Research progress of drug-loaded antibacterial coating of orthopedic metal implants_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZHANG Yao , XU Zhe , SUO Haiqiang ,  FENG Wei

Department of Bone and Joint Surgery, the First Hospital of Jilin University, Changchun Jilin, 130021, P.R.China;

Corresponding author：

FENG Wei, Email: doctorfengwei@126.com

Keywords：

Orthopedics; metal implants; antibacterial; drug-loaded coating

DOI：

10.7507/1002-1892.201704046

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the research progress of drug-loaded antibacterial coating of orthopedic metal implants in recent years. Methods The recent literature on the drug-loaded antibacterial coating of orthopedic metal implants were reviewed. The research status, classification, and development trend of drug-loaded antibacterial coating were summarized. Results The drug-loaded antibacterial coating of orthopedic metal implants can be divided into passive release type and active release type according to the mode of drug release. Passive drug release coating can release the drug continuously regardless of whether the presence of bacteria around the implants. Active drug release coating do not release the drug unless the presence of bacteria around the implants. Conclusion The sustained and stable release of drugs is a key problem to be solved in various antibacterial coatings research. The intelligent antibacterial coating which release antibiotics only in the presence of bacteria is the future direction of development.

Citation： ZHANG Yao, XU Zhe, SUO Haiqiang, FENG Wei. Research progress of drug-loaded antibacterial coating of orthopedic metal implants. Chinese Journal of Reparative and Reconstructive Surgery, 2017, 31(11): 1396-1401. doi: 10.7507/1002-1892.201704046 Copy

1.	谢辉, 张玉勤, 孟增东, 等. β 钛合金特性及其在骨科领域的应用现状和研究进展. 生物骨科材料与临床研究, 2013, 10(6): 29-32.
2.	Gbejuade HO, Lovering AM, Webb JC. The role of microbial biofilms in prosthetic joint infections. Acta Orthop, 2015, 86(2): 147-158.
3.	王家琦, 尚剑, 孙晔, 等. 钛合金表面抗菌涂层: 抗菌能力及生物相容性. 中国组织工程研究, 2015, 19(25): 4069-4075.
4.	Hirschfeld J, Akinoglu EM, Wirtz DC, et al. Long-term release of antibiotics by carbon nanotube-coated titanium alloy surfaces diminish biofilm formation by Staphylococcus epidermidis. Nanomedicine, 2017, 13(4): 1587-1593.
5.	Hess U, Mikolajczyk G, Treccani L, et al. Multi-loaded ceramic beads/matrix scaffolds obtained by combining ionotropic and freeze gelation for sustained and tuneable vancomycin release. Mater Sci Eng C Mater Biol Appl, 2016, 67: 542-553.
6.	Ghosh S, Wu V, Pernal S, et al. Self-Setting Calcium Phosphate Cements with Tunable Antibiotic Release Rates for Advanced Antimicrobial Applications. ACS Appl Mater Interfaces, 2016, 8(12): 7691-7708.
7.	张杭州, 田昂, 梁庆威, 等. 万古霉素/羟基磷灰石/二氧化钛纳米管的抗菌性能. 中国组织工程研究, 2016, 20(25): 3732-3737.
8.	Fazli Y, Shariatinia Z. Controlled release of cefazolin sodium antibiotic drug from electrospun chitosan-polyethylene oxide nanofibrous Mats. Mater Sci Eng C Mater Biol Appl, 2017, 71: 641-652.
9.	Fazli Y, Shariatinia Z, Kohsari I, et al. A novel chitosan-polyethylene oxide nanofibrous mat designed for controlled co-release of hydrocortisone and imipenem/cilastatin drugs. Int J Pharm, 2016, 513(1-2): 636-647.
10.	Wang D, Liu Q, Xiao D, et al. Microparticle entrapment for drug release from porous-surfaced bone implants. J Microencapsul, 2015, 32(5): 443-449.
11.	Lv H, Chen Z, Yang X, et al. Layer-by-layer self-assembly of minocycline-loaded chitosan/alginate multilayer on titanium substrates to inhibit biofilm formation. J Dent, 2014, 42(11): 1464-1472.
12.	McManamon C, de Silva JP, Delaney P, et al. Characteristics, interactions and coating adherence of heterogeneous polymer/drug coatings for biomedical devices. Mater Sci Eng C Mater Biol Appl, 2016, 59: 102-108.
13.	Xu Z, Lai Y, Wu D, et al. Antibacterial Effects and Biocompatibility of Titania Nanotubes with Octenidine Dihydrochloride/Poly (lactic-co-glycolic acid). Biomed Res Int, 2015, 2015: 836939.
14.	Kumeria T, Mon H, Aw MS, et al. Advanced biopolymer-coated drug-releasing titania nanotubes (TNTs) implants with simultaneously enhanced osteoblast adhesion and antibacterial properties. Colloids Surf B Biointerfaces, 2015, 130: 255-263.
15.	Jennings JA, Carpenter DP, Troxel KS, et al. Novel Antibiotic-loaded Point-of-care Implant Coating Inhibits Biofilm. Clin Orthop Relat Res, 2015, 473(7): 2270-2282.
16.	Braem A, De Cremer K, Delattin N, et al. Novel anti-infective implant substrates: controlled release of antibiofilm compounds from mesoporous silica-containing macroporous titanium. Colloids Surf B Biointerfaces, 2015, 126: 481-488.
17.	Qu H, Knabe C, Radin S, et al. Percutaneous external fixator pins with bactericidal micron-thin sol-gel films for the prevention of pin tract infection. Biomaterials, 2015, 62: 95-105.
18.	Antoci V, Adams CS, Parvizi J, et al. The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection. Biomaterials, 2008, 29(35): 4684-4690.
19.	Chen CP, Wickstrom E. Self-protecting bactericidal titanium alloy surface formed by covalent bonding of daptomycin bisphosphonates. Bioconjug Chem, 2010, 21(11): 1978-1986.
20.	Edupuganti OP, Antoci V Jr, King SB, et al. Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureuscolonization. Bioorg Med Chem Lett, 2007, 17(10): 2692-1696.
21.	Jose B, Antoci V Jr, Zeiger AR, et al. Vancomycin covalently bonded to titanium beads kills Staphylococcus aureus. Chem Biol, 2005, 12(9): 1041-1048.
22.	Pérez-Anes A, Gargouri M, Laure W, et al. Bioinspired Titanium Drug Eluting Platforms Based on a Poly-β-cyclodextrin-Chitosan Layer-by-Layer Self-Assembly Targeting Infections. ACS Appl Mater Interfaces, 2015, 7(23): 12882-12893.
23.	Radin S, Ducheyne P. Controlled release of vancomycin from thin sol-gel films on titanium alloy fracture plate material. Biomaterials, 2007, 28(9): 1721-1729.
24.	Adams CS, Antoci V Jr, Harrison G, et al. Controlled release of vancomycin from thin sol-gel films on implant surfaces successfully controls osteomyelitis. J Orthop Res, 2009, 27(6): 701-709.
25.	Dave R, Jayaraj P, Ajikumar PK, et al. Endogenously triggered electrospun fibres for tailored and controlled antibiotic release. J Biomater Sci Polym Ed, 2013, 24(11): 1305-1319.
26.	Balmayor ER, Tuzlakoglu K, Marques AP, et al. A novel enzymatically-mediated drug delivery carrier for bone tissue engineering applications: combining biodegradable starch-based microparticles and differentiation agents. J Mater Sci Mater Med, 2008, 19(4): 1617-1623.
27.	邵丽, 杨银, 邓阳全, 等. 温敏型聚合物 PNIPAAM 的合成及应用研究进展. 化工新型材料, 2008, 36(11): 5-7.
28.	Yu Q, Cho J, Shivapooja P, et al. Nanopatterned smart polymer surfaces for controlled attachment, killing, and release of bacteria. ACS Appl Mater Interfaces, 2013, 5(19): 9295-9304.
29.	Qiao M, Chen D, Ma X, et al. Injectable biodegradable temperature-responsive PLGA-PEG-PLGA copolymers: synthesis and effect of copolymer composition on the drug release from the copolymer-based hydrogels. Int J Pharm, 2005, 294(1-2): 103-112.
30.	Peng KT, Chen CF, Chu IM, et al. Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles. Biomaterials, 2010, 31(19): 5227-5236.
31.	Ding F, Deng H, Du Y, et al. Emerging chitin and chitosan nanofibrous materials for biomedical applications. Nanoscale, 2014, 6(16): 9477-9493.
32.	Swanson TE, Cheng X, Friedrich C. Development of chitosan-vancomycin antimicrobial coatings on titanium implants. J Biomed Mater Res A, 2011, 97(2): 167-176.
33.	Shi X, Wu H, Li Y, et al. Electrical signals guided entrapment and controlled release of antibiotics on titanium surface. J Biomed Mater Res A, 2013, 101(5): 1373-1378.
34.	王婉秦, 于德梅, 解云川. 聚吡咯及其共聚物的研究进展. 高分子材料科学与工程, 2011, 27(7): 175-178.
35.	汝小宁. 基于原电池原理构建聚吡咯药物自动释放体系的研究. 厦门: 厦门大学, 2011.
36.	Sirivisoot S, Pareta R, Webster TJ. Electrically controlled drug release from nanostructured polypyrrole coated on titanium. Nanotechnology, 2011, 22(8): 085101.
37.	Schmidt DJ, Moskowitz JS, Hammond PT. Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating. Chem Mater, 2010, 22(23): 6416-6425.
38.	Pavlukhina S, Lu Y, Patimetha A, et al. Polymer multilayers with pH-triggered release of antibacterial agents. Biomacromolecules, 2010, 11(12): 3448-3456.
39.	Ma L, Liu M, Liu H, et al. In vitro cytotoxicity and drug release properties of pH-and temperature-sensitive core-shell hydrogel microspheres. Int J Pharm, 2010, 385(1-2): 86-91.
40.	Pichavant L, Amador G, Jacqueline C, et al. pH-controlled delivery of gentamicin sulfate from orthopedic devices preventing nosocomial infections. J Control Release, 2012, 162(2): 373-381.
41.	Zhuk I, Jariwala F, Attygalle AB, et al. Self-defensive layer-by-layer films with bacteria-triggered antibiotic release. ACS Nano, 2014, 8(8): 7733-7745.
42.	Hizal F, Zhuk I, Sukhishvili S, et al. Impact of 3D Hierarchical Nanostructures on the Antibacterial Efficacy of a Bacteria-Triggered Self-Defensive Antibiotic Coating. ACS Appl Mater Interfaces, 2015, 7(36): 20304-20313.
43.	Inoue D, Kabata T, Ohtani K, et al. Inhibition of biofilm formation on iodine-supported titanium implants. Int Orthop, 2017, 41(6): 1093-1099.

1. 谢辉, 张玉勤, 孟增东, 等. β 钛合金特性及其在骨科领域的应用现状和研究进展. 生物骨科材料与临床研究, 2013, 10(6): 29-32.
2. Gbejuade HO, Lovering AM, Webb JC. The role of microbial biofilms in prosthetic joint infections. Acta Orthop, 2015, 86(2): 147-158.
3. 王家琦, 尚剑, 孙晔, 等. 钛合金表面抗菌涂层: 抗菌能力及生物相容性. 中国组织工程研究, 2015, 19(25): 4069-4075.
4. Hirschfeld J, Akinoglu EM, Wirtz DC, et al. Long-term release of antibiotics by carbon nanotube-coated titanium alloy surfaces diminish biofilm formation by Staphylococcus epidermidis. Nanomedicine, 2017, 13(4): 1587-1593.
5. Hess U, Mikolajczyk G, Treccani L, et al. Multi-loaded ceramic beads/matrix scaffolds obtained by combining ionotropic and freeze gelation for sustained and tuneable vancomycin release. Mater Sci Eng C Mater Biol Appl, 2016, 67: 542-553.
6. Ghosh S, Wu V, Pernal S, et al. Self-Setting Calcium Phosphate Cements with Tunable Antibiotic Release Rates for Advanced Antimicrobial Applications. ACS Appl Mater Interfaces, 2016, 8(12): 7691-7708.
7. 张杭州, 田昂, 梁庆威, 等. 万古霉素/羟基磷灰石/二氧化钛纳米管的抗菌性能. 中国组织工程研究, 2016, 20(25): 3732-3737.
8. Fazli Y, Shariatinia Z. Controlled release of cefazolin sodium antibiotic drug from electrospun chitosan-polyethylene oxide nanofibrous Mats. Mater Sci Eng C Mater Biol Appl, 2017, 71: 641-652.
9. Fazli Y, Shariatinia Z, Kohsari I, et al. A novel chitosan-polyethylene oxide nanofibrous mat designed for controlled co-release of hydrocortisone and imipenem/cilastatin drugs. Int J Pharm, 2016, 513(1-2): 636-647.
10. Wang D, Liu Q, Xiao D, et al. Microparticle entrapment for drug release from porous-surfaced bone implants. J Microencapsul, 2015, 32(5): 443-449.
11. Lv H, Chen Z, Yang X, et al. Layer-by-layer self-assembly of minocycline-loaded chitosan/alginate multilayer on titanium substrates to inhibit biofilm formation. J Dent, 2014, 42(11): 1464-1472.
12. McManamon C, de Silva JP, Delaney P, et al. Characteristics, interactions and coating adherence of heterogeneous polymer/drug coatings for biomedical devices. Mater Sci Eng C Mater Biol Appl, 2016, 59: 102-108.
13. Xu Z, Lai Y, Wu D, et al. Antibacterial Effects and Biocompatibility of Titania Nanotubes with Octenidine Dihydrochloride/Poly (lactic-co-glycolic acid). Biomed Res Int, 2015, 2015: 836939.
14. Kumeria T, Mon H, Aw MS, et al. Advanced biopolymer-coated drug-releasing titania nanotubes (TNTs) implants with simultaneously enhanced osteoblast adhesion and antibacterial properties. Colloids Surf B Biointerfaces, 2015, 130: 255-263.
15. Jennings JA, Carpenter DP, Troxel KS, et al. Novel Antibiotic-loaded Point-of-care Implant Coating Inhibits Biofilm. Clin Orthop Relat Res, 2015, 473(7): 2270-2282.
16. Braem A, De Cremer K, Delattin N, et al. Novel anti-infective implant substrates: controlled release of antibiofilm compounds from mesoporous silica-containing macroporous titanium. Colloids Surf B Biointerfaces, 2015, 126: 481-488.
17. Qu H, Knabe C, Radin S, et al. Percutaneous external fixator pins with bactericidal micron-thin sol-gel films for the prevention of pin tract infection. Biomaterials, 2015, 62: 95-105.
18. Antoci V, Adams CS, Parvizi J, et al. The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection. Biomaterials, 2008, 29(35): 4684-4690.
19. Chen CP, Wickstrom E. Self-protecting bactericidal titanium alloy surface formed by covalent bonding of daptomycin bisphosphonates. Bioconjug Chem, 2010, 21(11): 1978-1986.
20. Edupuganti OP, Antoci V Jr, King SB, et al. Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureuscolonization. Bioorg Med Chem Lett, 2007, 17(10): 2692-1696.
21. Jose B, Antoci V Jr, Zeiger AR, et al. Vancomycin covalently bonded to titanium beads kills Staphylococcus aureus. Chem Biol, 2005, 12(9): 1041-1048.
22. Pérez-Anes A, Gargouri M, Laure W, et al. Bioinspired Titanium Drug Eluting Platforms Based on a Poly-β-cyclodextrin-Chitosan Layer-by-Layer Self-Assembly Targeting Infections. ACS Appl Mater Interfaces, 2015, 7(23): 12882-12893.
23. Radin S, Ducheyne P. Controlled release of vancomycin from thin sol-gel films on titanium alloy fracture plate material. Biomaterials, 2007, 28(9): 1721-1729.
24. Adams CS, Antoci V Jr, Harrison G, et al. Controlled release of vancomycin from thin sol-gel films on implant surfaces successfully controls osteomyelitis. J Orthop Res, 2009, 27(6): 701-709.
25. Dave R, Jayaraj P, Ajikumar PK, et al. Endogenously triggered electrospun fibres for tailored and controlled antibiotic release. J Biomater Sci Polym Ed, 2013, 24(11): 1305-1319.
26. Balmayor ER, Tuzlakoglu K, Marques AP, et al. A novel enzymatically-mediated drug delivery carrier for bone tissue engineering applications: combining biodegradable starch-based microparticles and differentiation agents. J Mater Sci Mater Med, 2008, 19(4): 1617-1623.
27. 邵丽, 杨银, 邓阳全, 等. 温敏型聚合物 PNIPAAM 的合成及应用研究进展. 化工新型材料, 2008, 36(11): 5-7.
28. Yu Q, Cho J, Shivapooja P, et al. Nanopatterned smart polymer surfaces for controlled attachment, killing, and release of bacteria. ACS Appl Mater Interfaces, 2013, 5(19): 9295-9304.
29. Qiao M, Chen D, Ma X, et al. Injectable biodegradable temperature-responsive PLGA-PEG-PLGA copolymers: synthesis and effect of copolymer composition on the drug release from the copolymer-based hydrogels. Int J Pharm, 2005, 294(1-2): 103-112.
30. Peng KT, Chen CF, Chu IM, et al. Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles. Biomaterials, 2010, 31(19): 5227-5236.
31. Ding F, Deng H, Du Y, et al. Emerging chitin and chitosan nanofibrous materials for biomedical applications. Nanoscale, 2014, 6(16): 9477-9493.
32. Swanson TE, Cheng X, Friedrich C. Development of chitosan-vancomycin antimicrobial coatings on titanium implants. J Biomed Mater Res A, 2011, 97(2): 167-176.
33. Shi X, Wu H, Li Y, et al. Electrical signals guided entrapment and controlled release of antibiotics on titanium surface. J Biomed Mater Res A, 2013, 101(5): 1373-1378.
34. 王婉秦, 于德梅, 解云川. 聚吡咯及其共聚物的研究进展. 高分子材料科学与工程, 2011, 27(7): 175-178.
35. 汝小宁. 基于原电池原理构建聚吡咯药物自动释放体系的研究. 厦门: 厦门大学, 2011.
36. Sirivisoot S, Pareta R, Webster TJ. Electrically controlled drug release from nanostructured polypyrrole coated on titanium. Nanotechnology, 2011, 22(8): 085101.
37. Schmidt DJ, Moskowitz JS, Hammond PT. Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating. Chem Mater, 2010, 22(23): 6416-6425.
38. Pavlukhina S, Lu Y, Patimetha A, et al. Polymer multilayers with pH-triggered release of antibacterial agents. Biomacromolecules, 2010, 11(12): 3448-3456.
39. Ma L, Liu M, Liu H, et al. In vitro cytotoxicity and drug release properties of pH-and temperature-sensitive core-shell hydrogel microspheres. Int J Pharm, 2010, 385(1-2): 86-91.
40. Pichavant L, Amador G, Jacqueline C, et al. pH-controlled delivery of gentamicin sulfate from orthopedic devices preventing nosocomial infections. J Control Release, 2012, 162(2): 373-381.
41. Zhuk I, Jariwala F, Attygalle AB, et al. Self-defensive layer-by-layer films with bacteria-triggered antibiotic release. ACS Nano, 2014, 8(8): 7733-7745.
42. Hizal F, Zhuk I, Sukhishvili S, et al. Impact of 3D Hierarchical Nanostructures on the Antibacterial Efficacy of a Bacteria-Triggered Self-Defensive Antibiotic Coating. ACS Appl Mater Interfaces, 2015, 7(36): 20304-20313.
43. Inoue D, Kabata T, Ohtani K, et al. Inhibition of biofilm formation on iodine-supported titanium implants. Int Orthop, 2017, 41(6): 1093-1099.

Chinese Journal of Reparative and Reconstructive Surgery

Research progress of drug-loaded antibacterial coating of orthopedic metal implants

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content