The application and research progress of <i>in-situ</i> tissue engineering technology in bone and cartilage repair _Chinese Journal of Reparative and Reconstructive Surgery

Authors：

XING Fei , LI Lang , LIU Ming , DUAN Xin , LONG Ye ,  XIANG Zhou

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;

Corresponding author：

XIANG Zhou, Email: xiangzhou15@hotmail.com

Keywords：

In-situ tissue engineering; cytokines; stromal-derived factor; bone repair; cartilage repair

DOI：

10.7507/1002-1892.201712118

Video：

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Objective To review the application and research progress of in-situ tissue engineering technology in bone and cartilage repair. Methods The original articles about in-situ tissue engineering technology in bone and cartilage repair were extensively reviewed and analyzed. Results In-situ tissue engineering have been shown to be effective in repairing bone defects and cartilage defects, but biological mechanisms are inadequate. At present, most of researches are mainly focused on animal experiments, and the effect of clinical repair need to be further studied. Conclusion In-situ tissue engineering technology has wide application prospects in bone and cartilage tissue engineering. However, further study on the mechanism of related cytokines need to be conducted.

Citation： XING Fei, LI Lang, LIU Ming, DUAN Xin, LONG Ye, XIANG Zhou. The application and research progress of in-situ tissue engineering technology in bone and cartilage repair . Chinese Journal of Reparative and Reconstructive Surgery, 2018, 32(10): 1358-1364. doi: 10.7507/1002-1892.201712118 Copy

1.	Karargyris O, Polyzois VD, Karabinas P, et al. Papineau debridement, Ilizarov bone transport, and negative-pressure wound closure for septic bone defects of the tibia. Eur J Orthop Surg Traumatol, 2014, 24(6): 1013-1017.
2.	Reddi AH. Morphogenesis and tissue engineering of bone and cartilage: inductive signals, stem cells, and biomimetic biomaterials. Tissue Eng, 2000, 6(4): 351-359.
3.	Sengupta D, Waldman SD, Li S. From in vitro to in situ tissue engineering. Ann Biomed Eng, 2014, 42(7): 1537-1545.
4.	Bryan DJ, Tang JB, Holway AH, et al. Enhanced peripheral nerve regeneration elicited by cell-mediated events delivered via a bioresorbable PLGA guide. J Reconstr Microsurg, 2003, 19(2): 125-134.
5.	BelemaBedada F, Uchida S, Martire A, et al. Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2. Cell Stem Cell, 2008, 2(6): 566-575.
6.	Fu WL, Xiang Z, Huang FG, et al. Coculture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells on strontium-doped calcium polyphosphate scaffolds to generate vascularized engineered bone. Tissue Eng Part A, 2015, 21(5-6): 948-959.
7.	Evans CH, Palmer GD, Pascher A, et al. Facilitated endogenous repair: making tissue engineering simple, practical, and economical. Tissue Eng, 2007, 13(8): 1987-1993.
8.	Chen FM, Wu LA, Zhang M, et al. Homing of endogenous stem/progenitor cells for in situ tissue regeneration: Promises, strategies, and translational perspectives. Biomaterials, 2011, 32(12): 3189-3209.
9.	Rosales-Rocabado JM, Kaku M, Kitami M, et al. Osteoblastic differentiation and mineralization ability of periosteum-derived cells compared with bone marrow and calvaria-derived cells. J Oral Maxillofac Surg, 2014, 72(4): 694. e1-e9.
10.	Lin Z, Fateh A, Salem DM, et al. Periosteum: biology and applications in craniofacial bone regeneration. J Dent Res, 2014, 93(2): 109-116.
11.	Kaigler D, Wang Z, Horger K, et al. VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects. J Bone Miner Res, 2006, 21(5): 735-744.
12.	He Q, Zhao Y, Chen B, et al. Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor. Acta Biomater, 2011, 7(3): 1084-1093.
13.	Guo R, Xu S, Ma L, et al. Enhanced angiogenesis of gene-activated dermal equivalent for treatment of full thickness incisional wounds in a porcine model. Biomaterials, 2010, 31(28): 7308-7320.
14.	Wu S, Wang Z, Bharadwaj S, et al. Implantation of autologous urine derived stem cells expressing vascular endothelial growth factor for potential use in genitourinary reconstruction. J Urol, 2011, 186(2): 640-647.
15.	Fu WL, Xiang Z, Huang FG, et al. Combination of granulocyte colony-stimulating factor and CXCR4 antagonist AMD3100 for effective harvest of endothelial progenitor cells from peripheral blood and in vitro formation of primitive endothelial networks. Cell Tissue Bank, 2016, 17(1): 161-169.
16.	Thevenot PT, Nair AM, Shen J, et al. The effect of incorporation of SDF-1alpha into PLGA scaffolds on stem cell recruitment and the inflammatory response. Biomaterials, 2010, 31(14): 3997-4008.
17.	Liu X, Zhou C, Li Y, et al. SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition. PLoS One, 2013, 8(1): e54077.
18.	Binger T, Stich S, Andreas K, et al. Migration potential and gene expression profile of human mesenchymal stem cells induced by CCL25. Exp Cell Res, 2009, 315(8): 1468-1479.
19.	Ringe J, Strassburg S, Neumann K, et al. Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2. J Cell Biochem, 2007, 101(1): 135-146.
20.	Pin AL, Houle F, Fournier P, et al. Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression. J Biol Chem, 2012, 287(36): 30541-30551.
21.	Cheng P, Gao ZQ, Liu YH, et al. Platelet-derived growth factor BB promotes the migration of bone marrow-derived mesenchymal stem cells towards C6 glioma and up-regulates the expression of intracellular adhesion molecule-1. Neurosci Lett, 2009, 451(1): 52-56.
22.	Chamberlain G, Smith H, Rainger GE, et al. Mesenchymal stem cells exhibit firm adhesion, crawling, spreading and transmigration across aortic endothelial cells: effects of chemokines and shear. PLoS One, 2011, 6(9): e25663.
23.	Bader AR, Li T, Wang W, et al. Preparation and characterization of SDF-1α-chitosan-dextran sulfate nanoparticles. J Vis Exp, 2015, (95): 52323.
24.	Dutta D, Fauer C, Mulleneux HL, et al. Tunable controlled release of bioactive SDF-1α via protein specific interactions within fibrin/nanoparticle composites. J Mater Chem B, 2015, 3(40): 7963-7973.
25.	Tang T, Jiang H, Yu Y, et al. A new method of wound treatment: targeted therapy of skin wounds with reactive oxygen species-responsive nanoparticles containing SDF-1α. Int J Nanomedicine, 2015, 10: 6571-6585.
26.	Kao WT, Lin CY, Lee LT, et al. Investigation of MMP-2 and -9 in a highly invasive A431 tumor cell sub-line selected from a Boyden chamber assay. Anticancer Res, 2008, 28(4B): 2109-2120.
27.	Wang D, Zhu H, Liu Y, et al. The low chamber pancreatic cancer cells had stem-like characteristics in modified transwell system: is it a novel method to identify and enrich cancer stem-like cells? Biomed Res Int, 2014, 2014: 760303.
28.	Chang NJ, Jhung YR, Yao CK, et al. Hydrophilic gelatin and hyaluronic acid-treated PLGA scaffolds for cartilage tissue engineering. J Appl Biomater Funct Mater, 2013, 11(1): e45-e52.
29.	Rezwan K, Chen QZ, Blaker JJ, et al. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials, 2006, 27(18): 3413-3431.
30.	Singh D, Singh MR. Development of antibiotic and debriding enzyme-loaded PLGA microspheres entrapped in PVA-gelatin hydrogel for complete wound management. Artif Cells Blood Substit Immobil Biotechnol, 2012, 40(5): 345-353.
31.	Sharifiaghdas F, Naji M, Sarhangnejad R, et al. Comparing supportive properties of poly lactic-co-glycolic acid (PLGA), PLGA/collagen and human amniotic membrane for human urothelial and smooth muscle cells engineering. Urol J, 2014, 11(3): 1620-1628.
32.	Castilho M, Moseke C, Ewald A, et al. Direct 3D powder printing of biphasic calcium phosphate scaffolds for substitution of complex bone defects. Biofabrication, 2014, 6(1): 015006.
33.	Ouyang L, Yao R, Chen X, et al. 3D printing of HEK 293FT cell-laden hydrogel into macroporous constructs with high cell viability and normal biological functions. Biofabrication, 2015, 7(1): 015010.
34.	Xu QC, Wang ZG, Ji QX, et al. Systemically transplanted human gingiva-derived mesenchymal stem cells contributing to bone tissue regeneration. Int J Clin Exp Pathol, 2014, 7(8): 4922-4929.
35.	Sahota PS, Burn JL, Brown NJ, et al. Approaches to improve angiogenesis in tissue-engineered skin. Wound Repair Regen, 2004, 12(6): 635-642.
36.	Li S, Tu Q, Zhang J, et al. Systemically transplanted bone marrow stromal cells contributing to bone tissue regeneration. J Cell Physiol, 2008, 215(1): 204-209.
37.	Dashnyam K, Perez R, Lee EJ, et al. Hybrid scaffolds of gelatin-siloxane releasing stromal derived factor-1 effective for cell recruitment. J Biomed Mater Res A, 2014, 102(6): 1859-1867.
38.	Eman RM, Oner FC, Kruyt MC, et al. Stromal cell-derived factor-1 stimulates cell recruitment, vascularization and osteogenic differentiation. Tissue Eng Part A, 2014, 20(3-4): 466-473.
39.	Niu LN, Jiao K, Qi YP, et al. Intrafibrillar silicification of collagen scaffolds for sustained release of stem cell homing chemokine in hard tissue regeneration. FASEB J, 2012, 26(11): 4517-4529.
40.	Jin Q, Giannobile WV. SDF-1 enhances wound healing of critical-sized calvarial defects beyond self-repair capacity. PLoS One, 2014, 9(5): e97035.
41.	Shi J, Sun J, Zhang W, et al. Demineralized bone matrix scaffolds modified by CBD-SDF-1α promote bone regeneration via recruiting endogenous stem cells. ACS Appl Mater Interfaces, 2016. [Epub ahead of print].
42.	Jovanovic SA, Hunt DR, Bernard GW, et al. Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects. Clin Oral Implants Res, 2007, 18(2): 224-230.
43.	Allegrini S Jr, Yoshimoto M, Salles MB, et al. The effects of bovine BMP associated to HA in maxillary sinus lifting in rabbits. Ann Anat, 2003, 185(4): 343-349.
44.	Sun JL, Jiao K, Niu LN, et al. Intrafibrillar silicified collagen scaffold modulates monocyte to promote cell homing, angiogenesis and bone regeneration. Biomaterials, 2017, 113: 203-216.
45.	Cook SD, Patron LP, Salkeld SL, et al. Repair of articular cartilage defects with osteogenic protein-1(BMP-7) in dogs. J Bone Joint Surg Am, 2003, 85-A(Suppl 3): 116-123.
46.	Filová E, Rampichová M, Litvinec A, et al. A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs. Int J Pharm, 2013, 447(1-2): 139-149.
47.	Chen P, Tao J, Zhu S, et al. Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing. Biomaterials, 2015, 39: 114-123.
48.	张洪亮, 姜鑫, 张健. 微骨折术联合关节内注射tPRP修复兔膝关节软骨缺损的观察. 辽宁医学院学报, 2013, 34(2): 27-29.
49.	Dai Y, Shen T, Ma L, et al. Regeneration of osteochondral defects in vivo by a cell-free cylindrical poly (lactide-co-glycolide) scaffold with a radially oriented microstructure. J Tissue Eng Regen Med, 2018, 12(3): e1647-e1661.

1. Karargyris O, Polyzois VD, Karabinas P, et al. Papineau debridement, Ilizarov bone transport, and negative-pressure wound closure for septic bone defects of the tibia. Eur J Orthop Surg Traumatol, 2014, 24(6): 1013-1017.
2. Reddi AH. Morphogenesis and tissue engineering of bone and cartilage: inductive signals, stem cells, and biomimetic biomaterials. Tissue Eng, 2000, 6(4): 351-359.
3. Sengupta D, Waldman SD, Li S. From in vitro to in situ tissue engineering. Ann Biomed Eng, 2014, 42(7): 1537-1545.
4. Bryan DJ, Tang JB, Holway AH, et al. Enhanced peripheral nerve regeneration elicited by cell-mediated events delivered via a bioresorbable PLGA guide. J Reconstr Microsurg, 2003, 19(2): 125-134.
5. BelemaBedada F, Uchida S, Martire A, et al. Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2. Cell Stem Cell, 2008, 2(6): 566-575.
6. Fu WL, Xiang Z, Huang FG, et al. Coculture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells on strontium-doped calcium polyphosphate scaffolds to generate vascularized engineered bone. Tissue Eng Part A, 2015, 21(5-6): 948-959.
7. Evans CH, Palmer GD, Pascher A, et al. Facilitated endogenous repair: making tissue engineering simple, practical, and economical. Tissue Eng, 2007, 13(8): 1987-1993.
8. Chen FM, Wu LA, Zhang M, et al. Homing of endogenous stem/progenitor cells for in situ tissue regeneration: Promises, strategies, and translational perspectives. Biomaterials, 2011, 32(12): 3189-3209.
9. Rosales-Rocabado JM, Kaku M, Kitami M, et al. Osteoblastic differentiation and mineralization ability of periosteum-derived cells compared with bone marrow and calvaria-derived cells. J Oral Maxillofac Surg, 2014, 72(4): 694. e1-e9.
10. Lin Z, Fateh A, Salem DM, et al. Periosteum: biology and applications in craniofacial bone regeneration. J Dent Res, 2014, 93(2): 109-116.
11. Kaigler D, Wang Z, Horger K, et al. VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects. J Bone Miner Res, 2006, 21(5): 735-744.
12. He Q, Zhao Y, Chen B, et al. Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor. Acta Biomater, 2011, 7(3): 1084-1093.
13. Guo R, Xu S, Ma L, et al. Enhanced angiogenesis of gene-activated dermal equivalent for treatment of full thickness incisional wounds in a porcine model. Biomaterials, 2010, 31(28): 7308-7320.
14. Wu S, Wang Z, Bharadwaj S, et al. Implantation of autologous urine derived stem cells expressing vascular endothelial growth factor for potential use in genitourinary reconstruction. J Urol, 2011, 186(2): 640-647.
15. Fu WL, Xiang Z, Huang FG, et al. Combination of granulocyte colony-stimulating factor and CXCR4 antagonist AMD3100 for effective harvest of endothelial progenitor cells from peripheral blood and in vitro formation of primitive endothelial networks. Cell Tissue Bank, 2016, 17(1): 161-169.
16. Thevenot PT, Nair AM, Shen J, et al. The effect of incorporation of SDF-1alpha into PLGA scaffolds on stem cell recruitment and the inflammatory response. Biomaterials, 2010, 31(14): 3997-4008.
17. Liu X, Zhou C, Li Y, et al. SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition. PLoS One, 2013, 8(1): e54077.
18. Binger T, Stich S, Andreas K, et al. Migration potential and gene expression profile of human mesenchymal stem cells induced by CCL25. Exp Cell Res, 2009, 315(8): 1468-1479.
19. Ringe J, Strassburg S, Neumann K, et al. Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2. J Cell Biochem, 2007, 101(1): 135-146.
20. Pin AL, Houle F, Fournier P, et al. Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression. J Biol Chem, 2012, 287(36): 30541-30551.
21. Cheng P, Gao ZQ, Liu YH, et al. Platelet-derived growth factor BB promotes the migration of bone marrow-derived mesenchymal stem cells towards C6 glioma and up-regulates the expression of intracellular adhesion molecule-1. Neurosci Lett, 2009, 451(1): 52-56.
22. Chamberlain G, Smith H, Rainger GE, et al. Mesenchymal stem cells exhibit firm adhesion, crawling, spreading and transmigration across aortic endothelial cells: effects of chemokines and shear. PLoS One, 2011, 6(9): e25663.
23. Bader AR, Li T, Wang W, et al. Preparation and characterization of SDF-1α-chitosan-dextran sulfate nanoparticles. J Vis Exp, 2015, (95): 52323.
24. Dutta D, Fauer C, Mulleneux HL, et al. Tunable controlled release of bioactive SDF-1α via protein specific interactions within fibrin/nanoparticle composites. J Mater Chem B, 2015, 3(40): 7963-7973.
25. Tang T, Jiang H, Yu Y, et al. A new method of wound treatment: targeted therapy of skin wounds with reactive oxygen species-responsive nanoparticles containing SDF-1α. Int J Nanomedicine, 2015, 10: 6571-6585.
26. Kao WT, Lin CY, Lee LT, et al. Investigation of MMP-2 and -9 in a highly invasive A431 tumor cell sub-line selected from a Boyden chamber assay. Anticancer Res, 2008, 28(4B): 2109-2120.
27. Wang D, Zhu H, Liu Y, et al. The low chamber pancreatic cancer cells had stem-like characteristics in modified transwell system: is it a novel method to identify and enrich cancer stem-like cells? Biomed Res Int, 2014, 2014: 760303.
28. Chang NJ, Jhung YR, Yao CK, et al. Hydrophilic gelatin and hyaluronic acid-treated PLGA scaffolds for cartilage tissue engineering. J Appl Biomater Funct Mater, 2013, 11(1): e45-e52.
29. Rezwan K, Chen QZ, Blaker JJ, et al. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials, 2006, 27(18): 3413-3431.
30. Singh D, Singh MR. Development of antibiotic and debriding enzyme-loaded PLGA microspheres entrapped in PVA-gelatin hydrogel for complete wound management. Artif Cells Blood Substit Immobil Biotechnol, 2012, 40(5): 345-353.
31. Sharifiaghdas F, Naji M, Sarhangnejad R, et al. Comparing supportive properties of poly lactic-co-glycolic acid (PLGA), PLGA/collagen and human amniotic membrane for human urothelial and smooth muscle cells engineering. Urol J, 2014, 11(3): 1620-1628.
32. Castilho M, Moseke C, Ewald A, et al. Direct 3D powder printing of biphasic calcium phosphate scaffolds for substitution of complex bone defects. Biofabrication, 2014, 6(1): 015006.
33. Ouyang L, Yao R, Chen X, et al. 3D printing of HEK 293FT cell-laden hydrogel into macroporous constructs with high cell viability and normal biological functions. Biofabrication, 2015, 7(1): 015010.
34. Xu QC, Wang ZG, Ji QX, et al. Systemically transplanted human gingiva-derived mesenchymal stem cells contributing to bone tissue regeneration. Int J Clin Exp Pathol, 2014, 7(8): 4922-4929.
35. Sahota PS, Burn JL, Brown NJ, et al. Approaches to improve angiogenesis in tissue-engineered skin. Wound Repair Regen, 2004, 12(6): 635-642.
36. Li S, Tu Q, Zhang J, et al. Systemically transplanted bone marrow stromal cells contributing to bone tissue regeneration. J Cell Physiol, 2008, 215(1): 204-209.
37. Dashnyam K, Perez R, Lee EJ, et al. Hybrid scaffolds of gelatin-siloxane releasing stromal derived factor-1 effective for cell recruitment. J Biomed Mater Res A, 2014, 102(6): 1859-1867.
38. Eman RM, Oner FC, Kruyt MC, et al. Stromal cell-derived factor-1 stimulates cell recruitment, vascularization and osteogenic differentiation. Tissue Eng Part A, 2014, 20(3-4): 466-473.
39. Niu LN, Jiao K, Qi YP, et al. Intrafibrillar silicification of collagen scaffolds for sustained release of stem cell homing chemokine in hard tissue regeneration. FASEB J, 2012, 26(11): 4517-4529.
40. Jin Q, Giannobile WV. SDF-1 enhances wound healing of critical-sized calvarial defects beyond self-repair capacity. PLoS One, 2014, 9(5): e97035.
41. Shi J, Sun J, Zhang W, et al. Demineralized bone matrix scaffolds modified by CBD-SDF-1α promote bone regeneration via recruiting endogenous stem cells. ACS Appl Mater Interfaces, 2016. [Epub ahead of print].
42. Jovanovic SA, Hunt DR, Bernard GW, et al. Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects. Clin Oral Implants Res, 2007, 18(2): 224-230.
43. Allegrini S Jr, Yoshimoto M, Salles MB, et al. The effects of bovine BMP associated to HA in maxillary sinus lifting in rabbits. Ann Anat, 2003, 185(4): 343-349.
44. Sun JL, Jiao K, Niu LN, et al. Intrafibrillar silicified collagen scaffold modulates monocyte to promote cell homing, angiogenesis and bone regeneration. Biomaterials, 2017, 113: 203-216.
45. Cook SD, Patron LP, Salkeld SL, et al. Repair of articular cartilage defects with osteogenic protein-1(BMP-7) in dogs. J Bone Joint Surg Am, 2003, 85-A(Suppl 3): 116-123.
46. Filová E, Rampichová M, Litvinec A, et al. A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs. Int J Pharm, 2013, 447(1-2): 139-149.
47. Chen P, Tao J, Zhu S, et al. Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing. Biomaterials, 2015, 39: 114-123.
48. 张洪亮, 姜鑫, 张健. 微骨折术联合关节内注射tPRP修复兔膝关节软骨缺损的观察. 辽宁医学院学报, 2013, 34(2): 27-29.
49. Dai Y, Shen T, Ma L, et al. Regeneration of osteochondral defects in vivo by a cell-free cylindrical poly (lactide-co-glycolide) scaffold with a radially oriented microstructure. J Tissue Eng Regen Med, 2018, 12(3): e1647-e1661.

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The application and research progress of in-situ tissue engineering technology in bone and cartilage repair

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