Biomechanical study on nickel-titanium three-dimensional memory alloy mesh combined with autologous bone for living model of canine tibial plateau collapse fracture_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

YAN Xin’an , YAO Xiangyu ^△ ,  FANG Yue , LIANG Yu , YANG Yun , HUANG Fuguo

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;

Corresponding author：

FANG Yue, Email: fangyue1968@163.com

Keywords：

Nickel-titanium memory alloy; tibial plateau fracture; Beagle dog; biomechanics

DOI：

10.7507/1002-1892.201807024

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo evaluate the effect of nickel-titanium three-dimensional memory alloy mesh combined with autologous bone for living model of canine tibial plateau collapse fracture by biomechanical testing. MethodsSixteen healthy 12-month-old Beagle dogs were randomly divided into 4 group, 4 dogs in each group. The dogs were used to establish the tibial plateau collapse fracture model in groups A, B, and C. Then, the nickel-titanium three-dimensional memory alloy mesh combined with autologous bone (the fibula cortical bone particles), the artificial bone (nano-hydroxyapatite), and autologous fibula cortical bone particles were implanted to repair the bone defects within 4 hours after modeling in groups A, B, and C, respectively; and the plate and screws were fixed outside the bone defects. The dogs were not treated in group D, as normal control. At 5 months after operation, all animals were sacrificed and the tibial specimens were harvested and observed visually. The destructive axial compression experiments were carried out by the biomechanical testing machine. The displacement and the maximum failure load were recorded and the axial stiffness was calculated. ResultsAll animals stayed alive after operation, and all incisions healed. After 1-3 days of operation, the animals could stand and move, and no obvious limb deformity was found. The articular surfaces of the tibial plateau specimens were completely smooth at 5 months after operation. No obvious articular surface collapse was observed. The displacement and maximum failure load of specimens in groups A and D were significantly higher than those in groups B and C (P<0.05). But no significant difference was found between groups A and D and between groups B and C (P>0.05). ConclusionThe nickel-titanium three-dimensional memory alloy mesh combined with autologous bone for subarticular bone defect of tibial plateau in dogs has good biomechanical properties at 5 months after operation, and has better axial stiffness when compared with the artificial bone and autologous bone graft.

Citation： YAN Xin’an, YAO Xiangyu, FANG Yue, LIANG Yu, YANG Yun, HUANG Fuguo. Biomechanical study on nickel-titanium three-dimensional memory alloy mesh combined with autologous bone for living model of canine tibial plateau collapse fracture. Chinese Journal of Reparative and Reconstructive Surgery, 2018, 32(12): 1549-1553. doi: 10.7507/1002-1892.201807024 Copy

1.	Elsoe R, Larsen P, Nielsen NP, et al. Population-based epidemiology of tibial plateau fractures. Orthopedics, 2015, 38(9): e780-e786.
2.	Lachiewicz PF, Funcik T. Factors influencing the results of open reduction and internal fixation of tibial plateau fractures. Clin Orthop Relat Res, 1990, (259): 210-215.
3.	Hsu CJ, Chang WN, Wong CY. Surgical treatment of tibial plateau fracture in elderly patients. Arch Orthop Trauma Surg, 2001, 121(1-2): 67-70.
4.	Tscherne H, Lobenhoffer P. Tibial plateau fractures. Management and expected results. Clin Orthop Relat Res, 1993, (292): 87-100.
5.	McNamara IR, Smith TO, Shepherd KL, et al. Surgical fixation methods for tibial plateau fractures. Cochrane Database Syst Rev, 2015, (9): CD009679.
6.	Heikkilä JT, Kukkonen J, Aho AJ, et al. Bioactive glass granules: a suitable bone substitute material in the operative treatment of depressed lateral tibial plateau fractures: a prospective, randomized 1 year follow-up study. J Mater Sci Mater Med, 2011, 22(4): 1073-1080.
7.	晏兆魁, 梁羽, 方跃, 等. 镍钛三维记忆合金网复合自体骨治疗犬胫骨平台塌陷骨折模型生物力学试验. 中国修复重建外科杂志, 2018, 32(6): 722-725.
8.	Wheeler DL, Cross AR, Eschbach EJ, et al. Grafting of massive tibial subchondral bone defects in a caprine model using beta-tricalcium phosphate versus autograft. J Orthop Trauma, 2005, 19(2): 85-91.
9.	王岩, 译. 坎贝尔骨科手术学. 11 版. 北京: 人民军医出版社, 2009: 2472-2485.
10.	Morrison JB. Bioengineering analysis of force actions transmitted by the knee joint. Bio Med, 1968, 3: 164-170.
11.	Larsson S, Hannink G. Injectable bone-graft substitutes: current products, their characteristics and indications, and new developments. Injury, 2011, 42(Suppl 2): S30-S34.
12.	Cornell CN. Osteoconductive materials and their role as substitutes for autogenous bone grafts. Orthop Clin North Am, 1999, 30(4): 591-598.
13.	Goff T, Kanakaris NK, Giannoudis PV. Use of bone graft substitutes in the management of tibial plateau fractures. Injury, 2013, 44(Suppl 1): S86-S94.
14.	Sevcikova J, Pavkova Goldbergova M. Biocompatibility of NiTi alloys in the cell behaviour. Biometals, 2017, 30(2): 163-169.
15.	Li Y, Wang F, Hu P, et al. Feasibility of shape-memory Ni/Ti alloy wire containing tube elevators for transcrestal detaching maxillary sinus mucosa: Ex vivo study. Cell Physiol Biochem, 2016, 40(5): 944-952.
16.	王成健, 孟增东, 张玉勤, 等. 镍钛形状记忆合金的生物相容性研究进展. 生物骨科材料与临床研究, 2016, 13(1): 65-68, 72.
17.	林斌, 王岩, 赵卫东, 等. 镍钛记忆合金网球治疗股骨头缺血性坏死的生物力学及三维有限元分析. 中国矫形外科杂志, 2003, 11(15): 1059-1062.
18.	赵定麟, 张文明. 形状记忆合金椎间关节用于颈椎病前路减压术. 中华外科杂志, 1984, 22(7): 410-412.
19.	吕晓华, 陈根元, 曲国欣, 等. 镍钛形态记忆合金环抱器与重建钢板置入内固定治疗尺桡骨中段骨折的比较. 中国组织工程研究与临床康复, 2010, 14(52): 9827-9830.
20.	刘欣伟, 王攀峰, 付青格, 等. 动力髋螺钉结合记忆合金弓齿钉治疗股骨粗隆下 SeinsheimerⅤ型粉碎性骨折. 中国骨伤, 2010, 23(4): 288-290.
21.	Liu X, Xu S, Zhang C, et al. Application of a shape-memory alloy internal fixator for treatment of acetabular fractures with a follow-up of two to nine years in China. Int Orthop, 2010, 34(7): 1033-1040.
22.	Su JC, Liu XW, Yu BQ, et al. Shape memory Ni-Ti alloy swan-like bone connector for treatment of humeral shaft nonunion. Int Orthop, 2010, 34(3): 369-375.

1. Elsoe R, Larsen P, Nielsen NP, et al. Population-based epidemiology of tibial plateau fractures. Orthopedics, 2015, 38(9): e780-e786.
2. Lachiewicz PF, Funcik T. Factors influencing the results of open reduction and internal fixation of tibial plateau fractures. Clin Orthop Relat Res, 1990, (259): 210-215.
3. Hsu CJ, Chang WN, Wong CY. Surgical treatment of tibial plateau fracture in elderly patients. Arch Orthop Trauma Surg, 2001, 121(1-2): 67-70.
4. Tscherne H, Lobenhoffer P. Tibial plateau fractures. Management and expected results. Clin Orthop Relat Res, 1993, (292): 87-100.
5. McNamara IR, Smith TO, Shepherd KL, et al. Surgical fixation methods for tibial plateau fractures. Cochrane Database Syst Rev, 2015, (9): CD009679.
6. Heikkilä JT, Kukkonen J, Aho AJ, et al. Bioactive glass granules: a suitable bone substitute material in the operative treatment of depressed lateral tibial plateau fractures: a prospective, randomized 1 year follow-up study. J Mater Sci Mater Med, 2011, 22(4): 1073-1080.
7. 晏兆魁, 梁羽, 方跃, 等. 镍钛三维记忆合金网复合自体骨治疗犬胫骨平台塌陷骨折模型生物力学试验. 中国修复重建外科杂志, 2018, 32(6): 722-725.
8. Wheeler DL, Cross AR, Eschbach EJ, et al. Grafting of massive tibial subchondral bone defects in a caprine model using beta-tricalcium phosphate versus autograft. J Orthop Trauma, 2005, 19(2): 85-91.
9. 王岩, 译. 坎贝尔骨科手术学. 11 版. 北京: 人民军医出版社, 2009: 2472-2485.
10. Morrison JB. Bioengineering analysis of force actions transmitted by the knee joint. Bio Med, 1968, 3: 164-170.
11. Larsson S, Hannink G. Injectable bone-graft substitutes: current products, their characteristics and indications, and new developments. Injury, 2011, 42(Suppl 2): S30-S34.
12. Cornell CN. Osteoconductive materials and their role as substitutes for autogenous bone grafts. Orthop Clin North Am, 1999, 30(4): 591-598.
13. Goff T, Kanakaris NK, Giannoudis PV. Use of bone graft substitutes in the management of tibial plateau fractures. Injury, 2013, 44(Suppl 1): S86-S94.
14. Sevcikova J, Pavkova Goldbergova M. Biocompatibility of NiTi alloys in the cell behaviour. Biometals, 2017, 30(2): 163-169.
15. Li Y, Wang F, Hu P, et al. Feasibility of shape-memory Ni/Ti alloy wire containing tube elevators for transcrestal detaching maxillary sinus mucosa: Ex vivo study. Cell Physiol Biochem, 2016, 40(5): 944-952.
16. 王成健, 孟增东, 张玉勤, 等. 镍钛形状记忆合金的生物相容性研究进展. 生物骨科材料与临床研究, 2016, 13(1): 65-68, 72.
17. 林斌, 王岩, 赵卫东, 等. 镍钛记忆合金网球治疗股骨头缺血性坏死的生物力学及三维有限元分析. 中国矫形外科杂志, 2003, 11(15): 1059-1062.
18. 赵定麟, 张文明. 形状记忆合金椎间关节用于颈椎病前路减压术. 中华外科杂志, 1984, 22(7): 410-412.
19. 吕晓华, 陈根元, 曲国欣, 等. 镍钛形态记忆合金环抱器与重建钢板置入内固定治疗尺桡骨中段骨折的比较. 中国组织工程研究与临床康复, 2010, 14(52): 9827-9830.
20. 刘欣伟, 王攀峰, 付青格, 等. 动力髋螺钉结合记忆合金弓齿钉治疗股骨粗隆下 SeinsheimerⅤ型粉碎性骨折. 中国骨伤, 2010, 23(4): 288-290.
21. Liu X, Xu S, Zhang C, et al. Application of a shape-memory alloy internal fixator for treatment of acetabular fractures with a follow-up of two to nine years in China. Int Orthop, 2010, 34(7): 1033-1040.
22. Su JC, Liu XW, Yu BQ, et al. Shape memory Ni-Ti alloy swan-like bone connector for treatment of humeral shaft nonunion. Int Orthop, 2010, 34(3): 369-375.

Chinese Journal of Reparative and Reconstructive Surgery

Biomechanical study on nickel-titanium three-dimensional memory alloy mesh combined with autologous bone for living model of canine tibial plateau collapse fracture

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content