Effects of cartilage progenitor cells and microRNA-140 on repair of osteoarthritic cartilage injury_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

SI Haibo , LIANG Mingwei , CHENG Jingqiu ,  SHEN Bin

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;

Corresponding author：

SHEN Bin, Email: shenbin_1971@163.com

Keywords：

Osteoarthritis; cartilage progenitor cells; microRNA-140; repair of cartilage injury

DOI：

10.7507/1002-1892.201806060

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the effect of cartilage progenitor cells (CPCs) and microRNA-140 (miR-140) on the repair of osteoarthritic cartilage injury, and analyze their clinical prospects. Methods The recent researches regarding the CPCs, miR-140, and repair of cartilage in osteoarthritis (OA) disease were extensively reviewed and summarized. Results CPCs possess the characteristics of self-proliferation, expression of stem cell markers, and multi-lineage differentiation potential, and their chondrogenic ability is superior to other tissues-derived mesenchymal stem cells. CPCs are closely related to the development of OA, but the autonomic activation and chondrogenic ability of CPCs around the osteoarthritic cartilage lesion cannot meet the requirements of complete cartilage repair. miR-140 specifically express in cartilage, and has the potential to activate CPCs by inhibiting key molecules of Notch signaling pathway and enhance its chondrogenic ability, thus promoting the repair of osteoarthritic cartilage injury. Intra-articular delivery of drugs is one of the main methods of OA treatment, although intra-articular injection of miR-140 has a significant inhibitory effect on cartilage degeneration in rats, it also exhibit some limitations such as non-targeted aggregation, low bioavailability, and rapid clearance. So it is a good application prospect to construct a carrier with good safety, cartilage targeting, and high-efficiency for miR-140 based on articular cartilage characteristics. In addition, CPCs are mainly dispersed in the cartilage surface, while OA cartilage injury also begins from this layer, it is therefore essential to emphasize early intervention of OA. Conclusion miR-140 has the potential to activate CPCs and promote the repair of cartilage injury in early OA, and it is of great clinical significance to further explore the role of miR-140 in OA etiology and to develop new OA treatment strategies based on miR-140.

Citation： SI Haibo, LIANG Mingwei, CHENG Jingqiu, SHEN Bin. Effects of cartilage progenitor cells and microRNA-140 on repair of osteoarthritic cartilage injury. Chinese Journal of Reparative and Reconstructive Surgery, 2019, 33(5): 650-658. doi: 10.7507/1002-1892.201806060 Copy

1.	Loeser RF, Collins JA, Diekman BO. Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol, 2016, 12(7): 412-420.
2.	Park YB, Ha CW, Rhim JH, et al. Stem cell therapy for articular cartilage repair: review of the entity of cell populations used and the result of the clinical application of each entity. Am J Sports Med, 2018, 46(10): 2540-2552.
3.	McGonagle D, Baboolal TG, Jones E. Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis. Nat Rev Rheumatol, 2017, 13(12): 719-730.
4.	Zhang R, Ma J, Yao J. Molecular mechanisms of the cartilage-specific microRNA-140 in osteoarthritis. Inflamm Res, 2013, 62(10): 871-877.
5.	Miyaki S, Sato T, Inoue A, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev, 2010, 24(11): 1173-1185.
6.	陈蓟, 雷鸣, 刘弼, 等. MicroRNA 与骨关节炎. 中国矫形外科杂志, 2017, 25(19): 1783-1787.
7.	Mahboudi H, Soleimani M, Enderami SE, et al. Enhanced chondrogenesis differentiation of human induced pluripotent stem cells by MicroRNA-140 and transforming growth factor beta 3 (TGFβ3). Biologicals, 2018, 52: 30-36.
8.	Chen D, Shen J, Zhao W, et al. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res, 2017, 5: 16044.
9.	Lee WY, Wang B. Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives. J Orthop Translat, 2017, 9: 76-88.
10.	Li CY, Wu XY, Tong JB, et al. Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy. Stem Cell Res Ther, 2015, 6: 55.
11.	符培亮, 丛锐军, 陈松, 等. 滑膜间充质干细胞成纤维软骨分化条件初步探索. 中国修复重建外科杂志, 2015, 29(1): 81-91.
12.	张金丽, 刘志河, 汤文彬, 等. 大鼠脂肪来源干细胞对紫外线造成的软骨细胞 DNA 损伤的修复作用研究. 中国修复重建外科杂志, 2017, 31(5): 600-606.
13.	Confalonieri D, Schwab A, Walles H, et al. Advanced therapy medicinal products: a guide for bone marrow-derived MSC application in bone and cartilage tissue engineering. Tissue Eng Part B Rev, 2018, 24(2): 155-169.
14.	Goldberg A, Mitchell K, Soans J, et al. The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review. J Orthop Surg Res, 2017, 12(1): 39.
15.	Barbero A, Ploegert S, Heberer M, et al. Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes. Arthritis Rheum, 2003, 48(5): 1315-1325.
16.	Mantripragada VP, Bova WA, Boehm C, et al. Progenitor cells from different zones of human cartilage and their correlation with histopathological osteoarthritis progression. J Orthop Res, 2018, 38(6): 1728-1738.
17.	周建新, 杨晓斐, 李阳, 等. 软骨前体细胞的分离鉴定及 IL-1β 对其成软骨分化的影响. 中国修复重建外科杂志, 2015, 29(7): 863-869.
18.	Jiang Y, Cai Y, Zhang W, et al. Human cartilage-derived progenitor cells from committed chondrocytes for efficient cartilage repair and regeneration. Stem Cells Transl Med, 2016, 5(6): 733-744.
19.	Galipeau J, Krampera M, Barrett J, et al. International society for cellular therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials. Cytotherapy, 2016, 18(2): 151-159.
20.	Pretzel D, Linss S, Rochler S, et al. Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage. Arthritis Res Ther, 2011, 13(2): R64.
21.	Alsalameh S, Amin R, Gemba T, et al. Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage. Arthritis Rheum, 2004, 50(5): 1522-1532.
22.	Mazor M, Cesaro A, Ali M, et al. Progenitor cells from cartilage: grade specific differences in stem cell marker expression. Int J Mol Sci, 2017, 18(8): E1759.
23.	Xia Z, Ma P, Wu N, et al. Altered function in cartilage derived mesenchymal stem cell leads to OA-related cartilage erosion. Am J Transl Res, 2016, 8(2): 433-446.
24.	Seol D, McCabe DJ, Choe H, et al. Chondrogenic progenitor cells respond to cartilage injury. Arthritis Rheum, 2012, 64(11): 3626-3637.
25.	McCarthy HE, Bara JJ, Brakspear K, et al. The comparison of equine articular cartilage progenitor cells and bone marrow-derived stromal cells as potential cell sources for cartilage repair in the horse. Vet J, 2012, 192(3): 345-351.
26.	Tao T, Li Y, Gui C, et al. Fibronectin enhances cartilage repair by activating progenitor cells through integrin α5β1 receptor. Int J Mol Sci, 2018, 24(13-14): 1112-1124.
27.	Borakati A, Mafi R, Mafi P, et al. A systematic review and meta-analysis of clinical trials of mesenchymal stem cell therapy for cartilage repair. Curr Stem Cell Res Ther, 2018, 13(3): 215-225.
28.	Kumar H, Ha DH, Lee EJ, et al. Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study. Stem Cell Res Ther, 2017, 8(1): 262.
29.	Al-Najar M, Khalil H, Al-Ajlouni J, et al. Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase Ⅰ/Ⅱ study. J Orthop Surg Res, 2017, 12(1): 190.
30.	Togo T, Utani A, Naitoh M, et al. Identification of cartilage progenitor cells in the adult ear perichondrium: utilization for cartilage reconstruction. Lab Invest, 2006, 86(5): 445-457.
31.	Takebe T, Kobayashi S, Kan H, et al. Human elastic cartilage engineering from cartilage progenitor cells using rotating wall vessel bioreactor. Transplant Proc, 2012, 44(4): 1158-1161.
32.	Nugent M. MicroRNAs: exploring new horizons in osteoarthritis. Osteoarthritis Cartilage, 2016, 24(4): 573-580.
33.	冀全博, 徐亚梦, 王岩. miRNA 与骨关节炎软骨基质降解的研究进展. 中国修复重建外科杂志, 2016, 30(11): 1431-1436.
34.	Araldi E, Schipani E. MicroRNA-140 and the silencing of osteoarthritis. Genes Dev, 2010, 24(11): 1075-1080.
35.	Miyaki S, Nakasa T, Otsuki S, et al. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum, 2009, 60(9): 2723-2730.
36.	Swingler TE, Wheeler G, Carmont V, et al. The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis Rheum, 2012, 64(6): 1909-1919.
37.	张明, 刘立宏, 肖涛, 等. 实时荧光定量 PCR 检测骨性关节病人膝关节液中 miR-140 的表达. 中南大学学报 (医学版), 2012, 37(12): 1210-1214.
38.	Si HB, Zeng Y, Liu SY, et al. Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats. Osteoarthritis Cartilage, 2017, 25(10): 1698-1707.
39.	Si H, Zeng Y, Zhou Z, et al. Expression of miRNA-140 in chondrocytes and synovial fluid of knee joints in patients with osteoarthritis. Chin Med Sci J, 2016, 31(4): 207-212.
40.	Papaioannou G, Mirzamohammadi F, Lisse TS, et al. MicroRNA-140 provides robustness to the regulation of hypertrophic chondrocyte differentiation by the PTHrP-HDAC4 pathway. J Bone Miner Res, 2015, 30(6): 1044-1052.
41.	张洋洋, 彭效祥, 宋伟, 等. 核定位信号肽偶联核激酶底物短肽修饰壳聚糖介导微小 RNA-140 对兔关节软骨细胞作用的研究. 中国修复重建外科杂志, 2017, 31(10): 1256-1261.
42.	Hossein M, Masoud S, Hana HA, et al. New approach for differentiation of bone marrow mesenchymal stem cells toward chondrocyte cells with overexpression of microRNA-140. ASAIO J, 2018, 64(5): 662-672.
43.	Cao Z, Liu C, Bai Y, et al. Inhibitory effect of dihydroartemisinin on chondrogenic and hypertrophic differentiation of mesenchymal stem cells. Am J Transl Res, 2017, 9(6): 2748-2759.
44.	Grogan SP, Miyaki S, Asahara H, et al. Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis. Arthritis Res Ther, 2009, 11(3): R85.
45.	Li F, Shi W, Wan Y, et al. Prediction of target genes for miR-140-5p in pulmonary arterial hypertension using bioinformatics methods. FEBS Open Bio, 2017, 7(12): 1880-1890.
46.	Khayrullin A, Smith L, Mistry D, et al. Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. Biochem Biophys Res Commun, 2016, 479(3): 590-595.
47.	杨体敏, 斯海波, 吴元刚, 等. 收肌管神经阻滞联合环氧合酶 2 选择性抑制剂在人工全膝关节置换术后的序贯应用及疗效. 中国修复重建外科杂志, 2016, 30(9): 1065-1071.
48.	Si HB, Zeng Y, Shen B, et al. The influence of body mass index on the outcomes of primary total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc, 2015, 23(6): 1824-1832.
49.	Blasioli DJ, Kaplan DL. The roles of catabolic factors in the development of osteoarthritis. Tissue Eng Part B Rev, 2014, 20(4): 355-363.
50.	Liang ZJ, Zhuang H, Wang GX, et al. MiRNA-140 is a negative feedback regulator of MMP-13 in IL-1beta-stimulated human articular chondrocyte C28/I2 cells. Inflamm Res, 2012, 61(5): 503-509.
51.	Mackie EJ, Ahmed YA, Tatarczuch L, et al. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol, 2008, 40(1): 46-62.
52.	Orfanidou T, Iliopoulos D, Malizos KN, et al. Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes. J Cell Mol Med, 2009, 13(9b): 3186-3194.
53.	Chen CG, Thuillier D, Chin EN, et al. Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis. Arthritis Rheum, 2012, 64(10): 3278-3289.
54.	Javed A, Afzal F, Bae JS, et al. Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation. Cells Tissues Organs, 2009, 189(1-4): 133-137.
55.	Finnson KW, Chi Y, Bou-Gharios G, et al. TGF-b signaling in cartilage homeostasis and osteoarthritis. Front Biosci (Schol Ed), 2012, 4: 251-268.
56.	Varshney A, Panda JJ, Singh AK, et al. Targeted delivery of microRNA-199a-3p using self-assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice. Hepatology, 2018, 67(4): 1392-1407.
57.	Kawanishi Y, Nakasa T, Shoji T, et al. Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model. Arthritis Res Ther, 2014, 16(6): 488.
58.	Bottini M, Bhattacharya K, Fadeel B, et al. Nanodrugs to target articular cartilage: an emerging platform for osteoarthritis therapy. Nanomedicine, 2016, 12(2): 255-268.
59.	Maudens P, Meyer S, Seemayer CA, et al. Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy. Nanoscale, 2018, 10(4): 1845-1854.
60.	黄勇, 丰干钧, 刘立岷, 等. 椎间盘退变中微小 RNA 及其非病毒载体的研究进展. 中国修复重建外科杂志, 2017, 31(1): 116-121.
61.	Peng JS, Chen SY, Wu CL, et al. Amelioration of experimental autoimmune arthritis through targeting of synovial fibroblasts by intraarticular delivery of microRNAs 140-3p and 140-5p. Arthritis Rheumatol, 2016, 68(2): 370-381.
62.	Li R, Xu J, Wong DSH, et al. Self-assembled N-cadherin mimetic peptide hydrogels promote the chondrogenesis of mesenchymal stem cells through inhibition of canonical Wnt/beta-catenin signaling. Biomaterials, 2017, 145: 33-43.
63.	Bajpayee AG, Grodzinsky AJ. Cartilage-targeting drug delivery: can electrostatic interactions help? Nat Rev Rheumatol, 2017, 13(3): 183-193.
64.	Xiao X, Wang X, Wang Y, et al. Multi-functional peptide-microRNA nanocomplex for targeted microRNA delivery and function imaging. Chemistry, 2018, 24(9): 2277-2285.

1. Loeser RF, Collins JA, Diekman BO. Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol, 2016, 12(7): 412-420.
2. Park YB, Ha CW, Rhim JH, et al. Stem cell therapy for articular cartilage repair: review of the entity of cell populations used and the result of the clinical application of each entity. Am J Sports Med, 2018, 46(10): 2540-2552.
3. McGonagle D, Baboolal TG, Jones E. Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis. Nat Rev Rheumatol, 2017, 13(12): 719-730.
4. Zhang R, Ma J, Yao J. Molecular mechanisms of the cartilage-specific microRNA-140 in osteoarthritis. Inflamm Res, 2013, 62(10): 871-877.
5. Miyaki S, Sato T, Inoue A, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev, 2010, 24(11): 1173-1185.
6. 陈蓟, 雷鸣, 刘弼, 等. MicroRNA 与骨关节炎. 中国矫形外科杂志, 2017, 25(19): 1783-1787.
7. Mahboudi H, Soleimani M, Enderami SE, et al. Enhanced chondrogenesis differentiation of human induced pluripotent stem cells by MicroRNA-140 and transforming growth factor beta 3 (TGFβ3). Biologicals, 2018, 52: 30-36.
8. Chen D, Shen J, Zhao W, et al. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res, 2017, 5: 16044.
9. Lee WY, Wang B. Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives. J Orthop Translat, 2017, 9: 76-88.
10. Li CY, Wu XY, Tong JB, et al. Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy. Stem Cell Res Ther, 2015, 6: 55.
11. 符培亮, 丛锐军, 陈松, 等. 滑膜间充质干细胞成纤维软骨分化条件初步探索. 中国修复重建外科杂志, 2015, 29(1): 81-91.
12. 张金丽, 刘志河, 汤文彬, 等. 大鼠脂肪来源干细胞对紫外线造成的软骨细胞 DNA 损伤的修复作用研究. 中国修复重建外科杂志, 2017, 31(5): 600-606.
13. Confalonieri D, Schwab A, Walles H, et al. Advanced therapy medicinal products: a guide for bone marrow-derived MSC application in bone and cartilage tissue engineering. Tissue Eng Part B Rev, 2018, 24(2): 155-169.
14. Goldberg A, Mitchell K, Soans J, et al. The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review. J Orthop Surg Res, 2017, 12(1): 39.
15. Barbero A, Ploegert S, Heberer M, et al. Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes. Arthritis Rheum, 2003, 48(5): 1315-1325.
16. Mantripragada VP, Bova WA, Boehm C, et al. Progenitor cells from different zones of human cartilage and their correlation with histopathological osteoarthritis progression. J Orthop Res, 2018, 38(6): 1728-1738.
17. 周建新, 杨晓斐, 李阳, 等. 软骨前体细胞的分离鉴定及 IL-1β 对其成软骨分化的影响. 中国修复重建外科杂志, 2015, 29(7): 863-869.
18. Jiang Y, Cai Y, Zhang W, et al. Human cartilage-derived progenitor cells from committed chondrocytes for efficient cartilage repair and regeneration. Stem Cells Transl Med, 2016, 5(6): 733-744.
19. Galipeau J, Krampera M, Barrett J, et al. International society for cellular therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials. Cytotherapy, 2016, 18(2): 151-159.
20. Pretzel D, Linss S, Rochler S, et al. Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage. Arthritis Res Ther, 2011, 13(2): R64.
21. Alsalameh S, Amin R, Gemba T, et al. Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage. Arthritis Rheum, 2004, 50(5): 1522-1532.
22. Mazor M, Cesaro A, Ali M, et al. Progenitor cells from cartilage: grade specific differences in stem cell marker expression. Int J Mol Sci, 2017, 18(8): E1759.
23. Xia Z, Ma P, Wu N, et al. Altered function in cartilage derived mesenchymal stem cell leads to OA-related cartilage erosion. Am J Transl Res, 2016, 8(2): 433-446.
24. Seol D, McCabe DJ, Choe H, et al. Chondrogenic progenitor cells respond to cartilage injury. Arthritis Rheum, 2012, 64(11): 3626-3637.
25. McCarthy HE, Bara JJ, Brakspear K, et al. The comparison of equine articular cartilage progenitor cells and bone marrow-derived stromal cells as potential cell sources for cartilage repair in the horse. Vet J, 2012, 192(3): 345-351.
26. Tao T, Li Y, Gui C, et al. Fibronectin enhances cartilage repair by activating progenitor cells through integrin α5β1 receptor. Int J Mol Sci, 2018, 24(13-14): 1112-1124.
27. Borakati A, Mafi R, Mafi P, et al. A systematic review and meta-analysis of clinical trials of mesenchymal stem cell therapy for cartilage repair. Curr Stem Cell Res Ther, 2018, 13(3): 215-225.
28. Kumar H, Ha DH, Lee EJ, et al. Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study. Stem Cell Res Ther, 2017, 8(1): 262.
29. Al-Najar M, Khalil H, Al-Ajlouni J, et al. Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase Ⅰ/Ⅱ study. J Orthop Surg Res, 2017, 12(1): 190.
30. Togo T, Utani A, Naitoh M, et al. Identification of cartilage progenitor cells in the adult ear perichondrium: utilization for cartilage reconstruction. Lab Invest, 2006, 86(5): 445-457.
31. Takebe T, Kobayashi S, Kan H, et al. Human elastic cartilage engineering from cartilage progenitor cells using rotating wall vessel bioreactor. Transplant Proc, 2012, 44(4): 1158-1161.
32. Nugent M. MicroRNAs: exploring new horizons in osteoarthritis. Osteoarthritis Cartilage, 2016, 24(4): 573-580.
33. 冀全博, 徐亚梦, 王岩. miRNA 与骨关节炎软骨基质降解的研究进展. 中国修复重建外科杂志, 2016, 30(11): 1431-1436.
34. Araldi E, Schipani E. MicroRNA-140 and the silencing of osteoarthritis. Genes Dev, 2010, 24(11): 1075-1080.
35. Miyaki S, Nakasa T, Otsuki S, et al. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum, 2009, 60(9): 2723-2730.
36. Swingler TE, Wheeler G, Carmont V, et al. The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis Rheum, 2012, 64(6): 1909-1919.
37. 张明, 刘立宏, 肖涛, 等. 实时荧光定量 PCR 检测骨性关节病人膝关节液中 miR-140 的表达. 中南大学学报 (医学版), 2012, 37(12): 1210-1214.
38. Si HB, Zeng Y, Liu SY, et al. Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats. Osteoarthritis Cartilage, 2017, 25(10): 1698-1707.
39. Si H, Zeng Y, Zhou Z, et al. Expression of miRNA-140 in chondrocytes and synovial fluid of knee joints in patients with osteoarthritis. Chin Med Sci J, 2016, 31(4): 207-212.
40. Papaioannou G, Mirzamohammadi F, Lisse TS, et al. MicroRNA-140 provides robustness to the regulation of hypertrophic chondrocyte differentiation by the PTHrP-HDAC4 pathway. J Bone Miner Res, 2015, 30(6): 1044-1052.
41. 张洋洋, 彭效祥, 宋伟, 等. 核定位信号肽偶联核激酶底物短肽修饰壳聚糖介导微小 RNA-140 对兔关节软骨细胞作用的研究. 中国修复重建外科杂志, 2017, 31(10): 1256-1261.
42. Hossein M, Masoud S, Hana HA, et al. New approach for differentiation of bone marrow mesenchymal stem cells toward chondrocyte cells with overexpression of microRNA-140. ASAIO J, 2018, 64(5): 662-672.
43. Cao Z, Liu C, Bai Y, et al. Inhibitory effect of dihydroartemisinin on chondrogenic and hypertrophic differentiation of mesenchymal stem cells. Am J Transl Res, 2017, 9(6): 2748-2759.
44. Grogan SP, Miyaki S, Asahara H, et al. Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis. Arthritis Res Ther, 2009, 11(3): R85.
45. Li F, Shi W, Wan Y, et al. Prediction of target genes for miR-140-5p in pulmonary arterial hypertension using bioinformatics methods. FEBS Open Bio, 2017, 7(12): 1880-1890.
46. Khayrullin A, Smith L, Mistry D, et al. Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. Biochem Biophys Res Commun, 2016, 479(3): 590-595.
47. 杨体敏, 斯海波, 吴元刚, 等. 收肌管神经阻滞联合环氧合酶 2 选择性抑制剂在人工全膝关节置换术后的序贯应用及疗效. 中国修复重建外科杂志, 2016, 30(9): 1065-1071.
48. Si HB, Zeng Y, Shen B, et al. The influence of body mass index on the outcomes of primary total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc, 2015, 23(6): 1824-1832.
49. Blasioli DJ, Kaplan DL. The roles of catabolic factors in the development of osteoarthritis. Tissue Eng Part B Rev, 2014, 20(4): 355-363.
50. Liang ZJ, Zhuang H, Wang GX, et al. MiRNA-140 is a negative feedback regulator of MMP-13 in IL-1beta-stimulated human articular chondrocyte C28/I2 cells. Inflamm Res, 2012, 61(5): 503-509.
51. Mackie EJ, Ahmed YA, Tatarczuch L, et al. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol, 2008, 40(1): 46-62.
52. Orfanidou T, Iliopoulos D, Malizos KN, et al. Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes. J Cell Mol Med, 2009, 13(9b): 3186-3194.
53. Chen CG, Thuillier D, Chin EN, et al. Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis. Arthritis Rheum, 2012, 64(10): 3278-3289.
54. Javed A, Afzal F, Bae JS, et al. Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation. Cells Tissues Organs, 2009, 189(1-4): 133-137.
55. Finnson KW, Chi Y, Bou-Gharios G, et al. TGF-b signaling in cartilage homeostasis and osteoarthritis. Front Biosci (Schol Ed), 2012, 4: 251-268.
56. Varshney A, Panda JJ, Singh AK, et al. Targeted delivery of microRNA-199a-3p using self-assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice. Hepatology, 2018, 67(4): 1392-1407.
57. Kawanishi Y, Nakasa T, Shoji T, et al. Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model. Arthritis Res Ther, 2014, 16(6): 488.
58. Bottini M, Bhattacharya K, Fadeel B, et al. Nanodrugs to target articular cartilage: an emerging platform for osteoarthritis therapy. Nanomedicine, 2016, 12(2): 255-268.
59. Maudens P, Meyer S, Seemayer CA, et al. Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy. Nanoscale, 2018, 10(4): 1845-1854.
60. 黄勇, 丰干钧, 刘立岷, 等. 椎间盘退变中微小 RNA 及其非病毒载体的研究进展. 中国修复重建外科杂志, 2017, 31(1): 116-121.
61. Peng JS, Chen SY, Wu CL, et al. Amelioration of experimental autoimmune arthritis through targeting of synovial fibroblasts by intraarticular delivery of microRNAs 140-3p and 140-5p. Arthritis Rheumatol, 2016, 68(2): 370-381.
62. Li R, Xu J, Wong DSH, et al. Self-assembled N-cadherin mimetic peptide hydrogels promote the chondrogenesis of mesenchymal stem cells through inhibition of canonical Wnt/beta-catenin signaling. Biomaterials, 2017, 145: 33-43.
63. Bajpayee AG, Grodzinsky AJ. Cartilage-targeting drug delivery: can electrostatic interactions help? Nat Rev Rheumatol, 2017, 13(3): 183-193.
64. Xiao X, Wang X, Wang Y, et al. Multi-functional peptide-microRNA nanocomplex for targeted microRNA delivery and function imaging. Chemistry, 2018, 24(9): 2277-2285.

Previous Article
Progress in perioperative pain management of pediatric and adolescent spinal deformity corrective surgery

Chinese Journal of Reparative and Reconstructive Surgery

Effects of cartilage progenitor cells and microRNA-140 on repair of osteoarthritic cartilage injury

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Format

Content