RESEARCH PROGRESS OF MicroRNA IN OSTEOARTHRITIS CARTILAGE MATRIX DEGRADATION_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

JIQuanbo ¹ , XUYameng ² ,  WANGYan ¹

1. Department of Orthopaedics, General Hospital of Chinese PLA, Beijing, 100853, P.R.China;
2. Department of Traditional Chinese Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine;

Corresponding author：

WANGYan, Email: yanwang301@126.com

Keywords：

MicroRNA; Osteoarthritis; Cartilage; Matrix degradation

DOI：

10.7507/1002-1892.20160295

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the research progress of microRNA (miRNA) in the osteoarthritis (OA) cartilage matrix degradation. Methods The domestic and foreign related literature about the miRNA in the OA cartilage matrix degradation was reviewed, summarized, and analyzed. Results OA is a common chronic joint disease characterized by cartilage degeneration, its etiology and pathogenesis are still not completely clear. miRNA, a kind of small single stranded non-coding RNA molecule, is closely correlated with inflammatory mediators and various cytokines during the cartilage matrix degradation, suggesting that miRNAs have important regulatory functions at the molecule and cellular levels. Conclusion miRNA can serve as potential biomarkers and will give new insight into diagnosis and therapeutic strategies in OA.

Citation： JIQuanbo, XUYameng, WANGYan. RESEARCH PROGRESS OF MicroRNA IN OSTEOARTHRITIS CARTILAGE MATRIX DEGRADATION. Chinese Journal of Reparative and Reconstructive Surgery, 2016, 30(11): 1431-1436. doi: 10.7507/1002-1892.20160295 Copy

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2.	Vicente R, Noel D, Pers YM, et al. Deregulation and therapeutic potential of microRNAs in arthritic diseases. Nat Rev Rheumatol, 2016, 12(4): 211-220.
3.	Mirzamohammadi F, Papaioannou G, Kobayashi T. MicroRNAs in cartilage development, homeostasis, and disease. Curr Osteoporos Rep, 2014, 12(4): 410-419.
4.	Ji Q, Xu X, Zhang Q, et al. The IL-1beta/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis. J Mol Med (Berl), 2016, 94(7): 771-785.
5.	Rasheed Z, Al-Shobaili HA, Rasheed N, et al. Integrated study of globally expressed microRNAs in IL-1beta-stimulated human osteoarthritis chondrocytes and osteoarthritis relevant genes: a microarray and bioinformatics analysis. Nucleosides Nucleotides Nucleic Acids, 2016, 35(7): 335-355.
6.	Jones SW, Watkins G, Le Good N, et al. The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13. Osteoarthritis Cartilage, 2009, 17(4): 464-472.
7.	Li ZC, Han N, Li X, et al. Decreased expression of microRNA-130a correlates with TNF-α in the development of osteoarthritis. Int J Clin Exp Pathol, 2015, 8(3): 2555-2564.
8.	Tardif G, Pelletier JP, Fahmi H, et al. NFAT3 and TGF-ß/SMAD3 regulate the expression of miR-140 in osteoarthritis. Arthritis Res Ther, 2013, 15(6): R197.
9.	Li YP, Wei XC, Li PC, et al. The Role of miRNAs in Cartilage Homeostasis. Curr Genomics, 2015, 16(6): 393-404.
10.	Liu SC, Chuang SM, Hsu CJ, et al. CTGF increases vascular endothelial growth factor-dependent angiogenesis in human synovial fibroblasts by increasing miR-210 expression. Cell Death Dis, 2014, 5: e1485.
11.	Borgonio Cuadra VM, González-Huerta NC, Romero-Cordoba S, et al. Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways. PLoS One, 2014, 9(6): e97690.
12.	Beyer C, Zampetaki A, Lin NY, et al. Signature of circulating microRNAs in osteoarthritis. Ann Rheum Dis, 2015, 74(3): e18.
13.	Jingsheng S, Yibing W, Jun X, et al. MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis. J Bone Miner Metab, 2015, 33(1): 1-8.
14.	Weilner S, Grillari-Voglauer R, Redl H, et al. The role of microRNAs in cellular senescence and age-related conditions of cartilage and bone. Acta Orthop, 2015, 86(1): 92-99.
15.	Li YH, Tavallaee G, Tokar T, et al. Identification of synovial fluid microRNA signature in knee osteoarthritis: differentiating early-and late-stage knee osteoarthritis. Osteoarthritis Cartilage, 2016, 24(9): 1577-1586.
16.	Prasadam I, Batra J, Perry S, et al. Systematic identification, characterization and target gene analysis of microRNAs involved in osteoarthritis subchondral bone pathogenesis. Calcif Tissue Int, 2016, 99(1): 43-55.
17.	Ha M, Kim VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol, 2014, 15(8): 509-524.
18.	Ghasemi A, Fallah S, Ansari M. MiR-153 as a tumor suppressor in glioblastoma multiforme is downregulated by DNA methylation. Clin Lab, 2016, 62(4): 573-580.
19.	Swierczynski S, Klieser E, Illig R, et al. Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases. Expert Opin Biol Ther, 2015, 15(5): 651-664.
20.	Poddar S, Kesharwani D, Datta M. Histone deacetylase inhibition regulates miR-449a levels in skeletal muscle cells. Epigenetics, 2016, 11(8): 579-587.
21.	Wang Y, Hu X, Greshock J, et al. Genomic DNA copy-number alterations of the let-7 family in human cancers. PLoS One, 2012, 7(9): e44399.
22.	Liu X, Chen X, Yu X, et al. Regulation of microRNAs by epigenetics and their interplay involved in cancer. J Exp Clin Cancer Res, 2013, 32: 96.
23.	Xi Y, Shalgi R, Fodstad O, et al. Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer. Clin Cancer Res, 2006, 12(7 Pt 1): 2014-2024.
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29.	Oulas A, Karathanasis N, Louloupi A, et al. Prediction of miRNA targets. Methods Mol Biol, 2015, 1269: 207-229.
30.	Kunz M, Xiao K, Liang C, et al. Bioinformatics of cardiovascular miRNA biology. J Mol Cell Cardiol, 2015, 89(Pt A): 3-10.
31.	Imig J, Brunschweiger A, Brummer A, et al. miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction. Nat Chem Biol, 2015, 11(2): 107-114.
32.	Moore MJ, Scheel TK, Luna JM, et al. miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity. Nat Commun, 2015, 6: 8864.
33.	Zhao J, Luo R, Xu X, et al. High-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) reveals Argonaute-associated microRNAs and targets in Schistosoma japonicum. Parasit Vectors, 2015, 8: 589.
34.	Loeser RF, Goldring SR, Scanzello CR, et al. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum, 2012, 64(6): 1697-1707.
35.	Iliopoulos D, Malizos KN, Oikonomou P, et al. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PloS One, 2008, 3(11): e3740.
36.	Díaz-Prado S, Cicione C, Muiños-López E, et al. Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes. BMC Musculoskelet Disord, 2012, 13: 144.
37.	Akhtar N, Rasheed Z, Ramamurthy S, et al. MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum, 2010, 62(5): 1361-1371.
38.	Ji Q, Xu X, Xu Y, et al. miR-105/Runx2 axis mediates FGF2-induced ADAMTS expression in osteoarthritis cartilage. J Mol Med (Berl), 2016, 94(6): 681-694.
39.	Vonk LA, Kragten AH, Dhert WJ, et al. Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes. Osteoarthritis Cartilage, 2014, 22(1): 145-153.
40.	Santini P, Politi L, Vedova PD, et al. The inflammatory circuitry of miR-149 as a pathological mechanism in osteoarthritis. Rheumatol Int, 2014, 34(5): 711-716.
41.	Li Z, Meng D, Li G, et al. Overexpression of microRNA-210 promotes chondrocyte proliferation and extracellular matrix deposition by targeting HIF-3α in osteoarthritis. Mol Med Rep, 2016, 13(3): 2769-2776.
42.	Song J, Kim D, Lee CH, et al. MicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis. J Biomed Sci, 2013, 20: 31.
43.	Park SJ, Cheon EJ, Kim HA. MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1β-induced catabolic effects in human articular chondrocytes. Osteoarthritis Cartilage, 2013, 21(7): 981-989.
44.	Cui X, Wang S, Cai H, et al. Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1. Sci Rep, 2016, 6: 23117.
45.	Li L, Jia J, Liu X, et al. MicroRNA-16-5p Controls Development of Osteoarthritis by Targeting SMAD3 in Chondrocytes. Curr Pharm Des, 2015, 21(35): 5160-5167.
46.	Zhang Y, Jia J, Yang S, et al. MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes. Exp Mol Med, 2014, 46: e79.
47.	Kostopoulou F, Malizos KN, Papathanasiou I, et al. MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes. Arthritis Res Ther, 2015, 17: 42.
48.	Yang B, Kang X, Xing Y, et al. Effect of microRNA-145 on IL-1ß-induced cartilage degradation in human chondrocytes. FEBS Lett, 2014, 588(14): 2344-2352.
49.	Kauffman HF, van der Heide S, van der Laan S, et al. Standardization of allergenic extracts of Aspergillus fumigatus. Liberation of IgE-binding components during cultivation. Int Arch Allergy Appl Immunol, 1985, 76(2): 168-173.
50.	Zhang Z, Leong DJ, Xu L, et al. Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res Ther, 2016, 18(1):128.
51.	Miyaki S, Nakasa T, Otsuki S, et al. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum, 2009, 60(9): 2723-2730.
52.	Miyaki S, Sato T, Inoue A, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev, 2010, 24(11): 1173-1185.
53.	Liang Y, Duan L, Xiong J, et al. E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes. Arthritis Res Ther, 2016, 18(1): 105.
54.	Abouheif MM, Nakasa T, Shibuya H, et al. Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro. Rheumatology (Oxford), 2010, 49(11): 2054-2060.
55.	Dai L, Zhang X, Hu X, et al. Silencing of microRNA-101 prevents IL-1ß-induced extracellular matrix degradation in chondrocytes. Arthritis Res Ther, 2012, 14(6): R268.
56.	Martinez-Sanchez A, Dudek KA, Murphy CL. Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145). J Biol Chem, 2012, 287(2): 916-924.
57.	Rossato M, Curtale G, Tamassia N, et al. IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes. Proc Natl Acad Sci U S A, 2012, 109(45): E3101-3110.
58.	Tian GP, Chen WJ, He PP, et al. MicroRNA-467b targets LPL gene in RAW264.7 macrophages and attenuates lipid accumulation and proinflammatory cytokine secretion. Biochimie, 2012, 94(12): 2749-2755.
59.	Wang X, Guo Y, Wang C, et al. MicroRNA-142-3p Inhibits Chondrocyte Apoptosis and Inflammation in Osteoarthritis by Targeting HMGB1. Inflammation, 2016, 39(5): 1718-1728.
60.	Li J, Huang J, Dai L, et al. miR-146a, an IL-1ß responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4. Arthritis Res Ther, 2012, 14(2): R75.
61.	Hou C, Yang Z, Kang Y, et al. MiR-193b regulates early chondrogenesis by inhibiting the TGF-beta2 signaling pathway. FEBS Lett, 2015, 589(9): 1040-1047.
62.	Zhong N, Sun J, Min Z, et al. MicroRNA-337 is associated with chondrogenesis through regulating TGFBR2 expression. Osteoarthritis Cartilage, 2012, 20(6): 593-602.
63.	Swingler TE, Wheeler G, Carmont V, et al. The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis Rheum, 2012, 64(6): 1909-1919.
64.	Akhtar N, Makki MS, Haqqi TM. MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes. Arthritis Rheumatol, 2015, 67(2): 423-434.
65.	Lin AC, Seeto BL, Bartoszko JM, et al. Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nat Med, 2009, 15(12): 1421-1425.
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67.	Trenkmann M, Brock M, Gay RE, et al. Tumor necrosis factor α-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling. Arthritis Rheum, 2013, 65(4): 916-927.
68.	Hu F, Zhu W, Wang L. MicroRNA-203 up-regulates nitric oxide expression in temporomandibular joint chondrocytes via targeting TRPV4. Arch Oral Biol, 2013, 58(2): 192-199.
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1. Nugent M. MicroRNAs: exploring new horizons in osteoarthritis. Osteoarthritis Cartilage, 2016, 24(4): 573-580.
2. Vicente R, Noel D, Pers YM, et al. Deregulation and therapeutic potential of microRNAs in arthritic diseases. Nat Rev Rheumatol, 2016, 12(4): 211-220.
3. Mirzamohammadi F, Papaioannou G, Kobayashi T. MicroRNAs in cartilage development, homeostasis, and disease. Curr Osteoporos Rep, 2014, 12(4): 410-419.
4. Ji Q, Xu X, Zhang Q, et al. The IL-1beta/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis. J Mol Med (Berl), 2016, 94(7): 771-785.
5. Rasheed Z, Al-Shobaili HA, Rasheed N, et al. Integrated study of globally expressed microRNAs in IL-1beta-stimulated human osteoarthritis chondrocytes and osteoarthritis relevant genes: a microarray and bioinformatics analysis. Nucleosides Nucleotides Nucleic Acids, 2016, 35(7): 335-355.
6. Jones SW, Watkins G, Le Good N, et al. The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13. Osteoarthritis Cartilage, 2009, 17(4): 464-472.
7. Li ZC, Han N, Li X, et al. Decreased expression of microRNA-130a correlates with TNF-α in the development of osteoarthritis. Int J Clin Exp Pathol, 2015, 8(3): 2555-2564.
8. Tardif G, Pelletier JP, Fahmi H, et al. NFAT3 and TGF-ß/SMAD3 regulate the expression of miR-140 in osteoarthritis. Arthritis Res Ther, 2013, 15(6): R197.
9. Li YP, Wei XC, Li PC, et al. The Role of miRNAs in Cartilage Homeostasis. Curr Genomics, 2015, 16(6): 393-404.
10. Liu SC, Chuang SM, Hsu CJ, et al. CTGF increases vascular endothelial growth factor-dependent angiogenesis in human synovial fibroblasts by increasing miR-210 expression. Cell Death Dis, 2014, 5: e1485.
11. Borgonio Cuadra VM, González-Huerta NC, Romero-Cordoba S, et al. Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways. PLoS One, 2014, 9(6): e97690.
12. Beyer C, Zampetaki A, Lin NY, et al. Signature of circulating microRNAs in osteoarthritis. Ann Rheum Dis, 2015, 74(3): e18.
13. Jingsheng S, Yibing W, Jun X, et al. MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis. J Bone Miner Metab, 2015, 33(1): 1-8.
14. Weilner S, Grillari-Voglauer R, Redl H, et al. The role of microRNAs in cellular senescence and age-related conditions of cartilage and bone. Acta Orthop, 2015, 86(1): 92-99.
15. Li YH, Tavallaee G, Tokar T, et al. Identification of synovial fluid microRNA signature in knee osteoarthritis: differentiating early-and late-stage knee osteoarthritis. Osteoarthritis Cartilage, 2016, 24(9): 1577-1586.
16. Prasadam I, Batra J, Perry S, et al. Systematic identification, characterization and target gene analysis of microRNAs involved in osteoarthritis subchondral bone pathogenesis. Calcif Tissue Int, 2016, 99(1): 43-55.
17. Ha M, Kim VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol, 2014, 15(8): 509-524.
18. Ghasemi A, Fallah S, Ansari M. MiR-153 as a tumor suppressor in glioblastoma multiforme is downregulated by DNA methylation. Clin Lab, 2016, 62(4): 573-580.
19. Swierczynski S, Klieser E, Illig R, et al. Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases. Expert Opin Biol Ther, 2015, 15(5): 651-664.
20. Poddar S, Kesharwani D, Datta M. Histone deacetylase inhibition regulates miR-449a levels in skeletal muscle cells. Epigenetics, 2016, 11(8): 579-587.
21. Wang Y, Hu X, Greshock J, et al. Genomic DNA copy-number alterations of the let-7 family in human cancers. PLoS One, 2012, 7(9): e44399.
22. Liu X, Chen X, Yu X, et al. Regulation of microRNAs by epigenetics and their interplay involved in cancer. J Exp Clin Cancer Res, 2013, 32: 96.
23. Xi Y, Shalgi R, Fodstad O, et al. Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer. Clin Cancer Res, 2006, 12(7 Pt 1): 2014-2024.
24. Peter ME. Targeting of mRNAs by multiple miRNAs: the next step. Oncogene, 2010, 29(15): 2161-2164.
25. Carroll AP, Goodall GJ, Liu B. Understanding principles of miRNA target recognition and function through integrated biological and bioinformatics approaches. Wiley Interdiscip Rev RNA, 2014, 5(3): 361-379.
26. Moore AC, Winkjer JS, Tseng TT. Bioinformatics resources for MicroRNA discovery. Biomark Insights, 2015, 10(Suppl 4): 53-58.
27. Sharma AR, Sharma G, Lee SS, et al. miRNA-regulated key components of cytokine signaling pathways and inflammation in rheumatoid arthritis. Med Res Rev, 2016, 36(3): 425-439.
28. Afonso-Grunz F, Müller S. Principles of miRNA-mRNA interactions: beyond sequence complementarity. Cell Mol Life Sci, 2015, 72(16): 3127-3141.
29. Oulas A, Karathanasis N, Louloupi A, et al. Prediction of miRNA targets. Methods Mol Biol, 2015, 1269: 207-229.
30. Kunz M, Xiao K, Liang C, et al. Bioinformatics of cardiovascular miRNA biology. J Mol Cell Cardiol, 2015, 89(Pt A): 3-10.
31. Imig J, Brunschweiger A, Brummer A, et al. miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction. Nat Chem Biol, 2015, 11(2): 107-114.
32. Moore MJ, Scheel TK, Luna JM, et al. miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity. Nat Commun, 2015, 6: 8864.
33. Zhao J, Luo R, Xu X, et al. High-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) reveals Argonaute-associated microRNAs and targets in Schistosoma japonicum. Parasit Vectors, 2015, 8: 589.
34. Loeser RF, Goldring SR, Scanzello CR, et al. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum, 2012, 64(6): 1697-1707.
35. Iliopoulos D, Malizos KN, Oikonomou P, et al. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PloS One, 2008, 3(11): e3740.
36. Díaz-Prado S, Cicione C, Muiños-López E, et al. Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes. BMC Musculoskelet Disord, 2012, 13: 144.
37. Akhtar N, Rasheed Z, Ramamurthy S, et al. MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum, 2010, 62(5): 1361-1371.
38. Ji Q, Xu X, Xu Y, et al. miR-105/Runx2 axis mediates FGF2-induced ADAMTS expression in osteoarthritis cartilage. J Mol Med (Berl), 2016, 94(6): 681-694.
39. Vonk LA, Kragten AH, Dhert WJ, et al. Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes. Osteoarthritis Cartilage, 2014, 22(1): 145-153.
40. Santini P, Politi L, Vedova PD, et al. The inflammatory circuitry of miR-149 as a pathological mechanism in osteoarthritis. Rheumatol Int, 2014, 34(5): 711-716.
41. Li Z, Meng D, Li G, et al. Overexpression of microRNA-210 promotes chondrocyte proliferation and extracellular matrix deposition by targeting HIF-3α in osteoarthritis. Mol Med Rep, 2016, 13(3): 2769-2776.
42. Song J, Kim D, Lee CH, et al. MicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis. J Biomed Sci, 2013, 20: 31.
43. Park SJ, Cheon EJ, Kim HA. MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1β-induced catabolic effects in human articular chondrocytes. Osteoarthritis Cartilage, 2013, 21(7): 981-989.
44. Cui X, Wang S, Cai H, et al. Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1. Sci Rep, 2016, 6: 23117.
45. Li L, Jia J, Liu X, et al. MicroRNA-16-5p Controls Development of Osteoarthritis by Targeting SMAD3 in Chondrocytes. Curr Pharm Des, 2015, 21(35): 5160-5167.
46. Zhang Y, Jia J, Yang S, et al. MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes. Exp Mol Med, 2014, 46: e79.
47. Kostopoulou F, Malizos KN, Papathanasiou I, et al. MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes. Arthritis Res Ther, 2015, 17: 42.
48. Yang B, Kang X, Xing Y, et al. Effect of microRNA-145 on IL-1ß-induced cartilage degradation in human chondrocytes. FEBS Lett, 2014, 588(14): 2344-2352.
49. Kauffman HF, van der Heide S, van der Laan S, et al. Standardization of allergenic extracts of Aspergillus fumigatus. Liberation of IgE-binding components during cultivation. Int Arch Allergy Appl Immunol, 1985, 76(2): 168-173.
50. Zhang Z, Leong DJ, Xu L, et al. Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res Ther, 2016, 18(1):128.
51. Miyaki S, Nakasa T, Otsuki S, et al. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum, 2009, 60(9): 2723-2730.
52. Miyaki S, Sato T, Inoue A, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev, 2010, 24(11): 1173-1185.
53. Liang Y, Duan L, Xiong J, et al. E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes. Arthritis Res Ther, 2016, 18(1): 105.
54. Abouheif MM, Nakasa T, Shibuya H, et al. Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro. Rheumatology (Oxford), 2010, 49(11): 2054-2060.
55. Dai L, Zhang X, Hu X, et al. Silencing of microRNA-101 prevents IL-1ß-induced extracellular matrix degradation in chondrocytes. Arthritis Res Ther, 2012, 14(6): R268.
56. Martinez-Sanchez A, Dudek KA, Murphy CL. Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145). J Biol Chem, 2012, 287(2): 916-924.
57. Rossato M, Curtale G, Tamassia N, et al. IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes. Proc Natl Acad Sci U S A, 2012, 109(45): E3101-3110.
58. Tian GP, Chen WJ, He PP, et al. MicroRNA-467b targets LPL gene in RAW264.7 macrophages and attenuates lipid accumulation and proinflammatory cytokine secretion. Biochimie, 2012, 94(12): 2749-2755.
59. Wang X, Guo Y, Wang C, et al. MicroRNA-142-3p Inhibits Chondrocyte Apoptosis and Inflammation in Osteoarthritis by Targeting HMGB1. Inflammation, 2016, 39(5): 1718-1728.
60. Li J, Huang J, Dai L, et al. miR-146a, an IL-1ß responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4. Arthritis Res Ther, 2012, 14(2): R75.
61. Hou C, Yang Z, Kang Y, et al. MiR-193b regulates early chondrogenesis by inhibiting the TGF-beta2 signaling pathway. FEBS Lett, 2015, 589(9): 1040-1047.
62. Zhong N, Sun J, Min Z, et al. MicroRNA-337 is associated with chondrogenesis through regulating TGFBR2 expression. Osteoarthritis Cartilage, 2012, 20(6): 593-602.
63. Swingler TE, Wheeler G, Carmont V, et al. The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis Rheum, 2012, 64(6): 1909-1919.
64. Akhtar N, Makki MS, Haqqi TM. MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes. Arthritis Rheumatol, 2015, 67(2): 423-434.
65. Lin AC, Seeto BL, Bartoszko JM, et al. Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nat Med, 2009, 15(12): 1421-1425.
66. Taganov KD, Boldin MP, Chang KJ, et al. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A, 2006, 103(33): 12481-12486.
67. Trenkmann M, Brock M, Gay RE, et al. Tumor necrosis factor α-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling. Arthritis Rheum, 2013, 65(4): 916-927.
68. Hu F, Zhu W, Wang L. MicroRNA-203 up-regulates nitric oxide expression in temporomandibular joint chondrocytes via targeting TRPV4. Arch Oral Biol, 2013, 58(2): 192-199.
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Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH PROGRESS OF MicroRNA IN OSTEOARTHRITIS CARTILAGE MATRIX DEGRADATION

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