SCD40 ligand expression and inflammatory response in acute aortic dissection patients_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

HAN Lu ^1,3 , WANG Xiaolong ^2,3 , DAI Lu ^2,3 , LAN Feng ^2,3,4 ,  ZHANG Hongjia ^2,3,4

1. Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, P.R.China;
2. Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, P.R.China;
3. Beijing Lab for Cardiovascular Precision Medicine, Beijing, 100069, P.R.China;
4. Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, P.R.China;

Corresponding author：

ZHANG Hongjia, Email: zhanghongjia722@hotmail.com

Keywords：

Aortic dissection; cluster of differentiation 40L; vascular endothelial cells; inflammatory factors

DOI：

10.7507/1007-4848.201807039

Video：

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Objective To investigate the relationship of cluster of differentiation 40L (CD40L) between inflammatory response mediated by vascular endothelial injury and Stanford A type aortic dissection (STAAD). Methods In this study from August 2016 to February 2017, a total of 215 blood samples from 95 STAAD patients (67 males and 28 females aged 48.33±12.19 years) and 120 healthy volunteers (94 males and 26 females aged 48.64±10.13 years) were collected. The patients with aortic dissection were taken blood 1 hour before the operation and the healthy volunteers were taken blood from the elbow vein. All STAAD patients were diagnozed by computed tomography angiography (CTA) and patients with Marfan syndrome were excluded. Blood samples were tested by enzyme-linked immunosorbent assay (ELISA) for CD40L, vascular cell adhesion molecule (VCAM-1), E-selectin, interleukin-1 (IL-1) beta, IL-6, tumor necrosis factor-alpha (TNF-α) and so on. Results Compared with the healthy population, the level of SCD40L(26.87±5.50 ng/ml vs. 13.39±4.03 ng/ml, P<0.001) in the STAAD patients was significantly higher. E-Selectin (116.62±25.24 ng/ml vs. 77.05±14.30 ng/ml, P<0.001), VCAM-1 (P<0.001), TNF-α (55.35±9.12 ng/ml vs. 37.33±5.61 pg/ml, P<0.001), IL-1β (62.12±13.37 ng/ml vs. 48.68±9.86 pg/ml, P<0.001), IL-6 (499.54±90.45 ng/ml vs. 422.44±34.00 pg/ml, P<0.001) significantly increased. Conclusion The increased expression of SCD40L in STAAD patients and the inflammatory reaction induced by endothelial injury in aortic dissection patients are obvious.

Citation： HAN Lu, WANG Xiaolong, DAI Lu, LAN Feng, ZHANG Hongjia. SCD40 ligand expression and inflammatory response in acute aortic dissection patients. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2019, 26(4): 301-305. doi: 10.7507/1007-4848.201807039 Copy

1.	Hiratzka LF, Bakris GL, Beckman JA, et al. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease: executive summary. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Catheter Cardiovasc Interv, 2010, 76(2): E43-E86.
2.	Erbel R, Aboyans V, Boileau C, et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). Eur Heart J, 2014, 35(41): 2873-2926.
3.	Kurihara T, Shimizu-Hirota R, Shimoda M, et al. Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection. Circulation, 2012, 126(25): 3070-3080.
4.	肖正华, 古君, 胡佳, 等. 基于炎症反应变化程度的主动脉夹层病程分期的初步探讨. 中国胸心血管外科临床杂志, 2014, 21(6): 721-724.
5.	Aloui C, Prigent A, Sut C, et al. The signaling role of CD40 ligand in platelet biology and in platelet component transfusion. Int J Mol Sci, 2014, 15(12): 22342-22364.
6.	Lievens D, Eijgelaar WJ, Biessen EA, et al. The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost, 2009, 102(2): 206-214.
7.	Pope CA 3rd, Bhatnagar A, McCracken JP, et al. Exposure to gine particulate air pollution is associated with endothelial injury and systemic inflammation. Circ Res, 2016, 119(11): 1204-1214.
8.	Howard DP, Banerjee A, Fairhead JF, et al. Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control: 10-year results from the Oxford Vascular Study. Circulation, 2013, 127(20): 2031-2037.
9.	Pape LA, Awais M, Woznicki EM, et al. Presentation, diagnosis, and outcomes of acute aortic dissection: 17-year trends from the international registry of acute aortic dissection. J Am Coll Cardiol, 2015, 66(4): 350-358.
10.	Nienaber CA, Clough RE. Management of acute aortic dissection. Lancet, 2015, 385(9970): 800-811.
11.	Müller KA, Chatterjee M, Rath D, et al. Platelets, inflammation and anti-inflammatory effects of antiplatelet drugs in ACS and CAD. Thromb Haemost, 2015, 114(3): 498-518.
12.	Ren W, Liu Y, Wang X, et al. β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice. Sci Rep, 2016, 6: 28149.
13.	Morioka S, Inagaki M, Komatsu Y, et al. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood, 2012, 120(18): 3846-3857.
14.	Randhawa PK, Rylova S, Heinz JY, et al. The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration. Circ Res, 2011, 108(10): 1199-1208.
15.	Han L, Dai L, Zhao YF, et al. CD40L promotes development of acute aortic dissection via induction of inflammation and impairment of endothelial cell function. Aging (Albany NY), 2018,[Epub ahead of print].
16.	Schiro A, Wilkinson FL, Weston R, et al. Endothelial microparticles as conveyors of information in atherosclerotic disease. Atherosclerosis, 2014, 234(2): 295-302.
17.	Proietta M, Tritapepe L, Cifani N, et al. MMP-12 as a new marker of Stanford-A acute aortic dissection. Ann Med, 2014, 46(1): 44-48.
18.	Cifani N, Proietta M, Tritapepe L, et al. Stanford-A acute aortic dissection, inflammation, and metalloproteinases: a review. Ann Med, 2015, 47(6): 441-446.
19.	del Porto F, Proietta M, Tritapepe L, et al. Inflammation and immune response in acute aortic dissection. Ann Med, 2010, 42(8): 622-629.

1. Hiratzka LF, Bakris GL, Beckman JA, et al. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease: executive summary. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Catheter Cardiovasc Interv, 2010, 76(2): E43-E86.
2. Erbel R, Aboyans V, Boileau C, et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). Eur Heart J, 2014, 35(41): 2873-2926.
3. Kurihara T, Shimizu-Hirota R, Shimoda M, et al. Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection. Circulation, 2012, 126(25): 3070-3080.
4. 肖正华, 古君, 胡佳, 等. 基于炎症反应变化程度的主动脉夹层病程分期的初步探讨. 中国胸心血管外科临床杂志, 2014, 21(6): 721-724.
5. Aloui C, Prigent A, Sut C, et al. The signaling role of CD40 ligand in platelet biology and in platelet component transfusion. Int J Mol Sci, 2014, 15(12): 22342-22364.
6. Lievens D, Eijgelaar WJ, Biessen EA, et al. The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost, 2009, 102(2): 206-214.
7. Pope CA 3rd, Bhatnagar A, McCracken JP, et al. Exposure to gine particulate air pollution is associated with endothelial injury and systemic inflammation. Circ Res, 2016, 119(11): 1204-1214.
8. Howard DP, Banerjee A, Fairhead JF, et al. Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control: 10-year results from the Oxford Vascular Study. Circulation, 2013, 127(20): 2031-2037.
9. Pape LA, Awais M, Woznicki EM, et al. Presentation, diagnosis, and outcomes of acute aortic dissection: 17-year trends from the international registry of acute aortic dissection. J Am Coll Cardiol, 2015, 66(4): 350-358.
10. Nienaber CA, Clough RE. Management of acute aortic dissection. Lancet, 2015, 385(9970): 800-811.
11. Müller KA, Chatterjee M, Rath D, et al. Platelets, inflammation and anti-inflammatory effects of antiplatelet drugs in ACS and CAD. Thromb Haemost, 2015, 114(3): 498-518.
12. Ren W, Liu Y, Wang X, et al. β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice. Sci Rep, 2016, 6: 28149.
13. Morioka S, Inagaki M, Komatsu Y, et al. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood, 2012, 120(18): 3846-3857.
14. Randhawa PK, Rylova S, Heinz JY, et al. The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration. Circ Res, 2011, 108(10): 1199-1208.
15. Han L, Dai L, Zhao YF, et al. CD40L promotes development of acute aortic dissection via induction of inflammation and impairment of endothelial cell function. Aging (Albany NY), 2018,[Epub ahead of print].
16. Schiro A, Wilkinson FL, Weston R, et al. Endothelial microparticles as conveyors of information in atherosclerotic disease. Atherosclerosis, 2014, 234(2): 295-302.
17. Proietta M, Tritapepe L, Cifani N, et al. MMP-12 as a new marker of Stanford-A acute aortic dissection. Ann Med, 2014, 46(1): 44-48.
18. Cifani N, Proietta M, Tritapepe L, et al. Stanford-A acute aortic dissection, inflammation, and metalloproteinases: a review. Ann Med, 2015, 47(6): 441-446.
19. del Porto F, Proietta M, Tritapepe L, et al. Inflammation and immune response in acute aortic dissection. Ann Med, 2010, 42(8): 622-629.

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