RESEARCH PROGRESS OF TISSUE ENGINEERING TECHNIQUE IN ESOPHAGEAL DEFECT REPAIR AND RECONSTRUCTION_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

 HOUNan ¹ , MARuina ²

1. Department of Otlaryngology Head and Neck Surgery, the First Affiliated Hospital, Chengdu Medical College, Chengdu Sichuan, 610500, P.R.China;
2. Department of Otlaryngology Head and Neck Surgery, Tangdu Hospital, the Fourth Military Medical University;

Corresponding author：

HOUNan, Email: 110565888@qq.com

Keywords：

Tissue engineered esophagus; Functional reconstruction; Scaffold material; Seeding cell

DOI：

10.7507/1002-1892.20160064

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To review the research progress of the tissue engineering technique in the esophageal defect repair and reconstruction. Methods The recently published clinical and experimental literature at home and abroad on the scaffold materials and the seeding cells used in the tissue engineered esophageal reconstruction was consulted and summarized. Results A large number of basic researches and clinical applications show that the effect of the tissue engineered esophagus is close to the autologous structure and function of the esophagus and it could be used for the repair of the esophageal defect. However, those techniques have a long distance from the clinical application and need an acknowledged rule of technology. Conclusion Tissue engineering technique could provide an innovative theory for the esophageal defect reconstruction, but its clinical application need further research.

Citation： HOUNan, MARuina. RESEARCH PROGRESS OF TISSUE ENGINEERING TECHNIQUE IN ESOPHAGEAL DEFECT REPAIR AND RECONSTRUCTION. Chinese Journal of Reparative and Reconstructive Surgery, 2016, 30(3): 323-327. doi: 10.7507/1002-1892.20160064 Copy

1.	Shen Q, Shi P, Gao M, et al. Progress on materials and scaffold fabrications applied to esophageal tissue engineering. Mater Sci Eng C Mater Biol Appl, 2013, 33(4): 1860-1866.
2.	Londono R, Jobe BA, Hoppo T, et al. Esophagus and regenerative medicine. World J Gastroenterol, 2012, 18(47): 6894-6899.
3.	Ong GB, Lee TC. Pharyngogastric anastomosis after oesophago-pharyngectomy for carcinoma of the hypopharynx and cervical oesophagus. Br J Surg, 1960, 48: 193-200.
4.	Okumura Y, Mori K, Yamagata Y, et al. A two-stage operation for thoracic esophageal cancer: esophagectomy and subsequent reconstruction by a free jejunal flap. Surg Today, 2014, 44(2): 395-398.
5.	Tan B, Wang M, Chen X, et al. Tissue engineered esophagus by copper—small intestinal submucosa graft for esophageal repair in a canine model. Sci China Life Sci, 2014, 57(2): 248-255.
6.	Nieponice A, Ciotola FF, Nachman F, et al. Patch esophagoplasty: esophageal reconstruction using biologic scaffolds. Ann Thorac Surg, 2014, 97(1): 283-288.
7.	Vrana NE, Lavalle P, Dokmeci MR, et al. Engineering functional epithelium for regenerative medicine and in vitro organ models: a review. Tissue Eng Part B Rev, 2013, 19(6): 529-543.
8.	Chian KS, Leong MF, Kono K, et al. Regenerative medicine for oesophageal reconstruction after cancer treatment. Lancet, 2015, 16(2): e84-92.
9.	Berman EF. The experimental replacement of portions of the esophagus by a plastic tube. Ann Surg, 1952, 135(3): 337-343.
10.	Watanabe K, Mark JB. Segmental replacement of the thoracic esophagus with a silastic prosthesis. Am J Surg, 1971, 21(3): 238-240.
11.	Lynen Jansen P, Klinge U, Anurov M, et al. Surgical mesh as a scaffold for tissue regeneration in the esophagus. Eur Surg Res, 2004, 36(2): 104-111.
12.	Takimoto Y, Nakamura T, Teramachi M, et al. Replacement of long segments of the esophagus with a collagen-silicone composite tube. ASAIO J, 1995, 41(3): M605-608.
13.	Chung EJ, Ju HW, Park HJ, et al. Three-layered scaffolds for artificial esophagus using poly (ε-caprolactone) nanofibers and silk fibroin: An experimental study in a rat model. J Biomed Mater Res A, 2015, 103(6): 2057-2065.
14.	Oshikiri T, Yamamoto Y, Miki I, et al. Conservative reconstruction using stents as salvage therapy for disruption of esophago-gastric anastomosis. World J Gastroenterol, 2015, 21(28): 8723-8729.
15.	Badylak SF, Hoppo T, Nieponice A, et al. Esophageal preservation in five male patients after endoscopic inner-layer circumferential resection in the setting of superficial cancer: a regenerative medicine approach with a biologic scaffold. Tissue Eng Part A, 2011, 17(11-12): 1643-1650.
16.	Badylak S, Meurling S, Chen M, et al. Resorbable bioscaffold for esophageal repair in a dog model. Pediatr Surg, 2000, 35: 1097-1103.
17.	Tan B, Wei RQ, Xie HQ, et al. Tissue engineered esophagus by mesenchymal stem cell seeding for esophageal repair in a canine model. J Surg Res, 2013, 182(1): 40-48.
18.	Fan MR, Gong M, Da LC, et al. Tissue engineered esophagus scaffold constructed with porcine small intestinal submucosa and synthetic polymers. Biomed Mater, 2014, 9(1): 015012.
19.	Chiu PW. Novel endoscopic therapeutics for early gastric cancer. Clin Gastroenterol Hepatol, 2014, 12(1): 120-125.
20.	Isomoto H, Shikuwa S, Yamaguchi N, et al. Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study. Gut, 2009, 58(3): 331-336.
21.	Nieponice A, Ciotola FF, Nachman F, et al. Patch esophagoplasty: esophageal reconstruction using biologic scaffolds. Ann Thorac Surg, 2014, 97(1): 283-288.
22.	Jönsson L, Gatzinsky V, Jennische E, et al. Piglet model for studying esophageal regrowth after resection and interposition of a silicone stented small intestinal submucosa tube. Eur Surg Res, 2011, 46(4): 169-179.
23.	Desai KM, Diaz S, Dorward IG, et al. Histologic results 1 year after bioprosthetic repair of paraesophageal hernia in a canine model. Surg Endosc, 2006, 20(11): 1693-1697.
24.	Sjöqvist S, Jungebluth P, Lim ML, et al. Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats. Nat Commun, 2014, 5: 3562.
25.	Ott HC, Matthiesen TS, Goh SK, et al. Perfusion-decellularized matrix: using nature's platform to engineer bioartificial heart. Nat Med, 2008, 14(2): 213-221.
26.	Ott HC, Clippinger B, Conrad C, et al. Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med, 2010, 16(8): 927-933.
27.	Song JJ, Guyette JP, Gilpin SE, et al. Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat Med, 2013, 19(5): 646-651.
28.	Tapias LF, Ott HC. Decellularized scaffolds as a platform for bioengineered organs. Curr Opin Organ Transplant, 2014, 19(2): 145-152.
29.	Gilpin SE, Guyette JP, Gonzalez G. Perfusion decellularization of human and porcine lungs: Bringing the matrix to clinical scale. J Heart Lung Transplant, 2014, 33(3): 298-308.
30.	侯楠, 崔鹏程, 罗家胜, 等.去细胞支架的制备及喉肌再生可行性研究.中华耳鼻咽喉头颈外科杂志, 2009, 44(7): 586-590.
31.	Hou N, Cui P, Luo J, et al. Tissue-engineered larynx using perfusion-decellularized technique and mesenchymal stem cells in a rabbit model. Acta Otolaryngol, 2011, 131(6): 645-652.
32.	Sato M, Ando N, Ozawa S, et al. An artificial esophagus consisting of cultured human esophageal epithelial cells, polyglycolic acid mesh, and collagen. ASAIO J, 1994, 40(3): M389-392.
33.	Jensen T, Blanchette A, Vadasz S, et al. Biomimetic and synthetic esophageal tissue engineering. Biomaterials, 2015, 57: 133-141.
34.	Ohki T, Yamato M, Ota M, et al. Prevention of esophageal stricture after endoscopic submucosal dissection using tissue-engineered cell sheets. Gastroenterology, 2012, 143(3): 582-588.
35.	Poghosyan T, Gaujoux S, Vanneaux V, et al. In vitro development and characterization of a tissue-engineered conduit resembling esophageal wall using human and pig skeletal myoblast, oral epithelial cells, and biologic scaffolds. Tissue Eng Part A, 2013, 19(19-20): 2242-2252.
36.	Poghosyan T, Sfeir R, Michaud L, et al. Circumferential esophageal replacement using a tube-shaped tissue-engineered substitute: An experimental study in minipigs. Surgery, 2015, 158(1): 266-277.
37.	Saxena AK. Esophagus tissue engineering: designing and crafting the components for the "hybrid construct" approach. Eur J Pediatr Surg, 2014, 24(3): 246-262.
38.	Ding DC, Chang YH, Shyu WC, et al. Human umbilical cord mesenchymal stem cells: a new era for stem cell therapy. Cell Transplant, 2015, 24(3): 339-347.
39.	Harris DT. Umbilical cord tissue mesenchymal stem cells: characterization and clinical applications. Curr Stem Cell Res Ther, 2013, 8(5): 394-399.
40.	Coskun H, Can A. The assessment of the in vivo to in vitro cellular transition of human umbilical cord multipotentstromal cells. Placenta, 2015, 6(2): 232-239.
41.	谭波, 解慧琪.组织工程在食管修复重建外科中的应用.生物物理学报, 2011, 27(6): 475-482.

1. Shen Q, Shi P, Gao M, et al. Progress on materials and scaffold fabrications applied to esophageal tissue engineering. Mater Sci Eng C Mater Biol Appl, 2013, 33(4): 1860-1866.
2. Londono R, Jobe BA, Hoppo T, et al. Esophagus and regenerative medicine. World J Gastroenterol, 2012, 18(47): 6894-6899.
3. Ong GB, Lee TC. Pharyngogastric anastomosis after oesophago-pharyngectomy for carcinoma of the hypopharynx and cervical oesophagus. Br J Surg, 1960, 48: 193-200.
4. Okumura Y, Mori K, Yamagata Y, et al. A two-stage operation for thoracic esophageal cancer: esophagectomy and subsequent reconstruction by a free jejunal flap. Surg Today, 2014, 44(2): 395-398.
5. Tan B, Wang M, Chen X, et al. Tissue engineered esophagus by copper—small intestinal submucosa graft for esophageal repair in a canine model. Sci China Life Sci, 2014, 57(2): 248-255.
6. Nieponice A, Ciotola FF, Nachman F, et al. Patch esophagoplasty: esophageal reconstruction using biologic scaffolds. Ann Thorac Surg, 2014, 97(1): 283-288.
7. Vrana NE, Lavalle P, Dokmeci MR, et al. Engineering functional epithelium for regenerative medicine and in vitro organ models: a review. Tissue Eng Part B Rev, 2013, 19(6): 529-543.
8. Chian KS, Leong MF, Kono K, et al. Regenerative medicine for oesophageal reconstruction after cancer treatment. Lancet, 2015, 16(2): e84-92.
9. Berman EF. The experimental replacement of portions of the esophagus by a plastic tube. Ann Surg, 1952, 135(3): 337-343.
10. Watanabe K, Mark JB. Segmental replacement of the thoracic esophagus with a silastic prosthesis. Am J Surg, 1971, 21(3): 238-240.
11. Lynen Jansen P, Klinge U, Anurov M, et al. Surgical mesh as a scaffold for tissue regeneration in the esophagus. Eur Surg Res, 2004, 36(2): 104-111.
12. Takimoto Y, Nakamura T, Teramachi M, et al. Replacement of long segments of the esophagus with a collagen-silicone composite tube. ASAIO J, 1995, 41(3): M605-608.
13. Chung EJ, Ju HW, Park HJ, et al. Three-layered scaffolds for artificial esophagus using poly (ε-caprolactone) nanofibers and silk fibroin: An experimental study in a rat model. J Biomed Mater Res A, 2015, 103(6): 2057-2065.
14. Oshikiri T, Yamamoto Y, Miki I, et al. Conservative reconstruction using stents as salvage therapy for disruption of esophago-gastric anastomosis. World J Gastroenterol, 2015, 21(28): 8723-8729.
15. Badylak SF, Hoppo T, Nieponice A, et al. Esophageal preservation in five male patients after endoscopic inner-layer circumferential resection in the setting of superficial cancer: a regenerative medicine approach with a biologic scaffold. Tissue Eng Part A, 2011, 17(11-12): 1643-1650.
16. Badylak S, Meurling S, Chen M, et al. Resorbable bioscaffold for esophageal repair in a dog model. Pediatr Surg, 2000, 35: 1097-1103.
17. Tan B, Wei RQ, Xie HQ, et al. Tissue engineered esophagus by mesenchymal stem cell seeding for esophageal repair in a canine model. J Surg Res, 2013, 182(1): 40-48.
18. Fan MR, Gong M, Da LC, et al. Tissue engineered esophagus scaffold constructed with porcine small intestinal submucosa and synthetic polymers. Biomed Mater, 2014, 9(1): 015012.
19. Chiu PW. Novel endoscopic therapeutics for early gastric cancer. Clin Gastroenterol Hepatol, 2014, 12(1): 120-125.
20. Isomoto H, Shikuwa S, Yamaguchi N, et al. Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study. Gut, 2009, 58(3): 331-336.
21. Nieponice A, Ciotola FF, Nachman F, et al. Patch esophagoplasty: esophageal reconstruction using biologic scaffolds. Ann Thorac Surg, 2014, 97(1): 283-288.
22. Jönsson L, Gatzinsky V, Jennische E, et al. Piglet model for studying esophageal regrowth after resection and interposition of a silicone stented small intestinal submucosa tube. Eur Surg Res, 2011, 46(4): 169-179.
23. Desai KM, Diaz S, Dorward IG, et al. Histologic results 1 year after bioprosthetic repair of paraesophageal hernia in a canine model. Surg Endosc, 2006, 20(11): 1693-1697.
24. Sjöqvist S, Jungebluth P, Lim ML, et al. Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats. Nat Commun, 2014, 5: 3562.
25. Ott HC, Matthiesen TS, Goh SK, et al. Perfusion-decellularized matrix: using nature's platform to engineer bioartificial heart. Nat Med, 2008, 14(2): 213-221.
26. Ott HC, Clippinger B, Conrad C, et al. Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med, 2010, 16(8): 927-933.
27. Song JJ, Guyette JP, Gilpin SE, et al. Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat Med, 2013, 19(5): 646-651.
28. Tapias LF, Ott HC. Decellularized scaffolds as a platform for bioengineered organs. Curr Opin Organ Transplant, 2014, 19(2): 145-152.
29. Gilpin SE, Guyette JP, Gonzalez G. Perfusion decellularization of human and porcine lungs: Bringing the matrix to clinical scale. J Heart Lung Transplant, 2014, 33(3): 298-308.
30. 侯楠, 崔鹏程, 罗家胜, 等.去细胞支架的制备及喉肌再生可行性研究.中华耳鼻咽喉头颈外科杂志, 2009, 44(7): 586-590.
31. Hou N, Cui P, Luo J, et al. Tissue-engineered larynx using perfusion-decellularized technique and mesenchymal stem cells in a rabbit model. Acta Otolaryngol, 2011, 131(6): 645-652.
32. Sato M, Ando N, Ozawa S, et al. An artificial esophagus consisting of cultured human esophageal epithelial cells, polyglycolic acid mesh, and collagen. ASAIO J, 1994, 40(3): M389-392.
33. Jensen T, Blanchette A, Vadasz S, et al. Biomimetic and synthetic esophageal tissue engineering. Biomaterials, 2015, 57: 133-141.
34. Ohki T, Yamato M, Ota M, et al. Prevention of esophageal stricture after endoscopic submucosal dissection using tissue-engineered cell sheets. Gastroenterology, 2012, 143(3): 582-588.
35. Poghosyan T, Gaujoux S, Vanneaux V, et al. In vitro development and characterization of a tissue-engineered conduit resembling esophageal wall using human and pig skeletal myoblast, oral epithelial cells, and biologic scaffolds. Tissue Eng Part A, 2013, 19(19-20): 2242-2252.
36. Poghosyan T, Sfeir R, Michaud L, et al. Circumferential esophageal replacement using a tube-shaped tissue-engineered substitute: An experimental study in minipigs. Surgery, 2015, 158(1): 266-277.
37. Saxena AK. Esophagus tissue engineering: designing and crafting the components for the "hybrid construct" approach. Eur J Pediatr Surg, 2014, 24(3): 246-262.
38. Ding DC, Chang YH, Shyu WC, et al. Human umbilical cord mesenchymal stem cells: a new era for stem cell therapy. Cell Transplant, 2015, 24(3): 339-347.
39. Harris DT. Umbilical cord tissue mesenchymal stem cells: characterization and clinical applications. Curr Stem Cell Res Ther, 2013, 8(5): 394-399.
40. Coskun H, Can A. The assessment of the in vivo to in vitro cellular transition of human umbilical cord multipotentstromal cells. Placenta, 2015, 6(2): 232-239.
41. 谭波, 解慧琪.组织工程在食管修复重建外科中的应用.生物物理学报, 2011, 27(6): 475-482.

Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH PROGRESS OF TISSUE ENGINEERING TECHNIQUE IN ESOPHAGEAL DEFECT REPAIR AND RECONSTRUCTION

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