Surgical Treatment of Cardiac Tumors：Clinical Analysis of 181 Patients_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

WANG Yong , XIAO Yingbin , CHEN Lin , WANG Xuefeng , CHEN Baicheng , CHEN Jinjin , LIU Mei.

Department of Cardiovascular Surgery， PLA CardiovascularSurgery Institute，Xinqiao Hospital，Third Military Medical University，Chongqing 400037，P. R. China;;
Email：wy003236@hotmail. com;

Corresponding author：

Keywords：

Cardiac tumor; Diagnosis; Surgical treatment

DOI：

10.7507/1007-4848.20130049

Video：

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Objective To investigate surgical treatment strategies and analyze clinical outcomes of cardiac tumors. Methods Clinical data of 181 patients with cardiac tumors who underwent surgical treatment in Xinqiao Hospital of Third Military Medical University from January 1980 to December 2010 were analyzed retrospectively. There were 79 malepatients and 102 female patients with their age of 10 months-76 years （45.22±18.21 years） . A total of 179 patients underwent180 tumor resection surgeries under cardiopulmonary bypass （CPB）. Two patients with malignant tumors did notreceive surgical resection but exploratory thoracotomy. All the tumor specimens were examined by pathologists. ResultsThere were 169 patients （93.4%） with primary cardiac tumors, including 144 patients （79. 6%） with myxoma, 20 patients （11.0%） with other types of primary benign cardiac tumors, and 5 patients （2.8%） with primary malignant cardiac tumors. There were 12 patients （6.6%） with secondary cardiac tumors. There were 2 perioperative deaths （1.1%） in patients with primary cardiac tumors，including 1 patient with low cardiac output syndrome and another patient with postoperative multipleorgan dysfunction syndrome. All the 5 patients with primary malignant tumors died in postoperative 12 months. Patients with benign cardiac tumors were followed up for 6 months-15 years （2.41±1.08 years） without tumor recurrence. Among patients with secondary cardiac tumors，there was 1 perioperative death because of postoperative multiple organ dysfunction　syndrome，2 patients died within postoperative 1 year, and 3 patients died in the 3rd postoperative year during follow-up.　Conclusion Myxoma is the most common cardiac tumor. Complete surgical resection is the best treatment strategy forpatients with cardiac tumors. Clinical outcomes of patients with benign cardiac tumors are significantly better than those with malignant cardiac tumors. Prognosis of patients with primary malignant cardiac tumors is poor.

Citation： WANG Yong,XIAO Yingbin,CHEN Lin,WANG Xuefeng,CHEN Baicheng,CHEN Jinjin,LIU Mei.. Surgical Treatment of Cardiac Tumors：Clinical Analysis of 181 Patients. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2013, 20(2): 155-158. doi: 10.7507/1007-4848.20130049 Copy

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8.	Wee JO， Sepic JD， Mihaljevic T， et al. Metastatic carcinoid tumor of the heart. Ann Thorac Surg， 2003， 76 （5）：1721-1722.
9.	Mastroroberto P， Olivito S， Onorati F， et al. Papillary fibroblastoma of tricuspid valve with pulmonary embolization. Asian Cardiovasc Thorac Ann， 2006， 14 （3）：e53-e54.
10.	周维新，杨浣宜，王浩，等. 心脏原发良性肿瘤的临床分析及超声诊断价值. 中华超声影像学杂志， 2004， 13 （11）：14-16.
11.	Meng QG， Lai H， Lima J， et al. Echocardiographic and pathologic characteristics of primary cardiac tumors：a study of 149 cases. Int J Cardiol， 2002， 84 （1）：69-75.
12.	Neragi-Miandoab S， Kim J， Vlahakes GJ. Malignant tumours of the heart：a review of tumour type， diagnosis and therapy. Clin Oncol （R Coll Radiol）， 2007， 19 （10）：748-756.
13.	于坤，龙村，黑飞龙，等. 242例外科治疗的心脏肿瘤的临床分析. 中国肿瘤临床， 2006， 33 （15）：877-880， 884.
14.	韩劲松，安君，阎德民. 原发性心脏肿瘤232例临床分析. 中华外科杂志， 2006， 44 （2）：87-89.
15.	Karasu BB， Yeter E， Yilmazer D， et al. Primary valvular lipomatous hamartoma：a case report and a collective review of the literature. Cardiovasc Pathol， 2011， 20 （6）：377-380.
16.	Yuan SM， Shinfeld A， Raanani E. Tricuspid valve myxoma：a case report and a collective review of the literature. J Card Surg， 2009， 24 （1）：69-72.

1. 　Reynen K. Frequency of primary tumors of the heart. Am J Cardiol， 1996， 77 （1）：107.
2. 　Maraj S， Pressman GS， Figueredo VM. Primary cardiac tumors. Int J Cardiol， 2009， 133 （2）：152-156.
3. 　Jain D， Maleszewski JJ， Halushka MK . Benign cardiac tumors and tumorlike conditions. Ann Diagn Pathol， 2010， 14 （3）：215-230.
4. 　肖颖彬. 体外循环心脏跳动中心内直视手术的临床实践与研究进展. 第三军医大学学报， 2009， 31 （1）：21-23.
5. 　Qin C， Chen L， Xiao YB， et al. Giant primary leiomyoma of the right ventricle. J Card Surg， 2010， 25 （2）：169-171.
6. 　Huang ZX， Sun LZ， Du M， et al. Primary cardiac valve tumors：early and late results of surgical treatment in 10 patients. Ann Thorac Surg， 2003， 76 （5）：1609-1613.
7. 　Vander Salm TJ. Unusual primary tumors of the heart. Semin Thorac Cardiovasc Surg， 2000， 12 （2）：89-100.
8. 　Wee JO， Sepic JD， Mihaljevic T， et al. Metastatic carcinoid tumor of the heart. Ann Thorac Surg， 2003， 76 （5）：1721-1722.
9. 　Mastroroberto P， Olivito S， Onorati F， et al. Papillary fibroblastoma of tricuspid valve with pulmonary embolization. Asian Cardiovasc Thorac Ann， 2006， 14 （3）：e53-e54.
10. 　周维新，杨浣宜，王浩，等. 心脏原发良性肿瘤的临床分析及超声诊断价值. 中华超声影像学杂志， 2004， 13 （11）：14-16.
11. 　Meng QG， Lai H， Lima J， et al. Echocardiographic and pathologic characteristics of primary cardiac tumors：a study of 149 cases. Int J Cardiol， 2002， 84 （1）：69-75.
12. 　Neragi-Miandoab S， Kim J， Vlahakes GJ. Malignant tumours of the heart：a review of tumour type， diagnosis and therapy. Clin Oncol （R Coll Radiol）， 2007， 19 （10）：748-756.
13. 　于坤，龙村，黑飞龙，等. 242例外科治疗的心脏肿瘤的临床分析. 中国肿瘤临床， 2006， 33 （15）：877-880， 884.
14. 　韩劲松，安君，阎德民. 原发性心脏肿瘤232例临床分析. 中华外科杂志， 2006， 44 （2）：87-89.
15. 　Karasu BB， Yeter E， Yilmazer D， et al. Primary valvular lipomatous hamartoma：a case report and a collective review of the literature. Cardiovasc Pathol， 2011， 20 （6）：377-380.
16. 　Yuan SM， Shinfeld A， Raanani E. Tricuspid valve myxoma：a case report and a collective review of the literature. J Card Surg， 2009， 24 （1）：69-72.

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Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Surgical Treatment of Cardiac Tumors：Clinical Analysis of 181 Patients

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