Antifriction and anti-wear performances of bionic lubricating fluid containing gelatin nanoparticles for artificial joint materials_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

LI Weihua ¹ , LIANG Fengguang ¹ , DONG Shiyu ² , LÜ Weizhen ¹ , LIU Yantao ¹ , WANG Xiao ¹ ,  MA Jingyi ³

1. Department of Orthopaedics, Huaihe Hospital, Henan University, Kaifeng Henan, 475000, P. R. China;
2. Henan University of Science and Technology, Luoyang Henan, 471000, P. R. China;
3. Nanoengineering Technology Center of Henan University, Kaifeng Henan, 475004, P. R. China;

Corresponding author：

MA Jingyi, Email: mjy@henu.edu.cn

Keywords：

Gelatin nanoparticle; bionic joint lubricant; artificial joint material; antifriction; antiwear

DOI：

10.7507/1002-1892.202209035

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Objective The antifriction and antiwear effects of gelatin nanoparticles (GLN-NP) on artificial joint materials in bionic joint lubricant were investigated to provide a theoretical basis for the development of new bionic joint lubricant. Methods GLN-NP was prepared by cross-linking collagen acid (type A) gelatin with glutaraldehyde by acetone method, and the particle size and stability of GLN-NP were characterized. The biomimetic joint lubricants with different concentrations were prepared by mixing 5, 15, and 30 mg/mL GLN-NP with 15 and 30 mg/mL hyaluronic acid (HA), respectively. The friction reduction and antiwear effects of the biomimetic joint lubricants on zirconia ceramics were investigated on a tribometer. The cytotoxicity of each component of bionic joint lubricant on RAW264.7 mouse macrophages was evaluated by MTT assay. Results The particle size of GLN-NP was about 139 nm, and the particle size distribution index was 0.17, showing a single peak, indicating that the particle size of GLN-NP was uniform. In complete culture medium, pH7.4 PBS, and deionized water at simulated body temperature, the particle size of GLN-NP did not change more than 10 nm with time, indicating that GLN-NP had good dispersion stability and did not aggregate. Compared with 15 mg/mL HA, 30 mg/mL HA, and normal saline, the friction coefficient, wear scar depth, width, and wear volume were significantly reduced by adding different concentrations of GLN-NP (P<0.05); there was no significant difference between different concentrations of GLN-NP (P>0.05). Biocompatibility test showed that the cell survival rate of GLN-NP, HA, and HA+GLN-NP solution decreased slightly with the increase of concentration, but the cell survival rate was more than 90%, and there was no significant difference between groups (P>0.05). Conclusion The bionic joint fluid containing GLN-NP has good antifriction and antiwear effect. Among them, GLN-NP saline solution without HA has the best antifriction and antiwear effect.

Citation： LI Weihua, LIANG Fengguang, DONG Shiyu, LÜ Weizhen, LIU Yantao, WANG Xiao, MA Jingyi. Antifriction and anti-wear performances of bionic lubricating fluid containing gelatin nanoparticles for artificial joint materials. Chinese Journal of Reparative and Reconstructive Surgery, 2023, 37(2): 196-201. doi: 10.7507/1002-1892.202209035 Copy

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12.	Uflyand IE, Zhinzhilo VA, Burlakova VE. Metal-containing nanomaterials as lubricant additives: State-of-the-art and future development. Friction, 2019, 7(2): 93-116.
13.	Hu C, Bai M, Lv J, et al. Molecular dynamics simulation of mechanism of nanoparticle in improving load-carrying capacity of lubricant film. Computational Materials Science, 2015, 109: 97-103.
14.	阮春标, 胡经纬, 袁恒迪, 等. 可用于人工关节润滑的水凝胶蠕变缓释性能及理论模型. 西安交通大学报, 2022, 56(6): 97-103.
15.	Mendes BB, Daly AC, Reis RL, et al. Injectable hyaluronic acid and platelet lysate-derived granular hydrogels for biomedical applications. Acta Biomater, 2021, 119: 101-113.
16.	Gorbet MB, Sefton MV. Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes. Biomaterials, 2004, 25(26): 5681-5703.
17.	张禾蓉, 易达, 孟子晖, 等. 基于纳米水凝胶颗粒的毛细管电泳法分离DNA. 分析化学, 2019, 47(5): 772-778.
18.	Pilipenko IM, Korzhikov-Vlakh VA, Zakharova NV, et al. Thermo- and pH-sensitive glycosaminoglycans derivatives obtained by controlled grafting of poly (N-isopropylacrylamide). Carbohydr Polym, 2020, 248: 116764. doi: 10.1016/j.carbpol.2020.116764.
19.	Li CY, Hao XP, Wu ZL, et al. Photolithographically patterned hydrogels with programmed deformations. Chem Asian J, 2019, 14(1): 94-104.

1. 王莹莹, 郁惠敏, 刘蕾, 等. 含石墨烯仿生滑液对ZrO₂陶瓷人工关节材料的润滑作用研究. 摩擦学学报, 2018, 38(3): 319-326.
2. Ranuša M, Čípek P, Vrbka M, et al. Tribological behaviour of 3D printed materials for small joint implants: A pilot study. J Mech Behav Biomed Mater, 2022, 132: 105274. doi: 10.1016/j.jmbbm.2022.105274.
3. Asri RIM, Harun WSW, Samykano M, et al. Corrosion and surface modification on biocompatible metals: A review. Mater Sci Eng C Mater Biol Appl, 2017, 77: 1261-1274.
4. Hatamleh MM, Wu X, Alnazzawi A, et al. Surface characteristics and biocompatibility of cranioplasty titanium implants following different surface treatments. Dent Mater, 2018, 34(4): 676-683.
5. 梁风光. 含纳米颗粒的透明质酸溶液的制备及其对人工关节材料的润滑作用. 开封: 河南大学, 2018.
6. Richards L, Brown C, Stone MH, et al. Identification of nanometre-sized ultra-high molecular weight polyethylene wear particles in samples retrieved in vivo. J Bone Joint Surg (Br), 2008, 90(8): 1106-1113.
7. Saikko V, Vuorinen V, Revitzer H. Analysis of UHMWPE wear particles produced in the simulation of hip and knee wear mechanisms with the RandomPOD system. Biotribology, 2015, 12: 30-34.
8. Su CY, Chen CC, Huang YL, et al. Optimization of biomolecular additives for a reduction of friction in the artificial joint system. Tribology International, 2017, 111: 220-225.
9. Kang LJ, Yoon J, Rho JG, et al. Self-assembled hyaluronic acid nanoparticles for osteoarthritis treatment. Biomaterials, 2021, 275: 120967. doi: 10.1016/j.biomaterials.2021.120967.
10. Tiwari A, Karkhur Y, Maini L. Total hip replacement in tuberculosis of hip: A systematic review. J Clin Orthop Trauma, 2018, 9(1): 54-57.
11. Li XH, Cao Z, Zhang ZJ, et al. Surface-modification in situ of nano-SiO₂ and its structure and tribological properties. Applied Surface Science, 2020, 252(22): 856-861.
12. Uflyand IE, Zhinzhilo VA, Burlakova VE. Metal-containing nanomaterials as lubricant additives: State-of-the-art and future development. Friction, 2019, 7(2): 93-116.
13. Hu C, Bai M, Lv J, et al. Molecular dynamics simulation of mechanism of nanoparticle in improving load-carrying capacity of lubricant film. Computational Materials Science, 2015, 109: 97-103.
14. 阮春标, 胡经纬, 袁恒迪, 等. 可用于人工关节润滑的水凝胶蠕变缓释性能及理论模型. 西安交通大学报, 2022, 56(6): 97-103.
15. Mendes BB, Daly AC, Reis RL, et al. Injectable hyaluronic acid and platelet lysate-derived granular hydrogels for biomedical applications. Acta Biomater, 2021, 119: 101-113.
16. Gorbet MB, Sefton MV. Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes. Biomaterials, 2004, 25(26): 5681-5703.
17. 张禾蓉, 易达, 孟子晖, 等. 基于纳米水凝胶颗粒的毛细管电泳法分离DNA. 分析化学, 2019, 47(5): 772-778.
18. Pilipenko IM, Korzhikov-Vlakh VA, Zakharova NV, et al. Thermo- and pH-sensitive glycosaminoglycans derivatives obtained by controlled grafting of poly (N-isopropylacrylamide). Carbohydr Polym, 2020, 248: 116764. doi: 10.1016/j.carbpol.2020.116764.
19. Li CY, Hao XP, Wu ZL, et al. Photolithographically patterned hydrogels with programmed deformations. Chem Asian J, 2019, 14(1): 94-104.

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Antifriction and anti-wear performances of bionic lubricating fluid containing gelatin nanoparticles for artificial joint materials

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