• 1. Department of Orthopedics, Affiliated Hospital of North China University of Science and Technology, Tangshan Hebei, 063000, P.R.China;
  • 2. Graduate School of Hebei Medical University, Shijiazhuang Hebei, 050017, P.R.China;
  • 3. Medical Research Center, North China University of Science and Technology, Tangshan Hebei, 063000, P.R.China;
TIAN Faming, Email: tfm9911316@163.com; ZHANG Liu, Email: Zhliu130@sohu.com
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Objective  To review the research progress on protease-activated receptor 2 (PAR-2) in the pathogenesis of osteoarthritis (OA). Methods  The relevant literature about the mechanism of PAR-2 in the occurrence and development of OA in recent years was extensively reviewed and comprehensively analyzed. Results  Abnormal activation of PAR-2 plays an important role in responses to occurrence and development of OA. Through regulating production and releasing of a variety of cytokines (such as inflammatory factors, metabolic factors, pain factors, etc.), the PAR-2 can involve in pathophysiological progression of OA articular cartilage, subchondral bone, and synovial membrane, as well as occurrence and transmission of pain. Conclusion  PAR-2 participation in the development of OA has been confirmed. However, since PAR-2 is complicated and widespread, it is necessary to study the specific role of PAR-2 and the interaction between various signal pathways in the progression of OA, and to elucidate the potential pathophysiological mechanisms of PAR-2 participating in the process of OA, in the hope of exploring the new targets for the effective control of OA.

Citation: LÜ Qinglie, GOU Yu, TIAN Faming, ZHANG Liu. Research progress on protease-activated receptor 2 in pathogenesis of osteoarthritis. Chinese Journal of Reparative and Reconstructive Surgery, 2017, 31(12): 1517-1522. doi: 10.7507/1002-1892.201705025 Copy

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