Comparison of surgical treatment for cervical esophageal squamous cell carcinoma and upper thoracic esophageal squamous cell carcinoma: A propensity score matching analysis_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

WANG Wuping , MA Jie , ZHANG Jipeng , WANG Tao ,  LU Qiang ,  ZHAO Jinbo , YAN Xiaolong , LEI Jie , NI Yunfeng , HUANG Lijun , LI Xiaofe , JIANG Tao

Department of Thoracic Surgery, Tangdu Hospital, Air Force Military Medical University, Xi'an, 710032, P.R.China;

Corresponding author：

LU Qiang, Email: luqianglu@126.com; ZHAO Jinbo, Email: zhaojinbo@aliyun.com

Keywords：

Cervical esophageal squamous cell carcinoma; upper thoracic esophageal squamous cell carcinoma; surgery; prognosis; survival

DOI：

10.7507/1007-4848.202005005

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the clinical outcomes of larynx-preserving limited resection with total thoracic esophagectomy and gastric pull-up reconstruction for the treatment of cervical esophageal squamous cell carcinoma (ESCC) without tumor involvement of the larynx and hypopharynx compared with the upper thoracic ESCC.Methods Retrospective and comparative analysis of consecutive patients with cervical and upper thoracic ESCC who underwent R0 surgical resection from 2006 to 2011 in our center was performed. Kaplan-Meier method was used to calculate the patients’ survival.Results In total, 44 pairs of patients, including 71 males and 17 females with an average age of 60.66±8.49 years were enrolled in the study after propensity score matching. The baseline characteristics of the two groups of patients were well balanced. There was no statistical difference in the operation time (P=0.100), blood loss (P=0.685), mortality rate in 30 days (P=1.000), total complication rate (P=0.829), cervical anastomosis leakage (P=0.816), mechanical ventilation (P=1.000), normal oral diet within 15 days (P=0.822) and anastomosis recurrence rate (P=0.676) between the two groups. Survival analysis showed that there was no statistical difference in survival time between the cervical group [31.83 (95%CI 8.65-55.02) months] and upper thoracic group [37.73 (95%CI 25.29-50.18) months, P=0.533]. The 5-year survival rates were 32.6% and 42.1%, respectively.Conclusion Larynx-preserving limited resection with total thoracic esophagectomy and gastric pull-up reconstruction for the treatment of cervical ESCC without involvement of the larynx and hypopharynx may result in a similar clinical outcome to upper thoracic ESCC.

Citation： WANG Wuping, MA Jie, ZHANG Jipeng, WANG Tao, LU Qiang, ZHAO Jinbo, YAN Xiaolong, LEI Jie, NI Yunfeng, HUANG Lijun, LI Xiaofe, JIANG Tao. Comparison of surgical treatment for cervical esophageal squamous cell carcinoma and upper thoracic esophageal squamous cell carcinoma: A propensity score matching analysis. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2021, 28(6): 701-708. doi: 10.7507/1007-4848.202005005 Copy

1.	Lee DJ, Harris A, Gillette A, et al. Carcinoma of the cervical esophagus: Diagnosis, management, and results. South Med J, 1984, 77(11): 1365-1367.
2.	Grass GD, Cooper SL, Armeson K, et al. Cervical esophageal cancer: A population-based study. Head Neck, 2015, 37(6): 808-814.
3.	Tong DK, Law S, Kwong DL, et al. Current management of cervical esophageal cancer. World J Surg, 2011, 35(3): 600-607.
4.	Cooper JS, Guo MD, Herskovic A, et al. Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group, JAMA, 1999, 281(17): 1623-1627.
5.	Wang S, Liao Z, Chen Y, et al. Esophageal cancer located at the neck and upper thorax treated with concurrent chemoradiation: A single-institution experience. J Thorac Oncol, 2006, 1(3): 252-259.
6.	Uno T, Isobe K, Kawakami H, et al. Concurrent chemoradiation for patients with squamous cell carcinoma of the cervical esophagus. Dis Esophagus, 2007, 20: 12-18.
7.	Bidoli P, Bajetta E, Stani SC, et al. Ten-year survival with chemotherapy and radiotherapy in patients with squamous cell carcinoma of the esophagus. Cancer, 2002, 94(2): 352-361.
8.	Stuschke M, Stahl M, Wilke H, et al. Induction chemotherapy followed by concurrent chemotherapy and high-dose radiotherapy for locally advanced squamous cell carcinoma of the cervical oesophagus. Oncology, 1999, 57(2): 99-105.
9.	Chou SH, Li HP, Lee JY, et al. Radical resection or chemoradiotherapy for cervical esophageal cancer? World J Surg, 2010, 34(8): 1832-1839.
10.	Sun F, Li X, Lei D, et al. Surgical management of cervical esophageal carcinoma with larynx preservation and reconstruction. Int J Clin Exp Med, 2014, 7(9): 2771-2778.
11.	Ott K, Lordick F, Molls M, et al. Limited resection and free jejunal graft interposition for squamous cell carcinoma of the cervical oesophagus. Br J Surg, 2009, 96(3): 258-266.
12.	Daiko H, Hayashi R, Saikawa M, et al. Surgical management of carcinoma of the cervical esophagus. J Surg Oncol, 2007, 96(2): 166-172.
13.	Miyata H, Yamasaki M, Takahashi T, et al. Larynx-preserving limited resection and free jejunal graft for carcinoma of the cervical esophagus. World J Surg, 2013, 37(3): 551-557.
14.	Cao CN, Liu SY, Luo JW, et al. Pattern of failure in surgically treated patients with cervical esophageal squamous cell carcinoma. Otolaryngol Head Neck Surg, 2014, 151(2): 260-264.
15.	Wang HW, Chu PY, Kuo KT, et al. A reappraisal of surgical management for squamous cell carcinoma in the pharyngoesophageal junction. J Surg Oncol, 2006, 93(6): 468-476.
16.	Ferahkose Z, Bedirli A, Kerem M, et al. Comparison of free jejunal graft with gastric pull-up reconstruction after resection of hypopharyngeal and cervical esophageal carcinoma. Dis Esophagus, 2008, 21(4): 340-345.
17.	Shuangba H, Jingwu S, Yinfeng W, et al. Complication following gastric pull-up reconstruction for advanced hypopharyngeal or cervical esophageal carcinoma: A 20-year review in a Chinese institute. Am J Otolaryngol, 2011, 32(4): 275-278.
18.	Triboulet JP, Mariette C, Chevalier D, et al. Surgical management of carcinoma of the hypopharynx and cervical esophagus: Analysis of 209 cases. Arch Surg, 2001, 136(10): 1164-1170.
19.	Shirakawa Y, Naomoto Y, Noma K, et al. Free jejunal graft for hypopharyngeal and esophageal reconstruction. Langenbecks Arch Surg, 2004, 389(5): 387-390.
20.	Kadota H, Sakuraba M, Kimata Y, et al. Larynx-preserving esophagectomy and jejunal transfer for cervical esophageal carcinoma. Laryngoscope, 2009, 119(7): 1274-1280.
21.	Laterza E, Mosciaro O, Urso US, et al. Primary carcinoma of the hypopharynx and cervical esophagus: evolution of surgical therapy. Hepatogastroenterology, 1994, 41(3): 278-282.
22.	Lam KH, Wong J, Lim STK, et al. Pharyngogastric anastomosis following pharyngolaryngoesophagectomy: Analysis of 157 cases. World J Surg, 1981, 5(4): 509-516.
23.	Peracchia A, Bardini R, Ruol A, et al. Surgical management of carcinoma of the hypopharynx and cervical esophagus. Hepatogastroenterology, 1990, 37(4): 371-375.
24.	Sullivan MW, Talamonti MS, Sithanandam K, et al. Results of gastric interposition for reconstruction of the pharyngoesophagus. Surgery, 1999, 126(4): 666-672.
25.	Dudhat SB, Mistry RC, Fakih AR. Complications following gastric transposition after total laryngo-pharyngectomy. Eur J Surg Oncol, 1999, 25(1): 82-85.
26.	Chen SB, Yang XH, Weng HR, et al. Clinicopathological features and surgical treatment of cervical oesophageal cancer. Sci Rep, 2017, 7(1): 3272.

1. Lee DJ, Harris A, Gillette A, et al. Carcinoma of the cervical esophagus: Diagnosis, management, and results. South Med J, 1984, 77(11): 1365-1367.
2. Grass GD, Cooper SL, Armeson K, et al. Cervical esophageal cancer: A population-based study. Head Neck, 2015, 37(6): 808-814.
3. Tong DK, Law S, Kwong DL, et al. Current management of cervical esophageal cancer. World J Surg, 2011, 35(3): 600-607.
4. Cooper JS, Guo MD, Herskovic A, et al. Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group, JAMA, 1999, 281(17): 1623-1627.
5. Wang S, Liao Z, Chen Y, et al. Esophageal cancer located at the neck and upper thorax treated with concurrent chemoradiation: A single-institution experience. J Thorac Oncol, 2006, 1(3): 252-259.
6. Uno T, Isobe K, Kawakami H, et al. Concurrent chemoradiation for patients with squamous cell carcinoma of the cervical esophagus. Dis Esophagus, 2007, 20: 12-18.
7. Bidoli P, Bajetta E, Stani SC, et al. Ten-year survival with chemotherapy and radiotherapy in patients with squamous cell carcinoma of the esophagus. Cancer, 2002, 94(2): 352-361.
8. Stuschke M, Stahl M, Wilke H, et al. Induction chemotherapy followed by concurrent chemotherapy and high-dose radiotherapy for locally advanced squamous cell carcinoma of the cervical oesophagus. Oncology, 1999, 57(2): 99-105.
9. Chou SH, Li HP, Lee JY, et al. Radical resection or chemoradiotherapy for cervical esophageal cancer? World J Surg, 2010, 34(8): 1832-1839.
10. Sun F, Li X, Lei D, et al. Surgical management of cervical esophageal carcinoma with larynx preservation and reconstruction. Int J Clin Exp Med, 2014, 7(9): 2771-2778.
11. Ott K, Lordick F, Molls M, et al. Limited resection and free jejunal graft interposition for squamous cell carcinoma of the cervical oesophagus. Br J Surg, 2009, 96(3): 258-266.
12. Daiko H, Hayashi R, Saikawa M, et al. Surgical management of carcinoma of the cervical esophagus. J Surg Oncol, 2007, 96(2): 166-172.
13. Miyata H, Yamasaki M, Takahashi T, et al. Larynx-preserving limited resection and free jejunal graft for carcinoma of the cervical esophagus. World J Surg, 2013, 37(3): 551-557.
14. Cao CN, Liu SY, Luo JW, et al. Pattern of failure in surgically treated patients with cervical esophageal squamous cell carcinoma. Otolaryngol Head Neck Surg, 2014, 151(2): 260-264.
15. Wang HW, Chu PY, Kuo KT, et al. A reappraisal of surgical management for squamous cell carcinoma in the pharyngoesophageal junction. J Surg Oncol, 2006, 93(6): 468-476.
16. Ferahkose Z, Bedirli A, Kerem M, et al. Comparison of free jejunal graft with gastric pull-up reconstruction after resection of hypopharyngeal and cervical esophageal carcinoma. Dis Esophagus, 2008, 21(4): 340-345.
17. Shuangba H, Jingwu S, Yinfeng W, et al. Complication following gastric pull-up reconstruction for advanced hypopharyngeal or cervical esophageal carcinoma: A 20-year review in a Chinese institute. Am J Otolaryngol, 2011, 32(4): 275-278.
18. Triboulet JP, Mariette C, Chevalier D, et al. Surgical management of carcinoma of the hypopharynx and cervical esophagus: Analysis of 209 cases. Arch Surg, 2001, 136(10): 1164-1170.
19. Shirakawa Y, Naomoto Y, Noma K, et al. Free jejunal graft for hypopharyngeal and esophageal reconstruction. Langenbecks Arch Surg, 2004, 389(5): 387-390.
20. Kadota H, Sakuraba M, Kimata Y, et al. Larynx-preserving esophagectomy and jejunal transfer for cervical esophageal carcinoma. Laryngoscope, 2009, 119(7): 1274-1280.
21. Laterza E, Mosciaro O, Urso US, et al. Primary carcinoma of the hypopharynx and cervical esophagus: evolution of surgical therapy. Hepatogastroenterology, 1994, 41(3): 278-282.
22. Lam KH, Wong J, Lim STK, et al. Pharyngogastric anastomosis following pharyngolaryngoesophagectomy: Analysis of 157 cases. World J Surg, 1981, 5(4): 509-516.
23. Peracchia A, Bardini R, Ruol A, et al. Surgical management of carcinoma of the hypopharynx and cervical esophagus. Hepatogastroenterology, 1990, 37(4): 371-375.
24. Sullivan MW, Talamonti MS, Sithanandam K, et al. Results of gastric interposition for reconstruction of the pharyngoesophagus. Surgery, 1999, 126(4): 666-672.
25. Dudhat SB, Mistry RC, Fakih AR. Complications following gastric transposition after total laryngo-pharyngectomy. Eur J Surg Oncol, 1999, 25(1): 82-85.
26. Chen SB, Yang XH, Weng HR, et al. Clinicopathological features and surgical treatment of cervical oesophageal cancer. Sci Rep, 2017, 7(1): 3272.

Previous Article
新辅助治疗胃癌术后并发症的预防及处理
Next Article
新辅助治疗胃癌术后并发症的预防及处理

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Comparison of surgical treatment for cervical esophageal squamous cell carcinoma and upper thoracic esophageal squamous cell carcinoma: A propensity score matching analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content