人脱细胞羊膜治疗下肢静脉性溃疡的初步报告_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

袁丁 ¹ , 罗晗 ¹ , 黄斌 ¹ , 解慧琪 ² ,  赵纪春 ¹

1. ;
2. ;

Corresponding author：

赵纪春, Email: zhaojc3@163.com

Keywords：

人脱细胞羊膜; 下肢静脉性溃疡; 有效性; 安全性

DOI：

10.7507/1002-1892.20140313

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目的初步探讨人脱细胞羊膜（human acellular amniotic membranes，HAAM）治疗下肢静脉性溃疡（venous ulcers，VU）的安全性和有效性。方法 2013年1月-4月应用HAAM治疗4例左下肢VU男性患者。患者年龄60～65岁，平均62.3岁。病程4～13个月，平均7个月。溃疡范围3.0 cm×1.0 cm～5.0 cm×2.5 cm。疼痛视觉模拟评分（VAS）为6～8分，平均6.75分。结果治疗后3 d HAAM与溃疡创面贴附率达100%；治疗后1周均表现为促进创面愈合。2例创面完全愈合，2例经再次补充HAAM后创面面积及深度均改善。治疗期间疼痛VAS评分均逐渐降至0分。患者无局部皮肤炎症和全身过敏反应症状，随访3个月无复发。结论 HAAM治疗下肢VU操作简便，初步结果提示治疗安全且能较快有效改善创面。

Citation： 袁丁, 罗晗, 黄斌, 解慧琪, 赵纪春. 人脱细胞羊膜治疗下肢静脉性溃疡的初步报告. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(11): 1449-1450. doi: 10.7507/1002-1892.20140313 Copy

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1. Patel NP, Labropoulos N, Pappas PJ. Current management of venous ulceration. Plast Reconstr Surg, 2006, 117(7 Suppl):254S-260S.
2. O'Donnell TF Jr, Lau J. A systematic review of randomized controlled trials of wound dressings for chronic venous ulcer. J Vasc Surg, 2006, 44(5):1118-1125.
3. 罗静聪, 李秀群, 杨志明, 等.脱细胞羊膜的制备及其生物相容性研究.中国修复重建外科杂志, 2004, 18(2):108-111.
4. Beele H, de la Brassine M, Lambert J, et al. A prospective multicenter study of the efficacy and tolerabil ity of cryopreserved allogenic human keratinocytes to treat venous leg ulcers. Int J Low Extrem Wounds, 2005, 4(4):225-233.
5. Bailo M, Soncini M, Vertua E, et al. Engraftment potential of human amnion and chorion cells derived from term placenta. Transplantation, 2004, 78(10):1439-1448.
6. Walker AB, Cooney DR, Allen JE. Use of fresh amnion as a burn dressing. J Pediatr Surg, 1977, 12(3):391-395.
7. Ganatra MA. Amniotic membrane in surgery. J Pak Med Assoc, 2003, 53(1):29-32.

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人脱细胞羊膜治疗下肢静脉性溃疡的初步报告

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