• Department of Spinal Surgery, Zhongda Hospital, Southeast University, Nanjing Jiangsu, 210009, P. R. China;
WANGYuntao, Email: wangyttod@seu.edu.cn
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Objective To summarize the research situation of mesenchymal stem cells (MSCs) senescence, including the characteristics and mechanisms of senescence. Methods The original articles in recent years about MSCs senescence were extensively reviewed, and comprehensively analyzed. Results The senescence of MSCs which manifests as morphological senescence, reduced proliferation and differentiation potential, altered immunoregulation are found during the cultivation in experiment, which profoundly affects clinical application of MSCs. The research about the mechanisms of MSCs senescence includes telomere and telomerase, and stress-mediated injury etc, involving regulation of telomerase, and regulation of signal pathways of p53/p21, P13K/Akt, and Wnt/β-catenin etc. Conclusion The further study of senescence mechanisms will help to accelerate the clinical application of MSCs in the future.

Citation: ZHUHouyi, WANGFeng, WANGYuntao. DEVELOPMENT PROGRESS OF MESENCHYMAL STEM CELLS SENESCENCE. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(7): 899-904. doi: 10.7507/1002-1892.20150193 Copy

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