): 936-948.
28. Sedrakyan S, Da Sacco S, Milanesi A, et al. Injection of amniotic fluid stem cells delays progression of renal fibrosis. J Am Soc Nephrol, 2012, 23(4): 661-673.
29. Perin L, Sedrakyan S, Giuliani S, et al. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS One, 2010, 5(2): e9357.
30. Sun H, Feng K, Hu J, et al. Osteogenic differentiation of human amniotic fluid-derived stem cells induced by bone morphogenetic protein-7 and enhanced by nanofibrous scaffolds. Biomaterials, 2010, 31(6): 1133-1139.
31. De Coppi P, Bartsch G Jr, Siddiqui MM, et al. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol, 2007, 25(1): 100-106.
32. Peister A, Deutsch ER, Kolambkar Y, et al. Amniotic fluid stem cells produce robust mineral deposits on biodegradable scaffolds. Tissue Eng Part A, 2009, 15(10): 3129-3138.
33. Dupont KM, Boerckel JD, Stevens HY, et al. Synthetic scaffold coating with adeno-associated virus encoding BMP2 to promote endogenous bone repair. Cell Tissue Res, 2012, 347(3): 575-588.
34. Turner CG, Klein JD, Gray FL, et al. Craniofacial repair with fetal bone grafts engineered from amniotic mesenchymal stem cells. J Surg Res, 2012, 178(2): 785-790.
35. Kolambkar YM, Peister A, Soker S, et al. Chondrogenic differentiation of amniotic fluid-derived stem cells. J Mol Histol, 2007, 38(5): 405-413.
36. Iacono E, Merlo B, Pirrone A, et al. Effects of mesenchymal stem cells isolated from amniotic fluid and platelet-rich plasma gel on severe decubitus ulcers in a septic neonatal foal. Res Vet Sci, 2012, 93(3): 1439-1440.
37. Kim K, Doi A, Wen B, et al. Epigenetic memory in induced pluripotent stem cells. Nature, 2010, 467(7313): 285-290.
38. Fuchs C, Rosner M, Dolznig H, et al. Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem cell differentiation. Hum Mol Genet, 2012, 21(5): 1049-1061.
39. Phermthai T, Odglun Y, Julavijitphong S, et al. A novel method to derive amniotic fluid stem cells for therapeutic purposes. BMC Cell Biol, 2010, 11: 79.
40. Bitsika V, Roubelakis MG, Zagoura D, et al. Human amniotic fluid-derived mesenchymal stem cells as therapeutic vehicles: a novel approach for the treatment of bladder cancer. Stem Cells Dev, 2012, 21(7): 1097-1111.
41. Kang NH, Hwang KA, Yi BR, et al. Human amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse models. Cancer Gene Ther, 2012, 19(6): 412-419.
42. Rosner M, Siegel N, Fuchs C, et al. Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem cells. Nature Protocols, 2010, 5(6): 1081-1095.
43. Manuelpillai U, Moodley Y, Borlongan CV, et al. Amniotic membrane and amniotic cells: Potential therapeutic tools to combat tissue inflammation and fibrosis? Placenta, 2011, 32 Suppl 4: S320-S325.
44. 罗宏武, 黄湘俊, 黄飞舟, 等. 人羊膜上皮细胞横向分化及脾内移植的初步研究. 中国修复重建外科杂志, 2011, 25(2): 144-148.
45. 涂长玉, 程敏, 李华锋, 等. 羊水穿刺超声定位的有关问题探讨. 中国优生优育, 2009, 15(1): 25-26.

Previous Article
RESEARCH PROGRESS OF HEME OXYGENASE 1 IN BONE TISSUE ENGINEERING
Next Article
PROGRESS OF BONE CEMENT AUGMENTATION OF PEDICLE SCREW

Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH DEVELOPMENT OF AMNIOTIC FLUID-DERIVED STEM CELLS IN REGENERATIVE MEDICINE

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content