• Department of Burn and Plastic Surgery, the First Affiliated Hospital of PLA General Hospital, Beijing, 100048, P. R. China;
XIANGZhou, Email: xiangzhou15@hotmail.com
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Objective To review the research progress of the role of seed cells and related cytokines in angiogenesis of the vascularized tissue engineered bone. Methods The latest literature of tissue engineered bone angiogenesis was reviewed, including the common source of seed cells, biological characteristics, transformation mechanism, related cytokines, and signaling pathways in re-vascularization. Results Microsurgery technique, genetic technique, and co-culture system of vascularized tissue engineered bone have developed to a new level. Moreover, both the induction of introduced pluripotent stem cells and vascular endothelial growth factor-angiopoietins 1 transfected mesenchymal stem cells and endothelial progenitor cells have some advantages for bone regeneration and vascularization. However, all the techniques were not used in clinical practice. Conclusion Using techniques of genetically modified seed cells, related cytokines, and scaffolds may have bright prospects for building vascularized tissue engineered bone.

Citation: DUANXin, LIWei, XIANGZhou. RESEARCH PROGRESS OF ANGIOGENESIS IN VASCULARIZED TISSUE ENGINEERED BONE. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(2): 239-244. doi: 10.7507/1002-1892.20150050 Copy

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