CLINICAL APPLICATION OF LIQUID WOUND DRESSING IN TREATMENT OF CHRONIC ULCER WOUNDS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

WANGChen , LITing , LUOPengfei , LIUYingying , WUGuosheng , CHENGDasheng ,  BENDaofeng , XIAZhaofan

Department of Burn and Trauma Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, P. R. China;

Corresponding author：

BENDaofeng, Email: bendf2001@aliyun.com

Keywords：

Liquid wound dressing; Chronic ulcer wound; Bacterial biofilm; Wound healing

DOI：

10.7507/1002-1892.20160312

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the effectiveness of liquid wound dressing in the treatment of chronic ulcer wounds. Methods Between January 2014 and October 2015, 84 patients with chronic ulcer wounds were included and divided into 2 groups randomly. The chronic ulcer wounds were covered with liquid wound dressing in the treatment group (n=44) and were managed with iodophor in the control group (n=40). There was no significant difference in age, gender, causes, location, wound area, and disease duration between 2 groups (P > 0.05). The frequency of dress changing, effective rate of treatment, wound healing time, wound healing rate at 5, 10, and 20 days, positive rate of bacteria culture at 1, 5, and 10 days, and the rate of side effect were recorded and compared between 2 groups. Vancouver scar scale was used to evaluate scar formation. Results The effective rate of the treatment group (100%) was significantly higher than that of the control group (85%) (P=0.009). The frequency of dress changing in the treatment group[(11.36±3.40) times] was significantly lower than that in the control group[(16.94±4.51) times] (t=-6.231, P=0.000). The wound healing rates at 5, 10, and 20 days were significantly increased (P < 0.05) and the wound healing time was significantly decreased (t=-6.627, P=0.000) in the treatment group when compared with the control group. The positive rates of bacteria culture at 5 and 10 days in the treatment group were significantly lower than those in the control group (χ²=12.313, P=0.000; P=0.005), but no significant difference was found at 1 day (χ²=0.066, P=0.797). Side effect was observed in 4 cases of the control group. Vancouver scar scale score was 8.59±1.32 in the treatment group and was 9.85±1.65 in the control group, showing significant difference (t=-3.752, P=0.000). Conclusion The application of the liquid wound dressing in the treatment of chronic ulcer wound can improve the wound healing rate, shorten the healing time and decrease the frequency of dress change, which could promote the wound healing process.

Citation： WANGChen, LITing, LUOPengfei, LIUYingying, WUGuosheng, CHENGDasheng, BENDaofeng, XIAZhaofan. CLINICAL APPLICATION OF LIQUID WOUND DRESSING IN TREATMENT OF CHRONIC ULCER WOUNDS. Chinese Journal of Reparative and Reconstructive Surgery, 2016, 30(12): 1507-1511. doi: 10.7507/1002-1892.20160312 Copy

1.	Choi HK, Curhan G. Gout:epidemiology and lifestyle choices. Curr Opin Rheumatol, 2005, 17(3):341-345.
2.	黄晓元.加强创面感染的防治.中华损伤与修复杂志(电子版), 2015, 10(5):1-4.
3.	Jiang Y, Huang S, Fu X, et al. Epidemiology of chronic cutaneous wounds in China. Wound Repair Regen, 2011, 19(2):181-188.
4.	王永满, 陈峥.改性甲壳素创面修复凝露联合红光照射治疗慢性皮肤溃疡的效果观察.中国医学前沿杂志(电子版), 2015, 7(11):141-143.
5.	张陈威, 柳大烈, 梁智, 等.封闭式负压引流与人工真皮联合应用治疗下肢慢性溃疡.中国修复重建外科杂志, 2013, 27(8):1023-1024.
6.	闫欣, 刘中国, 尹治晖, 等.液体伤口敷料用于治疗皮肤浅表损伤的疗效与安全性临床研究.中国药物与临床, 2014, 14(1):69-70.
7.	姚玲凤, 周金才, 赵晓玲.庆大胰岛素高糖混合液外敷治疗下肢慢性溃疡的护理体会.中国社区医师(医学专业), 2010, 12(19):230.
8.	常菲, 房贺, 贲道锋, 等.无菌生物膜在小儿浅Ⅱ度烧伤创面中的临床应用.中华损伤与修复杂志(电子版), 2013, 8(4):30-33.
9.	姚兴伟, 孙伟晶, 韩德志, 等.小儿大面积深Ⅱ度烧伤休克期磨痂效果观察.中华损伤与修复杂志(电子版), 2013, 8(4):26-29.
10.	Bill JD, Berriman SJ, Noble DL, et al. Pilot study to evaluate a novel three-dimensional wound measurement device. Int Wound J, 2015.[Epub ahead of print].
11.	刘海兵, 唐丹, 曹海燕, 等.温哥华瘢痕量表的信度研究.中国康复医学杂志, 2006, 21(3):240-242.
12.	朱学骏.皮肤病学与性病学.北京:北京大学医学出版社, 2003:10-11.
13.	Hunt TK, Hopf HW. Wound healing and wound infection. What Surgeons and anesthesiologists can do. Surg Clin North Am, 1997, 77(3):587-606.
14.	Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms:a common cause of persistent infections. Science, 1999, 284(5418):1318-1322.
15.	James GA, Swogger E, Wolcott R, et al. Biofilms in chronic wounds. Wound Repair Regen, 2008, 16(1):37-44.
16.	Wolcott RD, Rhoads DD. A study of biofilm-based wound management in subjects with critical limb ischaemia. J Wound Care, 2008, 17(4):145-155.
17.	Andriessen AE, Eberlein T. Assessment of a wound cleansing solution in the treatment of problem wounds. Wounds, 2008, 20(6):171-175.
18.	Yasuda K, Ohmizo C, Katsu T. Potassium and tetraphenyl phosphonium ion-selective electrodes for monitoring changes in the permeability of bacterial outer and cytoplasmic membranes. J Microbiol Methods, 2003, 54(1):111-115.

1. Choi HK, Curhan G. Gout:epidemiology and lifestyle choices. Curr Opin Rheumatol, 2005, 17(3):341-345.
2. 黄晓元.加强创面感染的防治.中华损伤与修复杂志(电子版), 2015, 10(5):1-4.
3. Jiang Y, Huang S, Fu X, et al. Epidemiology of chronic cutaneous wounds in China. Wound Repair Regen, 2011, 19(2):181-188.
4. 王永满, 陈峥.改性甲壳素创面修复凝露联合红光照射治疗慢性皮肤溃疡的效果观察.中国医学前沿杂志(电子版), 2015, 7(11):141-143.
5. 张陈威, 柳大烈, 梁智, 等.封闭式负压引流与人工真皮联合应用治疗下肢慢性溃疡.中国修复重建外科杂志, 2013, 27(8):1023-1024.
6. 闫欣, 刘中国, 尹治晖, 等.液体伤口敷料用于治疗皮肤浅表损伤的疗效与安全性临床研究.中国药物与临床, 2014, 14(1):69-70.
7. 姚玲凤, 周金才, 赵晓玲.庆大胰岛素高糖混合液外敷治疗下肢慢性溃疡的护理体会.中国社区医师(医学专业), 2010, 12(19):230.
8. 常菲, 房贺, 贲道锋, 等.无菌生物膜在小儿浅Ⅱ度烧伤创面中的临床应用.中华损伤与修复杂志(电子版), 2013, 8(4):30-33.
9. 姚兴伟, 孙伟晶, 韩德志, 等.小儿大面积深Ⅱ度烧伤休克期磨痂效果观察.中华损伤与修复杂志(电子版), 2013, 8(4):26-29.
10. Bill JD, Berriman SJ, Noble DL, et al. Pilot study to evaluate a novel three-dimensional wound measurement device. Int Wound J, 2015.[Epub ahead of print].
11. 刘海兵, 唐丹, 曹海燕, 等.温哥华瘢痕量表的信度研究.中国康复医学杂志, 2006, 21(3):240-242.
12. 朱学骏.皮肤病学与性病学.北京:北京大学医学出版社, 2003:10-11.
13. Hunt TK, Hopf HW. Wound healing and wound infection. What Surgeons and anesthesiologists can do. Surg Clin North Am, 1997, 77(3):587-606.
14. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms:a common cause of persistent infections. Science, 1999, 284(5418):1318-1322.
15. James GA, Swogger E, Wolcott R, et al. Biofilms in chronic wounds. Wound Repair Regen, 2008, 16(1):37-44.
16. Wolcott RD, Rhoads DD. A study of biofilm-based wound management in subjects with critical limb ischaemia. J Wound Care, 2008, 17(4):145-155.
17. Andriessen AE, Eberlein T. Assessment of a wound cleansing solution in the treatment of problem wounds. Wounds, 2008, 20(6):171-175.
18. Yasuda K, Ohmizo C, Katsu T. Potassium and tetraphenyl phosphonium ion-selective electrodes for monitoring changes in the permeability of bacterial outer and cytoplasmic membranes. J Microbiol Methods, 2003, 54(1):111-115.

Chinese Journal of Reparative and Reconstructive Surgery

CLINICAL APPLICATION OF LIQUID WOUND DRESSING IN TREATMENT OF CHRONIC ULCER WOUNDS

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content