APPLICATION OF DIGITAL DESIGN AND THREE-DIMENSIONAL PRINTING TECHNIQUE ON INDIVIDUALIZED MEDICAL TREATMENT_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

QINMian ¹ ,  LIUYaxiong ¹ , HEJiankang ¹ , WANGLing ¹ , LIANQin ¹ , LIDichen ¹ , JINZhongmin ^1,2 , HESanhu ³ , LIGang ³ , LIUYanpu ⁴ , WANGZhen ⁵

1. State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an Shaanxi, 710049, P. R. China;
2. Institute of Medical and Biological Engineering, Leeds University, UK;
3. Department of Maxillofacial Surgery, School of Stomatology, Xi'an Jiaotong University;
4. Department of Oral and Maxillofacial Surgery, School of Stomatology, the Fourth Military Medical University;
5. Department of Orthopedics, Xijing Hospital, the Fourth Military Medical University;

Corresponding author：

LIUYaxiong, Email: yaxiongliu@mail.xjtu.edu.cn

Keywords：

Three-dimensional printing technique; Individualized medical treatment; Medical implant; Clinical application

DOI：

10.7507/1002-1892.20140065

Video：

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Objective To summarize the latest research development of the application of digital design and three-dimensional (3-D) printing technique on individualized medical treatment. Methods Recent research data and clinical literature about the application of digital design and 3-D printing technique on individualized medical treatment in Xi'an Jiaotong University and its cooperation unit were summarized, reviewed, and analyzed. Results Digital design and 3-D printing technique can design and manufacture individualized implant based on the patient's specific disease conditions. And the implant can satisfy the needs of specific shape and function of the patient, reducing dependence on the level of experience required for the doctor. So 3-D printing technique get more and more recognition of the surgeon on the individualized repair of human tissue. Xi'an Jiaotong University is the first unit to develop the commercial 3-D printer and conduct depth research on the design and manufacture of individualized medical implant. And complete technological processes and quality standards of product have been developed. Conclusion The individualized medical implant manufactured by 3-D printing technique can not only achieve personalized match but also meet the functional requirements and aesthetic requirements of patients. In addition, the individualized medical implant has the advantages of accurate positioning, stable connection, and high strength. So 3-D printing technique has broad prospects in the manufacture and application of individualized implant.

Citation： QINMian, LIUYaxiong, HEJiankang, WANGLing, LIANQin, LIDichen, JINZhongmin, HESanhu, LIGang, LIUYanpu, WANGZhen. APPLICATION OF DIGITAL DESIGN AND THREE-DIMENSIONAL PRINTING TECHNIQUE ON INDIVIDUALIZED MEDICAL TREATMENT. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(3): 286-291. doi: 10.7507/1002-1892.20140065 Copy

1.	刘葳, 李涤尘, 周丽斌, 等. 定制化柔性下颌骨钛替代物的有限元优化分析及动物试验. 机械工程学报, 2010, 46(5):133-138.
2.	王金涛, 刘美娟, 苗雷英, 等. 下颌骨缺损修复新进展. 吉林大学学报:医学版, 2005, 31(6):973-976.
3.	邱蔚六. 口腔颌面修复重建外科近况. 中国修复重建外科杂志, 2006, 20(4):339-343.
4.	Giannatsis J, Dedoussis V. Additive fabrication technologies applied to medicine and health care:a review. Int J Adv Manuf Technol, 2009, 40:116-127.
5.	龚振宇, 刘彦普, 周树夏, 等. 基于反求工程和快速原型的下颌骨缺损的修复. 中华口腔医学杂志, 2004, 39(1):9-11.
6.	Singare S, Dichen L, Bingheng L, et al. Design and fabrication of custom mandible titanium tray based on rapid prototyping. Med Eng Phys, 2004, 26(8):671-676.
7.	Singare S, Yaxiong L, Dichen L, et al. Fabrication of customized maxillo-facial prosthesis using computer-aided design and rapid prototyping techniques. Rapid Prototyping Journal, 2006, 12(4):206-213.
8.	王千, 刘亚雄, 杜如坤, 等. 利用布尔运算的定制化下颌骨替代物设计方法. 西安交通大学学报, 2009, 43(1):43-46.
9.	杨海欧, 林鑫, 陈静, 等. 激光成形制备生物医用钛合金材料研究进展. 铸造技术, 2011, 32(10):1431-1434.
10.	刘辉, 杨冠军, 于振涛, 等. 生物医用多孔钛合金材料的制备. 钛工业进展, 2010, 27(1):9-15.
11.	Ducan RL, Turner CH. Mechanotransduction and the functional response of bone tomechanical strain. Calcif Tissue Int, 1995, 57(5):344-358.
12.	刘亚雄, 王千, 贺健康, 等. 定制化钛合金假体光固化快速铸造工艺精度研究. 机械工程学报, 2013, 网络版:http://www.cnki.net/kcms/detail/11.2187.TH.20131009.1408.021.html.
13.	张安峰, 李涤尘, 卢秉恒. 激光直接金属快速成形技术的研究进展. 兵器材科科学与工程, 2007, 30(5):68-73.
14.	李伯琼. 多孔钛的孔隙特征和力学性能的研究. 大连:大连交通大学, 2005.
15.	Liu Yaxiong, Li Dichen, Lu Bingheng, et al. The customized mandible substitute based on rapid prototyping. Rapid Prototyping Journal, 2003, 9(3):167-174.
16.	刘亚雄, 李涤尘, 卢秉恒, 等. 快速原型在口腔颌面修复中的应用(1)——下颌骨替代物的原位设计. 实用口腔医学杂志, 2002, 18(5):395-397.
17.	刘亚雄, 李涤尘, 卢秉恒, 等. 快速原型在口腔颌面修复中的应用(2)——下颌骨替代物的个性化制造. 实用口腔医学杂志, 2003, 19(5):408-410.
18.	He J, Li D, Lu B, et al. Custom fabrication of composite tibial hemi-knee joint combining CAD/CAE/CAM techniques. Proc Inst Mech Eng H, 2006, 220(8):823-830.
19.	张虎, 李涤尘, 孙明林, 等. 定制化单侧膝关节假体设计与快速制造方法研究. 北京生物医学工程, 2003, 22(4):266-268, 273.
20.	郑淑贤, 赵万华, 卢秉恒. 残肢与接受腔的三维建模及力学分析. 中国康复, 2006, 21(1):52-54.

1. 刘葳, 李涤尘, 周丽斌, 等. 定制化柔性下颌骨钛替代物的有限元优化分析及动物试验. 机械工程学报, 2010, 46(5):133-138.
2. 王金涛, 刘美娟, 苗雷英, 等. 下颌骨缺损修复新进展. 吉林大学学报:医学版, 2005, 31(6):973-976.
3. 邱蔚六. 口腔颌面修复重建外科近况. 中国修复重建外科杂志, 2006, 20(4):339-343.
4. Giannatsis J, Dedoussis V. Additive fabrication technologies applied to medicine and health care:a review. Int J Adv Manuf Technol, 2009, 40:116-127.
5. 龚振宇, 刘彦普, 周树夏, 等. 基于反求工程和快速原型的下颌骨缺损的修复. 中华口腔医学杂志, 2004, 39(1):9-11.
6. Singare S, Dichen L, Bingheng L, et al. Design and fabrication of custom mandible titanium tray based on rapid prototyping. Med Eng Phys, 2004, 26(8):671-676.
7. Singare S, Yaxiong L, Dichen L, et al. Fabrication of customized maxillo-facial prosthesis using computer-aided design and rapid prototyping techniques. Rapid Prototyping Journal, 2006, 12(4):206-213.
8. 王千, 刘亚雄, 杜如坤, 等. 利用布尔运算的定制化下颌骨替代物设计方法. 西安交通大学学报, 2009, 43(1):43-46.
9. 杨海欧, 林鑫, 陈静, 等. 激光成形制备生物医用钛合金材料研究进展. 铸造技术, 2011, 32(10):1431-1434.
10. 刘辉, 杨冠军, 于振涛, 等. 生物医用多孔钛合金材料的制备. 钛工业进展, 2010, 27(1):9-15.
11. Ducan RL, Turner CH. Mechanotransduction and the functional response of bone tomechanical strain. Calcif Tissue Int, 1995, 57(5):344-358.
12. 刘亚雄, 王千, 贺健康, 等. 定制化钛合金假体光固化快速铸造工艺精度研究. 机械工程学报, 2013, 网络版:http://www.cnki.net/kcms/detail/11.2187.TH.20131009.1408.021.html.
13. 张安峰, 李涤尘, 卢秉恒. 激光直接金属快速成形技术的研究进展. 兵器材科科学与工程, 2007, 30(5):68-73.
14. 李伯琼. 多孔钛的孔隙特征和力学性能的研究. 大连:大连交通大学, 2005.
15. Liu Yaxiong, Li Dichen, Lu Bingheng, et al. The customized mandible substitute based on rapid prototyping. Rapid Prototyping Journal, 2003, 9(3):167-174.
16. 刘亚雄, 李涤尘, 卢秉恒, 等. 快速原型在口腔颌面修复中的应用(1)——下颌骨替代物的原位设计. 实用口腔医学杂志, 2002, 18(5):395-397.
17. 刘亚雄, 李涤尘, 卢秉恒, 等. 快速原型在口腔颌面修复中的应用(2)——下颌骨替代物的个性化制造. 实用口腔医学杂志, 2003, 19(5):408-410.
18. He J, Li D, Lu B, et al. Custom fabrication of composite tibial hemi-knee joint combining CAD/CAE/CAM techniques. Proc Inst Mech Eng H, 2006, 220(8):823-830.
19. 张虎, 李涤尘, 孙明林, 等. 定制化单侧膝关节假体设计与快速制造方法研究. 北京生物医学工程, 2003, 22(4):266-268, 273.
20. 郑淑贤, 赵万华, 卢秉恒. 残肢与接受腔的三维建模及力学分析. 中国康复, 2006, 21(1):52-54.

Chinese Journal of Reparative and Reconstructive Surgery

APPLICATION OF DIGITAL DESIGN AND THREE-DIMENSIONAL PRINTING TECHNIQUE ON INDIVIDUALIZED MEDICAL TREATMENT

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