EFFECT OF 1, 25-DIHYDROXYVITAMIN D3 ON POSTERIOR TRANSFORAMINAL LUMBAR INTERBODY FUSION IN PATIENTS WITH OSTEOPOROSIS AND LUMBAR DISC DEGENERATIVE DISEASE_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

XUYong , ZHOUMin , LIUHuan , ZHANGQunhu , HUZhiyi , ZHANGNing ,  RENYongxin

Department of Orthopaedics, the First Affiliated Hospital, Nanjing Medical University, Nanjing Jiangsu, 210029, P. R. China;

Corresponding author：

RENYongxin, Email: renyongxin@aliyun.com

Keywords：

Lumbar degenerative disease; Transforaminal lumbar interbody fusion; Osteoporosis; 1, 25-dihydroxyvitamin D3

DOI：

10.7507/1002-1892.20140213

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the role of 1,25-dihydroxyvitamin D3 in the posterior transforaminal lumbar interbody fusion (TLIF) for patients with osteoporosis and lumbar degenerative disease. Methods Between November 2011 and October 2012,44 patients with osteoporosis and lumbar degenerative disease were treated with TLIF and the clinical data were retrospectively analyzed.The patients were divided into 2 groups based on the administration of 1,25-dihydroxyvitamin D3.After TLIF operation,1,25-dihydroxyvitamin D3 was used in 21 patients (trial group),and was not used in 23 patients (control group).There was no significant difference in gender,age,etiology,affected segment,and disease duration between 2 groups (P>0.05).Lumbar interbody fusion was observed by X-ray and thin-section CT scan reconstruction of lumbar spine according to Brantigan assessment system at 6 months after operation and last follow-up.Clinical outcome was evaluated by Oswestry disability index (ODI) before and after operation. Results The patients of 2 groups were followed up 12-27 months (mean,14.5 months).No fixation loosening or breaking occurred during follow-up.ODI scores in both groups were significantly improved at 6 months after operation and last follow-up (P<0.05) when conpared with preoperative value.Although at preoperation there was no significant difference in ODI score between 2 groups (P>0.05),ODI score of trial group was significantly lower than that of control group at 6 months after operation and last follow-up (P<0.05).At 6 months after operation,the interbody fusion rate was 76.19% (16/21) in trial group and 43.48% (10/23) in control group,showing significant difference (χ²=3.60,P=0.03); at last follow-up,the fusion rate was 95.24% (20/21) in trial group and 65.22% (15/23) in control group,showing significant difference (χ²=4.38,P=0.02). Conclusion 1,25-dihydroxyvitamin D3 can improve the lumbar interbody fusion rate and general conditions in the patients with osteoporosis and lumbar degenerative disease.

Citation： XUYong, ZHOUMin, LIUHuan, ZHANGQunhu, HUZhiyi, ZHANGNing, RENYongxin. EFFECT OF 1, 25-DIHYDROXYVITAMIN D3 ON POSTERIOR TRANSFORAMINAL LUMBAR INTERBODY FUSION IN PATIENTS WITH OSTEOPOROSIS AND LUMBAR DISC DEGENERATIVE DISEASE. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(8): 969-972. doi: 10.7507/1002-1892.20140213 Copy

1.	田伟.积水潭实用骨科学.北京:人民卫生出版社,2008:560-564.
2.	胥少汀,葛宝丰,徐印坎.实用骨科学.北京:人民军医出版社,2012:26-30.
3.	Brumbaugh PF,Speer DP,Pitt MJ.1 alpha,25-Dihydroxyvitamin D3 a metabolite of vitamin D that promotes bone repair.Am J Pathol,1982,106(2):171-179.
4.	Fu L,Tang T,Miao Y,et al.Effect of 1,25-dihydroxy vitamin D3 on fracture healing and bone remodeling in ovariectomized rat femora.Bone,2009,44(5):893-898.
5.	覃芙,张兴群,陈四木.1,25-二羟基维生素D3对原发性骨质疏松骨折愈合的影响.中国医师杂志,2007,9(12):1604-1607.
6.	Brantigan JW,Steffee AD,Lewis ML,et al.Lumbar interbody fusion using the Brantigan I/F cage for posterior lumbar interbody fusion and the variable pediele screw placement system:two-year results from a Food and Drug Administration investigational device exemption clinical trial.Spine (Phila Pa 1976),2000,25(11):1437-1446.
7.	Kalb S,Perez-Orribo L,Kalani MY,et al.The influence of common medical conditions on the outcome of anterior lumbar interbody fusion.J Spinal Disord Tech,2013.[Epub ahead of print].
8.	Chin DK,Park JY,Yoon YS,et al.Prevalence of osteoporosis in patients requiring spine surgery:incidence and significance of osteoporosis in spine disease.Osteoporos Int,2007,18(9):1219-1224.
9.	Andersen T,Christensen FB,Langdahl BL,et al.Fusion mass bone quality after uninstrumented spinal fusion in older patients.Eur Spine J,2010,19(12):2200-2208.
10.	Omeroğlu H,Ateş Y,Akkuş O,et al.Biomechanical analysis of the effects of single high-dose vitamin D3 on fracture healing in a healthy rabbit model.Arch Orthop Trauma Surg,1997,116(5):271-274.
11.	Omeroğlu H,Omeroğlu S,Korkusuz F,et al.Effect of 25-OH-vitamin D on fracture healing in elderly rats.J Orthop Res,1999,17(5):795.
12.	Doetsch AM,Faber J,Lynnerup N,et al.The effects of calcium and vitamin D3 supplementation on the healing of the proximal humerus fracture:a randomized placebo-controlled study.Calcif Tissue Int,2004,75(3):183-188.
13.	Ceglia L,Niramitmahapanya S,da Silva Morais M,et al.A randomized study on the effect of vitamin D supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women.J Clin Endocrinol Metab,2013,98(12):E1927-1935.
14.	Girgis CM,Clifton-Bligh RJ,Turner N,et al.Effects of vitamin D in skeletal muscle:falls,strength,athletic performance and insulin sensitivity.Clin Endocrinol (Oxf),2014,80(2):169-181.
15.	Bunout D,de la Maza MP,Barrera G,et al.Association between sarcopenia and mortality in healthy older people.Australas J Ageing,2011,30(2):89-92.
16.	Gallagher JC.The effects of calcitriol on falls and fractures and physical performance tests.J Steroid Biochem Mol Biol,2004,89-90(1-5):497-501.
17.	Houston DK,Tooze JA,Neiberg RH,et al.25-hydroxyvitamin D status and change in physical performance and strength in older adults:the Health,Aging,and Body Composition Study.Am J Epidemiol,2012,176(11):1025-1034.
18.	Moreira-Pfrimer LD,Pedrosa MA,Teixeira L,et al.Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity:a randomized double-blind controlled trial.Ann Nutr Metab,2009,54(4):291-300.
19.	Menant JC,Close JC,Delbaere K,et al.Relationships between serum vitamin D levels,neuromuscular and neuropsychological function and falls in older men and women.Osteoporos Int,2012,23(3):981-989.
20.	Zhu K,Austin N,Devine A,et al.A randomized controlled trial of the effects of vitamin D on muscle strength and mobility in older women with vitamin D insufficiency.J Am Geriatr Soc,2010,58(11):2063-2068.
21.	Schacht E,Ringe JD.Alfacalcidol improves muscle power,muscle function and balance in elderly patients with reduced bone mass.Rheumatol Int,2012,32(1):207-215.

1. 田伟.积水潭实用骨科学.北京:人民卫生出版社,2008:560-564.
2. 胥少汀,葛宝丰,徐印坎.实用骨科学.北京:人民军医出版社,2012:26-30.
3. Brumbaugh PF,Speer DP,Pitt MJ.1 alpha,25-Dihydroxyvitamin D3 a metabolite of vitamin D that promotes bone repair.Am J Pathol,1982,106(2):171-179.
4. Fu L,Tang T,Miao Y,et al.Effect of 1,25-dihydroxy vitamin D3 on fracture healing and bone remodeling in ovariectomized rat femora.Bone,2009,44(5):893-898.
5. 覃芙,张兴群,陈四木.1,25-二羟基维生素D3对原发性骨质疏松骨折愈合的影响.中国医师杂志,2007,9(12):1604-1607.
6. Brantigan JW,Steffee AD,Lewis ML,et al.Lumbar interbody fusion using the Brantigan I/F cage for posterior lumbar interbody fusion and the variable pediele screw placement system:two-year results from a Food and Drug Administration investigational device exemption clinical trial.Spine (Phila Pa 1976),2000,25(11):1437-1446.
7. Kalb S,Perez-Orribo L,Kalani MY,et al.The influence of common medical conditions on the outcome of anterior lumbar interbody fusion.J Spinal Disord Tech,2013.[Epub ahead of print].
8. Chin DK,Park JY,Yoon YS,et al.Prevalence of osteoporosis in patients requiring spine surgery:incidence and significance of osteoporosis in spine disease.Osteoporos Int,2007,18(9):1219-1224.
9. Andersen T,Christensen FB,Langdahl BL,et al.Fusion mass bone quality after uninstrumented spinal fusion in older patients.Eur Spine J,2010,19(12):2200-2208.
10. Omeroğlu H,Ateş Y,Akkuş O,et al.Biomechanical analysis of the effects of single high-dose vitamin D3 on fracture healing in a healthy rabbit model.Arch Orthop Trauma Surg,1997,116(5):271-274.
11. Omeroğlu H,Omeroğlu S,Korkusuz F,et al.Effect of 25-OH-vitamin D on fracture healing in elderly rats.J Orthop Res,1999,17(5):795.
12. Doetsch AM,Faber J,Lynnerup N,et al.The effects of calcium and vitamin D3 supplementation on the healing of the proximal humerus fracture:a randomized placebo-controlled study.Calcif Tissue Int,2004,75(3):183-188.
13. Ceglia L,Niramitmahapanya S,da Silva Morais M,et al.A randomized study on the effect of vitamin D supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women.J Clin Endocrinol Metab,2013,98(12):E1927-1935.
14. Girgis CM,Clifton-Bligh RJ,Turner N,et al.Effects of vitamin D in skeletal muscle:falls,strength,athletic performance and insulin sensitivity.Clin Endocrinol (Oxf),2014,80(2):169-181.
15. Bunout D,de la Maza MP,Barrera G,et al.Association between sarcopenia and mortality in healthy older people.Australas J Ageing,2011,30(2):89-92.
16. Gallagher JC.The effects of calcitriol on falls and fractures and physical performance tests.J Steroid Biochem Mol Biol,2004,89-90(1-5):497-501.
17. Houston DK,Tooze JA,Neiberg RH,et al.25-hydroxyvitamin D status and change in physical performance and strength in older adults:the Health,Aging,and Body Composition Study.Am J Epidemiol,2012,176(11):1025-1034.
18. Moreira-Pfrimer LD,Pedrosa MA,Teixeira L,et al.Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity:a randomized double-blind controlled trial.Ann Nutr Metab,2009,54(4):291-300.
19. Menant JC,Close JC,Delbaere K,et al.Relationships between serum vitamin D levels,neuromuscular and neuropsychological function and falls in older men and women.Osteoporos Int,2012,23(3):981-989.
20. Zhu K,Austin N,Devine A,et al.A randomized controlled trial of the effects of vitamin D on muscle strength and mobility in older women with vitamin D insufficiency.J Am Geriatr Soc,2010,58(11):2063-2068.
21. Schacht E,Ringe JD.Alfacalcidol improves muscle power,muscle function and balance in elderly patients with reduced bone mass.Rheumatol Int,2012,32(1):207-215.

Previous Article
APPLICATION OF POSTERIOR SPINAL CANAL RECONSTRUCTION IN SURGERY OF INTRASPINAL TUMOR
Next Article
EFFECTIVENESS COMPARISON BETWEEN TWO KINDS OF PROCEDURES FOR TREATMENT OF TOTALLY DEGLOVED HAND

Chinese Journal of Reparative and Reconstructive Surgery

EFFECT OF 1, 25-DIHYDROXYVITAMIN D3 ON POSTERIOR TRANSFORAMINAL LUMBAR INTERBODY FUSION IN PATIENTS WITH OSTEOPOROSIS AND LUMBAR DISC DEGENERATIVE DISEASE

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content