APPLICATION AND RESEARCH PROGRESS OF BIO-DERIVED HYDROGELS IN TISSUE ENGINEERING_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

FUYuehe ,  LÜQing

Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;

Corresponding author：

LÜQing, Email: huaxilvqing@163.com

Keywords：

Tissue engineering; Bio-derived hydrogels; Scaffold; Decellularized extracellular matrix

DOI：

10.7507/1002-1892.20140225

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To review the properties of bio-derived hydrogels and their application and research progress in tissue engineering. Methods The literature concerning the biol-derived hydrogels was extensively reviewed and analyzed. Results Bio-derived hydrogels can be divided into single-component hydrogels (collagen,hyaluronic acid,chitosan,alginate,silk fibroin,etc.) and multi-component hydrogels[Matrigel,the extract of extracellular matrix (ECM),and decellularized ECM].They have favorable biocompatibility and bioactivity because they are mostly extracted from the ECM of biological tissue.Among them,hydrogels derived from decellularized ECM,whose composition and structure are more in line with the requirements of bionics,have incomparable advantages and prospects.This kind of scaffold is the closest to the natural environment of the cell growth. Conclusion Bio-derived hydrogels have been widely used in tissue engineering research.Although there still exist many problems,such as the poor mechanical properties,rapid degradation,the immunogenicity or safety,vascularization,sterilization methods,and so on,with the deep-going study of optimization mechanism,desirable bio-derived hydrogels could be obtained,and thus be applied to clinical application.

Citation： FUYuehe, LÜQing. APPLICATION AND RESEARCH PROGRESS OF BIO-DERIVED HYDROGELS IN TISSUE ENGINEERING. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(8): 1030-1036. doi: 10.7507/1002-1892.20140225 Copy

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2.	Naito H,Yoshimura M,Mizuno T,et al.The advantages of three-dimensional culture in a collagen hydrogel for stem cell differentiation.J Biomed Mater Res A,2013,101(10):2838-2845.
3.	Geckil H,Xu F,Zhang X,et al.Engineering hydrogels as extracellular matrix mimics.Nanomedicine (Lond),2010,5(3):469-484.
4.	Van Vlierberghe S,Dubruel P,Schacht E.Biopolymer-based hydrogels as scaffolds for tissue engineering applications:a review.Biomacromolecules,2011,12(5):1387-1408.
5.	Tan HP,Marra KG.Injectable,biodegradable hydrogels for tissue engineering applications.Materials,2010,3(3):1746-1767.
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8.	Wolf MT,Daly KA,Brennan-Pierce EP,et al.A hydrogel derived from decellularized dermal extracellular matrix.Biomaterials,2012,33(29):7028-7038.
9.	Park JW,Kang YD,Kim JS,et al.3D microenvironment of collagen hydrogel enhances the release of neurotrophic factors from human umbilical cord blood cells and stimulates the neurite outgrowth of human neural precursor cells.Biochem Biophys Res Commun,2014,447(3):400-406.
10.	Zhang X,Xu L,Huang X,et al.Structural study and preliminary biological evaluation on the collagen hydrogel crosslinked by γ-irradiation.J Biomed Mater Res A,2012,100(11):2960-2969.
11.	Ahn J,Kuffova L,Merrett K,et al.Cross-linked collagen hydrogels as corneal implants:effects of sterically bulky vs.non-bulky carbodiimides as cross-linkers.Acta Biomater,2013,9(8):7796-7805.
12.	Oh SA,Lee HY,Lee JH,et al.Collagen three-dimensional hydrogel matrix carrying basic fibroblast growth factor for the cultivation of mesenchymal stem cells and osteogenic differentiation.Tissue Eng Part A,2012,18(9-10):1087-1100.
13.	Chen CH,Shyu VB,Chen JP,et al.Selective laser sintered poly-caprolactone scaffold hybridized with collagen hydrogel for cartilage tissue engineering.Biofabrication,2014,6(1):015004.
14.	Xiao X,Pan S,Liu X,et al.In vivo study of the biocompatibility of a novel compressed collagen hydrogel scaffold for artificial corneas.J Biomed Mater Res A,2014,,12(6):1782-1787.
15.	Zhang X,Zhang Y,Chen W,et al.Biological behavior of fibroblast on contractile collagen hydrogel crosslinked by γ-irradiation.J Biomed Mater Res A,2013.[Epub ahead of print].
16.	Fakhari A,Berkland C.Applications and emerging trends of hyaluronic acid in tissue engineering,as a dermal filler and in osteoarthritis treatment.Acta Biomater,2013,9(7):7081-7092.
17.	Kenne L,Gohila S,Nilsson EM,et al.Modification and cross-linking parameters in hyaluronic acid hydrogels-definitions and analytical methods.Carbohydr Polym,2013,91(1):410-418.
18.	Guvendiren M,Perepelyuk M,Wells RG,et al.Hydrogels with differential and patterned mechanics to study stiffness-mediated myofibroblastic differentiation of hepatic stellate cells.Journal of the Mechanical Behavior of Biomedical Materials,2013.[Epub ahead of print].
19.	Duan B,Kapetanovic E,Hockaday LA,et al.Three-dimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells.Acta Biomater,2014,10(5):1836-1846.
20.	孔立红,王洋岗,刘本.壳聚糖温敏水凝胶的制备及体外药物释放的研究.湖北中医药大学学报,2012,14(6):24-26.
21.	Berger J,Reist M,Mayer JM,et al.Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications.Eur J Pharm Biopharm,2004,57(1):19-34.
22.	Wang H,Shi J,Wang Y,et al.Promotion of cardiac differentiation of brown adipose derived stem cells by chitosan hydrogel for repair after myocardial infarction.Biomaterials,2014,35(13):3986-3998.
23.	张翠荣,谢华飞,贾振宇,等.壳聚糖基敏感性凝胶的研究进展.材料导报A:综述篇,2012,26(3):92-95,100.
24.	Valmikinathan CM,Mukhatyar VJ,Jain A,et al.Photocrosslinkable chitosan based hydrogels for neural tissue engineering.Soft Matter,2012,8:1964-1976.
25.	Slaughter BV,Khurshid SS,Fisher OZ,et al.Hydrogels in regenerative medicine.Adv Mater,2009,21(32-33):3307-3329.
26.	宋鸿,张兰兰,赵晓军.藻酸盐凝胶三维培养条件下牛胰岛素-转铁蛋白-硒钠对兔关节软骨细胞表型的影响.解放军医学杂志,2009,34(2):159-162.
27.	Kim WS,Mooney DJ,Arany PR,et al.Adipose tissue engineering using injectable,oxidized alginate hydrogels.Tissue Eng Part A,2012,18(7-8):737-743.
28.	Chikar JA,Hendricks JL,Richardson-Burns SM,et al.The use of a dual PEDOT and RGD-functionalized alginate hydrogel coating to provide sustained drug delivery and improved cochlear implant function.Biomaterials,2012,33(7):1982-1990.
29.	Bouhadir KH,Lee KY,Alsberg E,et al.Degradation of partially oxidized alginate and its potential application for tissue engineering.Biotechnol Prog,2001,17(5):945-950.
30.	Chao PH,Yodmuang S,Wang X,et al.Silk hydrogel for cartilage tissue engineering.J Biomed Mater Res B Appl Biomater,2010,95(1):84-90.
31.	邓春闽,左保齐.再生丝素蛋白水凝胶.现代丝绸科学与技术,2012,27(6):249-252.
32.	邓春闽,钟天翼,许亚娟,等.泊洛沙姆对再生丝素蛋白凝胶化结构及形态的影响.丝绸,2013,50(1):4-9.
33.	Badylak SF,Weiss DJ,Caplan A,et al.Engineered whole organs and complex tissues.Lancet,2012,379(9819):943-952.
34.	杨志明.组织工程基础与临床.成都:四川科学技术出版社,2000:14-15.
35.	Singelyn JM,DeQuach JA,Seif-Naraghi SB,et al.Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering.Biomaterials,2009,30(29):5409-5416.
36.	DeQuach JA,Yuan SH,Goldstein LS,et al.Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds.Tissue Eng Part A,2011,17(21-22):2583-2592.
37.	Cheng MH,Uriel S,Brey EM.Tissue-derived materials for adipose regeneration//Gefen A.Bioengineering Research of Chronic Wounds.Springer Berlin Heidelberg,2009:281-299.
38.	Kleinman HK,McGarvey ML,Liotta LA,et al.Isolation and characterization of type IV procollagen,laminin,and heparan sulfate proteoglycan from the EHS sarcoma.Biochemistry,1982,21(24):6188-6193.
39.	Abberton KM,Bortolotto SK,Woods AA,et al.Myogel,a novel,basement membrane-rich,extracellular matrix derived from skeletal muscle,is highly adipogenic in vivo and in vitro.Cells Tissues Organs,2008,188(4):347-358.
40.	Piasecki JH,Gutowski KA,Moreno KM,et al.Purified viable fat suspended in matrigel improves volume longevity.Aesthet Surg J,2008,28(1):24-32.
41.	Uriel S,Labay E,Francis-Sedlak M,et al.Extraction and assembly of tissue-derived gels for cell culture and tissue engineering.Tissue Eng Part C Methods,2009,15(3):309-321.
42.	Cheng MH,Uriel S,Moya ML.Dermis-derived hydrogels support adipogenesis in vivo.J Biomed Mater Res A,2010,92(3):852-858.
43.	Hwang YS,Chiang PR,Hong WH,et al.Study in vivo intraocular biocompatibility of in situ gelation hydrogels:poly (2-ethyl oxazoline)-block-poly (ζ-caprolactone)-block-poly (2-ethyl oxazoline) copolymer,matrigel and pluronic F127.PLoS One,2013,8(7):e67495.
44.	Tottey S,Johnson SA,Crapo PM,et al.The effect of source animal age upon extracellular matrix scaffold properties.Biomaterials,2011,32(1):128-136.
45.	Wolf MT,Daly KA,Brennan-Pierce EP,et al.A hydrogel derived from decellularized dermal extracellular matrix.Biomaterials,2012,33(29):7028-7038.
46.	Singelyn JM,Sundaramurthy P,Johnson TD,et al.Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction.J Am Coll Cardiol,2012,59(8):751-763.
47.	Young DA,Ibrahim DO,Hu D,et al.Injectable hydrogel scaffold from decellularized human lipoaspirate.Acta Biomater,2011,7(3):1040-1049.
48.	Okada M,Payne TR,Oshima H,et al.Differential efficacy of gels derived from small intestinal submucosa as an injectable biomaterial for myocardial infarct repair.Biomaterials,2010,31(30):7678-7683.
49.	Seif-Naraghi SB,Salvatore MA,Schup-Magoffin PJ,et al.Design and characterization of an injectable pericardial matrix gel:a potentially autologous scaffold for cardiac tissue engineering.Tissue Eng Part A,2010,16(6):2017-2027.
50.	Medberry CJ,Crapo PM,Siu BF,et al.Hydrogels derived from central nervous system extracellular matrix.Biomaterials,2013,34(4):1033-1040.
51.	DeQuach JA,Lin JE,Cam C,et al.Injectable skeletal muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model.Eur Cell Mater,2012,23:400-412.
52.	Hopper RA,Woodhouse K,Semple JL.Acellularization of human placenta with preservation of the basement membrane:a potential matrix for tissue engineering.Ann Plast Surg,2003,51(6):598-602.
53.	Crapo PM,Gilbert TW,Badylak SF.An overview of tissue and whole organ decellularization processes.Biomaterials,2011,32(12):3233-3243.

1. Tibbitt MW,Anseth KS.Hydrogels as extracellular matrix mimics for 3D cell culture.Biotechnol Bioeng,2009,103(4):655-663.
2. Naito H,Yoshimura M,Mizuno T,et al.The advantages of three-dimensional culture in a collagen hydrogel for stem cell differentiation.J Biomed Mater Res A,2013,101(10):2838-2845.
3. Geckil H,Xu F,Zhang X,et al.Engineering hydrogels as extracellular matrix mimics.Nanomedicine (Lond),2010,5(3):469-484.
4. Van Vlierberghe S,Dubruel P,Schacht E.Biopolymer-based hydrogels as scaffolds for tissue engineering applications:a review.Biomacromolecules,2011,12(5):1387-1408.
5. Tan HP,Marra KG.Injectable,biodegradable hydrogels for tissue engineering applications.Materials,2010,3(3):1746-1767.
6. Peppas NA,Hilt JZ,Khademhosseini A,et al.Hydrogels in biology and medicine:from molecular principles to bionanotechnology.Adv Mater,2006,18:1345-1360.
7. Lee KY,Mooney DJ.Hydrogels for tissue engineering.Chem Rev,2001,101(7):1869-1879.
8. Wolf MT,Daly KA,Brennan-Pierce EP,et al.A hydrogel derived from decellularized dermal extracellular matrix.Biomaterials,2012,33(29):7028-7038.
9. Park JW,Kang YD,Kim JS,et al.3D microenvironment of collagen hydrogel enhances the release of neurotrophic factors from human umbilical cord blood cells and stimulates the neurite outgrowth of human neural precursor cells.Biochem Biophys Res Commun,2014,447(3):400-406.
10. Zhang X,Xu L,Huang X,et al.Structural study and preliminary biological evaluation on the collagen hydrogel crosslinked by γ-irradiation.J Biomed Mater Res A,2012,100(11):2960-2969.
11. Ahn J,Kuffova L,Merrett K,et al.Cross-linked collagen hydrogels as corneal implants:effects of sterically bulky vs.non-bulky carbodiimides as cross-linkers.Acta Biomater,2013,9(8):7796-7805.
12. Oh SA,Lee HY,Lee JH,et al.Collagen three-dimensional hydrogel matrix carrying basic fibroblast growth factor for the cultivation of mesenchymal stem cells and osteogenic differentiation.Tissue Eng Part A,2012,18(9-10):1087-1100.
13. Chen CH,Shyu VB,Chen JP,et al.Selective laser sintered poly-caprolactone scaffold hybridized with collagen hydrogel for cartilage tissue engineering.Biofabrication,2014,6(1):015004.
14. Xiao X,Pan S,Liu X,et al.In vivo study of the biocompatibility of a novel compressed collagen hydrogel scaffold for artificial corneas.J Biomed Mater Res A,2014,,12(6):1782-1787.
15. Zhang X,Zhang Y,Chen W,et al.Biological behavior of fibroblast on contractile collagen hydrogel crosslinked by γ-irradiation.J Biomed Mater Res A,2013.[Epub ahead of print].
16. Fakhari A,Berkland C.Applications and emerging trends of hyaluronic acid in tissue engineering,as a dermal filler and in osteoarthritis treatment.Acta Biomater,2013,9(7):7081-7092.
17. Kenne L,Gohila S,Nilsson EM,et al.Modification and cross-linking parameters in hyaluronic acid hydrogels-definitions and analytical methods.Carbohydr Polym,2013,91(1):410-418.
18. Guvendiren M,Perepelyuk M,Wells RG,et al.Hydrogels with differential and patterned mechanics to study stiffness-mediated myofibroblastic differentiation of hepatic stellate cells.Journal of the Mechanical Behavior of Biomedical Materials,2013.[Epub ahead of print].
19. Duan B,Kapetanovic E,Hockaday LA,et al.Three-dimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells.Acta Biomater,2014,10(5):1836-1846.
20. 孔立红,王洋岗,刘本.壳聚糖温敏水凝胶的制备及体外药物释放的研究.湖北中医药大学学报,2012,14(6):24-26.
21. Berger J,Reist M,Mayer JM,et al.Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications.Eur J Pharm Biopharm,2004,57(1):19-34.
22. Wang H,Shi J,Wang Y,et al.Promotion of cardiac differentiation of brown adipose derived stem cells by chitosan hydrogel for repair after myocardial infarction.Biomaterials,2014,35(13):3986-3998.
23. 张翠荣,谢华飞,贾振宇,等.壳聚糖基敏感性凝胶的研究进展.材料导报A:综述篇,2012,26(3):92-95,100.
24. Valmikinathan CM,Mukhatyar VJ,Jain A,et al.Photocrosslinkable chitosan based hydrogels for neural tissue engineering.Soft Matter,2012,8:1964-1976.
25. Slaughter BV,Khurshid SS,Fisher OZ,et al.Hydrogels in regenerative medicine.Adv Mater,2009,21(32-33):3307-3329.
26. 宋鸿,张兰兰,赵晓军.藻酸盐凝胶三维培养条件下牛胰岛素-转铁蛋白-硒钠对兔关节软骨细胞表型的影响.解放军医学杂志,2009,34(2):159-162.
27. Kim WS,Mooney DJ,Arany PR,et al.Adipose tissue engineering using injectable,oxidized alginate hydrogels.Tissue Eng Part A,2012,18(7-8):737-743.
28. Chikar JA,Hendricks JL,Richardson-Burns SM,et al.The use of a dual PEDOT and RGD-functionalized alginate hydrogel coating to provide sustained drug delivery and improved cochlear implant function.Biomaterials,2012,33(7):1982-1990.
29. Bouhadir KH,Lee KY,Alsberg E,et al.Degradation of partially oxidized alginate and its potential application for tissue engineering.Biotechnol Prog,2001,17(5):945-950.
30. Chao PH,Yodmuang S,Wang X,et al.Silk hydrogel for cartilage tissue engineering.J Biomed Mater Res B Appl Biomater,2010,95(1):84-90.
31. 邓春闽,左保齐.再生丝素蛋白水凝胶.现代丝绸科学与技术,2012,27(6):249-252.
32. 邓春闽,钟天翼,许亚娟,等.泊洛沙姆对再生丝素蛋白凝胶化结构及形态的影响.丝绸,2013,50(1):4-9.
33. Badylak SF,Weiss DJ,Caplan A,et al.Engineered whole organs and complex tissues.Lancet,2012,379(9819):943-952.
34. 杨志明.组织工程基础与临床.成都:四川科学技术出版社,2000:14-15.
35. Singelyn JM,DeQuach JA,Seif-Naraghi SB,et al.Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering.Biomaterials,2009,30(29):5409-5416.
36. DeQuach JA,Yuan SH,Goldstein LS,et al.Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds.Tissue Eng Part A,2011,17(21-22):2583-2592.
37. Cheng MH,Uriel S,Brey EM.Tissue-derived materials for adipose regeneration//Gefen A.Bioengineering Research of Chronic Wounds.Springer Berlin Heidelberg,2009:281-299.
38. Kleinman HK,McGarvey ML,Liotta LA,et al.Isolation and characterization of type IV procollagen,laminin,and heparan sulfate proteoglycan from the EHS sarcoma.Biochemistry,1982,21(24):6188-6193.
39. Abberton KM,Bortolotto SK,Woods AA,et al.Myogel,a novel,basement membrane-rich,extracellular matrix derived from skeletal muscle,is highly adipogenic in vivo and in vitro.Cells Tissues Organs,2008,188(4):347-358.
40. Piasecki JH,Gutowski KA,Moreno KM,et al.Purified viable fat suspended in matrigel improves volume longevity.Aesthet Surg J,2008,28(1):24-32.
41. Uriel S,Labay E,Francis-Sedlak M,et al.Extraction and assembly of tissue-derived gels for cell culture and tissue engineering.Tissue Eng Part C Methods,2009,15(3):309-321.
42. Cheng MH,Uriel S,Moya ML.Dermis-derived hydrogels support adipogenesis in vivo.J Biomed Mater Res A,2010,92(3):852-858.
43. Hwang YS,Chiang PR,Hong WH,et al.Study in vivo intraocular biocompatibility of in situ gelation hydrogels:poly (2-ethyl oxazoline)-block-poly (ζ-caprolactone)-block-poly (2-ethyl oxazoline) copolymer,matrigel and pluronic F127.PLoS One,2013,8(7):e67495.
44. Tottey S,Johnson SA,Crapo PM,et al.The effect of source animal age upon extracellular matrix scaffold properties.Biomaterials,2011,32(1):128-136.
45. Wolf MT,Daly KA,Brennan-Pierce EP,et al.A hydrogel derived from decellularized dermal extracellular matrix.Biomaterials,2012,33(29):7028-7038.
46. Singelyn JM,Sundaramurthy P,Johnson TD,et al.Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction.J Am Coll Cardiol,2012,59(8):751-763.
47. Young DA,Ibrahim DO,Hu D,et al.Injectable hydrogel scaffold from decellularized human lipoaspirate.Acta Biomater,2011,7(3):1040-1049.
48. Okada M,Payne TR,Oshima H,et al.Differential efficacy of gels derived from small intestinal submucosa as an injectable biomaterial for myocardial infarct repair.Biomaterials,2010,31(30):7678-7683.
49. Seif-Naraghi SB,Salvatore MA,Schup-Magoffin PJ,et al.Design and characterization of an injectable pericardial matrix gel:a potentially autologous scaffold for cardiac tissue engineering.Tissue Eng Part A,2010,16(6):2017-2027.
50. Medberry CJ,Crapo PM,Siu BF,et al.Hydrogels derived from central nervous system extracellular matrix.Biomaterials,2013,34(4):1033-1040.
51. DeQuach JA,Lin JE,Cam C,et al.Injectable skeletal muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model.Eur Cell Mater,2012,23:400-412.
52. Hopper RA,Woodhouse K,Semple JL.Acellularization of human placenta with preservation of the basement membrane:a potential matrix for tissue engineering.Ann Plast Surg,2003,51(6):598-602.
53. Crapo PM,Gilbert TW,Badylak SF.An overview of tissue and whole organ decellularization processes.Biomaterials,2011,32(12):3233-3243.

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APPLICATION AND RESEARCH PROGRESS OF BIO-DERIVED HYDROGELS IN TISSUE ENGINEERING

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