APPLICATION PROGRESS OF SEED CELLS IN TISSUE ENGINEERED NERVE_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

LIChunbo ,  CHENZenggan , CHENTongyi , ZHANGFeng , ZHOUJianping

Department of Orthopedics, Zhongshan Hospital of Fudan University, Shanghai, 200032, P. R. China;

Corresponding author：

CHENZenggan, Email: chen.zenggan@zs-hospital.sh.cn

Keywords：

Nerve tissue engineering; Schwann cells; Stem cells; Genetically modified cells; Nerve conduits; Peripheral nerve defect

DOI：

10.7507/1002-1892.20140038

Video：

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Objective To summarize the applications of Schwann cells (SCs), stem cells, and genetically modified cells (GMCs) in repair of peripheral nerve defects. Methods The literature of original experimental study and clinical research related with SCs, stem cells, and GMCs was reviewed and analyzed. Results SCs play a key role in repair of peripheral nerve defects; the stem cells can be induced to differentiate into SCs, which can be implanted into nerve conduits to promote the repair of peripheral nerve defect; genetically modified technology can enhance the function of SCs and different stem cells, which has been regarded as a new option for tissue engineered nerve. Conclusion Although great progress has been made in tissue engineered nerve recently, mostly limited to the experimental stage. The research of seed cells in application of tissue engineered nerve need be studied deeply.

Citation： LIChunbo, CHENZenggan, CHENTongyi, ZHANGFeng, ZHOUJianping. APPLICATION PROGRESS OF SEED CELLS IN TISSUE ENGINEERED NERVE. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(2): 173-178. doi: 10.7507/1002-1892.20140038 Copy

1.	Khuong HT,Midha R.Advances in nerve repair.Curr Neurol Neurosci Rep,2013,13(1):322.
2.	Whitlock EL,Tuffaha SH,Luciano JP,et al.Processed allografts and type I collagen conduits for repair of peripheral nerve gaps.Muscle Nerve,2009,39(6):787-799.
3.	Krarup C,Archibald SJ,Madison RD.Factors that influence peripheral nerve regeneration:an electrophysiological study of the monkey median nerve.Ann Neurol,2002,51(1):69-81.
4.	Walsh S,Midha R.Use of stem cells to augment nerve injury repair.Neurosurgery,2009,65(4 Suppl):A80-86.
5.	Kidd GJ,Ohno N,Trapp BD.Biology of Schwann cells.Handb Clin Neurol,2013,115:55-79.
6.	Morrissey TK,Kleitman N,Bunge RP.Isolation and functional characterization of Schwann cells derived from adult peripheral nerve.J Neurosci,1991,11(8):2433-2442.
7.	Levi AD,Bunge RP.Studies of myelin formation after transplantation of human Schwann cells into the severe combined immunodeficient mouse.Exp Neurol,1994,130(1):41-52.
8.	Hood B,Levene HB,Levi AD.Transplantation of autologous Schwann cells for the repair of segmental peripheral nerve defects.Neurosurg Focus,2009,26(2):E4.
9.	Mosahebi A,Woodward B,Wiberg M,et al.Retroviral labeling of Schwann cells:in vitro characterization and in vivo transplantation to improve peripheral nerve regeneration.Glia,2001,34(1):8-17.
10.	Berrocal YA,Almeida VW,Gupta R,et al.Transplantation of Schwann cells in a collagen tube for the repair of large,segmental peripheral nerve defects in rats.J Neurosurg,2013,119(3):720-732.
11.	Zarbakhsh S,Bakhtiyari M,Faghihi A,et al.The effects of schwann and bone marrow stromal stem cells on sciatic nerve injury in rat:a comparison of functional recovery.Cell J,2012,14(1):39-46.
12.	Hsu YC,Chen SL,Wang DY,et al.Stem cell-based therapy in neural repair.Biomed J,2013,36(3):98-105.
13.	Ziegler L,Grigoryan S,Yang IH,et al.Efficient generation of schwann cells from human embryonic stem cell-derived neurospheres.Stem Cell Rev,2011,7(2):394-403.
14.	Cui L,Jiang J,Wei L,et al.Transplantation of embryonic stem cells improves nerve repair and functional recovery after severe sciatic nerve axotomy in rats.Stem Cells,2008,26(5):1356-1365.
15.	Hematti P.Human embryonic stem cell-derived mesenchymal progenitors:an overview.Methods Mol Biol,2011,690:163-174.
16.	Takahashi K,Tanabe K,Ohnuki M,et al.Induction of pluripotent stem cells from adult human fibroblasts by defined factors.Cell,2007,131(5):861-872.
17.	Wang A,Tang Z,Park IH,et al.Induced pluripotent stem cells for neural tissue engineering.Biomaterials,2011,32(22):5023-5032.
18.	Ikeda M,Uemura T,Takamatsu K,et al.Acceleration of peripheral nerve regeneration using nerve conduits in combination with induced pluripotent stem cell technology and a basic fibroblast growth factor drug delivery system.J Biomed Mater Res A,2013.[Epub ahead of print].
19.	Hsu YC,Chen SL,Wang DY,et al.Stem cell-based therapy in neural repair.Biomed J,2013,36(3):98-105.
20.	黄喜军,朱庆棠,江丽,等.去细胞异种神经复合同种异体脂肪干细胞修复猕猴周围神经缺损的免疫反应研究.中国修复重建外科杂志,2012,26(8):993-1000.
21.	Kim N,Cho SG.Clinical applications of mesenchymal stem cells.Korean J Intern Med,2013,28(4):387-402.
22.	Keilhoff G,Stang F,Goihl A,et al.Transdifferentiated mesenchymal stem cells as alternative therapy in supporting nerve regeneration and myelination.Cell Mol Neurobiol,2006,26(7-8):1235-1252.
23.	Ao Q,Fung CK,Tsui AY,et al.The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells.Biomaterials,2011,32(3):787-796.
24.	Yang Y,Yuan X,Ding F,et al.Repair of rat sciatic nerve gap by a silk fibroin-based scaffold added with bone marrow mesenchymal stem cells.Tissue Eng Part A,2011,17(17-18):2231-2244.
25.	Xue C,Hu N,Gu Y,et al.Joint use of a chitosan/PLGA scaffold and MSCs to bridge an extra large gap in dog sciatic nerve.Neurorehabil Neural Repair,2012,26(1):96-106.
26.	Shen CC,Yang YC,Liu BS.Peripheral nerve repair of transplanted undifferentiated adipose tissue-derived stem cells in a biodegradable reinforced nerve conduit.J Biomed Mater Res A,2012,100(1):48-63.
27.	Peng J,Wang Y,Zhang L,et al.Human umbilical cord Wharton's jelly-derived mesenchymal stem cells differentiate into a Schwann-cell phenotype and promote neurite outgrowth in vitro.Brain Res Bull,2011,84(3):235-243.
28.	Yan-Wu G,Yi-Quan K,Ming L,et al.Human umbilical cord-derived schwann-like cell transplantation combined with neurotrophin-3 administration in dyskinesia of rats with spinal cord injury.Neurochem Res,2011,36(5):783-792.
29.	Jiang TM,Yang ZJ,Kong CZ,et al.Schwann-like cells can be induction from human nestin-positive amniotic fluid mesenchymal stem cells.In Vitro Cell Dev Biol Anim,2010,46(9):793-800.
30.	Tong L,Ji L,Wang Z,et al.Differentiation of neural stem cells into Schwann-like cells in vitro.Biochem Biophys Res Commun,2010,401(4):592-597.
31.	Liard O,Segura S,Sagui E,et al.Adult-brain-derived neural stem cells grafting into a vein bridge increases postlesional recovery and regeneration in a peripheral nerve of adult pig.Stem Cells Int,2012,2012:128732.
32.	Xu L,Zhou S,Feng GY,et al.Neural stem cells enhance nerve regeneration after sciatic nerve injury in rats.Mol Neurobiol,2012,46(2):265-274.
33.	Li BC,Jiao SS,Xu C,et al.PLGA conduit seeded with olfactory ensheathing cells for bridging sciatic nerve defect of rats.J Biomed Mater Res A,2010,94(3):769-780.
34.	Radtke C,Kocsis JD.Peripheral nerve injuries and transplantation of olfactory ensheathing cells for axonal regeneration and remyelination:fact or fiction? Int J Mol Sci,2012,13(10):12911-12924.
35.	Liu Q,Spusta SC,Mi R,et al.Human neural crest stem cells derived from human ESCs and induced pluripotent stem cells:induction,maintenance,and differentiation into functional schwann cells.Stem Cells Transl Med,2012,1(4):266-278.
36.	Lin H,Liu F,Zhang C,et al.Characterization of nerve conduits seeded with neurons and Schwann cells derived from hair follicle neural crest stem cells.Tissue Eng Part A,2011,17(13-14):1691-1698.
37.	Mii S,Duong J,Tome Y,et al.The role of hair follicle nestin-expressing stem cells during whisker sensory-nerve growth in long-term 3D culture.J Cell Biochem,2013,114(7):1674-1684.
38.	Amoh Y,Aki R,Hamada Y,et al.Nestin-positive hair follicle pluripotent stem cells can promote regeneration of impinged peripheral nerve injury.J Dermatol,2012,39(1):33-38.
39.	Yu H,Kumar SM,Kossenkov AV,et al.Stem cells with neural crest characteristics derived from the bulge region of cultured human hair follicles.J Invest Dermatol,2010,130(5):1227-1236.
40.	Amoh Y,Kanoh M,Niiyama S,et al.Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral-nerve injury:an advantageous alternative to ES and iPS cells.J Cell Biochem,2009,107(5):1016-1020.
41.	Daly W,Yao L,Zeugolis D,et al.A biomaterials approach to peripheral nerve regeneration:bridging the peripheral nerve gap and enhancing functional recovery.J R Soc Interface,2012,9(67):202-221.
42.	Li Q,Ping P,Jiang H,et al.Nerve conduit filled with GDNF gene-modified Schwann cells enhances regeneration of the peripheral nerve.Microsurgery,2006,26(2):116-121.
43.	Timmer M,Robben S,Müller-Ostermeyer F,et al.Axonal regeneration across long gaps in silicone chambers filled with Schwann cells overexpressing high molecular weight FGF-2.Cell Transplant,2003,12(3):265-277.
44.	Haastert K,Lipokatic E,Fischer M,et al.Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms.Neurobiol Dis,2006,21(1):138-153.
45.	施新革,宗海斌,董玉珍,等.神经营养因子3基因修饰的雪旺细胞对神经损伤的修复作用.军事医学,2011,15(7):556-558.
46.	郑明辉,张志坚,黄东煜,等.脑源性神经营养因子基因修饰骨髓间充质干细胞治疗坐骨神经损伤.中国组织工程研究与临床康复,2009,13(1):120-124.

1. Khuong HT,Midha R.Advances in nerve repair.Curr Neurol Neurosci Rep,2013,13(1):322.
2. Whitlock EL,Tuffaha SH,Luciano JP,et al.Processed allografts and type I collagen conduits for repair of peripheral nerve gaps.Muscle Nerve,2009,39(6):787-799.
3. Krarup C,Archibald SJ,Madison RD.Factors that influence peripheral nerve regeneration:an electrophysiological study of the monkey median nerve.Ann Neurol,2002,51(1):69-81.
4. Walsh S,Midha R.Use of stem cells to augment nerve injury repair.Neurosurgery,2009,65(4 Suppl):A80-86.
5. Kidd GJ,Ohno N,Trapp BD.Biology of Schwann cells.Handb Clin Neurol,2013,115:55-79.
6. Morrissey TK,Kleitman N,Bunge RP.Isolation and functional characterization of Schwann cells derived from adult peripheral nerve.J Neurosci,1991,11(8):2433-2442.
7. Levi AD,Bunge RP.Studies of myelin formation after transplantation of human Schwann cells into the severe combined immunodeficient mouse.Exp Neurol,1994,130(1):41-52.
8. Hood B,Levene HB,Levi AD.Transplantation of autologous Schwann cells for the repair of segmental peripheral nerve defects.Neurosurg Focus,2009,26(2):E4.
9. Mosahebi A,Woodward B,Wiberg M,et al.Retroviral labeling of Schwann cells:in vitro characterization and in vivo transplantation to improve peripheral nerve regeneration.Glia,2001,34(1):8-17.
10. Berrocal YA,Almeida VW,Gupta R,et al.Transplantation of Schwann cells in a collagen tube for the repair of large,segmental peripheral nerve defects in rats.J Neurosurg,2013,119(3):720-732.
11. Zarbakhsh S,Bakhtiyari M,Faghihi A,et al.The effects of schwann and bone marrow stromal stem cells on sciatic nerve injury in rat:a comparison of functional recovery.Cell J,2012,14(1):39-46.
12. Hsu YC,Chen SL,Wang DY,et al.Stem cell-based therapy in neural repair.Biomed J,2013,36(3):98-105.
13. Ziegler L,Grigoryan S,Yang IH,et al.Efficient generation of schwann cells from human embryonic stem cell-derived neurospheres.Stem Cell Rev,2011,7(2):394-403.
14. Cui L,Jiang J,Wei L,et al.Transplantation of embryonic stem cells improves nerve repair and functional recovery after severe sciatic nerve axotomy in rats.Stem Cells,2008,26(5):1356-1365.
15. Hematti P.Human embryonic stem cell-derived mesenchymal progenitors:an overview.Methods Mol Biol,2011,690:163-174.
16. Takahashi K,Tanabe K,Ohnuki M,et al.Induction of pluripotent stem cells from adult human fibroblasts by defined factors.Cell,2007,131(5):861-872.
17. Wang A,Tang Z,Park IH,et al.Induced pluripotent stem cells for neural tissue engineering.Biomaterials,2011,32(22):5023-5032.
18. Ikeda M,Uemura T,Takamatsu K,et al.Acceleration of peripheral nerve regeneration using nerve conduits in combination with induced pluripotent stem cell technology and a basic fibroblast growth factor drug delivery system.J Biomed Mater Res A,2013.[Epub ahead of print].
19. Hsu YC,Chen SL,Wang DY,et al.Stem cell-based therapy in neural repair.Biomed J,2013,36(3):98-105.
20. 黄喜军,朱庆棠,江丽,等.去细胞异种神经复合同种异体脂肪干细胞修复猕猴周围神经缺损的免疫反应研究.中国修复重建外科杂志,2012,26(8):993-1000.
21. Kim N,Cho SG.Clinical applications of mesenchymal stem cells.Korean J Intern Med,2013,28(4):387-402.
22. Keilhoff G,Stang F,Goihl A,et al.Transdifferentiated mesenchymal stem cells as alternative therapy in supporting nerve regeneration and myelination.Cell Mol Neurobiol,2006,26(7-8):1235-1252.
23. Ao Q,Fung CK,Tsui AY,et al.The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells.Biomaterials,2011,32(3):787-796.
24. Yang Y,Yuan X,Ding F,et al.Repair of rat sciatic nerve gap by a silk fibroin-based scaffold added with bone marrow mesenchymal stem cells.Tissue Eng Part A,2011,17(17-18):2231-2244.
25. Xue C,Hu N,Gu Y,et al.Joint use of a chitosan/PLGA scaffold and MSCs to bridge an extra large gap in dog sciatic nerve.Neurorehabil Neural Repair,2012,26(1):96-106.
26. Shen CC,Yang YC,Liu BS.Peripheral nerve repair of transplanted undifferentiated adipose tissue-derived stem cells in a biodegradable reinforced nerve conduit.J Biomed Mater Res A,2012,100(1):48-63.
27. Peng J,Wang Y,Zhang L,et al.Human umbilical cord Wharton's jelly-derived mesenchymal stem cells differentiate into a Schwann-cell phenotype and promote neurite outgrowth in vitro.Brain Res Bull,2011,84(3):235-243.
28. Yan-Wu G,Yi-Quan K,Ming L,et al.Human umbilical cord-derived schwann-like cell transplantation combined with neurotrophin-3 administration in dyskinesia of rats with spinal cord injury.Neurochem Res,2011,36(5):783-792.
29. Jiang TM,Yang ZJ,Kong CZ,et al.Schwann-like cells can be induction from human nestin-positive amniotic fluid mesenchymal stem cells.In Vitro Cell Dev Biol Anim,2010,46(9):793-800.
30. Tong L,Ji L,Wang Z,et al.Differentiation of neural stem cells into Schwann-like cells in vitro.Biochem Biophys Res Commun,2010,401(4):592-597.
31. Liard O,Segura S,Sagui E,et al.Adult-brain-derived neural stem cells grafting into a vein bridge increases postlesional recovery and regeneration in a peripheral nerve of adult pig.Stem Cells Int,2012,2012:128732.
32. Xu L,Zhou S,Feng GY,et al.Neural stem cells enhance nerve regeneration after sciatic nerve injury in rats.Mol Neurobiol,2012,46(2):265-274.
33. Li BC,Jiao SS,Xu C,et al.PLGA conduit seeded with olfactory ensheathing cells for bridging sciatic nerve defect of rats.J Biomed Mater Res A,2010,94(3):769-780.
34. Radtke C,Kocsis JD.Peripheral nerve injuries and transplantation of olfactory ensheathing cells for axonal regeneration and remyelination:fact or fiction? Int J Mol Sci,2012,13(10):12911-12924.
35. Liu Q,Spusta SC,Mi R,et al.Human neural crest stem cells derived from human ESCs and induced pluripotent stem cells:induction,maintenance,and differentiation into functional schwann cells.Stem Cells Transl Med,2012,1(4):266-278.
36. Lin H,Liu F,Zhang C,et al.Characterization of nerve conduits seeded with neurons and Schwann cells derived from hair follicle neural crest stem cells.Tissue Eng Part A,2011,17(13-14):1691-1698.
37. Mii S,Duong J,Tome Y,et al.The role of hair follicle nestin-expressing stem cells during whisker sensory-nerve growth in long-term 3D culture.J Cell Biochem,2013,114(7):1674-1684.
38. Amoh Y,Aki R,Hamada Y,et al.Nestin-positive hair follicle pluripotent stem cells can promote regeneration of impinged peripheral nerve injury.J Dermatol,2012,39(1):33-38.
39. Yu H,Kumar SM,Kossenkov AV,et al.Stem cells with neural crest characteristics derived from the bulge region of cultured human hair follicles.J Invest Dermatol,2010,130(5):1227-1236.
40. Amoh Y,Kanoh M,Niiyama S,et al.Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral-nerve injury:an advantageous alternative to ES and iPS cells.J Cell Biochem,2009,107(5):1016-1020.
41. Daly W,Yao L,Zeugolis D,et al.A biomaterials approach to peripheral nerve regeneration:bridging the peripheral nerve gap and enhancing functional recovery.J R Soc Interface,2012,9(67):202-221.
42. Li Q,Ping P,Jiang H,et al.Nerve conduit filled with GDNF gene-modified Schwann cells enhances regeneration of the peripheral nerve.Microsurgery,2006,26(2):116-121.
43. Timmer M,Robben S,Müller-Ostermeyer F,et al.Axonal regeneration across long gaps in silicone chambers filled with Schwann cells overexpressing high molecular weight FGF-2.Cell Transplant,2003,12(3):265-277.
44. Haastert K,Lipokatic E,Fischer M,et al.Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms.Neurobiol Dis,2006,21(1):138-153.
45. 施新革,宗海斌,董玉珍,等.神经营养因子3基因修饰的雪旺细胞对神经损伤的修复作用.军事医学,2011,15(7):556-558.
46. 郑明辉,张志坚,黄东煜,等.脑源性神经营养因子基因修饰骨髓间充质干细胞治疗坐骨神经损伤.中国组织工程研究与临床康复,2009,13(1):120-124.

Chinese Journal of Reparative and Reconstructive Surgery

APPLICATION PROGRESS OF SEED CELLS IN TISSUE ENGINEERED NERVE

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