RESEARCH PROGRESS OF microRNA IN INTERVERTEBRAL DISC DEGENERATION_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

LIXinhua , CUIJian , SUNGuixin , TANJun ,  LILijun

Department of Spine Surgery, the East Hospital Affiliated to Tongji University, Shanghai, 200092, P. R. China;

Corresponding author：

LILijun, Email: liliju@163.com

Keywords：

microRNA; Intervertebral disc degeneration; Gene diagnosis; Gene therapy

DOI：

10.7507/1002-1892.20150283

Video：

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Objective To comprehensively analyze the relationship between microRNAs and intervertebral disc degeneration at home and abroad. Methods The literature about the relationship between microRNAs and intervertebral disc degeneration was reviewed and analyzed. Results MicroRNA can lead to intervertebral disc degeneration by regulating the gene expression, thus influencing the cell's apoptosis and proliferation, increasing of the production of inflammatory mediator and protease, which play important roles in intervertebral disc degeneration. Conclusion MicroRNA is a research focus in the field of intervertebral disc degeneration. Further research of the relationship between microRNAs and intervertebral disc degeneration will help to identify the pathogenesis of intervertebral disc degeneration and furnish the new ideal for the diagnosis and treatment of intervertebral disc degeneration.

Citation： LIXinhua, CUIJian, SUNGuixin, TANJun, LILijun. RESEARCH PROGRESS OF microRNA IN INTERVERTEBRAL DISC DEGENERATION. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(10): 1312-1316. doi: 10.7507/1002-1892.20150283 Copy

1.	魏见伟, 王德春, 胡有谷. 基质金属蛋白酶及其抑制因子与腰椎间盘退变关系的研究进展. 中国脊柱脊髓杂志, 2006, 16(4):304-306.
2.	Liu G, Cao P, Chen H, et al. MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K. PLoS One, 2013, 8(9):e75251.
3.	Ziats MN, Rennert OM. Aberrant expression of long noncoding RNAs in autistic brain. J Mol Neurosci, 2013, 49(3):589-593.
4.	王鹏, 周庄, 张恒, 等. 椎体软骨下骨与椎间盘退变. 中国修复重建外科杂志, 2015, 29(3):377-380.
5.	Trout JJ, Buckwalter JA, Moore KC. Ultrastructure of the human intervertebral disc:Ⅱ. Cells of the nucleus pulposus. Anat Rec, 1982, 204(4):307-314.
6.	Gruber HE, Hanley EN Jr. Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls. Spine (Phila Pa 1976), 1998, 23(7):751-757.
7.	Liu L, Chen Q, Lai R, et al. Elevated expression of mature miR-21 and miR-155 in cancerous gastric tissues from Chinese patients with gastric cancer. J Biomed Res, 2010, 24(3):187-197.
8.	Chen DF GB, Xie Q. MicroRNA155 is induced in activated CD4(+) T cells of TNBS-induced colitis in mice. World J Gastroenterol, 2010, 16(7):854-861.
9.	Wang HQ, Yu XD, Liu ZH, et al. Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3. J Pathol, 2011, 225(2):232-242.
10.	Peng H, Wang X, Zhang P, et al. MiR-27a promotes cell proliferation and etastasis in renal cell carcinoma. Int J Clin Exp Pathol, 2015, 8(2):2259-2266.
11.	王涛, 马信龙, 张晓林, 等. 人退变腰椎间盘差异性表达microRNA 的筛选及JNK通路参与椎间盘退变的探讨. 中华骨科杂志, 2013, 33(7):770-775.
12.	Li Z, Shen J, Wu WK, et al. Leptin induces cyclin D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT, PI3K/ Akt and MEK/ERK pathways. PLoS One, 2012, 7(12):e53176.
13.	Nataka K, Ohuchida K, Mizumoto K, et al. MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis. Surgery, 2011, 150(5):916-922.
14.	Yu X, Li Z, Shen J, et al. MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration. PLoS One, 2013, 8(12):e83080.
15.	Liu H, Huang X, Liu X, et al. miR-21 promotes human nucleus pulposus cell proliferation through PTEN/AKT signaling. Int J Mol Sci, 2014, 15(3):4007-4018.
16.	胡凯. MicroRNA及蛋白水解酶在人退变髓核组织中的表达及作用的实验研究. 苏州:苏州大学, 2014.
17.	Gu SX, Li X, Hamilton JL, et al. MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc. Gene, 2015, 555(2):80-87.
18.	Fang L, Deng Z, Shatseva T, et al. MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-beta8. Oncogene, 2011, 30(7):806-821.
19.	Yu XF, Zou J, Bao ZJ, et al. miR-93 suppresses proliferation and colony formation of human colon cancer stem cells. World J Gastroenterol, 2011, 17(42):4711-4717.
20.	Jing W, Jiang W. MicroRNA-93 regulates collagen loss by targeting MMP3 in human nucleus pulposus cells. Cell Prolif, 2015, 48(3): 284-292.
21.	陈宇飞. miR-129-5p在椎间盘退变中的作用及其表观遗传调控研究. 西安:第四军医大学, 2014.
22.	Zhao B, Yu Q, Li H, et al. Characterization of microRNA expression profiles in patients with intervertebral disc degeneration. Int J Mol Med, 2014, 33(1):43-50.
23.	Ohrt-Nissen S, Dossing KB, Rossing M, et al. Characterization of miRNA expression in human degenerative lumbar disks. Connect Tissue Res, 2013, 54(3):197-203.
24.	Colombier P, Clouet J, Hamel O, et al. The lumbar intervertebral disc:from embryonic development to degeneration. Joint Bone Spine, 2014, 81(2):125-129.
25.	Miyaki S, Nakasa T, Otsuki S, et al. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1. Arthritis Rheum, 2009, 60(9):2723-2730.
26.	Miyaki S, Sato T, Inoue A, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev, 2010, 24(11):1173-1185.
27.	程细高, 贾惊宇, 吴添龙, 等. miR-140-5P参与调控颈椎软骨终板退变. 南昌大学学报:医学版, 2014, 54(5):1-5.
28.	Nakamura Y, Inloes JB, Katagiri T, et al. Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling. Mol Cell Biol, 2011, 31(14):3019-3028.
29.	Yang H, Fang F, Chang R, et al. MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor beta receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma. Hepatology, 2013, 58(1):205-217.
30.	Selbach M, Schwanhausser B, Thierfelder N, et al. Widespread changes in protein synthesis induced by microRNAs. Nature, 2008, 455(7209):58-63.

1. 魏见伟, 王德春, 胡有谷. 基质金属蛋白酶及其抑制因子与腰椎间盘退变关系的研究进展. 中国脊柱脊髓杂志, 2006, 16(4):304-306.
2. Liu G, Cao P, Chen H, et al. MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K. PLoS One, 2013, 8(9):e75251.
3. Ziats MN, Rennert OM. Aberrant expression of long noncoding RNAs in autistic brain. J Mol Neurosci, 2013, 49(3):589-593.
4. 王鹏, 周庄, 张恒, 等. 椎体软骨下骨与椎间盘退变. 中国修复重建外科杂志, 2015, 29(3):377-380.
5. Trout JJ, Buckwalter JA, Moore KC. Ultrastructure of the human intervertebral disc:Ⅱ. Cells of the nucleus pulposus. Anat Rec, 1982, 204(4):307-314.
6. Gruber HE, Hanley EN Jr. Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls. Spine (Phila Pa 1976), 1998, 23(7):751-757.
7. Liu L, Chen Q, Lai R, et al. Elevated expression of mature miR-21 and miR-155 in cancerous gastric tissues from Chinese patients with gastric cancer. J Biomed Res, 2010, 24(3):187-197.
8. Chen DF GB, Xie Q. MicroRNA155 is induced in activated CD4(+) T cells of TNBS-induced colitis in mice. World J Gastroenterol, 2010, 16(7):854-861.
9. Wang HQ, Yu XD, Liu ZH, et al. Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3. J Pathol, 2011, 225(2):232-242.
10. Peng H, Wang X, Zhang P, et al. MiR-27a promotes cell proliferation and etastasis in renal cell carcinoma. Int J Clin Exp Pathol, 2015, 8(2):2259-2266.
11. 王涛, 马信龙, 张晓林, 等. 人退变腰椎间盘差异性表达microRNA 的筛选及JNK通路参与椎间盘退变的探讨. 中华骨科杂志, 2013, 33(7):770-775.
12. Li Z, Shen J, Wu WK, et al. Leptin induces cyclin D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT, PI3K/ Akt and MEK/ERK pathways. PLoS One, 2012, 7(12):e53176.
13. Nataka K, Ohuchida K, Mizumoto K, et al. MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis. Surgery, 2011, 150(5):916-922.
14. Yu X, Li Z, Shen J, et al. MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration. PLoS One, 2013, 8(12):e83080.
15. Liu H, Huang X, Liu X, et al. miR-21 promotes human nucleus pulposus cell proliferation through PTEN/AKT signaling. Int J Mol Sci, 2014, 15(3):4007-4018.
16. 胡凯. MicroRNA及蛋白水解酶在人退变髓核组织中的表达及作用的实验研究. 苏州:苏州大学, 2014.
17. Gu SX, Li X, Hamilton JL, et al. MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc. Gene, 2015, 555(2):80-87.
18. Fang L, Deng Z, Shatseva T, et al. MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-beta8. Oncogene, 2011, 30(7):806-821.
19. Yu XF, Zou J, Bao ZJ, et al. miR-93 suppresses proliferation and colony formation of human colon cancer stem cells. World J Gastroenterol, 2011, 17(42):4711-4717.
20. Jing W, Jiang W. MicroRNA-93 regulates collagen loss by targeting MMP3 in human nucleus pulposus cells. Cell Prolif, 2015, 48(3): 284-292.
21. 陈宇飞. miR-129-5p在椎间盘退变中的作用及其表观遗传调控研究. 西安:第四军医大学, 2014.
22. Zhao B, Yu Q, Li H, et al. Characterization of microRNA expression profiles in patients with intervertebral disc degeneration. Int J Mol Med, 2014, 33(1):43-50.
23. Ohrt-Nissen S, Dossing KB, Rossing M, et al. Characterization of miRNA expression in human degenerative lumbar disks. Connect Tissue Res, 2013, 54(3):197-203.
24. Colombier P, Clouet J, Hamel O, et al. The lumbar intervertebral disc:from embryonic development to degeneration. Joint Bone Spine, 2014, 81(2):125-129.
25. Miyaki S, Nakasa T, Otsuki S, et al. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1. Arthritis Rheum, 2009, 60(9):2723-2730.
26. Miyaki S, Sato T, Inoue A, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev, 2010, 24(11):1173-1185.
27. 程细高, 贾惊宇, 吴添龙, 等. miR-140-5P参与调控颈椎软骨终板退变. 南昌大学学报:医学版, 2014, 54(5):1-5.
28. Nakamura Y, Inloes JB, Katagiri T, et al. Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling. Mol Cell Biol, 2011, 31(14):3019-3028.
29. Yang H, Fang F, Chang R, et al. MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor beta receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma. Hepatology, 2013, 58(1):205-217.
30. Selbach M, Schwanhausser B, Thierfelder N, et al. Widespread changes in protein synthesis induced by microRNAs. Nature, 2008, 455(7209):58-63.

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RESEARCH PROGRESS OF microRNA IN INTERVERTEBRAL DISC DEGENERATION

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