PROGRESS IN DISC DEGENERATION MODELS AND CALCITONIN THERAPY_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

LIUBinbin ¹ ,  ZHANGLiu ¹ , TIANFaming ² , WANGWenya ³

1. Department of Orthopaedic Surgery, Hebei United University Affiliated Hospital, Tangshan Hebei, 063000, P. R. China;
2. Medical Research Center of Hebei United University, Tangshan Hebei, 063000, P. R. China;
3. Department of Pathology, Hebei United University, Tangshan Hebei, 063000, P. R. China;

Corresponding author：

ZHANGLiu, Email: zhliu130@sohu.com

Keywords：

Disc degeneration; Animal model; Calcitonin

DOI：

10.7507/1002-1892.20140229

Video：

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Objective To review the disc degeneration models and the current treatment status of calcitonin. Methods Recent literature concerning the disc degeneration models and the calcitonin treatment of disc degeneration was extensively reviewed and summarized. Results Different models of disc degeneration have advantages and disadvantages; calcitonin can relieve disc degeneration at different degrees in vitro and in vivo studies. Conclusion Disc degeneration model for the study of disc degeneration mechanism offers a variety of ideas,and the results of calcitonin treatment in the disc degeneration model can provide the basis for future experiments.

Citation： LIUBinbin, ZHANGLiu, TIANFaming, WANGWenya. PROGRESS IN DISC DEGENERATION MODELS AND CALCITONIN THERAPY. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(8): 1051-1054. doi: 10.7507/1002-1892.20140229 Copy

1.	Nitta T,Fukushima T,Nakamuta H,et al.Glucocorticoid-induced secondary osteopenia in femalerats:a time course study as compared with ovariectomy-induced osteopenia and response to salmon calcitonin.Jpn J Pharmacol,1999,79(3):379-386.
2.	Feigh M,Andreassen KV,Hjuler ST,et al.Oral salmon calcitonin protects against impaired fasting glycemia,glucose intolerance,and obesity induced by high-fat diet and ovariectomy in rats.Menopause,2013,20(7):785-794.
3.	Wang T,Zhang L,Huang C,et al.Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats.Calcif Tissue Int,2004,75(3):205-213.
4.	Kavuncu V,Sahin S,Baydas G,et al.A comparison of estrogen and two different doses of calcitonin in ovariectomized rats.Yonsei Med J,2003,44(3):508-516.
5.	王文雅,张柳,王哲彦,等.降钙素对去卵巢大鼠椎间盘退变的影响.重庆医学,2011,40(26):2608-2610,I0002.
6.	王文雅,张柳,汪韬,等.降钙素治疗延缓卵巢切除大鼠腰椎间盘退变.解剖学杂志,2008,31(2):158-161.
7.	Leung VY,Chan WC,Hung SC,et al.Matrix remodeling during intervertebral disc growth and degeneration detected by multichromatic FAST staining.J Histochem Cytochem,2009,57(3):249-256.
8.	Huang KY,Yan JJ,Hsieh CC,et al.The in vivo biological effects of intradiscal recombinant human bone morphogenetic protein-2 on the injured intervertebral disc:an animal experiment.Spine (Phila Pa 1976),2007,32(11):1174-1180.
9.	Melrose J,Roberts S,Smith S,et al.Increased nerve and blood vessel ingrowth associated with proteoglycan depletion in an ovine anular lesion model of experimental disc degeneration.Spine (Phila Pa 1976),2002,27(12):1278-1285.
10.	Kim KS,Yoon ST,Li J,et al.Disc degeneration in the rabbit:a biochemical and radiological comparison between four disc injury models.Spine (Phila Pa 1976),2005,30(1):33-37.
11.	金格勒,王武昌,盛伟斌,等.兔侧后方腰椎融合模型的建立和效果评价.中华实验外科杂志,2006,23(7):882.
12.	Phillips FM,Reuben J,Wetzel FT.Intervertebral disc degeneration adjacent to a lumbar fusion.J Bone Joint Surg (Br),2002,84(2):289-294.
13.	Hoogendoorn RJ,Helder MN,Wuisman PI,et al.Adjacent segment degeneration:observations in a goat spinal fusion study.Spine (Phila Pa 1976),2008,33(12):1337-1343.
14.	Kiely PD,Brecevich AT,Taher F,et al.Evaluation of a new formulation of demineralized bone matrix putty in a rabbit posterolateral spinal fusion model.Spine J,2014.doi:10.1016/j.spinee.2014.01.053.
15.	Liu Y,Fan Y,Cao D,et al.Calcitonin enhanced lumbar spinal fusion in a New Zealand rabbit model:a study with mophologic and molecular analysis.Spine (Phila Pa 1976),2012,37(3):E139-146.
16.	范彧,吴志宏,仉建国,等.降钙素对脊柱植骨融合兔模型病理过程的影响.中国医学科学院学报,2006,28(4):574-578,F0003.
17.	Oda H,Matsuzaki H,Tokuhashi Y,et al.Degeneration of intervertebral discs due to smoking:experimental assessment in a rat-smoking model.J Orthop Sci,2004,9(2):135-141.
18.	吴振凯,陈文钧,黄煌渊,等.骨髓间充质干细胞透明质酸钠溶液修复大鼠早期退变椎间盘的作用.复旦学报:医学版,2007,34(5):723-726.
19.	Krebs J,Ferguson SJ,Goss BG,et al.Effects of vertebral bone augmentation on intervertebral discs.J Biomed Mater Res B Appl Biomater,2012,100(3):660-667.
20.	Chen S,Liao M,Li J,et al.The correlation between microvessel pathological changes of the endplate and degeneration of the intervertebral disc in diabetic rats.Exp Ther Med,2013,5(3):711-717.
21.	Illien-Junger S,Grosjean F,Laudier DM,et al.Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes.PLoS One,2013,8(5):e64302.
22.	Maeda S,Kokubun S.Changes with age in proteoglycan synthesis in cells cultured in vitro from the inner and outer rabbit annulus fibrosus.Responses to interleukin-1andinterleukin-1receptorantagonistprotein.Spine (Phila Pa 1976),2000,25(2):166-169.
23.	Le Maitre CL,Freemont AJ,Hoyland JA.The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration.Arthritis Res Ther,2005,7(4):R732-745.
24.	綦惠,赵丹慧,田伟.基质金属蛋白酶与椎间盘退变研究的新进展.中国脊柱脊髓杂志,2010,20(1):69-72.
25.	Chen WH,Zeng R,Lo WC,et al.The role of the ERK1/2 pathway as an alternative to the aging-diminished cyclic AMP pathway in calcitonin-mediated chondrogenesis in human nucleus pulposus.Biomaterials,2012,33(33):8256-8264.
26.	Kepler CK,Markova DZ,Dibra F,et al.Expression and relationship of proinflammatory chemokine RANTES/CCL5 and cytokine IL-1β in painful human intervertebral discs.Spine (Phila Pa 1976),2013,38(11):873-880.
27.	Gruber HE,Hoelscher GL,Ingram JA,et al.Genome-wide analysis of pain-,nerve-and neurotrophin-related gene expression in the degenerating human annulus.Mol Pain,2012,10(8):63.
28.	Orita S,Eguchi Y,Kamoda H,et al.Brain-derived neurotrophic factor inhibition at the punctured intervertebral disc downregulates the production of calcitonin gene-related peptide in dorsal root ganglia in rats.Spine (Phila Pa 1976),2011,36(21):1737-1743.

1. Nitta T,Fukushima T,Nakamuta H,et al.Glucocorticoid-induced secondary osteopenia in femalerats:a time course study as compared with ovariectomy-induced osteopenia and response to salmon calcitonin.Jpn J Pharmacol,1999,79(3):379-386.
2. Feigh M,Andreassen KV,Hjuler ST,et al.Oral salmon calcitonin protects against impaired fasting glycemia,glucose intolerance,and obesity induced by high-fat diet and ovariectomy in rats.Menopause,2013,20(7):785-794.
3. Wang T,Zhang L,Huang C,et al.Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats.Calcif Tissue Int,2004,75(3):205-213.
4. Kavuncu V,Sahin S,Baydas G,et al.A comparison of estrogen and two different doses of calcitonin in ovariectomized rats.Yonsei Med J,2003,44(3):508-516.
5. 王文雅,张柳,王哲彦,等.降钙素对去卵巢大鼠椎间盘退变的影响.重庆医学,2011,40(26):2608-2610,I0002.
6. 王文雅,张柳,汪韬,等.降钙素治疗延缓卵巢切除大鼠腰椎间盘退变.解剖学杂志,2008,31(2):158-161.
7. Leung VY,Chan WC,Hung SC,et al.Matrix remodeling during intervertebral disc growth and degeneration detected by multichromatic FAST staining.J Histochem Cytochem,2009,57(3):249-256.
8. Huang KY,Yan JJ,Hsieh CC,et al.The in vivo biological effects of intradiscal recombinant human bone morphogenetic protein-2 on the injured intervertebral disc:an animal experiment.Spine (Phila Pa 1976),2007,32(11):1174-1180.
9. Melrose J,Roberts S,Smith S,et al.Increased nerve and blood vessel ingrowth associated with proteoglycan depletion in an ovine anular lesion model of experimental disc degeneration.Spine (Phila Pa 1976),2002,27(12):1278-1285.
10. Kim KS,Yoon ST,Li J,et al.Disc degeneration in the rabbit:a biochemical and radiological comparison between four disc injury models.Spine (Phila Pa 1976),2005,30(1):33-37.
11. 金格勒,王武昌,盛伟斌,等.兔侧后方腰椎融合模型的建立和效果评价.中华实验外科杂志,2006,23(7):882.
12. Phillips FM,Reuben J,Wetzel FT.Intervertebral disc degeneration adjacent to a lumbar fusion.J Bone Joint Surg (Br),2002,84(2):289-294.
13. Hoogendoorn RJ,Helder MN,Wuisman PI,et al.Adjacent segment degeneration:observations in a goat spinal fusion study.Spine (Phila Pa 1976),2008,33(12):1337-1343.
14. Kiely PD,Brecevich AT,Taher F,et al.Evaluation of a new formulation of demineralized bone matrix putty in a rabbit posterolateral spinal fusion model.Spine J,2014.doi:10.1016/j.spinee.2014.01.053.
15. Liu Y,Fan Y,Cao D,et al.Calcitonin enhanced lumbar spinal fusion in a New Zealand rabbit model:a study with mophologic and molecular analysis.Spine (Phila Pa 1976),2012,37(3):E139-146.
16. 范彧,吴志宏,仉建国,等.降钙素对脊柱植骨融合兔模型病理过程的影响.中国医学科学院学报,2006,28(4):574-578,F0003.
17. Oda H,Matsuzaki H,Tokuhashi Y,et al.Degeneration of intervertebral discs due to smoking:experimental assessment in a rat-smoking model.J Orthop Sci,2004,9(2):135-141.
18. 吴振凯,陈文钧,黄煌渊,等.骨髓间充质干细胞透明质酸钠溶液修复大鼠早期退变椎间盘的作用.复旦学报:医学版,2007,34(5):723-726.
19. Krebs J,Ferguson SJ,Goss BG,et al.Effects of vertebral bone augmentation on intervertebral discs.J Biomed Mater Res B Appl Biomater,2012,100(3):660-667.
20. Chen S,Liao M,Li J,et al.The correlation between microvessel pathological changes of the endplate and degeneration of the intervertebral disc in diabetic rats.Exp Ther Med,2013,5(3):711-717.
21. Illien-Junger S,Grosjean F,Laudier DM,et al.Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes.PLoS One,2013,8(5):e64302.
22. Maeda S,Kokubun S.Changes with age in proteoglycan synthesis in cells cultured in vitro from the inner and outer rabbit annulus fibrosus.Responses to interleukin-1andinterleukin-1receptorantagonistprotein.Spine (Phila Pa 1976),2000,25(2):166-169.
23. Le Maitre CL,Freemont AJ,Hoyland JA.The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration.Arthritis Res Ther,2005,7(4):R732-745.
24. 綦惠,赵丹慧,田伟.基质金属蛋白酶与椎间盘退变研究的新进展.中国脊柱脊髓杂志,2010,20(1):69-72.
25. Chen WH,Zeng R,Lo WC,et al.The role of the ERK1/2 pathway as an alternative to the aging-diminished cyclic AMP pathway in calcitonin-mediated chondrogenesis in human nucleus pulposus.Biomaterials,2012,33(33):8256-8264.
26. Kepler CK,Markova DZ,Dibra F,et al.Expression and relationship of proinflammatory chemokine RANTES/CCL5 and cytokine IL-1β in painful human intervertebral discs.Spine (Phila Pa 1976),2013,38(11):873-880.
27. Gruber HE,Hoelscher GL,Ingram JA,et al.Genome-wide analysis of pain-,nerve-and neurotrophin-related gene expression in the degenerating human annulus.Mol Pain,2012,10(8):63.
28. Orita S,Eguchi Y,Kamoda H,et al.Brain-derived neurotrophic factor inhibition at the punctured intervertebral disc downregulates the production of calcitonin gene-related peptide in dorsal root ganglia in rats.Spine (Phila Pa 1976),2011,36(21):1737-1743.

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PROGRESS IN DISC DEGENERATION MODELS AND CALCITONIN THERAPY

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