RESEARCH AND PROSPECT OF MESENCHYMAL STEM CELLS IN FEMALE FERTILITY PRESERVATION_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

JIAYingxian ,  LIShangwei , WANGYan

Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;

Corresponding author：

LIShangwei, Email: lswivf01@sina.com

Keywords：

Mesenchymal stem cells; Fertility preservation; Ovarian tissue cryopreservation; Ovarian tissue transplantation

DOI：

10.7507/1002-1892.20160062

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective Fertility preservation (FP) technology has gradually been concerned by scholars all over the world due to the increasing survival rate of cancer patients. To review the recent progress of mesenchymal stem cells (MSCs) in female FP. Methods The recent original literature about MSCs in female FP was extensively reviewed. Results MSCs have the advantages of rich source, easy isolation and amplification, and capacities for multipotential differentiation and migration so that they can be used to avoid the ethical and legal controversy which have great potential of FP for the damage of ovarian tissue and reproductive endocrine disorders. In addition, MSCs can be induced to differentiate into a specific condition, which is expected to be the resource in oocyte-like cells that can be used as a steady cell source for the future experiments and clinical application. Conclusion MSCs have great potential to provide new research ideas for future FP technology.

Citation： JIAYingxian, LIShangwei, WANGYan. RESEARCH AND PROSPECT OF MESENCHYMAL STEM CELLS IN FEMALE FERTILITY PRESERVATION. Chinese Journal of Reparative and Reconstructive Surgery, 2016, 30(3): 314-319. doi: 10.7507/1002-1892.20160062 Copy

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2.	Bastings L, Baysal O, Beerendonk CC, et al. Referral for fertility preservation counselling in female cancer patients. Hum Reprod, 2014, 29(10): 2228-2237.
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5.	Rangappa S, Entwistle JW, Wechsler AS, et al. Cardiomyocyte-mediated contact programs human mesenchymal stem cells to express cardiogenic phenotype. J Thorac Cardiovasc Surg, 2003, 126(1): 124-132.
6.	Ranganath SH, Levy O, Inamdar MS, et al. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell, 2012, 10(3): 244-258.
7.	Tang WP, Akahoshi T, Piao JS, et al. Basic fibroblast growth factor-treated adipose tissue-derived mesenchymal stem cell infusion to ameliorate liver cirrhosis via paracrine hepatocyte growth factor. J Gastroenterol Hepatol, 2015, 30(6): 1065-1074.
8.	Chen J, Li C, Chen L. The role of microvesicles derived from mesenchymal stem cells in lung diseases. Biomed Res Int, 2015, 2015: 985814.
9.	Wyles CC, Houdek MT, Behfar A, et al. Mesenchymal stem cell therapy for osteoarthritis: current perspectives. Stem Cells Cloning, 2015, 8: 117-124.
10.	Faulknor RA, Olekson MA, Nativ NI, et al. Mesenchymal stromal cells reverse hypoxia-mediated suppression of alpha-smooth muscle actin expression in human dermal fibroblasts. Biochem Biophys Res Commun, 2015, 458(1): 8-13.
11.	Shirazi R, Zarnani AH, Soleimani M, et al. BMP4 can generate primordial germ cells from bone-marrow-derived pluripotent stem cells. Cell Biol Int, 2012, 36(12): 1185-1193.
12.	吕品, 何玲, 柴惠霞.类胚体诱导脐带MSCs向生殖细胞的分化.中国组织工程研究, 2012, 16(23): 4217-4221.
13.	LI Cai-xia, WANG Feng-ying, LIANG Zhi-qing, et al. In vitro female germline potential of human umbilical cord-derived matrix stem cells.中国组织工程研究与临床康复, 2010, 14(40): 7583-7587.
14.	Petru E. Fertility preservation and infertility treatment in breast cancer patients. Wien Med Wochenschr, 2010, 160(19-20): 487-492.
15.	Jemal A, Clegg LX, Ward E, et al. Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer, 2004, 101(1): 3-27.
16.	Robbins HL, Zahoor A, Jones K. Fertility preservation in young cancer patients-too little, too late. Support Care Cancer, 2015, 23(12): 2395-2397.
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27.	Susiarjo M, Hassold TJ, Freeman E, et al. Bisphenol A exposure in utero disrupts early oogenesis in the mouse. PLoS Genet, 2007, 3(1): e5.
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37.	Moodley Y, Ilancheran S, Samuel C, et al. Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair. Am J Respir Crit Care Med, 2010, 182(5): 643-651.
38.	Liu Y, Mu R, Wang S, et al. Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis. Arthritis Res Ther, 2010, 12(6): R210.
39.	Zhang Z, Lin H, Shi M, et al. Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. J Gastroenterol Hepatol, 2012, 27 Suppl 2: 112-120.
40.	Di NM, Carlo-Stella C, Magni M, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood, 2002, 99(10): 3838-3843.
41.	Borovskaya TG, Goldberg VE, Fomina TI, et al. Morphological and functional state of rat ovaries in early and late periods after administration of platinum cytostatics. Bull Exp Biol Med, 2004, 137(4): 331-335.
42.	Abd-Allah SH, Shalaby SM, Pasha HF, et al. Mechanistic action of mesenchymal stem cell injection in the treatment of chemically induced ovarian failure in rabbits. Cytotherapy, 2013, 15(1): 64-75.
43.	Guo JQ, Gao X, Lin ZJ, et al. BMSCs reduce rat granulosa cell apoptosis induced by cisplatin and perimenopause. BMC Cell Biol, 2013, 14: 18.
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1. Loren AW, Mangu PB, Beck LN, et al. Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol, 2013, 31(19): 2500-2510.
2. Bastings L, Baysal O, Beerendonk CC, et al. Referral for fertility preservation counselling in female cancer patients. Hum Reprod, 2014, 29(10): 2228-2237.
3. Yang K, Park HJ, Han S, et al. Recapitulation of in vivo-like paracrine signals of human mesenchymal stem cells for functional neuronal differentiation of human neural stem cells in a 3D microfluidic system. Biomaterials, 2015, 63: 177-188.
4. Gutiérrez-Fernández M, Rodríguez-Frutos B, Ramos-Cejudo J, et al. Effects of intravenous administration of allogenic bone marrow-and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke. Stem Cell Res Ther, 2013, 4(1): 11.
5. Rangappa S, Entwistle JW, Wechsler AS, et al. Cardiomyocyte-mediated contact programs human mesenchymal stem cells to express cardiogenic phenotype. J Thorac Cardiovasc Surg, 2003, 126(1): 124-132.
6. Ranganath SH, Levy O, Inamdar MS, et al. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell, 2012, 10(3): 244-258.
7. Tang WP, Akahoshi T, Piao JS, et al. Basic fibroblast growth factor-treated adipose tissue-derived mesenchymal stem cell infusion to ameliorate liver cirrhosis via paracrine hepatocyte growth factor. J Gastroenterol Hepatol, 2015, 30(6): 1065-1074.
8. Chen J, Li C, Chen L. The role of microvesicles derived from mesenchymal stem cells in lung diseases. Biomed Res Int, 2015, 2015: 985814.
9. Wyles CC, Houdek MT, Behfar A, et al. Mesenchymal stem cell therapy for osteoarthritis: current perspectives. Stem Cells Cloning, 2015, 8: 117-124.
10. Faulknor RA, Olekson MA, Nativ NI, et al. Mesenchymal stromal cells reverse hypoxia-mediated suppression of alpha-smooth muscle actin expression in human dermal fibroblasts. Biochem Biophys Res Commun, 2015, 458(1): 8-13.
11. Shirazi R, Zarnani AH, Soleimani M, et al. BMP4 can generate primordial germ cells from bone-marrow-derived pluripotent stem cells. Cell Biol Int, 2012, 36(12): 1185-1193.
12. 吕品, 何玲, 柴惠霞.类胚体诱导脐带MSCs向生殖细胞的分化.中国组织工程研究, 2012, 16(23): 4217-4221.
13. LI Cai-xia, WANG Feng-ying, LIANG Zhi-qing, et al. In vitro female germline potential of human umbilical cord-derived matrix stem cells.中国组织工程研究与临床康复, 2010, 14(40): 7583-7587.
14. Petru E. Fertility preservation and infertility treatment in breast cancer patients. Wien Med Wochenschr, 2010, 160(19-20): 487-492.
15. Jemal A, Clegg LX, Ward E, et al. Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer, 2004, 101(1): 3-27.
16. Robbins HL, Zahoor A, Jones K. Fertility preservation in young cancer patients-too little, too late. Support Care Cancer, 2015, 23(12): 2395-2397.
17. Kim JK, Song YR, Kim MG, et al. Clinical significance of subclinical carotid atherosclerosis and its relationship with echocardiographic parameters in non-diabetic chronic kidney disease patients. BMC Cardiovasc Disord, 2013, 13: 96.
18. Brougham MF, Wallace WH. Subfertility in children and young people treated for solid and haematological malignancies. Br J Haematol, 2005, 131(2): 143-155.
19. Busacca M, Riparini J, Somigliana E, et al. Postsurgical ovarian failure after laparoscopic excision of bilateral endometriomas. Am J Obstet Gynecol, 2006, 195(2): 421-425.
20. Garcia-Velasco JA, Domingo J, Cobo A, et al. Five years' experience using oocyte vitrification to preserve fertility for medical and nonmedical indications. Fertil Steril, 2013, 99(7): 1994-1999.
21. Brevini TA, Cillo F, Antonini S, et al. Effects of endocrine disrupters on the oocytes and embryos of farm animals. Reprod Domest Anim, 2005, 40(4): 291-299.
22. Habert R, Muczynski V, Grisin T, et al. Concerns about the widespread use of rodent models for human risk assessments of endocrine disruptors. Reproduction, 2014, 147(4): R119-129.
23. Marques-Pinto A, Carvalho D. Human infertility: are endocrine disruptors to blame. Endocr Connect, 2013, 2(3): R15-29.
24. Bretveld R, Brouwers M, Ebisch I, et al. Influence of pesticides on male fertility. Scand J Work Environ Health, 2007, 33(1): 13-28.
25. Balabanič D, Rupnik M, Klemenčič AK. Negative impact of endocrine-disrupting compounds on human reproductive health. Reprod Fertil Dev, 2011, 23(3): 403-416.
26. 章靖一, 任慕兰.环境干扰物对卵泡发育和卵巢功能的影响.中国妇幼健康研究, 2008, 19(3): 260-263.
27. Susiarjo M, Hassold TJ, Freeman E, et al. Bisphenol A exposure in utero disrupts early oogenesis in the mouse. PLoS Genet, 2007, 3(1): e5.
28. Petro EM, Leroy JL, Van Cruchten SJ, et al. Endocrine disruptors and female fertility: focus on (bovine) ovarian follicular physiology. Theriogenology, 2012, 78(9): 1887-1900.
29. Petro EM, Leroy JL, Covaci A, et al. Endocrine-disrupting chemicals in human follicular fluid impair in vitro oocyte developmental competence. Hum Reprod, 2012, 27(4): 1025-1033.
30. Sonigo C, Sermondade N, Benard J, et al. The past, present and future of fertility preservation in cancer patients. Future Oncol, 2015. [Epub ahead of print].
31. Varghese AC, du Plessis SS, Falcone T, et al. Cryopreservation/transplantation of ovarian tissue and in vitro maturation of follicles and oocytes: challenges for fertility preservation. Reprod Biol Endocrinol, 2008, 6: 47.
32. Alvarez M, Solé M, Devesa M, et al. Live birth using vitrified—warmed oocytes in invasive ovarian cancer: case report and literature review. Reprod Biomed Online, 2014, 28(6): 663-668.
33. Demeestere I, Simon P, Dedeken L, et al. Live birth after autograft of ovarian tissue cryopreserved during childhood. Hum Reprod, 2015, 30(9): 2107-2109.
34. Bianco P, Robey PG, Simmons PJ. Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell, 2008, 2(4): 313-319.
35. Dawn B, Bolli R. Adult bone marrow-derived cells: regenerative potential, plasticity, and tissue commitment. Basic Res Cardiol, 2005, 100(6): 494-503.
36. 赵江宁, 陈运贤. MSCs的免疫调节机制及其在器官移植中的临床应用.器官移植, 2011, 2(2): 116-120.
37. Moodley Y, Ilancheran S, Samuel C, et al. Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair. Am J Respir Crit Care Med, 2010, 182(5): 643-651.
38. Liu Y, Mu R, Wang S, et al. Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis. Arthritis Res Ther, 2010, 12(6): R210.
39. Zhang Z, Lin H, Shi M, et al. Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. J Gastroenterol Hepatol, 2012, 27 Suppl 2: 112-120.
40. Di NM, Carlo-Stella C, Magni M, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood, 2002, 99(10): 3838-3843.
41. Borovskaya TG, Goldberg VE, Fomina TI, et al. Morphological and functional state of rat ovaries in early and late periods after administration of platinum cytostatics. Bull Exp Biol Med, 2004, 137(4): 331-335.
42. Abd-Allah SH, Shalaby SM, Pasha HF, et al. Mechanistic action of mesenchymal stem cell injection in the treatment of chemically induced ovarian failure in rabbits. Cytotherapy, 2013, 15(1): 64-75.
43. Guo JQ, Gao X, Lin ZJ, et al. BMSCs reduce rat granulosa cell apoptosis induced by cisplatin and perimenopause. BMC Cell Biol, 2013, 14: 18.
44. Xu M, Uemura R, Dai Y, et al. In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function. J Mol Cell Cardiol, 2007, 42(2): 441-448.
45. Ghadami M, El-Demerdash E, Zhang D, et al. Bone marrow transplantation restores follicular maturation and steroid hormones production in a mouse model for primary ovarian failure. PLoS One, 2012, 7(3): e32462.
46. Liang W, Lu C, Li J, et al. p73alpha regulates the sensitivity of bone marrow mesenchymal stem cells to DNA damage agents. Toxicology, 2010, 270(1): 49-56.
47. Nisolle M, Casanas-Roux F, Qu J, et al. Histologic and ultrastructural evaluation of fresh and frozen-thawed human ovarian xenografts in nude mice. Fertil Steril, 2000, 74(1): 122-129.
48. Casey R, Li WW. Factors controlling ocular angiogenesis. Am J Ophthalmol, 1997, 124(4): 521-529.
49. Nilsson E, Parrott JA, Skinner MK. Basic fibroblast growth factor induces primordial follicle development and initiates folliculogenesis. Mol Cell Endocrinol, 2001, 175(1-2): 123-130.
50. Gao JM, Yan J, Li R, et al. Improvement in the quality of heterotopic allotransplanted mouse ovarian tissues with basic fibroblast growth factor and fibrin hydrogel. Hum Reprod, 2013, 28(10): 2784-2793.
51. Xu J, Lawson MS, Yeoman RR, et al. Secondary follicle growth and oocyte maturation during encapsulated three-dimensional culture in rhesus monkeys: effects of gonadotrophins, oxygen and fetuin. Hum Reprod, 2011, 26(5): 1061-1072.
52. Yang H, Lee HH, Lee HC, et al. Assessment of vascular endothelial growth factor expression and apoptosis in the ovarian graft: can exogenous gonadotropin promote angiogenesis after ovarian transplantation. Fertil Steril, 2008, 90(4 Suppl): 1550-1558.
53. Xia X, Yin T, Yan J, et al. Mesenchymal stem cells enhance angiogenesis and follicle survival in human cryopreserved ovarian cortex transplantation. Cell Trasplant, 2015, 24(10): 1999-2010.
54. Sassoli C, Pini A, Chellini F, et al. Bone marrow mesenchymal stromal cells stimulate skeletal myoblast proliferation through the paracrine release of VEGF. PLoS One, 2012, 7(7): e37512.
55. Hsiao ST, Asgari A, Lokmic Z, et al. Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue. Stem Cells Dev, 2012, 21(12): 2189-2203.
56. Roubelakis MG, Tsaknakis G, Pappa KI, et al. Spindle shaped human mesenchymal stem/stromal cells from amniotic fluid promote neovascularization. PLoS One, 2013, 8(1): e54747.
57. 张芍, 何援利, 王雪峰.大鼠骨髓MSCs对大鼠窦前卵泡体外培养的影响.解放军医学杂志, 2010, 35(11): 1374-1376.
58. Xiong N, Zhang Z, Huang J, et al. VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson's disease. Gene Ther, 2011, 18(4): 394-402.
59. Hollweck T, Marschmann M, Hartmann I, et al. Comparative analysis of adherence, viability, proliferation and morphology of umbilical cord tissue-derived mesenchymal stem cells seeded on different titanium-coated expanded polytetrafluoroethylene scaffolds. Biomed Mater, 2010, 5(6): 065004.
60. Sordi V, Malosio ML, Marchesi F, et al. Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets. Blood, 2005, 106(2): 419-427.
61. Honczarenko M, Le Y, Swierkowski M, et al. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells, 2006, 24(4): 1030-1041.
62. Polykandriotis E, Horch RE, Arkudas A, et al. Intrinsic versus extrinsic vascularization in tissue engineering. Adv Exp Med Biol, 2006, 585: 311-326.
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Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH AND PROSPECT OF MESENCHYMAL STEM CELLS IN FEMALE FERTILITY PRESERVATION

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