Research progress of pulmonary hypertension due to left heart disease_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

QIAN Hong ,  GUO Yingqiang

Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;

Corresponding author：

GUO Yingqiang, Email: drguoyq@hotmail.com

Keywords：

Pulmonary hypertension; diagnosis; pulmonary hypertension due to left heart disease

DOI：

10.7507/1007-4848.201805072

Video：

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Abstract Full text Figures/Tables Video References Cited by

Pulmonary hypertension due to left heart disease (PH-LHD) is the most common in various types of pulmonary hypertension. Although there are many treatments for pulmonary hypertension, it may be harmful when we adopt treatment without detrimental diagnosis and classification of pulmonary hypertension. Therefore, it is very crucial to have accurate diagnosis and classification of pulmonary hypertension before making treatment decisions. However, there are still some difficulties in the classification of pulmonary hypertension in clinical work. It is a great challenge with limited treatment to solve the PH-LHD which often has complicated pathophysiological mechanisms of precapillary and postcapillary pulmonary hypertension. Here, we review the research status of PH-LHD.

Citation： QIAN Hong, GUO Yingqiang. Research progress of pulmonary hypertension due to left heart disease. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2019, 26(4): 394-403. doi: 10.7507/1007-4848.201805072 Copy

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1. Rosenkranz S. Pulmonary hypertension 2015: Current definitions, terminology, and novel treatment options. Clin Res Cardiol, 2015, 104(3): 197-207.
2. Simonneau G, Gatzoulis MA, Adatia I, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol, 2013, 62(25): D34-D41.
3. Galie`N, Hoeper MM, Humbert M, et al. ESC Committee for Practice Guidelines (CPG). Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J, 2009, 30(20): 2493-2537.
4. Hansdottir S, Groskreutz DJ, Gehlbach BK. WHO's in second?: A practical review of World Health Organization group 2 pulmonary hypertension. Chest, 2013, 144(2): 638-650.
5. Guazzi M, Borlaug BA. Pulmonary hypertension due to left heart disease. Circulation, 2012, 126(8): 975-990.
6. Hoeper MM, Barberà JA, Channick RN, et al. Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension. J Am Coll Cardiol, 2009, 54(1 Suppl): S85-S96.
7. Vachiéry JL, Adir Y, Barberà JA, et al. Pulmonary hypertension due to left heart diseases. J Am Coll Cardiol, 2013, 62(25 Suppl): D100-108.
8. Schwartzenberg S, Redfield MM, From AM, et al. Effects of vasodilation in heart failure with preserved or reduced ejection fraction implications of distinct pathophysiologies on response to therapy. J Am Coll Cardiol, 2012, 59(5): 442-451.
9. Borlaug BA, Kane GC, Melenovsky V, et al. Abnormal right ventricular pulmonary artery coupling with exercise in heart failure with preserved ejection fraction. Eur Heart J, 2016, 37(43): 3293-3302.
10. Shah SJ, Kitzman DW, Borlaug BA, et al. Phenotype-specific treatment of heart failure with preserved ejection fraction: a multiorgan roadmap. Circulation, 2016, 134(1): 73-90.
11. Hassoun PM, Mouthon L, Barberà JA, et al. Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol, 2009, 54(1 Suppl): S10-S19.
12. Opitz CF, Hoeper MM, Gibbs JS, et al. Pre-capillary, combined, and post-capillary pulmonary hypertension: a pathophysiological continuum. J Am Coll Cardiol, 2016, 68(4): 368-378.
13. Guha A, Amione-Guerra J, Park MH. Epidemiology of pulmonary hypertension in left heart disease. Prog Cardiovasc Dis, 2016, 59(1): 3-10.
14. McLaughlin VV, Shah SJ, Souza R, et al. Management of pulmonary arterial hypertension. J Am Coll Cardiol, 2015, 65(18): 1976-1997.
15. MacIver DH, Adeniran I, MacIver IR, et al. Physiological mechanisms of pulmonary hypertension. Am Heart J, 2016, 180: 1-11.
16. Opotowsky AR. Clinical evaluation and management of pulmonary hypertension in the adult with congenital heart disease. Circulation, 2015, 131(2): 200-210.
17. Rich JD, Rich S. Clinical diagnosis of pulmonary hypertension. Circulation, 2014, 130(20): 1820-1830.
18. Jamous F. Pulmonary hypertension. Chest, 2014, 145(2): 432-433.
19. Dunlap B, Weyer G. Pulmonary hypertension: diagnosis and treatment. Am Fam Physician, 2016, 94(6): 463-469.
20. Hemnes AR. Pulmonary arterial hypertension treatment guidelines: new answers and even more questions. Chest, 2014, 146(2): 239-241.
21. White RJ. Estrogen: Friend or Foe in pulmonary hypertension? Am J Respir Crit Care Med, 2016, 193(10): 1084-1086.
22. Barnett CF, De Marco T. Treatment of advanced group 2 PH. Prog Cardiovasc Dis, 2016, 59(1): 78-86.
23. Preston IR. Properly diagnosing pulmonary arterial hypertension. Am J Cardiol, 2013, 111(8 Suppl): 2C-9C.
24. Naeije R, D'Alto M. The Diagnostic challenge of group 2 pulmonary hypertension. Prog Cardiovasc Dis, 2016, 59(1): 22-29.
25. Muneuchi J, Nagatomo Y, Watanabe M, et al. Relationship between pulmonary arterial resistance and compliance among patients with pulmonary arterial hypertension and congenital heart disease. J Thorac Cardiovasc Surg, 2016, 152(2): 507-513.
26. Reddy S, Bernstein D. Molecular mechanisms of right ventricular failure. Circulation, 2015, 132(18): 1734-1742.
27. Lala A, Pinney SP. Recognizing pulmonary hypertension and right ventricular dysfunction in heart failure. Prog Cardiovasc Dis, 2016, 58(4): 416-424.
28. Gerges C, Gerges M, Skoro-Sajer N. Hemodynamic thresholds for pre-capillary pulmonary hypertension. Chest, 2016, 149(4): 1061-1073.
29. Gargani L, Pignone A, Agoston G, et al. Clinical and echocardiographic correlations of exercise-induced pulmonary hypertension in systemic sclerosis: a multicenter study. Am Heart J, 2013, 165(2): 200-207.
30. Vanderpool RR, Naeije R. Progress in pulmonary hypertension with left heart failure. beyond new definitions and acronyms. Am J Respir Crit Care Med, 2015, 192(10): 1152-1154.
31. Burger IA, Husmann L, Herzog BA, et al. Main pulmonary artery diameter from attenuation correction CT scans in cardiac SPECT accurately predicts pulmonary hypertension. J Nucl Cardiol, 2011, 18(4): 634-641.
32. Wilcox SR, Kabrhel C, Channick RN. Pulmonary hypertension and right ventricular failure in emergency medicine. Ann Emerg Med, 2015, 66(6): 619-628.
33. Schermuly RT, Ghofrani HA, Wilkins MR, et al. Mechanisms of disease: pulmonary arterial hypertension. Nat Rev Cardiol, 2011, 8(8): 443-455.
34. Tsukashita M, Takayama H, Takeda K, et al. Effect of pulmonary vascular resistance before left ventricular assist device implantation on short- and long-term post-transplant survival. J Thorac Cardiovasc Surg, 2015, 150(5): 1352-1360.
35. Sciancalepore MA, Maffessanti F, Patel AR, et al. Three-dimensional analysis of interventricular septal curvature from cardiac magnetic resonance images for the evaluation of patients with pulmonary hypertension. Int J Cardiovasc Imaging, 2012, 28(5): 1073-1085.
36. Proietti M, Marra AM, Tassone EJ, et al. Frequency of left ventricular hypertrophy in non-valvular atrial fibrillation. Am J Cardiol, 2015, 116(6): 877-882.
37. Hernández-Rivera H, Martínez-González H, Casal J, et al. Pulmonary arterial hypertension: from pathophysiology to management. Bol Asoc Med P R, 2011, 103(1): 34-40.
38. Murray F, Maclean MR, Insel PA. Role of phosphodiesterases in adult-onset pulmonary arterial hypertension. Handb Exp Pharmacol, 2011, (204): 279-305.
39. Chemla D, Humbert M, Sitbon O, et al. Systolic and mean pulmonary artery pressures: are they interchangeable in patients with pulmonary hypertension? Chest, 2015, 147(4): 943-950.
40. Kammerlander AA, Marzluf BA, Graf A, et al. Right ventricular dysfunction, but not tricuspid regurgitation, is associated with outcome late after left heart valve procedure. J Am Coll Cardiol, 2014, 64(24): 2633-2642.
41. Zhou X, Wang D, Castro CY, et al. A pulmonary hypertension model induced by continuous pulmonary air embolization. J Surg Res, 2011, 170(1): e11-e16.
42. Tan Q, Kerestes H, Percy MJ, et al. Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation. J Biol Chem, 2013, 288(24): 17134-17144.
43. Lakshminrusimha S, Konduri GG, Steinhorn RH. Considerations in the management of hypoxemic respiratory failure and persistent pulmonary hypertension in term and late preterm neonates. J Perinatol, 2016, 36(Suppl 2): S12-S19.
44. Guazzi M, Phillips SA, Arena R, et al. Endothelial dysfunction and lung capillary injury in cardiovascular diseases. Prog Cardiovasc Dis, 2015, 57(5): 454-462.
45. Azarbar S, Dupuis J. Lung capillary injury and repair in left heart disease: a new target for therapy? Clin Sci (Lond), 2014, 127(2): 65-76.
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