Application progress of indocyanine green angiography in lymphedema_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

CHEN Yujie ,  MU Lan

Plastic and Aesthetic Surgery Department, Peking University People’s Hospital, Beijing, 100044, P.R.China;

Corresponding author：

MU Lan, Email: mulan666@aliyun.com

Keywords：

Indocyanine green; dynamic fluorescence tracer; lymphedema

DOI：

10.7507/1002-1892.201904104

Video：

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Objective To summarize the application progress of indocyanine green (ICG) angiography in diagnosis and treatment of lymphedema.Methods The literature related to dynamic imaging tracing of lymphedema at home and abroad was reviewed extensively. And the research status and progress of ICG angiography in diagnosis and treatment of lymphedema were retrospectively analyzed.Results ICG angiography can be used as the gold standard for the diagnosis of lymphedema at present and the classification of lymphedema severity, selection of surgical incisions and methods, and intraoperative operation. It can also be used to observe lymphatic drainage and regeneration within 1.5 cm of subcutaneous and determine the prognosis.Conclusion Compared with traditional methods, ICG angiography has more obvious advantages and value in diagnosis and treatment of lymphedema. However, it also has problems such as slow development speed and difficulty in developing deep lymphatic vessels (nodes).

Citation： CHEN Yujie, MU Lan. Application progress of indocyanine green angiography in lymphedema. Chinese Journal of Reparative and Reconstructive Surgery, 2019, 33(12): 1589-1592. doi: 10.7507/1002-1892.201904104 Copy

1.	Struk S, Honart JF, Qassemyar Q, et al. Use of indocyanine green angiography in oncological and reconstructive breast surgery. Annales de Chirurgie Plastique Esthétique, 2018, 63(1): 54-61.
2.	柳泽洋, 宋达疆, 李赞, 等. 吲哚菁绿造影在乳房重建中的应用进展. 中国修复重建外科杂志, 2018, 32(11): 1463-1468.
3.	Ietto G, Amico F, Soldini G, et al. Real-time intraoperative fluorescent lymphography: A new technique for lymphatic sparing surgery. Transplant Proc, 2016, 48(9): 3073-3078.
4.	Unno N, Inuzuka K, Suzuki M, et al. Preliminary experience with a novel fluorescence lymphography using indocyanine green in patients with secondary lymphedema. J Vasc Surg, 2007, 45(5): 1016-1021.
5.	Ogata F, Azuma R, Kikuchi M, et al. Novel lymphography using indocyanine green dye for near-infrared fluorescence labeling. Ann Plast Surg, 2007, 58(6): 652-655.
6.	Yamamoto T, Narushima M, Doi K, et al. Characteristic indocyanine green lymphography findings in lower extremity lymphedema: the generation of a novel lymphedema severity staging system using dermal backflow patterns. Plast Reconstr Surg, 2011, 127(5): 1979-1986.
7.	Yamamoto T, Yoshimatsu H, Narushima M, et al. Indocyanine green lymphography findings in primary leg lymphedema. Eur J Vasc Endovasc Surg, 2015, 49(1): 95-102.
8.	Qin ES, Bowen MJ, Chen WF. Diagnostic accuracy of bioimpedance spectroscopy in patients with lymphedema: A retrospective cohort analysis. J Plast Reconstr Aesthet Surg, 2018, 71(7): 1041-1050.
9.	Hayashi A, Hayashi N, Yoshimatsu H, et al. Effective and efficient lymphaticovenular anastomosis using preoperative ultrasound detection technique of lymphatic vessels in lower extremity lymphedema. J Surg Oncol, 2018, 117(2): 290-298.
10.	Zaleska MT, Olszewski WL. The effectiveness of intermittent pneumatic compression in therapy of lymphedema of lower limbs: methods of evaluation and results. Lymphatic Research and Biology, 2019, 17(1): 60-69.
11.	Tashiro K, Yamashita S, Koshima I, et al. Visualization of accessory lymphatic pathways in secondary upper extremity lymphedema using indocyanine green lymphography. Ann Plast Surg, 2017, 79(4): 393-396.
12.	Hara H, Mihara M. Indocyanine green lymphographic and lymphoscintigraphic findings in genital lymphedema—genital pathway score. Lymphat Res Biol, 2017, 15(4): 356-359.
13.	Miranda Garcé M, Pons G, Mirapeix R, et al. Intratissue lymphovenous communications in the mechanism of action of vascularized lymph node transfer. J Surg Oncol, 2017, 115(1): 27-31.
14.	Chen WF, Zhao H, Yamamoto T, et al. Indocyanine green lymphographic evidence of surgical efficacy following microsurgical and supermicrosurgical lymphedema reconstructions. J Reconstr Microsurgery, 2016, 32(9): 688-698.
15.	Yamamoto T, Narushima M, Yoshimatsu H, et al. Dynamic indocyanine green (ICG) lymphography for breast cancer-related arm lymphedema. Ann Plast Surg, 2014, 73(6): 706-709.
16.	Yamamoto T, Iida T, Matsuda N, et al. Indocyanine green (ICG)-enhanced lymphography for evaluation of facial lymphoedema. J Plast Reconstr Aesthet Surg, 2011, 64(11): 1541-1544.
17.	Brar H, Hogen L, Covens A. Cost-effectiveness of sentinel node biopsy and pathological ultrastaging in patients with early-stage cervical cancer. Cancer, 2017, 123(10): 1751-1759.
18.	Aung T, Taeger C, Geis S, et al. The use of integrated indocyanine green fluorescence microscope camera for intraoperative lymphography of supermicrosurgery. Clin Hemorheol Microcirc, 2018. [Epub ahead of print].
19.	Yang JC, Wu SC, Chiang MH, et al. Intraoperative identification and definition of " functional” lymphatic collecting vessels for supermicrosurgical lymphatico-venous anastomosis in treating lymphedema patients. J Surg Oncol, 2018, 117(5): 994-1000.
20.	李广学, 穆籣, 刘岩, 等. 吲哚菁绿淋巴造影在超显微淋巴管静脉吻合中的应用. 中华整形外科杂志, 2018, 34(4): 271-273.
21.	Mu L, Peng Z, Zang H, et al. Operating microscope with near infrared imaging function for indocyanine green lymphography in prevention of lymphedema with lymphaticovenous anastomosis immediately after mastectomy and axillary dissection. Microsurgery, 2017, 37(4): 354-355.
22.	Campisi CC, Larcher L, Lavagno R, et al. Microsurgical primary prevention of lymphatic injuries following breast cancer treatment. Plast Reconstr Surg, 2012, 130(5): 749e-750e.
23.	杨锴, 穆籣, 刘岩, 等. 吲哚菁绿血管造影在皮瓣手术中的应用价值. 中国修复重建外科杂志, 2015, 29(9): 1113-1116.
24.	DiSipio T, Rye S, Newman B, et al. Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. Lancet Oncol, 2013, 14(6): 500-515.
25.	Yamamoto T, Yoshimatsu H, Narushima M, et al. A modified side-to-end lymphaticovenular anastomosis. Microsurgery, 2013, 33(2): 130-133.
26.	Winters H, Tielemans HJP, Hameeteman M, et al. The efficacy of lymphaticovenular anastomosis in breast cancer-related lymphedema. Breast Cancer Res Treat, 2017, 165(2): 321-327.
27.	Granzow JW, Soderberg JM, Kaji AH, et al. Review of current surgical treatments for lymphedema. Ann Surg Oncol, 2014, 21(4): 1195-1201.
28.	Garza RM, Ooi ASH, Falk J, et al. The relationship between clinical and indocyanine green staging in lymphedema. Lymphat Res Biol, 2019, 17(3): 329-333.
29.	Yamamoto T, Narushima M, Koshima I. Lymphatic vessel diameter in female pelvic cancer‐related lower extremity lymphedematous limbs. J Surg Oncol, 2018, 117(6): 1157-1163.
30.	Seki Y, Kajikawa A, Yamamoto T, et al. The dynamic-lymphaticovenular anastomosis method for breast cancer treatment-related lymphedema: creation of functional lymphaticovenular anastomoses with use of preoperative dynamic ultrasonography. J Plast Reconstr Aesthet Surg, 2019, 72(1): 62-70.

1. Struk S, Honart JF, Qassemyar Q, et al. Use of indocyanine green angiography in oncological and reconstructive breast surgery. Annales de Chirurgie Plastique Esthétique, 2018, 63(1): 54-61.
2. 柳泽洋, 宋达疆, 李赞, 等. 吲哚菁绿造影在乳房重建中的应用进展. 中国修复重建外科杂志, 2018, 32(11): 1463-1468.
3. Ietto G, Amico F, Soldini G, et al. Real-time intraoperative fluorescent lymphography: A new technique for lymphatic sparing surgery. Transplant Proc, 2016, 48(9): 3073-3078.
4. Unno N, Inuzuka K, Suzuki M, et al. Preliminary experience with a novel fluorescence lymphography using indocyanine green in patients with secondary lymphedema. J Vasc Surg, 2007, 45(5): 1016-1021.
5. Ogata F, Azuma R, Kikuchi M, et al. Novel lymphography using indocyanine green dye for near-infrared fluorescence labeling. Ann Plast Surg, 2007, 58(6): 652-655.
6. Yamamoto T, Narushima M, Doi K, et al. Characteristic indocyanine green lymphography findings in lower extremity lymphedema: the generation of a novel lymphedema severity staging system using dermal backflow patterns. Plast Reconstr Surg, 2011, 127(5): 1979-1986.
7. Yamamoto T, Yoshimatsu H, Narushima M, et al. Indocyanine green lymphography findings in primary leg lymphedema. Eur J Vasc Endovasc Surg, 2015, 49(1): 95-102.
8. Qin ES, Bowen MJ, Chen WF. Diagnostic accuracy of bioimpedance spectroscopy in patients with lymphedema: A retrospective cohort analysis. J Plast Reconstr Aesthet Surg, 2018, 71(7): 1041-1050.
9. Hayashi A, Hayashi N, Yoshimatsu H, et al. Effective and efficient lymphaticovenular anastomosis using preoperative ultrasound detection technique of lymphatic vessels in lower extremity lymphedema. J Surg Oncol, 2018, 117(2): 290-298.
10. Zaleska MT, Olszewski WL. The effectiveness of intermittent pneumatic compression in therapy of lymphedema of lower limbs: methods of evaluation and results. Lymphatic Research and Biology, 2019, 17(1): 60-69.
11. Tashiro K, Yamashita S, Koshima I, et al. Visualization of accessory lymphatic pathways in secondary upper extremity lymphedema using indocyanine green lymphography. Ann Plast Surg, 2017, 79(4): 393-396.
12. Hara H, Mihara M. Indocyanine green lymphographic and lymphoscintigraphic findings in genital lymphedema—genital pathway score. Lymphat Res Biol, 2017, 15(4): 356-359.
13. Miranda Garcé M, Pons G, Mirapeix R, et al. Intratissue lymphovenous communications in the mechanism of action of vascularized lymph node transfer. J Surg Oncol, 2017, 115(1): 27-31.
14. Chen WF, Zhao H, Yamamoto T, et al. Indocyanine green lymphographic evidence of surgical efficacy following microsurgical and supermicrosurgical lymphedema reconstructions. J Reconstr Microsurgery, 2016, 32(9): 688-698.
15. Yamamoto T, Narushima M, Yoshimatsu H, et al. Dynamic indocyanine green (ICG) lymphography for breast cancer-related arm lymphedema. Ann Plast Surg, 2014, 73(6): 706-709.
16. Yamamoto T, Iida T, Matsuda N, et al. Indocyanine green (ICG)-enhanced lymphography for evaluation of facial lymphoedema. J Plast Reconstr Aesthet Surg, 2011, 64(11): 1541-1544.
17. Brar H, Hogen L, Covens A. Cost-effectiveness of sentinel node biopsy and pathological ultrastaging in patients with early-stage cervical cancer. Cancer, 2017, 123(10): 1751-1759.
18. Aung T, Taeger C, Geis S, et al. The use of integrated indocyanine green fluorescence microscope camera for intraoperative lymphography of supermicrosurgery. Clin Hemorheol Microcirc, 2018. [Epub ahead of print].
19. Yang JC, Wu SC, Chiang MH, et al. Intraoperative identification and definition of " functional” lymphatic collecting vessels for supermicrosurgical lymphatico-venous anastomosis in treating lymphedema patients. J Surg Oncol, 2018, 117(5): 994-1000.
20. 李广学, 穆籣, 刘岩, 等. 吲哚菁绿淋巴造影在超显微淋巴管静脉吻合中的应用. 中华整形外科杂志, 2018, 34(4): 271-273.
21. Mu L, Peng Z, Zang H, et al. Operating microscope with near infrared imaging function for indocyanine green lymphography in prevention of lymphedema with lymphaticovenous anastomosis immediately after mastectomy and axillary dissection. Microsurgery, 2017, 37(4): 354-355.
22. Campisi CC, Larcher L, Lavagno R, et al. Microsurgical primary prevention of lymphatic injuries following breast cancer treatment. Plast Reconstr Surg, 2012, 130(5): 749e-750e.
23. 杨锴, 穆籣, 刘岩, 等. 吲哚菁绿血管造影在皮瓣手术中的应用价值. 中国修复重建外科杂志, 2015, 29(9): 1113-1116.
24. DiSipio T, Rye S, Newman B, et al. Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. Lancet Oncol, 2013, 14(6): 500-515.
25. Yamamoto T, Yoshimatsu H, Narushima M, et al. A modified side-to-end lymphaticovenular anastomosis. Microsurgery, 2013, 33(2): 130-133.
26. Winters H, Tielemans HJP, Hameeteman M, et al. The efficacy of lymphaticovenular anastomosis in breast cancer-related lymphedema. Breast Cancer Res Treat, 2017, 165(2): 321-327.
27. Granzow JW, Soderberg JM, Kaji AH, et al. Review of current surgical treatments for lymphedema. Ann Surg Oncol, 2014, 21(4): 1195-1201.
28. Garza RM, Ooi ASH, Falk J, et al. The relationship between clinical and indocyanine green staging in lymphedema. Lymphat Res Biol, 2019, 17(3): 329-333.
29. Yamamoto T, Narushima M, Koshima I. Lymphatic vessel diameter in female pelvic cancer‐related lower extremity lymphedematous limbs. J Surg Oncol, 2018, 117(6): 1157-1163.
30. Seki Y, Kajikawa A, Yamamoto T, et al. The dynamic-lymphaticovenular anastomosis method for breast cancer treatment-related lymphedema: creation of functional lymphaticovenular anastomoses with use of preoperative dynamic ultrasonography. J Plast Reconstr Aesthet Surg, 2019, 72(1): 62-70.

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Application progress of indocyanine green angiography in lymphedema

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