PROGRESS OF ALGINATE DERIVATIVES BASED ON BIOMEDICAL MATERIALS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

WEIXiaojuan ^1,2 ,  GUQisheng ^1,3 , WANGQingsheng ³ , XIAOJimin ³

1. Shanghai Qisheng Institution of Biomaterials & Technology, Shanghai, 200061, P. R. China;
2. College of Engineering, Peking University;
3. Shandong Enoch Biotechnology Co,. Ltd;

Corresponding author：

GUQisheng, Email: qishenggu@163.com

Keywords：

Alginate derivatives; Biomedical materials

DOI：

10.7507/1002-1892.20150108

Video：

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Objective To summarize the current research status of alginate derivatives based on biomedical materials, and analyze several key points as novel clinical products. Methods The general preparation and application methods of alginate derivatives based on biomedical materials at home and abroad were reviewed. The present status and problems were analyzed. Results The derivation methods to prepare alginate derivatives include crosslink, sulfation, biological factors derivatization, hydrophobic modification, and graft copolymerization. With excellent bionic performance of structure and properties, many alginate derivatives are available for tissue engineering scaffolds, artificial organs, and drug delivery systems etc. However, more systematic applied basic research data should be collected and statistically analyzed for risk managements. Conclusion Alginate derivatives have good feasibility as novel medical products, meanwhile, systematic evaluation and verification should be executed for their safety, effectiveness, and suitability.

Citation： WEIXiaojuan, GUQisheng, WANGQingsheng, XIAOJimin. PROGRESS OF ALGINATE DERIVATIVES BASED ON BIOMEDICAL MATERIALS. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(4): 508-512. doi: 10.7507/1002-1892.20150108 Copy

1.	Giri TK, Thakur D, Alexander A, et al. Alginate based hydrogel as a potential biopolymeric carrier for drug delivery and cell delivery systems:present status and applications. Curr Drug Deliv, 2012, 9(6):539-555.
2.	位晓娟, 奚廷斐, 顾其胜, 等. 医用海藻酸基生物材料的研究进展. 中国修复重建外科杂志, 2013, 27 (8):1015-1020.
3.	d'Ayala GG, Malinconico M, Laurienzo P. Marine derived polysaccharides for biomedical applications:chemical modification approaches. Molecules, 2008, 13 (9):2069-2106.
4.	Pawar SN, Edgar KJ. Alginate derivatization:a review of chemistry, properties and applications. Biomaterials, 2012, 33(11):3279-3305.
5.	Lee KY, Mooney DJ. Alginate:properties and biomedical applications. Prog Polym Sci, 2012, 37(1):106-126.
6.	Draget KI. Alginates//Phillips GO, Williams PA. Handbook of hydrocolloids. Boca Raton, CRC Press, 2009:379-395.
7.	Mørch YA, Donati I, Strand BL, et al. Effect of Ca²⁺, Ba²⁺, and Sr²⁺ on alginate microbeads. Biomacromolecules, 2006, 7(5):1471-1480.
8.	Chang C, Zhang L, Zhou J, et al. Structure and properties of hydrogels prepared from cellulose in NaOH/urea aqueous solutions. Carbohydr Polym, 2010, 82(1):122-127.
9.	Chan AW, Whitney RA, Neufeld RJ. Kinetic controlled synthesis of pH-responsive network alginate. Biomacromolecules, 2008, 9(9):2536-2545.
10.	Chan AW, Whitney RA, Neufeld RJ. Semisynthesis of a controlled stimuli-responsive alginate hydrogel. Biomacromolecules, 2009, 10(3):609-616.
11.	Kim JH, Jegal J, Kim JH, et al. Enantioselective permeation of alphaamino acid optical isomers through crosslinked sodium alginate membranes. J Appl Polym Sci, 2003, 89:3046-3051.
12.	Leone G, Torricelli P, Chiumiento A, et al. Amidic alginate hydrogel for nucleus pulposus replacement. J Biomed Mater Res A, 2008, 84(2):391-401.
13.	Huang R, Du Y, Yang J. Preparation and in vitro anticoagulant activities of alginate sulfate and its quaterized derivatives. Carbohydr Polym, 2003, 52(1):19-24.
14.	Fan L, Jiang L, Xu Y, et al. Synthesis and anticoagulant activity of sodium alginate sulfates. Carbohydr Polym, 2011, 83(4):1797-1803.
15.	Freeman I, Kedem A, Cohen S. The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins. Biomaterials, 2008, 29(22):3260-3268.
16.	Rowley JA, Madlambayan G, Mooney DJ. Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials, 1999, 20(1):45-53.
17.	Donati I, Vetere A, Gamini A, et al. Galactose-substituted alginate:preliminary characterization and study of gelling properties. Biomacromolecules, 2003, 4(3):624-631.
18.	Tian M, Han B, Tan H, et al. Preparation and characterization of galactosylated alginate-chitosan oligomer microcapsule for hepatocytes microencapsulation. Carbohydr Polym, 2014, 112(4):502-511.
19.	Sakai S, Matsuyama T, Hirose K, et al. In situ simultaneous protein-polysaccharide bioconjugation and hydrogelation using horseradish peroxidase. Biomacromolecules, 2010, 11(5):1370-1375.
20.	Liu Y, Sakai S, Taya M. Impact of the composition of alginate and gelatin derivatives in bioconjugated hydrogels on the fabrication of cell sheets and spherical tissues with living cell sheaths. Acta Biomater, 2013, 9(5):6616-6623.
21.	Fan LH, Cao M, Gao S, et al. Preparation and characterization of sodium alginate modified with collagen peptides. Carbohydr Polym, 2013, 93(2):380-385.
22.	Leonard M, Rastello De Boisseson M, Hubert P, et al. Production of microspheres based on hydrophobically associating alginate derivatives by dispersion/gelation in aqueous sodium chloride solutions. J Biomed Mater Res A, 2004, 68(2):335-342.
23.	Burckbuchler V, Kjøniksen AL, Galant C, et al. Rheological and structural characterization of the interactions between cyclodextrin compounds and hydrophobically modified alginate. Biomacromolecules, 2006, 7(6):1871-1878.
24.	Ghahramanpoor MK, Hassani Najafabadi SA, Abdouss M, et al. A hydrophobically-modified alginate gel system:utility in the repair of articular cartilage defects. J Mater Sci Mater Med, 2011, 22(10):2365-2375.
25.	Yao B, Ni C, Xiong C, et al. Hydrophobic modification of sodium alginate and its application in drug controlled release. Bioprocess Biosyst Eng, 2010, 33(4):457-463.
26.	Mandal S, Basu SK, Sa B. Ca²⁺ ion cross-linked interpenetrating network matrix tablets of polyacrylamide-grafted-sodium alginate and sodium alginate for sustained release of diltiazem hydrochloride. Carbohydr Polym, 2010, 82(3):867-873.
27.	Kim JH, Lee SB, Kim SJ, et al. Rapid temperature/pH response of porous alginate-g-poly(N-isopropylacrylamide) hydrogels. Polymer, 2002, 43(26):7549-7558.

1. Giri TK, Thakur D, Alexander A, et al. Alginate based hydrogel as a potential biopolymeric carrier for drug delivery and cell delivery systems:present status and applications. Curr Drug Deliv, 2012, 9(6):539-555.
2. 位晓娟, 奚廷斐, 顾其胜, 等. 医用海藻酸基生物材料的研究进展. 中国修复重建外科杂志, 2013, 27 (8):1015-1020.
3. d'Ayala GG, Malinconico M, Laurienzo P. Marine derived polysaccharides for biomedical applications:chemical modification approaches. Molecules, 2008, 13 (9):2069-2106.
4. Pawar SN, Edgar KJ. Alginate derivatization:a review of chemistry, properties and applications. Biomaterials, 2012, 33(11):3279-3305.
5. Lee KY, Mooney DJ. Alginate:properties and biomedical applications. Prog Polym Sci, 2012, 37(1):106-126.
6. Draget KI. Alginates//Phillips GO, Williams PA. Handbook of hydrocolloids. Boca Raton, CRC Press, 2009:379-395.
7. Mørch YA, Donati I, Strand BL, et al. Effect of Ca²⁺, Ba²⁺, and Sr²⁺ on alginate microbeads. Biomacromolecules, 2006, 7(5):1471-1480.
8. Chang C, Zhang L, Zhou J, et al. Structure and properties of hydrogels prepared from cellulose in NaOH/urea aqueous solutions. Carbohydr Polym, 2010, 82(1):122-127.
9. Chan AW, Whitney RA, Neufeld RJ. Kinetic controlled synthesis of pH-responsive network alginate. Biomacromolecules, 2008, 9(9):2536-2545.
10. Chan AW, Whitney RA, Neufeld RJ. Semisynthesis of a controlled stimuli-responsive alginate hydrogel. Biomacromolecules, 2009, 10(3):609-616.
11. Kim JH, Jegal J, Kim JH, et al. Enantioselective permeation of alphaamino acid optical isomers through crosslinked sodium alginate membranes. J Appl Polym Sci, 2003, 89:3046-3051.
12. Leone G, Torricelli P, Chiumiento A, et al. Amidic alginate hydrogel for nucleus pulposus replacement. J Biomed Mater Res A, 2008, 84(2):391-401.
13. Huang R, Du Y, Yang J. Preparation and in vitro anticoagulant activities of alginate sulfate and its quaterized derivatives. Carbohydr Polym, 2003, 52(1):19-24.
14. Fan L, Jiang L, Xu Y, et al. Synthesis and anticoagulant activity of sodium alginate sulfates. Carbohydr Polym, 2011, 83(4):1797-1803.
15. Freeman I, Kedem A, Cohen S. The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins. Biomaterials, 2008, 29(22):3260-3268.
16. Rowley JA, Madlambayan G, Mooney DJ. Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials, 1999, 20(1):45-53.
17. Donati I, Vetere A, Gamini A, et al. Galactose-substituted alginate:preliminary characterization and study of gelling properties. Biomacromolecules, 2003, 4(3):624-631.
18. Tian M, Han B, Tan H, et al. Preparation and characterization of galactosylated alginate-chitosan oligomer microcapsule for hepatocytes microencapsulation. Carbohydr Polym, 2014, 112(4):502-511.
19. Sakai S, Matsuyama T, Hirose K, et al. In situ simultaneous protein-polysaccharide bioconjugation and hydrogelation using horseradish peroxidase. Biomacromolecules, 2010, 11(5):1370-1375.
20. Liu Y, Sakai S, Taya M. Impact of the composition of alginate and gelatin derivatives in bioconjugated hydrogels on the fabrication of cell sheets and spherical tissues with living cell sheaths. Acta Biomater, 2013, 9(5):6616-6623.
21. Fan LH, Cao M, Gao S, et al. Preparation and characterization of sodium alginate modified with collagen peptides. Carbohydr Polym, 2013, 93(2):380-385.
22. Leonard M, Rastello De Boisseson M, Hubert P, et al. Production of microspheres based on hydrophobically associating alginate derivatives by dispersion/gelation in aqueous sodium chloride solutions. J Biomed Mater Res A, 2004, 68(2):335-342.
23. Burckbuchler V, Kjøniksen AL, Galant C, et al. Rheological and structural characterization of the interactions between cyclodextrin compounds and hydrophobically modified alginate. Biomacromolecules, 2006, 7(6):1871-1878.
24. Ghahramanpoor MK, Hassani Najafabadi SA, Abdouss M, et al. A hydrophobically-modified alginate gel system:utility in the repair of articular cartilage defects. J Mater Sci Mater Med, 2011, 22(10):2365-2375.
25. Yao B, Ni C, Xiong C, et al. Hydrophobic modification of sodium alginate and its application in drug controlled release. Bioprocess Biosyst Eng, 2010, 33(4):457-463.
26. Mandal S, Basu SK, Sa B. Ca²⁺ ion cross-linked interpenetrating network matrix tablets of polyacrylamide-grafted-sodium alginate and sodium alginate for sustained release of diltiazem hydrochloride. Carbohydr Polym, 2010, 82(3):867-873.
27. Kim JH, Lee SB, Kim SJ, et al. Rapid temperature/pH response of porous alginate-g-poly(N-isopropylacrylamide) hydrogels. Polymer, 2002, 43(26):7549-7558.

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