Biomechanical study of nickel-titanium three-dimensional memory alloy mesh and autologous bone in treatment of canine tibial plateau collapse fracture_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

YAN Zhaokui , LIANG Yu ^Δ ,  FANG Yue , YAO Xiangyu , MA Kunlong , HUANG Fuguo

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;

Corresponding author：

FANG Yue, Email: fangyue1968@163.com

Keywords：

Nickel-titanium alloy; three-dimensional memory alloy mesh; tibial plateau fracture; biomechanics; dog

DOI：

10.7507/1002-1892.201709068

Video：

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ObjectiveTo evaluate the biomechanical effect of a nickel-titanium (Ni-Ti) three-dimensional memory alloy mesh in treating a canine tibial plateau collapse fracture model and to lay a foundation for further experiments in vivo.MethodsSixteen tibial plateau specimens of 8 adult Beagle dogs were harvested. Twelve specimens were taken to prepare canine tibial plateau collapse fracture models (Schatzker type Ⅲ) and randomly divided into groups A, B, and C, with 4 specimens in each group. Four normal tibia specimens were used as blank control group (group D). In groups A and B, the bone defects were repaired with Ni-Ti three-dimensional shape memory alloy mesh combined with autologous bone and simple autologous bone respectively, and fixed with the lateral plate and screw. In group C, the bone defect was directly fixed with the lateral plate and screw. By using a biomechanical tester, a progressive load (0-1 700 N) was loaded vertically above the femoral condyle. The maximum failure load was recorded and the stiffness was calculated according to the load-displacement curve.ResultsThe maximum failure loads in groups A, B, C, and D were (1 624.72±7.02), (1 506.57±3.37), (1 102.00±1.83), and (1 767.64±24.56) N, respectively; and the stiffnesses were (129.72±20.83), (96.54±27.05), (74.96±17.70), and (169.01±35.62) N/mm, respectively. The maximum failure load and stiffness in group A were significantly higher than those in groups B and C, but which were significantly lower than those in group D (P<0.05).ConclusionNi-Ti three-dimensional memory alloy mesh combined with autologous bone can repair the Schatzker type Ⅲ tibial plateau collapse fracture, which has better biomechanical properties than simple autologous bone grafting.

Citation： YAN Zhaokui, LIANG Yu, FANG Yue, YAO Xiangyu, MA Kunlong, HUANG Fuguo. Biomechanical study of nickel-titanium three-dimensional memory alloy mesh and autologous bone in treatment of canine tibial plateau collapse fracture. Chinese Journal of Reparative and Reconstructive Surgery, 2018, 32(6): 722-725. doi: 10.7507/1002-1892.201709068 Copy

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19.	吕晓华, 陈根元, 曲国欣, 等. 镍钛形态记忆合金环抱器与重建钢板置入内固定治疗尺桡骨中段骨折的比较. 中国组织工程研究与临床康复, 2010, 52(14): 9827-9830.
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1. Marsh JL, Slongo TF, Agel J, et al. Fracture and dislocation classification compendium-2007: Orthopaedic Trauma Association classification, database and outcomes committee. J Orthop Trauma, 2007, 21(10 Suppl): S1-133.
2. 贾涛, 张雅丽, 贾明聪. 胫骨平台骨折 225 例的流行病学特征及临床分析. 骨与关节损伤杂志, 2004, 19(9): 623-624.
3. 蔡春水, 张毅, 赵新建, 等. 胫骨平台塌陷和劈裂骨折的手术治疗. 中国矫形外科杂志, 2003, 11(23): 1611-1612.
4. 刘文亮, 肖鹏, 梁恒星, 等. 新型复合型人工气管移植实验研究. 中国修复重建外科杂志, 2013, 23(3): 330-334.
5. Wressnegger A, Kaider A, Funovics MA. Self-expanding nitinol stents of high versus low chronic outward force in de novo femoropopliteal occlusive arterial lesions (BIOFLEX-COF trial): study protocol for a randomized controlled trial. Trails, 2017, 18(1): 594.
6. Rawlinson JN. Morbidity after anterior cervical decompression and fusion. The influence of the donor site on recovery, and the results of a trial of surgibone compared to autologous bone. Acta Neurochir (Wien), 1994, 131(1-2): 106-118.
7. Blokhuis TJ, Calori GM, Schmidmaier G. Autograft versus BMPs for the treatment of non-unions: what is the evidence. Injury, 2013, 44(Suppl 1): S40-S42.
8. Boden SD. Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute. Spine (Phila Pa 1976), 2002, 27(16 Suppl 1): S26-S31.
9. Cornell CN. Osteoconductive materials and their role as substitutes for autogenous bone grafts. Orthop Clin North Am, 1999, 30(4): 591-598.
10. Lattanzi W, Pola E, Pecorini G, et al. Gene therapy for in vivo bone formation:recent advances. Eur Rev Med Pharmacol Sci, 2005, 9(3): 167-174.
11. 罗越魁, 郭鹏鸣, 李斌, 等. 镍钛合金支架联合自体心包重建长段气管的动物实验. 中国修复重建外科杂志, 2015, 11(29): 1419-1422.
12. Serrano C, Lostalé F, Rodríguez-Panadero F, et al. Tracheal self-expandable metallic stents: a comparative study of three different stents in a rabbit model. Arch Bronconeumol, 2016, 52(3): 123-130.
13. Haykal S, Salna M, Waddell TK, et al. Advances in tracheal reconstruction. Plast Reconstr Surg Glob Open, 2014, 2(7): e178.
14. 刘欣伟, 王攀峰, 付青格, 等. 动力髋螺钉结合记忆合金弓齿钉治疗股骨粗隆下 Seinsheimer Ⅴ型粉碎性骨折. 中国骨伤, 2010, 23(4): 288-290.
15. Liu X, Xu S, Zhang C, et al. Application of a shape-memory alloy internal fixator for treatment of acetabular fractures with a follow-up of two to nine years in China. Int Orthop, 2010, 34(7): 1033-1040.
16. Su J, Liu X, Yu B, et al. Shape memory Ni-Ti alloy swan-like bone connector for treatment of humeral shaft nonunion. Int Orthop, 2010, 34(3): 369-375.
17. 林斌, 王岩, 赵卫东, 等. 镍钛记忆合金网球治疗股骨头缺血性坏死的生物力学及三维有限元分析. 中国矫形外科杂志, 2003, 11(15): 1059-1062.
18. 赵定麟, 张文明. 形状记忆合金椎间关节用于颈椎病前路减压术. 中华外科杂志, 1984, 22(7): 410-412.
19. 吕晓华, 陈根元, 曲国欣, 等. 镍钛形态记忆合金环抱器与重建钢板置入内固定治疗尺桡骨中段骨折的比较. 中国组织工程研究与临床康复, 2010, 52(14): 9827-9830.
20. 王岩, 赵德伟, 王继芳, 等. 镍-钛记忆合金网球治疗成人股骨头缺血性坏死初步报告. 中华外科杂志, 1998, 36(10): 579-581.

Chinese Journal of Reparative and Reconstructive Surgery

Biomechanical study of nickel-titanium three-dimensional memory alloy mesh and autologous bone in treatment of canine tibial plateau collapse fracture

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