• 1. Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;
  • 2. Department of Spinal Surgery, Weifang People’s Hospital, Weifang Shandong, 261000, P.R.China;
WANG Guanglin, Email: wglfrank@163.com
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Objective  To review the research progress of graphene and its derivatives in repair of peripheral nerve defect. Methods  The related literature of graphene and its derivatives in repair of peripheral nerve defect in recent years was extensively reviewed. Results  It is confirmed by in vitro and in vivo experiments that graphene and its derivatives can promote cell adhesion, proliferation, differentiation and neurite growth effectively. They have good electrical conductivity, excellent mechanical properties, larger specific surface area, and other advantages when compared with traditional materials. The three-dimensional scaffold can improve the effect of nerve repair. Conclusion  The metabolic pathways and long-term reaction of graphene and its derivatives in the body are unclear. How to regulate their biodegradation and explain the electric coupling reaction mechanism between cells and materials also need to be further explored.

Citation: YAO Ruzhan, WANG Bingwu, WANG Guanglin. Research progress of graphene and its derivatives in repair of peripheral nerve defect. Chinese Journal of Reparative and Reconstructive Surgery, 2018, 32(11): 1483-1487. doi: 10.7507/1002-1892.201804096 Copy

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