CLINICAL STUDY ON PLATELET RICH PLASMA IN TOTAL HIP ARTHROPLASTY WOUND_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

DONGPeilong ,  TANGXiaobo , WANGJian , WANGHairong , BIANWeiwei , WUXuhua

Department of Orthopedics, Jianhu Hospital, Nantong University, Yancheng Jiangsu, 224700, P. R. China;

Corresponding author：

TANGXiaobo, Email: txb5122@sina.com

Keywords：

Platelet rich plasma; Total hip arthroplasty; Wound healing

DOI：

10.7507/1002-1892.20140098

Video：

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Objective To investigate the effect of platelet rich plasma (PRP) in promoting wound healing of total hip arthroplasty (THA). Methods Between January 2011 and January 2012, 80 patients scheduled for THA and accorded with the inclusion criteria were divided into 2 groups:wounds were treated with PRP in 40 patients (PRP group) and with normal saline in 40 patients (control group). There was no significant difference in gender, age, disease duration, injury causes, sides, fracture type, and preoperative Harris hip scores between 2 groups (P>0.05). Routine drainage and functional exercise were performed after operation. Results The postoperative drainage volume of PRP group[(137±26) mL] was significantly lower than that of control group[(424±39) mL] (t=38.726, P=0.000). At 4 days after operation, no inflammatory reaction was observed in 34 cases of PRP group and in 30 cases of control group, mild inflammatory reaction in 5 cases of PRP group and in 6 cases of control group, moderate inflammatory reaction in 1 case of PRP group and in 4 cases of control group; there was no significant difference between 2 groups (χ²=2.141, P=0.343). Wound healed by first intention in 40 patients of PRP group and in 39 patients of control group, showing no significant difference between 2 groups (P=1.000). The average follow-up period was 9 months (range, 6-12 months). The Harris hip scores of PRP group (90.2±2.5) and control group (89.3±3.1) at last follow-up were significantly better than those before operation (39.6±8.9 and 39.2±9.2 respectively) (t=34.618, P=0.000; t=32.638, P=0.000), but no significant difference was found between 2 groups (t=1.429, P=0.153). Conclusion Using PRP in THA wound can reduce postoperative drainage volume, improve the healing of operation incision. It is a safe, effective, and promising procedure in treatment of THA wound.

Citation： DONGPeilong, TANGXiaobo, WANGJian, WANGHairong, BIANWeiwei, WUXuhua. CLINICAL STUDY ON PLATELET RICH PLASMA IN TOTAL HIP ARTHROPLASTY WOUND. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(4): 432-434. doi: 10.7507/1002-1892.20140098 Copy

1.	Lacci KM, Dardik A. Platelet-rich plasma:support for its use in wound healing. Yale J Biol Med, 2010, 83(1):1-9.
2.	吕明, 张洪, 郭盛杰. 髋关节后外侧入路中软组织松解对髋关节张力的影响. 中华骨科杂志, 2009, 29(3):252-256.
3.	仇建军, 张长青, 郭彦杰, 等. PRP促进骨折修复的临床实验研究. 中国修复重建外科杂志, 2009, 23(7):784-787.
4.	苏超, 张焕虎. 富血小板血浆的发展及在普通外科中的应用. 中华全科医学, 2012, 10(6):940-941.
5.	张莉, 郁淼, 王浩, 等. PRP结合组织工程皮肤修复裸鼠巨大创面的实验研究. 现代生物医学进展, 2012, 12(6):1065-1074.
6.	Anitua E, Aguirre JJ, Algorta J, et al. Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers. J Biomed Mater Res B Appl Biomater, 2008, 84(2):415-421.
7.	Sánchez-González DJ, Méndez-Bolaina E, Trejo-Bahena NI. Platelet-rich plasma peptides:key for regeneration. Int J Pept, 2012, 2012:532519.
8.	Sampson S, Gerhardt M, Mandelbaum B. Platelet rich plasma injection grafts for musculoskeletal injuries:a review. Curr Rev Musculoskelet Med, 2008, 1(3-4):165-174.
9.	Freymiller EG. Platelet-rich plasma:evidence to support its use. J Oral Maxillofac Surg, 2004, 62(8):1046.
10.	Kaux JF, Crielaard JM. Platelet-rich plasma application in the management of chronic tendinopathies. Acta Orthop Belg, 2013, 79(1):10-15.
11.	边晓为, 马宁, 张莉, 等. PRP/nHA/Co复合材料修复牙周组织缺损的应用研究. 口腔医学研究, 2012, 28(2):110-113.
12.	Brass L. Understanding and evaluating platelet function. Hematology Am Soc Hematol Educ Program, 2010, 2010:387-396.
13.	Xie X, Wu H, Zhao S, et al. The effect of platelet-rich plasma on patterns of gene expression in a dog model of anterior cruciate ligament reconstruction. J Surg Res, 2013, 180(1):80-88.
14.	Yoshida R, Murray MM. Peripheral blood mononuclear cells enhance the anabolic effects of platelet-rich plasma on anterior cruciate ligament fibroblasts. J Orthop Res, 2013, 31(1):29-34.
15.	Taylor DW, Petrera M, Hendry M. A systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries. Clin J Sport Med, 2011, 21(4):344-352.
16.	Cheng M, Johnson VM, Murray MM. Effects of age and platelet-rich plasma on ACL cell viability and collagen gene expression. J Orthop Res, 2012, 30(1):79-85.
17.	Peng L, Bhatia N, Parker AC, et al. Endogenous vitronectin and plasminogen activator inhibitor-1 promote neointima formation in murine carotid arteries. Arterioscler Thromb Vasc Biol, 2002, 22(6):934-939.

1. Lacci KM, Dardik A. Platelet-rich plasma:support for its use in wound healing. Yale J Biol Med, 2010, 83(1):1-9.
2. 吕明, 张洪, 郭盛杰. 髋关节后外侧入路中软组织松解对髋关节张力的影响. 中华骨科杂志, 2009, 29(3):252-256.
3. 仇建军, 张长青, 郭彦杰, 等. PRP促进骨折修复的临床实验研究. 中国修复重建外科杂志, 2009, 23(7):784-787.
4. 苏超, 张焕虎. 富血小板血浆的发展及在普通外科中的应用. 中华全科医学, 2012, 10(6):940-941.
5. 张莉, 郁淼, 王浩, 等. PRP结合组织工程皮肤修复裸鼠巨大创面的实验研究. 现代生物医学进展, 2012, 12(6):1065-1074.
6. Anitua E, Aguirre JJ, Algorta J, et al. Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers. J Biomed Mater Res B Appl Biomater, 2008, 84(2):415-421.
7. Sánchez-González DJ, Méndez-Bolaina E, Trejo-Bahena NI. Platelet-rich plasma peptides:key for regeneration. Int J Pept, 2012, 2012:532519.
8. Sampson S, Gerhardt M, Mandelbaum B. Platelet rich plasma injection grafts for musculoskeletal injuries:a review. Curr Rev Musculoskelet Med, 2008, 1(3-4):165-174.
9. Freymiller EG. Platelet-rich plasma:evidence to support its use. J Oral Maxillofac Surg, 2004, 62(8):1046.
10. Kaux JF, Crielaard JM. Platelet-rich plasma application in the management of chronic tendinopathies. Acta Orthop Belg, 2013, 79(1):10-15.
11. 边晓为, 马宁, 张莉, 等. PRP/nHA/Co复合材料修复牙周组织缺损的应用研究. 口腔医学研究, 2012, 28(2):110-113.
12. Brass L. Understanding and evaluating platelet function. Hematology Am Soc Hematol Educ Program, 2010, 2010:387-396.
13. Xie X, Wu H, Zhao S, et al. The effect of platelet-rich plasma on patterns of gene expression in a dog model of anterior cruciate ligament reconstruction. J Surg Res, 2013, 180(1):80-88.
14. Yoshida R, Murray MM. Peripheral blood mononuclear cells enhance the anabolic effects of platelet-rich plasma on anterior cruciate ligament fibroblasts. J Orthop Res, 2013, 31(1):29-34.
15. Taylor DW, Petrera M, Hendry M. A systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries. Clin J Sport Med, 2011, 21(4):344-352.
16. Cheng M, Johnson VM, Murray MM. Effects of age and platelet-rich plasma on ACL cell viability and collagen gene expression. J Orthop Res, 2012, 30(1):79-85.
17. Peng L, Bhatia N, Parker AC, et al. Endogenous vitronectin and plasminogen activator inhibitor-1 promote neointima formation in murine carotid arteries. Arterioscler Thromb Vasc Biol, 2002, 22(6):934-939.

Chinese Journal of Reparative and Reconstructive Surgery

CLINICAL STUDY ON PLATELET RICH PLASMA IN TOTAL HIP ARTHROPLASTY WOUND

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