Relationship between Platelet and Prognosis of the Total Correction of Tetralogy of Fallot_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHAOJun-fei ,  ANQi

Department of Cardiovascular Surgery Division, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

ANQi, Email: huaxianqi2015@163.com

Keywords：

Platelet; Tetralogy of Fallot; Prognosis

DOI：

10.7507/1007-4848.20150186

Video：

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Objective To explore the relationship between platelet and prognosis of the total correction of tetralogy of Fallot (TOF). Methods We included 11 dead patients with TOF at age of 0-6 years as a death group between 2011 and 2014 year. There were 7 male and 4 female patients at age of 18.6±16.4 months in the death group. We selected 11 matched survival patients according to age, gender of the patients as a survival group. There were also 7 male and 4 female patients at age of 19.4±16.7 months in the death group. The patients were divided into a high-platelet group and a low-platelet group. There were 6 male and 5 female patients in the high-platelet group. While there were 8 male and 3 female patients in the low-platelet group. Inflammatory cytokine and mortality were compared between the two groups. Results Post-operative count of platelet in the death group was significantly lower than that in the live group, while post-operative interleukin-6 (IL-6) and C reactive protein (CRP) were much higher than those in the death group (P<0.05). Mortality was higher in the low-platelet group than that in the high-platelet group (P<0.05). Conclusion Platelets may alleviate inflammatory response and reduce mortality, which played a great role of protection.

Citation： ZHAOJun-fei, ANQi. Relationship between Platelet and Prognosis of the Total Correction of Tetralogy of Fallot. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(8): 744-747. doi: 10.7507/1007-4848.20150186 Copy

1.	Apitz C, Webb GD, Redington AN. Tetralogy of Fallot. Lancet, 2009, 374(9699):1462-1471.
2.	Stephens RS, Shah AS, Whitman GJ. Lung injury and acute respiratory distress syndrome after cardiac surgery. Ann Thorac Surg, 2013, 95(3):1122-1129.
3.	Suzuki T. Additional lung-protective perfusion techniques during cardiopulmonary bypass. Ann Thorac Cardiovasc Surg, 2010, 16(3):150-155.
4.	Bhattacharya J, Matthay MA. Regulation and repair of the alveolarcapillary barrier in acute lung injury. Annu Rev Physiol, 2013, 75:593-615.
5.	Boyle EM Jr, Pohlman TH, Johnson MC, et al. Endothelial cell injury in cardiovascular surgery:the systemic inflammatory response. Ann Thorac Surg, 1997, 63(1):277-284.
6.	Noris M, Remuzzi G. New insights into circulating cell-endothelium interactions and their significance for glomerular pathophysiology. Am J Kidney Dis, 1995, 26:541-548.
7.	Kotani N, Hashimoto H, Sessler DI, et al. Neutrophil number and interleukin-8 and elastase concentrations in bronchoalveolar lavage fluid correlate with decreased arterial oxygenation after cardiopulmonary bypass. Anesth Analg, 2000, 90(5):1046-1051.
8.	Ho-Tin-Noe B, Demers M, Wagner DD. How platelets safeguard vascular integrity. J Thromb Haemost, 2011, 9(Suppl 1):56-65.
9.	Uthoff K, Zehr KJ, Geerling R, et al. Inhibition of platelet adhesion during cardiopulmonary bypass reduces postoperative bleeding. Circulation, 1994, 90 (5 Pt 2):2669-2674.
10.	McGregor L, Martin J, McGregor JL. Platelet-leukocyte aggregates and derived microparticles in inflammation, vascular remodelling and thrombosis. Front Biosci, 2006, 11:830-837.
11.	Chen J, López JA. Interactions of platelets with subendothelium and endothelium. Microcirculation, 2005, 12(3):235-246.
12.	Zhang N, Zhang WJ, Cai HQ, et al. Platelet adhesion and fusion to endothelial cell facilitate the metastasis of tumor cell in hypoxiareoxygenation condition. Clin Exp Metastasis, 2011, 28(1):1-12.
13.	de Boer HC, Verseyden C, Ulfman LH, et al. Fibrin and activated platelets cooperatively guide stem cells to a vascular injury and promote differentiation towards an endothelial cell phenotype. Arterioscler Thromb Vasc Biol, 2006, 26(7):1653-1659.
14.	Devi S, Kuligowski MP, Kwan RY, et al. Platelet recruitment to the inflamed glomerulus occurs via an alphaⅡbbeta3/GPVI-dependent pathway. Am J Pathol, 2010, 177(3):1131-1142.
15.	Slotta JE, Braun OO, Menger MD, et al. Capture of platelets to the endothelium of the femoral vein is mediated by CD62P and CD162. Platelets, 2009, 20(7):505-512.
16.	Guay J, Ruest P, Lortie L. Cardiopulmonary bypass induces significant platelet activation in children undergoing open-heart surgery. Eur J Anaesthesiol, 2004, 21(12):953-956.
17.	Giannini S, Falcinelli E, Bury L, et al. Interaction with damaged vessel wall in vivo in humans induces platelets to express CD40L resulting in endothelial activation with no effect of aspirin intake. Am J Physiol Heart Circ Physiol, 2011, 300(6):2072-2079.
18.	Misoph M, Babin-Ebell J. Inter-individual variations in cytokine levels following cardiopulmonary bypass. Heart Vessels, 1997, 12(3):119-127.
19.	Celik JB, Gormus N, Okesli S, et al. Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass:effects on TNF-alpha, IL-6, IL-8, IL-10. Perfusion, 2004, 19(3):185-191.
20.	Braun OO, Slotta JE, Menger MD, et al. Primary and secondary capture of platelets onto inflamed femoral artery endothelium is dependent on P-selectin and PSGL-1. Eur J Pharmacol, 2008, 592(1-3):128-132.

1. Apitz C, Webb GD, Redington AN. Tetralogy of Fallot. Lancet, 2009, 374(9699):1462-1471.
2. Stephens RS, Shah AS, Whitman GJ. Lung injury and acute respiratory distress syndrome after cardiac surgery. Ann Thorac Surg, 2013, 95(3):1122-1129.
3. Suzuki T. Additional lung-protective perfusion techniques during cardiopulmonary bypass. Ann Thorac Cardiovasc Surg, 2010, 16(3):150-155.
4. Bhattacharya J, Matthay MA. Regulation and repair of the alveolarcapillary barrier in acute lung injury. Annu Rev Physiol, 2013, 75:593-615.
5. Boyle EM Jr, Pohlman TH, Johnson MC, et al. Endothelial cell injury in cardiovascular surgery:the systemic inflammatory response. Ann Thorac Surg, 1997, 63(1):277-284.
6. Noris M, Remuzzi G. New insights into circulating cell-endothelium interactions and their significance for glomerular pathophysiology. Am J Kidney Dis, 1995, 26:541-548.
7. Kotani N, Hashimoto H, Sessler DI, et al. Neutrophil number and interleukin-8 and elastase concentrations in bronchoalveolar lavage fluid correlate with decreased arterial oxygenation after cardiopulmonary bypass. Anesth Analg, 2000, 90(5):1046-1051.
8. Ho-Tin-Noe B, Demers M, Wagner DD. How platelets safeguard vascular integrity. J Thromb Haemost, 2011, 9(Suppl 1):56-65.
9. Uthoff K, Zehr KJ, Geerling R, et al. Inhibition of platelet adhesion during cardiopulmonary bypass reduces postoperative bleeding. Circulation, 1994, 90 (5 Pt 2):2669-2674.
10. McGregor L, Martin J, McGregor JL. Platelet-leukocyte aggregates and derived microparticles in inflammation, vascular remodelling and thrombosis. Front Biosci, 2006, 11:830-837.
11. Chen J, López JA. Interactions of platelets with subendothelium and endothelium. Microcirculation, 2005, 12(3):235-246.
12. Zhang N, Zhang WJ, Cai HQ, et al. Platelet adhesion and fusion to endothelial cell facilitate the metastasis of tumor cell in hypoxiareoxygenation condition. Clin Exp Metastasis, 2011, 28(1):1-12.
13. de Boer HC, Verseyden C, Ulfman LH, et al. Fibrin and activated platelets cooperatively guide stem cells to a vascular injury and promote differentiation towards an endothelial cell phenotype. Arterioscler Thromb Vasc Biol, 2006, 26(7):1653-1659.
14. Devi S, Kuligowski MP, Kwan RY, et al. Platelet recruitment to the inflamed glomerulus occurs via an alphaⅡbbeta3/GPVI-dependent pathway. Am J Pathol, 2010, 177(3):1131-1142.
15. Slotta JE, Braun OO, Menger MD, et al. Capture of platelets to the endothelium of the femoral vein is mediated by CD62P and CD162. Platelets, 2009, 20(7):505-512.
16. Guay J, Ruest P, Lortie L. Cardiopulmonary bypass induces significant platelet activation in children undergoing open-heart surgery. Eur J Anaesthesiol, 2004, 21(12):953-956.
17. Giannini S, Falcinelli E, Bury L, et al. Interaction with damaged vessel wall in vivo in humans induces platelets to express CD40L resulting in endothelial activation with no effect of aspirin intake. Am J Physiol Heart Circ Physiol, 2011, 300(6):2072-2079.
18. Misoph M, Babin-Ebell J. Inter-individual variations in cytokine levels following cardiopulmonary bypass. Heart Vessels, 1997, 12(3):119-127.
19. Celik JB, Gormus N, Okesli S, et al. Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass:effects on TNF-alpha, IL-6, IL-8, IL-10. Perfusion, 2004, 19(3):185-191.
20. Braun OO, Slotta JE, Menger MD, et al. Primary and secondary capture of platelets onto inflamed femoral artery endothelium is dependent on P-selectin and PSGL-1. Eur J Pharmacol, 2008, 592(1-3):128-132.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Relationship between Platelet and Prognosis of the Total Correction of Tetralogy of Fallot

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