Research progress of nanomaterials in osteomyelitis treatment_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

WANG Peilin ,  LIN Haodong

Department of Orthopaedics, Shanghai General Hospital, Shanghai, 200080, P.R.China;

Corresponding author：

LIN Haodong, Email: haodonglin@hotmail.com

Keywords：

Osteomyelitis; nanomaterials; bone defect; local drug delivery system; osteogenic differentiation; osteoclastic differentiation; antibacterial

DOI：

10.7507/1002-1892.202012044

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To review the related studies on the application of nanomaterials in the treatment of osteomyelitis, and to provide new ideas for the research and clinical treatment of osteomyelitis.Methods The literature about the treatment of osteomyelitis with nanomaterials at home and abroad in recent years was reviewed and analyzed.Results At present, surgical treatment and antibiotic application are the main treatment options for osteomyelitis. But there are many defects such as antibiotic resistance, residual bone defect, and low effective concentration of local drugs. The application of nanomaterials can make up for the above defects. In recent years, nanomaterials play an important role in the treatment of osteomyelitis by filling bone defects, establishing local drug delivery system, and self-antibacterial properties.Conclusion It will provide a new idea and an important research direction for the treatment of osteomyelitis to fully study the related characteristics of nanomaterials and select beneficial materials to make drug delivery system or substitute drugs.

Citation： WANG Peilin, LIN Haodong. Research progress of nanomaterials in osteomyelitis treatment. Chinese Journal of Reparative and Reconstructive Surgery, 2021, 35(5): 648-655. doi: 10.7507/1002-1892.202012044 Copy

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1. Cortés-Penfield NW, Kulkarni PA. The history of antibiotic treatment of osteomyelitis. Open Forum Infect Dis, 2019, 6(5): ofz181. doi: 10.1093/ofid/ofz181.
2. Schmitt SK. Osteomyelitis. Infect Dis Clin North Am, 2017, 31(2): 325-338.
3. Kavanagh N, Ryan EJ, Widaa A, et al. Staphylococcal osteomyelitis: Disease progression, treatment challenges, and future directions. Clin Microbiol Rev, 2018, 31(2): e00084-17. doi: 10.1128/CMR.00084-17.
4. Li A, Xie J, Li J. Recent advances in functional nanostructured materials for bone-related diseases. J Mater Chem B, 2019, 7(4): 509-527.
5. Loh KP, Ho D, Chiu GNC, et al. Clinical applications of carbon nanomaterials in diagnostics and therapy. Adv Mater, 2018, 30(47): e1802368. doi: 10.1002/adma.201802368.
6. Pirzada M, Altintas Z. Nanomaterials for healthcare biosensing applications. Sensors (Basel), 2019, 19(23): 5311. doi: 10.3390/s19235311.
7. Venugopal J, Prabhakaran MP, Low S, et al. Nanotechnology for nanomedicine and delivery of drugs. Curr Pharm Des, 2008, 14(22): 2184-2200.
8. Curtis A, Wilkinson C. Nantotechniques and approaches in biotechnology. Trends Biotechnol, 2001, 19(3): 97-101.
9. Nauth A, Schemitsch E, Norris B, et al. Critical-size bone defects: Is there a consensus for diagnosis and treatment? J Orthop Trauma, 2018, 32 Suppl 1: S7-S11.
10. Lu H, Liu Y, Guo J, et al. Biomaterials with antibacterial and osteoinductive properties to repair infected bone defects. Int J Mol Sci, 2016, 17(3): 334. doi: 10.3390/ijms17030334.
11. Franci G, Falanga A, Galdiero S, et al. Silver nanoparticles as potential antibacterial agents. Molecules, 2015, 20(5): 8856-8874.
12. Tan H, Ma R, Lin C, et al. Quaternized chitosan as an antimicrobial agent: antimicrobial activity, mechanism of action and biomedical applications in orthopedics. Int J Mol Sci, 2013, 14(1): 1854-1869.
13. Herath TDK, Larbi A, Teoh SH, et al. Neutrophil-mediated enhancement of angiogenesis and osteogenesis in a novel triple cell co-culture model with endothelial cells and osteoblasts. J Tissue Eng Regen Med, 2018, 12(2): e1221-e1236.
14. Wang J, Guo J, Liu J, et al. BMP-functionalised coatings to promote osteogenesis for orthopaedic implants. Int J Mol Sci, 2014, 15(6): 10150-10168.
15. Shen X, Zhang Y, Gu Y, et al. Sequential and sustained release of SDF-1 and BMP-2 from silk fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration. Biomaterials, 2016, 106: 205-216.
16. Wang Q, Zhang Y, Li B, et al. Controlled dual delivery of low doses of BMP-2 and VEGF in a silk fibroin-nanohydroxyapatite scaffold for vascularized bone regeneration. J Mater Chem B, 2017, 5(33): 6963-6972.
17. Mahon OR, Browe DC, Gonzalez-Fernandez T, et al. Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner. Biomaterials, 2020, 239: 119833. doi: 10.1016/j.biomaterials.2020.119833.
18. Min J, Choi KY, Dreaden EC, et al. Designer dual therapy nanolayered implant coatings eradicate biofilms and accelerate bone tissue repair. ACS Nano, 2016, 10(4): 4441-4450.
19. Li D, Li Y, Shrestha A, et al. Effects of programmed local delivery from a micro/nano-hierarchical surface on titanium implant on infection clearance and osteogenic induction in an infected bone defect. Adv Healthc Mater, 2019, 8(11): e1900002. doi: 10.1002/adhm.201900002.
20. Kubasiewicz-Ross P, Hadzik J, Seeliger J, et al. New nano-hydroxyapatite in bone defect regeneration: A histological study in rats. Ann Anat, 2017, 213: 83-90.
21. da Silva Brum I, Frigo L, Lana Devita R, et al. Histomorphometric, immunohistochemical, ultrastructural characterization of a nano-hydroxyapatite/beta-tricalcium phosphate composite and a bone xenograft in sub-critical size bone defect in rat calvaria. Materials (Basel), 2020, 13(20): 4598. doi: 10.3390/ma13204598.
22. Bal Z, Korkusuz F, Ishiguro H, et al. A novel nano-hydroxyapatite/synthetic polymer/bone morphogenetic protein-2 composite for efficient bone regeneration. Spine J, 2021. doi: 10.1016/j.spinee.2021.01.019.
23. Zhou K, Yu P, Shi X, et al. Hierarchically porous hydroxyapatite hybrid scaffold incorporated with reduced graphene oxide for rapid bone ingrowth and repair. ACS Nano, 2019, 13(8): 9595-9606.
24. Yan J, Xia D, Zhou W, et al. pH-responsive silk fibroin-based CuO/Ag micro/nano coating endows polyetheretherketone with synergistic antibacterial ability, osteogenesis, and angiogenesis. Acta Biomater, 2020, 115: 220-234.
25. Schlickewei C, Klatte TO, Wildermuth Y, et al. A bioactive nano-calcium phosphate paste for in-situ transfection of BMP-7 and VEGF-A in a rabbit critical-size bone defect: results of an in vivo study. J Mater Sci Mater Med, 2019, 30(2): 15. doi: 10.1007/s10856-019-6217-y.
26. Song Y, Lin K, He S, et al. Nano-biphasic calcium phosphate/polyvinyl alcohol composites with enhanced bioactivity for bone repair via low-temperature three-dimensional printing and loading with platelet-rich fibrin. Int J Nanomedicine, 2018, 13: 505-523.
27. Thabit AK, Fatani DF, Bamakhrama MS, et al. Antibiotic penetration into bone and joints: An updated review. Int J Infect Dis, 2019, 81: 128-136.
28. Masters EA, Trombetta RP, de Mesy Bentley KL, et al. Evolving concepts in bone infection: redefining “biofilm”, “acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”. Bone Res, 2019, 7: 20. doi: 10.1038/s41413-019-0061-z.
29. Bidault P, Chandad F, Grenier D. Risk of bacterial resistance associated with systemic antibiotic therapy in periodontology. J Can Dent Assoc, 2007, 73(8): 721-725.
30. Nandi SK, Mukherjee P, Roy S, et al. Local antibiotic delivery systems for the treatment of osteomyelitis—A review. Materials Science and Engineering: C, 2009, 29(8): 2478-2485.
31. Nandi SK, Bandyopadhyay S, Das P, et al. Understanding osteomyelitis and its treatment through local drug delivery system. Biotechnol Adv, 2016, 34(8): 1305-1317.
32. Wang Q, Chen C, Liu W, et al. Levofloxacin loaded mesoporous silica microspheres/nano-hydroxyapatite/polyurethane composite scaffold for the treatment of chronic osteomyelitis with bone defects. Sci Rep, 2017, 7: 41808. doi: 10.1038/srep41808.
33. Krishnan AG, Biswas R, Menon D, et al. Biodegradable nanocomposite fibrous scaffold mediated local delivery of vancomycin for the treatment of MRSA infected experimental osteomyelitis. Biomater Sci, 2020, 8(9): 2653-2665.
34. Saidykhan L, Abu Bakar MZ, Rukayadi Y, et al. Development of nanoantibiotic delivery system using cockle shell-derived aragonite nanoparticles for treatment of osteomyelitis. Int J Nanomedicine, 2016, 11: 661-673.
35. Tao J, Zhang Y, Shen A, et al. Injectable chitosan-based thermosensitive hydrogel/nanoparticle-loaded system for local delivery of vancomycin in the treatment of osteomyelitis. Int J Nanomedicine, 2020, 15: 5855-5871.
36. Al Thaher Y, Perni S, Prokopovich P. Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material. Adv Colloid Interface Sci, 2017, 249: 234-247.
37. Shen SC, Ng WK, Dong YC, et al. Nanostructured material formulated acrylic bone cements with enhanced drug release. Mater Sci Eng C Mater Biol Appl, 2016, 58: 233-241.
38. Shen SC, Letchmanan K, Chow PS, et al. Antibiotic elution and mechanical property of TiO₂ nanotubes functionalized PMMA-based bone cements. J Mech Behav Biomed Mater, 2019, 91: 91-98.
39. David MZ, Daum RS. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev, 2010, 23(3): 616-687.
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