DEVELOPMENT OF CELL SHEET ENGINEERING TECHNOLOGY IN ENGINEERING VASCULARIZED TISSUE_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

CHENJia ¹ , MADongyang ² ,  RENLiling ¹

1. School of Stomatology, Lanzhou University, Lanzhou Gansu, 730000, P. R. China;
2. Department of Oral and Maxillofacial Surgery, Lanzhou General Hospital, Lanzhou Command of Chinese People's Liberation Army, Lanzhou Gansu, 730000, P. R. China;

Corresponding author：

RENLiling, Email: renlil@lzu.edu.cn

Keywords：

Vascularization; Cell sheet engineering technology; Bone mesenchymal stem cells; Endothelial cells; Tissue engineering

DOI：

10.7507/1002-1892.20150077

Video：

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Objective To review the development of cell sheet engineering technology in engineering vascularized tissue. Methods The literature about cell sheet engineering technology and engineering vascularized tissue was reviewed, analyzed, and summarized. Results Although there are many methods to engineer vascularized tissue, cell sheet engineering technology provides a promising potential to develop a vascularized tissue. Recently, cell sheet engineering technology has become a hot topic in engineering vascularized tissue. Co-culturing endothelial cells on a cell sheet, endothelial cells are able to form three-dimensional prevascularized networks and microvascular cavities in the cell sheet, which facilitate the formation of functional vascular networks in the transplanted tissue. Conclusion Cell sheet engineering technology is a promising strategy to engineer vascularized tissue, which is still being studied to explore more potential.

Citation： CHENJia, MADongyang, RENLiling. DEVELOPMENT OF CELL SHEET ENGINEERING TECHNOLOGY IN ENGINEERING VASCULARIZED TISSUE. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(3): 368-371. doi: 10.7507/1002-1892.20150077 Copy

1.	Nomi M, Atala A, Coppi PD, et al. Principals of neovascularization for tissue engineering. Mol Aspects Med, 2002, 23(6):463-483.
2.	Yu H, VandeVord PJ, Mao L, et al. Improved tissue-engineered bone regeneration by endothelial cell mediated vascularization. Biomaterials, 2009, 30(4):508-517.
3.	Cassell OC, Hofer SO, Morrison WA, et al. Vascularisation of tissue-engineered grafts:the regulation of angiogenesis in reconstructive surgery and in disease states. Br J Plast Surg, 2002, 55(8):603-610.
4.	张蓉. 基于细胞膜片技术构建血管化组织工程骨的实验研究. 西安:第四军医大学, 2012.
5.	Levenberg S, Rouwkema J, Macdonald M, et al. Engineering vascularized skeletal muscle tissue. Nat Biotechnol, 2005, 23(7):879-884.
6.	Rouwkema J, de Boer J, van Blitterswijk CA. Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct. Tissue Eng, 2006, 12(9):2685-2693.
7.	Tremblay PL, Hudon V, Berthod F, et al. Inosculation of tissue-engineered capillaries with the host's vasculature in a reconstructed skin transplanted on mice. Am J Transplant, 2005, 5(5):1002-1010.
8.	Sekiya S, Shimizu T, Yamato M, et al. Bioengineered cardiac cell sheet grafts have intrinsic angiogenic potential. Biochem Biophys Res Commun, 2006, 341(2):573-582.
9.	Sekine H, Shimizu T, Hobo K, et al. Endothelial cell coculture within tissue-engineered cardiomyocyte sheets enhances neovascularization and improves cardiac function of ischemic hearts. Circulation, 2008, 118(14 suppl):S145-S152.
10.	Fujioka N, Morimoto Y, Takeuchi K, et al. Difference in infrared spectra from cultured cells dependent on cell-harvesting method. Appl Spectrosc, 2003, 57(2):241-243.
11.	Hutmacher DW, Schantz JT, Lam CX, et al. State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective. J Tissue Eng Regen Med, 2007, 1(4):245-260.
12.	Rouwkema J, Boer JD, van Blitterswijk CA. Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct. Tissue Eng, 2006, 12(9):2685-2693.
13.	Verseijden F, Posthumus-van Sluijs SJ, Farrell E, et al. Prevascular structures promote vascularization in engineered human adipose tissue constructs upon implantation. Cell Transplant, 2010, 19(8):1007-1020.
14.	Elloumi-Hannachi I, Yamato M, Okano T. Cell sheet engineering:a unique nanotechnology for scaffold-free tissue reconstruction with clinical applications in regenerative medicine. J Intern Med, 2010, 267(1):54-70.
15.	Ohki T, Yamato M, Ota M, et al. Prevention of esophageal stricture after endoscopic submucosal dissection using tissue-engineered cell sheets. Gastroenterology, 2012, 143(3):582-588.e1-2.
16.	Iwata T, Yamato M, Zhang Z, et al. Validation of human periodontal ligament-derived cells as a reliable source for cytotherapeutic use. J Clin Periodontol, 2010, 37(12):1088-1099.
17.	Sawa Y, Miyagawa S, Sakaguchi T, et al. Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM:report of a case. Surg Today, 2012, 42(2):181-184.
18.	Miyahara Y, Nagaya N, Kataoka M, et al. Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med, 2006, 12(4):459-465.
19.	赵洁. 基于细胞膜片技术构建小口径组织工程血管. 西安:西北大学, 2010.
20.	Ohashi K, Yokoyama T, Yamato M, et al. Engineering functional two- and three-dimensional liver systems in vivo using hepatic tissue sheets. Nat Med, 2007, 13(7):880-885.
21.	Asakawa N, Shimizu T, Tsuda Y, et al. Pre-vascularization of in vitro three-dimensional tissues created by cell sheet engineering. Biomaterials, 2010, 31(14):3903-3909.
22.	Sasagawa T, Shimizu T, Sekiya S, et al. Design of prevascularized three-dimensional cell-dense tissues using a cell sheet stacking manipulation technology. Biomaterials, 2010, 31(7):1646-1654.
23.	Zhou Y, Chen F, Ho ST, et al. Combined marrow stromal cell-sheet techniques and high-strength biodegradable composite scaffolds for engineered functional bone grafts. Biomaterials, 2007, 28(5):814-824.
24.	Chen F, Zhou Y, Barnabas ST, et al. Engineering tubular bone constructs. J Biomech, 2007, 40 Suppl 1:S73-S79.
25.	Gao Z, Chen F, Zhang J, et al. Vitalisation of tubular coral scaffolds with cell sheets for regeneration of long bones:a preliminary study in nude mice. Br J Oral Maxillofac Surg, 2009, 47(2):116-122.
26.	黄辉, 张森林, 刘向辉, 等. 细胞-膜片复合珊瑚支架修复兔颅骨极限缺损的实验研究. 口腔颌面外科杂志, 2011, 21(4):256-260.
27.	Syed-Picard FN, Larkin LM, Shaw CM, et al. Three-dimensional engineered bone from bone marrow stromal cells and their autogenous extracellular matrix. Tissue Eng Part A, 2008, 15(1):187-195.
28.	Ma D, Ren L, Liu Y, et al. Engineering scaffold-free bone tissue using bone marrow stromal cell sheets. J Orthop Res, 2010, 28(5):697-702.
29.	Ma D, Ren L, Yao H, et al. Locally injection of cell sheet fragments enhances new bone formation in mandibular distraction osteogenesis:a rabbit model. J Orthop Res, 2013, 31(7):1082-1088.
30.	Ma D, Yao H, Tian W, et al. Enhancing bone formation by transplantation of a scaffold-free tissue-engineered periosteum in a rabbit model. Clin Oral Implants Res, 2011, 22(10):1193-1199.
31.	任利玲, 刘斌, 马东洋, 等. 预血管化细胞膜片的构建. 中国细胞生物学学报, 2014, 36(3):338-342.
32.	Ren L, Kang Y, Browne C, et al. Fabrication, vascularization and osteogenic properties of a novel synthetic biomimetic induced membrane for the treatment of large bone defects. Bone, 2014, 64:173-182.
33.	Kang Y, Ren L, Yang YP. Engineering vascularized bone grafts by integrating a biomimetic periosteum and β-TCP scaffold. ACS Appl Mater Interfaces, 2014, 6 (12):9622-9633.
34.	Mendes LF, Pirraco RP, Szymczyk W, et al. Perivascular-like cells contribute to the stability of the vascular network of osteogenic tissue formed from cell sheet-based constructs. PLoS One, 2012, 7(7):e41051.
35.	Zhang R, Gao Z, Geng W, et al. Engineering vascularized bone graft with osteogenic and angiogenic lineage differentiated bone marrow mesenchymal stem cells. Artif Organs, 2012, 36(12):1036-1046.

1. Nomi M, Atala A, Coppi PD, et al. Principals of neovascularization for tissue engineering. Mol Aspects Med, 2002, 23(6):463-483.
2. Yu H, VandeVord PJ, Mao L, et al. Improved tissue-engineered bone regeneration by endothelial cell mediated vascularization. Biomaterials, 2009, 30(4):508-517.
3. Cassell OC, Hofer SO, Morrison WA, et al. Vascularisation of tissue-engineered grafts:the regulation of angiogenesis in reconstructive surgery and in disease states. Br J Plast Surg, 2002, 55(8):603-610.
4. 张蓉. 基于细胞膜片技术构建血管化组织工程骨的实验研究. 西安:第四军医大学, 2012.
5. Levenberg S, Rouwkema J, Macdonald M, et al. Engineering vascularized skeletal muscle tissue. Nat Biotechnol, 2005, 23(7):879-884.
6. Rouwkema J, de Boer J, van Blitterswijk CA. Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct. Tissue Eng, 2006, 12(9):2685-2693.
7. Tremblay PL, Hudon V, Berthod F, et al. Inosculation of tissue-engineered capillaries with the host's vasculature in a reconstructed skin transplanted on mice. Am J Transplant, 2005, 5(5):1002-1010.
8. Sekiya S, Shimizu T, Yamato M, et al. Bioengineered cardiac cell sheet grafts have intrinsic angiogenic potential. Biochem Biophys Res Commun, 2006, 341(2):573-582.
9. Sekine H, Shimizu T, Hobo K, et al. Endothelial cell coculture within tissue-engineered cardiomyocyte sheets enhances neovascularization and improves cardiac function of ischemic hearts. Circulation, 2008, 118(14 suppl):S145-S152.
10. Fujioka N, Morimoto Y, Takeuchi K, et al. Difference in infrared spectra from cultured cells dependent on cell-harvesting method. Appl Spectrosc, 2003, 57(2):241-243.
11. Hutmacher DW, Schantz JT, Lam CX, et al. State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective. J Tissue Eng Regen Med, 2007, 1(4):245-260.
12. Rouwkema J, Boer JD, van Blitterswijk CA. Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct. Tissue Eng, 2006, 12(9):2685-2693.
13. Verseijden F, Posthumus-van Sluijs SJ, Farrell E, et al. Prevascular structures promote vascularization in engineered human adipose tissue constructs upon implantation. Cell Transplant, 2010, 19(8):1007-1020.
14. Elloumi-Hannachi I, Yamato M, Okano T. Cell sheet engineering:a unique nanotechnology for scaffold-free tissue reconstruction with clinical applications in regenerative medicine. J Intern Med, 2010, 267(1):54-70.
15. Ohki T, Yamato M, Ota M, et al. Prevention of esophageal stricture after endoscopic submucosal dissection using tissue-engineered cell sheets. Gastroenterology, 2012, 143(3):582-588.e1-2.
16. Iwata T, Yamato M, Zhang Z, et al. Validation of human periodontal ligament-derived cells as a reliable source for cytotherapeutic use. J Clin Periodontol, 2010, 37(12):1088-1099.
17. Sawa Y, Miyagawa S, Sakaguchi T, et al. Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM:report of a case. Surg Today, 2012, 42(2):181-184.
18. Miyahara Y, Nagaya N, Kataoka M, et al. Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med, 2006, 12(4):459-465.
19. 赵洁. 基于细胞膜片技术构建小口径组织工程血管. 西安:西北大学, 2010.
20. Ohashi K, Yokoyama T, Yamato M, et al. Engineering functional two- and three-dimensional liver systems in vivo using hepatic tissue sheets. Nat Med, 2007, 13(7):880-885.
21. Asakawa N, Shimizu T, Tsuda Y, et al. Pre-vascularization of in vitro three-dimensional tissues created by cell sheet engineering. Biomaterials, 2010, 31(14):3903-3909.
22. Sasagawa T, Shimizu T, Sekiya S, et al. Design of prevascularized three-dimensional cell-dense tissues using a cell sheet stacking manipulation technology. Biomaterials, 2010, 31(7):1646-1654.
23. Zhou Y, Chen F, Ho ST, et al. Combined marrow stromal cell-sheet techniques and high-strength biodegradable composite scaffolds for engineered functional bone grafts. Biomaterials, 2007, 28(5):814-824.
24. Chen F, Zhou Y, Barnabas ST, et al. Engineering tubular bone constructs. J Biomech, 2007, 40 Suppl 1:S73-S79.
25. Gao Z, Chen F, Zhang J, et al. Vitalisation of tubular coral scaffolds with cell sheets for regeneration of long bones:a preliminary study in nude mice. Br J Oral Maxillofac Surg, 2009, 47(2):116-122.
26. 黄辉, 张森林, 刘向辉, 等. 细胞-膜片复合珊瑚支架修复兔颅骨极限缺损的实验研究. 口腔颌面外科杂志, 2011, 21(4):256-260.
27. Syed-Picard FN, Larkin LM, Shaw CM, et al. Three-dimensional engineered bone from bone marrow stromal cells and their autogenous extracellular matrix. Tissue Eng Part A, 2008, 15(1):187-195.
28. Ma D, Ren L, Liu Y, et al. Engineering scaffold-free bone tissue using bone marrow stromal cell sheets. J Orthop Res, 2010, 28(5):697-702.
29. Ma D, Ren L, Yao H, et al. Locally injection of cell sheet fragments enhances new bone formation in mandibular distraction osteogenesis:a rabbit model. J Orthop Res, 2013, 31(7):1082-1088.
30. Ma D, Yao H, Tian W, et al. Enhancing bone formation by transplantation of a scaffold-free tissue-engineered periosteum in a rabbit model. Clin Oral Implants Res, 2011, 22(10):1193-1199.
31. 任利玲, 刘斌, 马东洋, 等. 预血管化细胞膜片的构建. 中国细胞生物学学报, 2014, 36(3):338-342.
32. Ren L, Kang Y, Browne C, et al. Fabrication, vascularization and osteogenic properties of a novel synthetic biomimetic induced membrane for the treatment of large bone defects. Bone, 2014, 64:173-182.
33. Kang Y, Ren L, Yang YP. Engineering vascularized bone grafts by integrating a biomimetic periosteum and β-TCP scaffold. ACS Appl Mater Interfaces, 2014, 6 (12):9622-9633.
34. Mendes LF, Pirraco RP, Szymczyk W, et al. Perivascular-like cells contribute to the stability of the vascular network of osteogenic tissue formed from cell sheet-based constructs. PLoS One, 2012, 7(7):e41051.
35. Zhang R, Gao Z, Geng W, et al. Engineering vascularized bone graft with osteogenic and angiogenic lineage differentiated bone marrow mesenchymal stem cells. Artif Organs, 2012, 36(12):1036-1046.

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